{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T21:58:14Z","timestamp":1788904694986,"version":"build-2803163510"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,16]],"date-time":"2023-12-16T00:00:00Z","timestamp":1702684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Research in Microbial Sciences"],"published-print":{"date-parts":[[2024]]},"DOI":"10.1016\/j.crmicr.2023.100217","type":"journal-article","created":{"date-parts":[[2023,12,23]],"date-time":"2023-12-23T17:17:55Z","timestamp":1703351875000},"page":"100217","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Acridones as promising drug candidates against Oropouche virus"],"prefix":"10.1016","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7627-621X","authenticated-orcid":false,"given":"Marielena Vogel","family":"Saivish","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela de Lima","family":"Menezes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roosevelt Alves","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia Ribeiro","family":"de Assis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor da Silva","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto Laino","family":"Fulco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarita Maria Secco","family":"Avilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael Josef","family":"Eberle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor de Andrade","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Korostov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayara Lucia","family":"Webber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gislaine Celestino Dutra","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maur\u00edcio Lacerda","family":"Nogueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Carolina Gomes","family":"Jardim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Octavio","family":"Regasin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f4nika Aparecida","family":"Coronado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina Colombelli","family":"Pacca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.crmicr.2023.100217_bib0001","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.softx.2015.06.001","article-title":"GROMACS: high performance molecular simulations through multi-level parallelism from laptops to supercomputers","volume":"1\u20132","author":"Abraham","year":"2015","journal-title":"SoftwareX"},{"key":"10.1016\/j.crmicr.2023.100217_bib0002","first-page":"15","article-title":"Neural infection by oropouche virus in adult human brain slices induces an inflammatory and toxic response","author":"Almeida","year":"2021","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.crmicr.2023.100217_bib0003","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1080\/1040841X.2017.1307805","article-title":"Bunyaviridae RdRps: structure, motifs, and RNA synthesis machinery","volume":"43","author":"Amroun","year":"2017","journal-title":"Crit. Rev. Microbiol."},{"key":"10.1016\/j.crmicr.2023.100217_bib0004","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/s13205-018-1239-6","article-title":"Identification of curcumin derivatives as human LMTK3 inhibitors for breast cancer: a docking, dynamics, and MM\/PBSA approach","volume":"8","author":"Anbarasu","year":"2018","journal-title":"3 Biotech"},{"key":"10.1016\/j.crmicr.2023.100217_bib0005","doi-asserted-by":"crossref","first-page":"912","DOI":"10.3201\/eid1306.061114","article-title":"Reemergence of Oropouche fever, northern Brazil","volume":"13","author":"Azevedo","year":"2007","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.crmicr.2023.100217_bib0006","doi-asserted-by":"crossref","first-page":"732","DOI":"10.4269\/ajtmh.2012.11-0485","article-title":"Identification of Oropouche Orthobunyavirus in the cerebrospinal fluid of three patients in the Amazonas, Brazil","volume":"86","author":"Bastos","year":"2012","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.crmicr.2023.100217_bib0007","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1002\/jmv.23953","article-title":"Detection of Herpesvirus, Enterovirus, and Arbovirus infection in patients with suspected central nervous system viral infection in the Western Brazilian Amazon","volume":"86","author":"Bastos","year":"2014","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.crmicr.2023.100217_bib0008","doi-asserted-by":"crossref","first-page":"139","DOI":"10.2174\/187152007780058669","article-title":"Acridine and Acridone derivatives, anticancer properties and synthetic methods: where are we now?","volume":"7","author":"Belmont","year":"2007","journal-title":"Anticancer Agents Med. Chem."