{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T23:55:07Z","timestamp":1781567707362,"version":"3.54.5"},"reference-count":64,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R01-GM084947"],"award-info":[{"award-number":["R01-GM084947"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Research Council of Norway","doi-asserted-by":"publisher","award":["262652"],"award-info":[{"award-number":["262652"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Research Council of Norway","doi-asserted-by":"publisher","award":["276070"],"award-info":[{"award-number":["276070"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006691","name":"Harvard Medical School","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008730","name":"Den Norske Kreftforening","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008730","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports Methods"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.crmeth.2025.101220","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T05:53:22Z","timestamp":1762322002000},"page":"101220","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["EyaHOST, a modular genetic system for investigation of intercellular and tumor-host interactions in Drosophila melanogaster"],"prefix":"10.1016","volume":"5","author":[{"given":"Jos\u00e9","family":"Teles-Reis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rojyar","family":"Khezri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina Gon\u00e7alves","family":"Antunes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Micheli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia Alfonso","family":"Gomez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Dillard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9150-2676","authenticated-orcid":false,"given":"Tor Erik","family":"Rusten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.crmeth.2025.101220_bib1","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1534\/genetics.117.202390","article-title":"Taking Stock of the Drosophila Research Ecosystem","volume":"206","author":"Bilder","year":"2017","journal-title":"Genetics"},{"key":"10.1016\/j.crmeth.2025.101220_bib2","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/0092-8674(89)90033-0","article-title":"The FLP recombinase of yeast catalyzes site-specific recombination in the Drosophila genome","volume":"59","author":"Golic","year":"1989","journal-title":"Cell"},{"key":"10.1016\/j.crmeth.2025.101220_bib3","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1006\/meth.1998.0591","article-title":"Use of FLP\/FRT system to study Drosophila development","volume":"14","author":"Theodosiou","year":"1998","journal-title":"Methods"},{"key":"10.1016\/j.crmeth.2025.101220_bib4","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1242\/dev.117.4.1223","article-title":"Analysis of genetic mosaics in developing and adult Drosophila tissues","volume":"117","author":"Xu","year":"1993","journal-title":"Development"},{"key":"10.1016\/j.crmeth.2025.101220_bib5","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/978-1-4939-7169-5_13","article-title":"FLPing Genes On and Off in Drosophila","volume":"1642","author":"Weasner","year":"2017","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.crmeth.2025.101220_bib6","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1093\/genetics\/131.3.643","article-title":"Use of a yeast site-specific recombinase to produce female germline chimeras in Drosophila","volume":"131","author":"Chou","year":"1992","journal-title":"Genetics"},{"key":"10.1016\/j.crmeth.2025.101220_bib7","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1093\/genetics\/144.4.1673","article-title":"The autosomal FLP-DFS technique for generating germline mosaics in Drosophila melanogaster","volume":"144","author":"Chou","year":"1996","journal-title":"Genetics"},{"key":"10.1016\/j.crmeth.2025.101220_bib8","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1242\/dev.127.4.851","article-title":"Analysis of Drosophila photoreceptor axon guidance in eye-specific mosaics","volume":"127","author":"Newsome","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.crmeth.2025.101220_bib9","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1093\/genetics\/152.4.1631","article-title":"A genetic method for generating Drosophila eyes composed exclusively of mitotic clones of a single genotype","volume":"152","author":"Stowers","year":"1999","journal-title":"Genetics"},{"key":"10.1016\/j.crmeth.2025.101220_bib10","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1242\/dev.118.2.401","article-title":"Targeted gene expression as a means of altering cell fates and generating dominant phenotypes","volume":"118","author":"Brand","year":"1993","journal-title":"Development"},{"key":"10.1016\/j.crmeth.2025.101220_bib11","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1038\/nprot.2006.320","article-title":"A protocol for mosaic analysis with a repressible cell marker (MARCM) in Drosophila","volume":"1","author":"Wu","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.crmeth.2025.101220_bib12","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0166-2236(00)01791-4","article-title":"Mosaic analysis with a repressible cell marker (MARCM) for Drosophila neural development","volume":"24","author":"Lee","year":"2001","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.crmeth.2025.101220_bib13","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1126\/science.1088474","article-title":"A genetic screen in Drosophila for metastatic behavior","volume":"302","author":"Pagliarini","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.crmeth.2025.101220_bib14","doi-asserted-by":"crossref","first-page":"5769","DOI":"10.1093\/emboj\/cdg548","article-title":"scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila","volume":"22","author":"Brumby","year":"2003","journal-title":"EMBO J."