{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:05:38Z","timestamp":1792605938815,"version":"4.5.0"},"reference-count":57,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,13]],"date-time":"2022-12-13T00:00:00Z","timestamp":1670889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K99ES031050"],"award-info":[{"award-number":["K99ES031050"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports Methods"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.crmeth.2022.100381","type":"journal-article","created":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T11:08:51Z","timestamp":1672916931000},"page":"100381","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Social behavioral profiling by unsupervised deep learning reveals a stimulative effect of dopamine D3 agonists on zebrafish sociality"],"prefix":"10.1016","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4667-891X","authenticated-orcid":false,"given":"Yijie","family":"Geng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Yates","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0727-3469","authenticated-orcid":false,"given":"Randall T.","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.crmeth.2022.100381_bib1","doi-asserted-by":"crossref","first-page":"e441","DOI":"10.1542\/peds.2007-0984","article-title":"Psychotropic medication use among Medicaid-enrolled children with autism spectrum disorders","volume":"121","author":"Mandell","year":"2008","journal-title":"Pediatrics"},{"key":"10.1016\/j.crmeth.2022.100381_bib2","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s00787-015-0780-7","article-title":"Clinical predictors of antipsychotic use in children and adolescents with autism spectrum disorders: a historical open cohort study using electronic health records","volume":"25","author":"Downs","year":"2016","journal-title":"Eur. Child Adolesc. Psychiatry"},{"key":"10.1016\/j.crmeth.2022.100381_bib3","doi-asserted-by":"crossref","first-page":"dmm039446","DOI":"10.1242\/dmm.039446","article-title":"The zebrafish subcortical social brain as a model for studying social behavior disorders","volume":"12","author":"Geng","year":"2019","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.crmeth.2022.100381_bib4","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nchembio.307","article-title":"Rapid behavior-based identification of neuroactive small molecules in the zebrafish","volume":"6","author":"Kokel","year":"2010","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.crmeth.2022.100381_bib5","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nchembio.2097","article-title":"Zebrafish behavioral profiling identifies multitarget antipsychotic-like compounds","volume":"12","author":"Bruni","year":"2016","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.crmeth.2022.100381_bib6","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1126\/science.1183090","article-title":"Zebrafish behavioral profiling links drugs to biological targets and rest\/wake regulation","volume":"327","author":"Rihel","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.crmeth.2022.100381_bib7","doi-asserted-by":"crossref","first-page":"eaav1966","DOI":"10.1126\/sciadv.aav1966","article-title":"High-throughput screening for selective appetite modulators: a multibehavioral and translational drug discovery strategy","volume":"4","author":"Jordi","year":"2018","journal-title":"Sci. Adv."},{"key":"10.1016\/j.crmeth.2022.100381_bib8","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3389\/fncir.2015.00039","article-title":"Development of social behavior in young zebrafish","volume":"9","author":"Dreosti","year":"2015","journal-title":"Front. Neural Circuits"},{"key":"10.1016\/j.crmeth.2022.100381_bib9","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1016\/j.cub.2018.06.016","article-title":"Forebrain control of behaviorally driven social orienting in zebrafish","volume":"28","author":"Stednitz","year":"2018","journal-title":"Curr. Biol."},{"key":"10.1016\/j.crmeth.2022.100381_bib10","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.bbr.2007.07.007","article-title":"Quantification of shoaling behaviour in zebrafish (Danio rerio)","volume":"184","author":"Miller","year":"2007","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.crmeth.2022.100381_bib11","doi-asserted-by":"crossref","first-page":"100942","DOI":"10.1016\/j.isci.2020.100942","article-title":"Genetic control of collective behavior in zebrafish","volume":"23","author":"Tang","year":"2020","journal-title":"iScience"},{"key":"10.1016\/j.crmeth.2022.100381_bib12","doi-asserted-by":"crossref","first-page":"20140672","DOI":"10.1098\/rsif.2014.0672","article-title":"Mapping the stereotyped behaviour of freely moving fruit flies","volume":"11","author":"Berman","year":"2014","journal-title":"J.