},{"key":"10.1016\/j.crmicr.2023.100217_bib0009","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.1063\/1.448118","article-title":"Molecular dynamics with coupling to an external bath","volume":"81","author":"Berendsen","year":"1984","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.crmicr.2023.100217_bib0010","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1099\/jgv.0.000808","article-title":"Hepatitis C virus in vitro replication is efficiently inhibited by acridone Fac4","volume":"98","author":"Campos","year":"2017","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.crmicr.2023.100217_bib0011","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1590\/0074-02760150123","article-title":"Detection of Oropouche virus segment S in patients and inCulex quinquefasciatus in the state of Mato Grosso, Brazil","volume":"110","author":"Cardoso","year":"2015","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.crmicr.2023.100217_bib0012","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1248\/cpb.57.1246","article-title":"Isolation of acridone alkaloids and N-[(4-monoterpenyloxy)phenylethyl]-substituted sulfur-containing propanamide derivatives from Glycosmis parva and their anti-herpes simplex virus activity","volume":"57","author":"Chansriniyom","year":"2009","journal-title":"Chem. Pharm. Bull. (Tokyo)"},{"key":"10.1016\/j.crmicr.2023.100217_bib0013","first-page":"84","article-title":"Silent emergence of Mayaro and Oropouche viruses in humans in Central Brazil","volume":"62","author":"da Costa","year":"2017","journal-title":"Int. J. Infect. Dis. IJID Off. Publ. Int. Soc. Infect. Dis."},{"key":"10.1016\/j.crmicr.2023.100217_bib0014","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1002\/jmv.24722","article-title":"Oropouche virus is detected in peripheral blood leukocytes from patients","volume":"89","author":"de Souza Luna","year":"2017","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.crmicr.2023.100217_bib0015","doi-asserted-by":"crossref","first-page":"5189","DOI":"10.1021\/acs.jpcb.8b11491","article-title":"Ensemble docking in drug discovery: how many protein configurations from molecular dynamics simulations are needed to reproduce known ligand binding?","volume":"123","author":"Evangelista Falcon","year":"2019","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.crmicr.2023.100217_bib0016","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0166-3542(99)00045-5","article-title":"Acridone derivatives are selective inhibitors of HIV-1 replication in chronically infected cells","volume":"43","author":"Fujiwara","year":"1999","journal-title":"Antiviral Res."},{"key":"10.1016\/j.crmicr.2023.100217_bib0017","doi-asserted-by":"crossref","first-page":"15776","DOI":"10.1039\/C7RA01026E","article-title":"Recent developments in the synthesis and biological activity of acridine\/acridone analogues","volume":"7","author":"Gensicka-Kowalewska","year":"2017","journal-title":"RSC Adv."},{"key":"10.1016\/j.crmicr.2023.100217_bib0018","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1128\/AAC.3.5.537","article-title":"Antiviral activity and induction of interferon-like substance by Quinacrine and Acranil","volume":"3","author":"Gl\u00e1z","year":"1973","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.crmicr.2023.100217_bib0019","doi-asserted-by":"crossref","first-page":"e01119","DOI":"10.1128\/JVI.01127-19","article-title":"Evolutionary dynamics of Oropouche virus in South America","volume":"94","author":"Gutierrez","year":"2020","journal-title":"J. Virol."},{"key":"10.1016\/j.crmicr.2023.100217_bib0020","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/jhet.5570410104","article-title":"Synthesis of acrimarins from 1,3,5-trioxygenated-9-acridone derivatives","volume":"41","author":"Herath","year":"2004","journal-title":"J. Heterocycl. Chem."