},{"key":"10.1016\/j.crmeth.2025.101220_bib15","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3389\/fgene.2019.00051","article-title":"Drosophila melanogaster: A Model Organism to Study Cancer","volume":"10","author":"Mirzoyan","year":"2019","journal-title":"Front. Genet."},{"key":"10.1016\/j.crmeth.2025.101220_bib16","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1158\/2159-8290.CD-21-1059","article-title":"Hallmarks of Cancer: New Dimensions","volume":"12","author":"Hanahan","year":"2022","journal-title":"Cancer Discov."},{"key":"10.1016\/j.crmeth.2025.101220_bib17","article-title":"Tumor models in various Drosophila tissues","volume":"13","author":"Gong","year":"2021","journal-title":"WIREs Mech. Dis."},{"key":"10.1016\/j.crmeth.2025.101220_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22168873","article-title":"Ras(V12); scrib(-\/-) Tumors: A Cooperative Oncogenesis Model Fueled by Tumor\/Host Interactions","volume":"22","author":"Dillard","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.crmeth.2025.101220_bib19","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1002\/glia.21148","article-title":"Drosophila melanogaster as a model system for human brain cancers","volume":"59","author":"Read","year":"2011","journal-title":"Glia"},{"key":"10.1016\/j.crmeth.2025.101220_bib20","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/s41568-021-00387-5","article-title":"Tumour-host interactions through the lens of Drosophila","volume":"21","author":"Bilder","year":"2021","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.crmeth.2025.101220_bib21","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0896-6273(00)80701-1","article-title":"Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis","volume":"22","author":"Lee","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/j.crmeth.2025.101220_bib22","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1016\/j.devcel.2021.09.009","article-title":"An Oatp transporter-mediated steroid sink promotes tumor-induced cachexia in Drosophila","volume":"56","author":"Santabarbara-Ruiz","year":"2021","journal-title":"Dev. Cell"},{"key":"10.1016\/j.crmeth.2025.101220_bib23","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.1016\/j.devcel.2021.08.008","article-title":"Tumor-derived MMPs regulate cachexia in a Drosophila cancer model","volume":"56","author":"Lodge","year":"2021","journal-title":"Dev. Cell"},{"key":"10.1016\/j.crmeth.2025.101220_bib24","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020107336","article-title":"Host autophagy mediates organ wasting and nutrient mobilization for tumor growth","volume":"40","author":"Khezri","year":"2021","journal-title":"EMBO J."},{"key":"10.1016\/j.crmeth.2025.101220_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22158317","article-title":"Drosophila Larval Models of Invasive Tumorigenesis for In Vivo Studies on Tumour\/Peripheral Host Tissue Interactions during Cancer Cachexia","volume":"22","author":"Hodgson","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.crmeth.2025.101220_bib26","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.devcel.2015.03.001","article-title":"Malignant Drosophila tumors interrupt insulin signaling to induce cachexia-like wasting","volume":"33","author":"Figueroa-Clarevega","year":"2015","journal-title":"Dev. Cell"},{"key":"10.1016\/j.crmeth.2025.101220_bib27","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.039727","article-title":"Spz\/Toll-6 signal guides organotropic metastasis in Drosophila","volume":"12","author":"Mishra-Gorur","year":"2019","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.crmeth.2025.101220_bib28","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nature20815","article-title":"Microenvironmental autophagy promotes tumour growth","volume":"541","author":"Katheder","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.crmeth.2025.101220_bib29","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/onc.2015.137","article-title":"Rho1-Wnd signaling regulates loss-of-cell polarity-induced cell invasion in Drosophila","volume":"35","author":"Ma","year":"2016","journal-title":"Oncogene"},{"key":"10.1016\/j.crmeth.2025.101220_bib30","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.03189","article-title":"The transcriptional response to tumorigenic polarity loss in Drosophila","volume":"4","author":"Bunker","year":"2015","journal-title":"eLife"},{"key":"10.1016\/j.crmeth.2025.101220_bib31","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/nature14298","article-title":"The Drosophila TNF receptor Grindelwald couples loss of cell polarity and neoplastic growth","volume":"522","author":"Andersen","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.crmeth.2025.101220_bib32","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2013.392","article-title":"Src42A modulates tumor invasion and cell death via Ben\/dUev1a-mediated JNK activation in Drosophila","volume":"4","author":"Ma","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.crmeth.2025.101220_bib33","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ydbio.2010.11.036","article-title":"Regulation of Hippo signaling by Jun kinase signaling during compensatory cell proliferation and regeneration, and in neoplastic tumors","volume":"350","author":"Sun","year":"2011","journal-title":"Dev. Biol."