\u00a0R. Soc. Interface"},{"key":"10.1016\/j.crmeth.2022.100381_bib13","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/3-540-45103-X_50","article-title":"Two-frame motion estimation based on polynomial expansion","volume":"2749","author":"Farneb\u00e4ck","year":"2003","journal-title":"Lect Notes Comput Sc"},{"key":"10.1016\/j.crmeth.2022.100381_bib14","first-page":"2579","article-title":"Visualizing high-dimensional data using t-SNE","volume":"9","author":"Van der Maaten","year":"2008","journal-title":"J.\u00a0Mach. Learn. Res."},{"key":"10.1016\/j.crmeth.2022.100381_bib15","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.neucom.2013.11.045","article-title":"Parametric nonlinear dimensionality reduction using kernel t-SNE","volume":"147","author":"Gisbrecht","year":"2015","journal-title":"Neurocomputing"},{"key":"10.1016\/j.crmeth.2022.100381_bib16","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1101\/sqb.2014.79.024711","article-title":"Dopaminergic dynamics contributing to social behavior","volume":"79","author":"Gunaydin","year":"2014","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"10.1016\/j.crmeth.2022.100381_bib17","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.neubiorev.2011.12.009","article-title":"The reciprocal interaction between serotonin and social behaviour","volume":"36","author":"Kiser","year":"2012","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.crmeth.2022.100381_bib18","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1111\/bph.13808","article-title":"Mu opioid receptor, social behaviour and autism spectrum disorder: reward matters","volume":"175","author":"Pellissier","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.crmeth.2022.100381_bib19","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.expneurol.2017.04.017","article-title":"The valproic acid-induced rodent model of autism","volume":"299","author":"Nicolini","year":"2018","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.crmeth.2022.100381_bib20","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ntt.2018.01.002","article-title":"Developmental and behavioral alterations in zebrafish embryonically exposed to valproic acid (VPA): an aquatic model for autism","volume":"66","author":"Chen","year":"2018","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.crmeth.2022.100381_bib21","article-title":"Top2a promotes the development of social behavior via PRC2 and H3K27me3","author":"Geng","year":"2021","journal-title":"bioRxiv"},{"key":"10.1016\/j.crmeth.2022.100381_bib22","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/nmeth.1328","article-title":"High-throughput ethomics in large groups of Drosophila","volume":"6","author":"Branson","year":"2009","journal-title":"Nat. Methods"},{"key":"10.1016\/j.crmeth.2022.100381_bib23","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/nmeth.1310","article-title":"Automated monitoring and analysis of social behavior in Drosophila","volume":"6","author":"Dankert","year":"2009","journal-title":"Nat. Methods"},{"key":"10.1016\/j.crmeth.2022.100381_bib24","doi-asserted-by":"crossref","first-page":"180679","DOI":"10.1098\/rsos.180679","article-title":"Zebrafish aggression on the sub-second time scale: evidence for mutual motor coordination and multi-functional attack manoeuvres","volume":"5","author":"Laan","year":"2018","journal-title":"R.\u00a0Soc. Open Sci."},{"key":"10.1016\/j.crmeth.2022.100381_bib25","doi-asserted-by":"crossref","first-page":"E5351","DOI":"10.1073\/pnas.1515982112","article-title":"Automated measurement of mouse social behaviors using depth sensing, video tracking, and machine learning","volume":"112","author":"Hong","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1016\/j.crmeth.2022.100381_bib26","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/nmeth.1924","article-title":"Computerized video analysis of social interactions in mice","volume":"9","author":"de Chaumont","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.crmeth.2022.100381_bib27","doi-asserted-by":"crossref","first-page":"10149","DOI":"10.1073\/pnas.1703817114","article-title":"Discrete modes of social information processing predict individual behavior of fish in a group","volume":"114","author":"Harpaz","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1016\/j.crmeth.2022.100381_bib28","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1073\/pnas.1211447110","article-title":"A dictionary of behavioral motifs reveals clusters of genes affecting Caenorhabditis elegans locomotion","volume":"110","author":"Brown","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1016\/j.crmeth.2022.100381_bib29","doi-asserted-by":"crossref","first-page":"7286","DOI":"10.1073\/pnas.1007868108","article-title":"Emergence of long timescales and stereotyped behaviors in