},{"key":"10.1016\/j.crmicr.2023.100217_bib0021","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1002\/(SICI)1096-987X(199709)18:12<1463::AID-JCC4>3.0.CO;2-H","article-title":"LINCS: a linear constraint solver for molecular simulations","volume":"18","author":"Hess","year":"1997","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.crmicr.2023.100217_bib0022","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/0021-9991(74)90010-2","article-title":"Quiet high-resolution computer models of a plasma","volume":"14","author":"Hockney","year":"1974","journal-title":"J. Comput. Phys."},{"key":"10.1016\/j.crmicr.2023.100217_bib0023","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1021\/ci100275a","article-title":"Assessing the performance of the MM\/PBSA and MM\/GBSA methods. 1. the accuracy of binding free energy calculations based on molecular dynamics simulations","volume":"51","author":"Hou","year":"2011","journal-title":"J. Chem. Inf. Model."},{"key":"10.1016\/j.crmicr.2023.100217_bib0024","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1002\/wcms.90","article-title":"Car-Parrinello molecular dynamics: car-Parrinello molecular dynamics","volume":"2","author":"Hutter","year":"2012","journal-title":"Wiley Interdiscip. Rev. Comput. Mol. Sci."},{"key":"10.1016\/j.crmicr.2023.100217_bib0025","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0304-3835(03)00008-9","article-title":"Cancer chemopreventive activity of acridone alkaloids on Epstein\u2013Barr virus activation and two-stage mouse skin carcinogenesis","volume":"193","author":"Itoigawa","year":"2003","journal-title":"Cancer Lett."},{"key":"10.1016\/j.crmicr.2023.100217_bib0026","doi-asserted-by":"crossref","first-page":"375","DOI":"10.3109\/10409239309078440","article-title":"Evolution and taxonomy of positive-strand RNA viruses: implications of comparative analysis of amino acid sequences","volume":"28","author":"Koonin","year":"1993","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"10.1016\/j.crmicr.2023.100217_bib0027","first-page":"659","article-title":"[Intracellular localization of cycloferon, its binding with DNA and stimulation of cytokines expression after exposure to cycloferon]","volume":"42","author":"Kovalenko","year":"2000","journal-title":"Tsitologiia"},{"key":"10.1016\/j.crmicr.2023.100217_bib0028","doi-asserted-by":"crossref","DOI":"10.1515\/BC.2009.040","article-title":"Amidinoanthracyclines \u2013 a new group of potential anti-hepatitis C virus compounds","volume":"390","author":"Krawczyk","year":"2009","journal-title":"Biol. Chem."},{"key":"10.1016\/j.crmicr.2023.100217_bib0029","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.bmc.2018.01.001","article-title":"9-Aminoacridine-based agents impair the bovine viral diarrhea virus (BVDV) replication targeting the RNA-dependent RNA polymerase (RdRp)","volume":"26","author":"Loddo","year":"2018","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.crmicr.2023.100217_bib0030","doi-asserted-by":"crossref","DOI":"10.1177\/11779322211021430","article-title":"Inhibitory potential of phytochemicals on interleukin-6-mediated T-Cell reduction in COVID-19 patients: a computational approach","volume":"15","author":"Malik","year":"2021","journal-title":"Bioinforma. Biol. Insights"},{"key":"10.1016\/j.crmicr.2023.100217_bib0031","doi-asserted-by":"crossref","first-page":"3354","DOI":"10.1021\/jm801608u","article-title":"Inhibition of subgenomic hepatitis C virus RNA replication by acridone derivatives: identification of an NS3 helicase inhibitor","volume":"52","author":"Manfroni","year":"2009","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.crmicr.2023.100217_bib0032","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s12929-015-0134-2","article-title":"Antiviral activity of an N-allyl acridone against dengue virus","volume":"22","author":"Mazzucco","year":"2015","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.crmicr.2023.100217_bib0033","first-page":"179","article-title":"Tetrazolium (MTT) assay for cellular viability and activity","volume":"79","author":"Morgan","year":"1998","journal-title":"Methods Mol. Biol. Clifton NJ"},{"key":"10.1016\/j.crmicr.2023.100217_bib0034","unstructured":"Motulsky, H., Christopoulos, A., n.d. Fitting models to biological data using linear and nonlinear regression 351."