},{"key":"10.1016\/j.crmeth.2025.101220_bib34","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.jgg.2011.09.005","article-title":"Deciphering tumor-suppressor signaling in flies: genetic link between Scribble\/Dlg\/Lgl and the Hippo pathways","volume":"38","author":"Enomoto","year":"2011","journal-title":"J Genet Genomics"},{"key":"10.1016\/j.crmeth.2025.101220_bib35","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/nature08702","article-title":"Interaction between Ras(V12) and scribbled clones induces tumour growth and invasion","volume":"463","author":"Wu","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.crmeth.2025.101220_bib36","doi-asserted-by":"crossref","first-page":"14651","DOI":"10.1073\/pnas.1009376107","article-title":"A tumor-suppressing mechanism in Drosophila involving cell competition and the Hippo pathway","volume":"107","author":"Menendez","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.crmeth.2025.101220_bib37","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.devcel.2010.05.014","article-title":"Oncogenic Ras diverts a host TNF tumor suppressor activity into tumor promoter","volume":"18","author":"Cordero","year":"2010","journal-title":"Dev. Cell"},{"key":"10.1016\/j.crmeth.2025.101220_bib38","doi-asserted-by":"crossref","first-page":"5294","DOI":"10.1038\/sj.emboj.7601401","article-title":"JNK- and Fos-regulated Mmp1 expression cooperates with Ras to induce invasive tumors in Drosophila","volume":"25","author":"Uhlirova","year":"2006","journal-title":"EMBO J."},{"key":"10.1016\/j.crmeth.2025.101220_bib39","doi-asserted-by":"crossref","first-page":"E7291","DOI":"10.1073\/pnas.1701791114","article-title":"Feedback amplification loop drives malignant growth in epithelial tissues","volume":"114","author":"Muzzopappa","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.crmeth.2025.101220_bib40","doi-asserted-by":"crossref","first-page":"5351","DOI":"10.1073\/pnas.97.10.5351","article-title":"LexA chimeras reveal the function of Drosophila Fos as a context-dependent transcriptional activator","volume":"97","author":"Szuts","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.crmeth.2025.101220_bib41","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.cell.2010.02.025","article-title":"The Q system: a repressible binary system for transgene expression, lineage tracing, and mosaic analysis","volume":"141","author":"Potter","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.crmeth.2025.101220_bib42","doi-asserted-by":"crossref","first-page":"3002","DOI":"10.1016\/j.cub.2023.05.071","article-title":"Systemic coagulopathy promotes host lethality in a new Drosophila tumor model","volume":"33","author":"Hsi","year":"2023","journal-title":"Curr. Biol."},{"key":"10.1016\/j.crmeth.2025.101220_bib43","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2020120118","article-title":"Tumors overcome the action of the wasting factor ImpL2 by locally elevating Wnt\/Wingless","volume":"118","author":"Lee","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.crmeth.2025.101220_bib44","doi-asserted-by":"crossref","first-page":"14198","DOI":"10.1073\/pnas.1111704108","article-title":"Multiple new site-specific recombinases for use in manipulating animal genomes","volume":"108","author":"Nern","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.crmeth.2025.101220_bib45","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nmeth.1561","article-title":"A versatile in vivo system for directed dissection of gene expression patterns","volume":"8","author":"Gohl","year":"2011","journal-title":"Nat. Methods"},{"key":"10.1016\/j.crmeth.2025.101220_bib46","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nmeth.3250","article-title":"Improved and expanded Q-system reagents for genetic manipulations","volume":"12","author":"Riabinina","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.crmeth.2025.101220_bib47","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1038\/s41598-022-05991-5","article-title":"Computed tomography with segmentation and quantification of individual organs in a D. melanogaster tumor model","volume":"12","author":"Holland","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.crmeth.2025.101220_bib48","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1242\/dmm.000950","article-title":"An innate immune response of blood cells to tumors and tissue damage in Drosophila","volume":"1","author":"Pastor-Pareja","year":"2008","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.crmeth.2025.101220_bib49","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.94073","article-title":"Expanding the Drosophila toolkit for dual control of gene expression","volume":"12","author":"Zirin","year":"2024","journal-title":"eLife"},{"key":"10.1016\/j.crmeth.2025.101220_bib50","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.devcel.2015.02.012","article-title":"Systemic organ wasting induced by localized expression of the secreted insulin\/IGF antagonist ImpL2","volume":"33","author":"Kwon","year":"2015","journal-title":"Dev. Cell"},{"key":"10.1016\/j.crmeth.2025.101220_bib51","doi-asserted-by":"crossref","first-page":"3984","DOI":"10.1016\/j.cub.2021.06.064","article-title":"Sequential oncogenic mutations influence cell competition","volume":"31","author":"Kohashi","year":"2021","journal-title":"Curr. Biol."