Caenorhabditis elegans","volume":"108","author":"Stephens","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1016\/j.crmeth.2022.100381_bib30","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1073\/pnas.1813476116","article-title":"Adaptive, locally linear models of complex dynamics","volume":"116","author":"Costa","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1016\/j.crmeth.2022.100381_bib31","doi-asserted-by":"crossref","first-page":"e1000028","DOI":"10.1371\/journal.pcbi.1000028","article-title":"Dimensionality and dynamics in the behavior of C. elegans","volume":"4","author":"Stephens","year":"2008","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.crmeth.2022.100381_bib32","doi-asserted-by":"crossref","first-page":"e17227","DOI":"10.7554\/eLife.17227","article-title":"Resolving coiled shapes reveals new reorientation behaviors in C. elegans","volume":"5","author":"Broekmans","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.crmeth.2022.100381_bib33","doi-asserted-by":"crossref","first-page":"20160466","DOI":"10.1098\/rsif.2016.0466","article-title":"Hierarchical compression of Caenorhabditis elegans locomotion reveals phenotypic differences in the organization of behaviour","volume":"13","author":"Gomez-Marin","year":"2016","journal-title":"J.\u00a0R. Soc. Interface"},{"key":"10.1016\/j.crmeth.2022.100381_bib34","doi-asserted-by":"crossref","first-page":"20150899","DOI":"10.1098\/rsif.2015.0899","article-title":"Searching for motifs in the behaviour of larval Drosophila melanogaster and Caenorhabditis elegans reveals continuity between behavioural states","volume":"12","author":"Szigeti","year":"2015","journal-title":"J.\u00a0R. Soc. Interface"},{"key":"10.1016\/j.crmeth.2022.100381_bib35","doi-asserted-by":"crossref","first-page":"11943","DOI":"10.1073\/pnas.1607601113","article-title":"Predictability and hierarchy in Drosophila behavior","volume":"113","author":"Berman","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"10.1016\/j.crmeth.2022.100381_bib36","doi-asserted-by":"crossref","first-page":"015002","DOI":"10.1088\/1478-3975\/14\/1\/015002","article-title":"Systematic exploration of unsupervised methods for mapping behavior","volume":"14","author":"Todd","year":"2017","journal-title":"Phys. Biol."},{"key":"10.1016\/j.crmeth.2022.100381_bib37","doi-asserted-by":"crossref","first-page":"e46409","DOI":"10.7554\/eLife.46409","article-title":"The manifold structure of limb coordination in walking Drosophila","volume":"8","author":"DeAngelis","year":"2019","journal-title":"Elife"},{"key":"10.1016\/j.crmeth.2022.100381_bib38","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/s41592-018-0234-5","article-title":"Fast animal pose estimation using deep neural networks","volume":"16","author":"Pereira","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.crmeth.2022.100381_bib39","doi-asserted-by":"crossref","first-page":"e34275","DOI":"10.7554\/eLife.34275","article-title":"Optogenetic dissection of descending behavioral control in Drosophila","volume":"7","author":"Cande","year":"2018","journal-title":"Elife"},{"key":"10.1016\/j.crmeth.2022.100381_bib40","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.cub.2017.12.002","article-title":"Structure of the zebrafish locomotor repertoire revealed with unsupervised behavioral clustering","volume":"28","author":"Marques","year":"2018","journal-title":"Curr. Biol."},{"key":"10.1016\/j.crmeth.2022.100381_bib41","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.cub.2019.11.022","article-title":"Deconstructing hunting behavior reveals a tightly coupled stimulus-response loop","volume":"30","author":"Mearns","year":"2020","journal-title":"Curr. Biol."},{"key":"10.1016\/j.crmeth.2022.100381_bib42","doi-asserted-by":"crossref","first-page":"e04878","DOI":"10.7554\/eLife.04878","article-title":"A dedicated visual pathway for prey detection in larval zebrafish","volume":"3","author":"Semmelhack","year":"2014","journal-title":"Elife"},{"key":"10.1016\/j.crmeth.2022.100381_bib43","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0408-19.2020","article-title":"Hierarchical compression reveals sub-second to day-long structure in larval zebrafish behavior","volume":"7","author":"Ghosh","year":"2020","journal-title":"eNeuro"},{"key":"10.1016\/j.crmeth.2022.100381_bib44","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.neuron.2015.11.031","article-title":"Mapping sub-second structure in mouse behavior","volume":"88","author":"Wiltschko","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.crmeth.2022.100381_bib45","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.cell.2018.04.019","article-title":"The striatum organizes 3D behavior via moment-to-moment action selection","volume":"174","author":"Markowitz","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.crmeth.2022.100381_bib46","doi-asserted-by":"crossref","first-page":"015006","DOI":"10.1088\/1478-3975\/aa5c50","article-title":"An unsupervised method for quantifying the behavior of paired animals","volume":"14","author":"Klibaite","year":"2017","journal-title":"Phys. Biol."