},{"key":"10.1016\/j.crmicr.2023.100217_bib0035","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.3201\/eid1512.090917","article-title":"Oropouche fever outbreak, Manaus, Brazil, 2007\u20132008","volume":"15","author":"Mour\u00e3o","year":"2009","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.crmicr.2023.100217_bib0036","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1021\/ct3010485","article-title":"Improved generalized born solvent model parameters for protein simulations","volume":"9","author":"Nguyen","year":"2013","journal-title":"J. Chem. Theory Comput."},{"key":"10.1016\/j.crmicr.2023.100217_bib0037","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.virol.2012.07.008","article-title":"Endonuclease substrate selectivity characterized with full-length PA of influenza A virus polymerase","volume":"433","author":"Noble","year":"2012","journal-title":"Virology"},{"key":"10.1016\/j.crmicr.2023.100217_bib0038","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1758-2946-3-33","article-title":"Open Babel: an open chemical toolbox","volume":"3","author":"O'Boyle","year":"2011","journal-title":"J. Cheminformatics"},{"key":"10.1016\/j.crmicr.2023.100217_bib0039","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1021\/ct100578z","article-title":"PROPKA3: consistent treatment of internal and surface residues in Empirical p K a predictions","volume":"7","author":"Olsson","year":"2011","journal-title":"J. Chem. Theory Comput."},{"key":"10.1016\/j.crmicr.2023.100217_bib0040","doi-asserted-by":"crossref","DOI":"10.3389\/fitd.2021.737436","article-title":"Emergent Arboviruses: a review about Mayaro virus and Oropouche orthobunyavirus","volume":"2","author":"Pereira","year":"2021","journal-title":"Front. Trop. Dis."},{"key":"10.1016\/j.crmicr.2023.100217_bib0041","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera - a visualization system for exploratory research and analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.crmicr.2023.100217_bib0042","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/pro.3943","article-title":"UCSF ChimeraX\u00a0: structure visualization for researchers, educators, and developers","volume":"30","author":"Pettersen","year":"2021","journal-title":"Protein Sci."},{"key":"10.1016\/j.crmicr.2023.100217_bib0043","first-page":"246","article-title":"[Meningitis associated with Oropouche virus infections]","volume":"24","author":"Pinheiro","year":"1982","journal-title":"Rev. Inst. Med. Trop. Sao Paulo"},{"key":"10.1016\/j.crmicr.2023.100217_bib0044","doi-asserted-by":"crossref","first-page":"149","DOI":"10.4269\/ajtmh.1981.30.149","article-title":"Oropouche virus. I. A review of clinical, epidemiological, and ecological findings","volume":"30","author":"Pinheiro","year":"1981","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.crmicr.2023.100217_bib0045","first-page":"246","article-title":"Meningite associada \u00e1s infec\u00e7\u00f5es por v\u00edrus Oropouche","volume":"4","author":"Pinheiro","year":"1982","journal-title":"Meningite Assoc. \u00c1s Infec\u00e7\u00f5es Por V\u00edrus Oropouche"},{"key":"10.1016\/j.crmicr.2023.100217_bib0046","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1001101","article-title":"Bunyaviridae RNA polymerases (L-protein) have an N-terminal, influenza-like endonuclease domain, essential for viral cap-dependent transcription","volume":"6","author":"Reguera","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.crmicr.2023.100217_bib0047","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.micinf.2017.11.013","article-title":"Oropouche fever, an emergent disease from the Americas","volume":"20","author":"Romero-Alvarez","year":"2018","journal-title":"Microbes Infect."