},{"key":"10.1016\/j.crmeth.2025.101220_bib52","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.cub.2018.11.007","article-title":"Competition for Space Induces Cell Elimination through Compaction-Driven ERK Downregulation","volume":"29","author":"Moreno","year":"2019","journal-title":"Curr. Biol."},{"key":"10.1016\/j.crmeth.2025.101220_bib53","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/j.cub.2022.01.016","article-title":"Yorkie drives supercompetition by non-autonomous induction of autophagy via bantam microRNA in Drosophila","volume":"32","author":"Nagata","year":"2022","journal-title":"Curr. Biol."},{"key":"10.1016\/j.crmeth.2025.101220_bib54","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1001140","article-title":"dMyc functions downstream of Yorkie to promote the supercompetitive behavior of hippo pathway mutant cells","volume":"6","author":"Ziosi","year":"2010","journal-title":"PLoS Genet."},{"key":"10.1016\/j.crmeth.2025.101220_bib55","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1146\/annurev.cellbio.21.012804.093845","article-title":"Caspase-dependent cell death in Drosophila","volume":"22","author":"Hay","year":"2006","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.crmeth.2025.101220_bib56","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1038\/cdd.2008.50","article-title":"Regulation of apoptosis in Drosophila","volume":"15","author":"Steller","year":"2008","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.crmeth.2025.101220_bib57","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1038\/cdd.2017.47","article-title":"Killers creating new life: caspases drive apoptosis-induced proliferation in tissue repair and disease","volume":"24","author":"Fogarty","year":"2017","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.crmeth.2025.101220_bib58","doi-asserted-by":"crossref","first-page":"9319","DOI":"10.1128\/JVI.00247-07","article-title":"Baculovirus caspase inhibitors P49 and P35 block virus-induced apoptosis downstream of effector caspase DrICE activation in Drosophila melanogaster cells","volume":"81","author":"Lannan","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.crmeth.2025.101220_bib59","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1534\/genetics.110.119917","article-title":"Refinement of tools for targeted gene expression in Drosophila","volume":"186","author":"Pfeiffer","year":"2010","journal-title":"Genetics"},{"key":"10.1016\/j.crmeth.2025.101220_bib60","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1002537","article-title":"Epithelial Tumors Originate in Tumor Hotspots, a Tissue-Intrinsic Microenvironment","volume":"14","author":"Tamori","year":"2016","journal-title":"PLoS Biol."},{"key":"10.1016\/j.crmeth.2025.101220_bib61","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1016\/j.devcel.2021.07.002","article-title":"Interaction between Ras and Src clones causes interdependent tumor malignancy via Notch signaling in Drosophila","volume":"56","author":"Enomoto","year":"2021","journal-title":"Dev. Cell"},{"key":"10.1016\/j.crmeth.2025.101220_bib62","doi-asserted-by":"crossref","DOI":"10.3389\/fncir.2020.603397","article-title":"The Drosophila Split Gal4 System for Neural Circuit Mapping","volume":"14","author":"Luan","year":"2020","journal-title":"Front. Neural Circuits"},{"key":"10.1016\/j.crmeth.2025.101220_bib63","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/978-1-4939-6371-3_3","article-title":"The Q-System: A Versatile Expression System for Drosophila","volume":"1478","author":"Riabinina","year":"2016","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.crmeth.2025.101220_bib64","doi-asserted-by":"crossref","first-page":"3835","DOI":"10.1038\/s41598-022-07852-7","article-title":"A LexAop > UAS > QUAS trimeric plasmid to generate inducible and interconvertible Drosophila overexpression transgenes","volume":"12","author":"Wendler","year":"2022","journal-title":"Sci. Rep."}],"container-title":["Cell Reports Methods"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667237525002565?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667237525002565?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T23:31:15Z","timestamp":1781566275000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2667237525002565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":64,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S2667237525002565"],"URL":"https:\/\/doi.org\/10.1016\/j.crmeth.2025.101220","relation":{},"ISSN":["2667-2375"],"issn-type":[{"value":"2667-2375","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"EyaHOST, a modular genetic system for investigation of intercellular and tumor-host interactions in Drosophila melanogaster","name":"articletitle","label":"Article Title"},{"value":"Cell Reports Methods","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.crmeth.2025.101220","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101220"}}