},{"key":"10.1016\/j.crmeth.2022.100381_bib47","doi-asserted-by":"crossref","first-page":"e1008230","DOI":"10.1371\/journal.pcbi.1008230","article-title":"Paired fruit flies synchronize behavior: uncovering social interactions in Drosophila melanogaster","volume":"16","author":"Klibaite","year":"2020","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.crmeth.2022.100381_bib48","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/s41592-018-0295-5","article-title":"idtracker.ai: tracking all individuals in small or large collectives of unmarked animals","volume":"16","author":"Romero-Ferrero","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.crmeth.2022.100381_bib49","article-title":"3D tracking swimming fish school with learned kinematic model using LSTM network","author":"Wang","year":"2017","journal-title":"IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP)"},{"key":"10.1016\/j.crmeth.2022.100381_bib50","doi-asserted-by":"crossref","first-page":"e1007354","DOI":"10.1371\/journal.pcbi.1007354","article-title":"Deep attention networks reveal the rules of collective motion in zebrafish","volume":"15","author":"Heras","year":"2019","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.crmeth.2022.100381_bib51","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1177\/0269881108098144","article-title":"Dopaminergic challenges in social anxiety disorder: evidence for dopamine D3 desensitisation following successful treatment with serotonergic antidepressants","volume":"24","author":"Hood","year":"2010","journal-title":"J.\u00a0Psychopharmacol."},{"key":"10.1016\/j.crmeth.2022.100381_bib52","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0006-8993(96)00288-0","article-title":"Dopamine D3 agonists disrupt social behavior in rats","volume":"721","author":"Kagaya","year":"1996","journal-title":"Brain Res."},{"key":"10.1016\/j.crmeth.2022.100381_bib53","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0166-4328(00)00193-5","article-title":"D(3) and D(2) dopamine receptor agonists differentially modulate isolation-induced social-emotional reactivity in mice","volume":"114","author":"Gendreau","year":"2000","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.crmeth.2022.100381_bib54","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.neuron.2015.12.039","article-title":"Estrogens suppress a behavioral phenotype in zebrafish mutants of the autism risk gene, CNTNAP2","volume":"89","author":"Hoffman","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.crmeth.2022.100381_bib55","doi-asserted-by":"crossref","first-page":"e4041","DOI":"10.7717\/peerj.4041","article-title":"Zebrafish swimming in the flow: a particle image velocimetry study","volume":"5","author":"Mwaffo","year":"2017","journal-title":"PeerJ"},{"key":"10.1016\/j.crmeth.2022.100381_bib56","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3389\/fninf.2015.00007","article-title":"Bonsai: an event-based framework for processing and controlling data streams","volume":"9","author":"Lopes","year":"2015","journal-title":"Front. Neuroinform."},{"key":"10.1016\/j.crmeth.2022.100381_bib57","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.patrec.2005.11.005","article-title":"Efficient adaptive density estimation per image pixel for the task of background subtraction","volume":"27","author":"Zivkovic","year":"2006","journal-title":"Pattern Recogn. Lett."}],"container-title":["Cell Reports Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667237522002867?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667237522002867?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T08:02:13Z","timestamp":1757404933000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2667237522002867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":57,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["S2667237522002867"],"URL":"https:\/\/doi.org\/10.1016\/j.crmeth.2022.100381","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.09.24.461752","asserted-by":"object"}]},"ISSN":["2667-2375"],"issn-type":[{"value":"2667-2375","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Social behavioral profiling by unsupervised deep learning reveals a stimulative effect of dopamine D3 agonists on zebrafish sociality","name":"articletitle","label":"Article Title"},{"value":"Cell Reports Methods","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.crmeth.2022.100381","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s).","name":"copyright","label":"Copyright"}],"article-number":"100381"}}