},{"key":"10.1016\/j.crmicr.2023.100217_bib0048","series-title":"RStudio: Integrated Development Environment for R","year":"2021"},{"key":"10.1016\/j.crmicr.2023.100217_bib0049","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3390\/v10040175","article-title":"Oropouche fever: a review","volume":"10","author":"Sakkas","year":"2018","journal-title":"Viruses"},{"key":"10.1016\/j.crmicr.2023.100217_bib0050","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.ejmech.2005.11.006","article-title":"Synthesis and biological evaluation of modified acridines: the effect of N- and O- substituent in the nitrogenated ring on antitumor activity","volume":"41","author":"S\u00e1nchez","year":"2006","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.crmicr.2023.100217_bib0051","doi-asserted-by":"crossref","first-page":"3827","DOI":"10.3390\/v6103827","article-title":"Spread of Oropouche virus into the central nervous system in mouse","volume":"6","author":"Santos","year":"2014","journal-title":"Viruses"},{"key":"10.1016\/j.crmicr.2023.100217_bib0052","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.2174\/0929867311320190002","article-title":"Acridones as antiviral agents: synthesis, chemical and biological properties","volume":"20","author":"Sepulveda","year":"2013","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.crmicr.2023.100217_bib0053","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1177\/095632020801900106","article-title":"Synthesis and evaluation of N-substituted acridones as antiviral agents against Haemorrhagic fever viruses","volume":"19","author":"Sep\u00falveda","year":"2008","journal-title":"Antivir. Chem. Chemother."},{"key":"10.1016\/j.crmicr.2023.100217_bib0054","doi-asserted-by":"crossref","first-page":"3296","DOI":"10.1080\/07391102.2020.1846624","article-title":"Identification of natural inhibitors against prime targets of SARS-CoV-2 using molecular docking, molecular dynamics simulation and MM-PBSA approaches","volume":"40","author":"Sharma","year":"2022","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.crmicr.2023.100217_bib0055","series-title":"Key Heterocycle Cores For Designing Multitargeting Molecules","author":"Silakari","year":"2018"},{"key":"10.1016\/j.crmicr.2023.100217_bib0056","doi-asserted-by":"crossref","first-page":"17703","DOI":"10.1038\/s41598-019-54169-z","article-title":"A diarylamine derived from anthranilic acid inhibits ZIKV replication","volume":"9","author":"Silva","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.crmicr.2023.100217_bib0057","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ijid.2019.04.011","article-title":"First outbreak of Oropouche fever reported in a non-endemic western region of the Peruvian Amazon: molecular diagnosis and clinical characteristics","volume":"83","author":"Silva-Caso","year":"2019","journal-title":"Int. J. Infect. Dis."},{"key":"10.1016\/j.crmicr.2023.100217_bib0058","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1186\/1756-0500-5-367","article-title":"ACPYPE - antechamber python parser interface","volume":"5","author":"Sousa da Silva","year":"2012","journal-title":"BMC Res. Notes"},{"key":"10.1016\/j.crmicr.2023.100217_bib0059","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.1021\/jm901741p","article-title":"Synthesis of new acridone derivatives, inhibitors of NS3 helicase, which efficiently and specifically inhibit subgenomic HCV replication","volume":"53","author":"Stankiewicz-Drogo\u0144","year":"2010","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.crmicr.2023.100217_bib0060","doi-asserted-by":"crossref","first-page":"8846","DOI":"10.1016\/j.bmc.2008.08.074","article-title":"New acridone-4-carboxylic acid derivatives as potential inhibitors of Hepatitis C virus infection","volume":"16","author":"Stankiewicz-Drogon","year":"2008","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.crmicr.2023.100217_bib0061","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1055\/s-2006-958104","article-title":"Studies on the inhibitory effects of some acridone alkaloids on Epstein-Barr Virus activation","volume":"61","author":"Takemura","year":"1995","journal-title":"Planta Med."},{"key":"10.1016\/j.crmicr.2023.100217_bib0062","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.18.1.20","article-title":"High-yield interferon induction by 10-carboxymethyl-9-acridanone in mice and hamsters","author":"Taylor","year":"1980","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.crmicr.2023.100217_bib0063","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.antiviral.2011.05.005","article-title":"Acridine derivatives as anti-BVDV agents","volume":"91","author":"Tonelli","year":"2011","journal-title":"Antiviral Res."},{"key":"10.1016\/j.crmicr.2023.100217_bib0064","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.4269\/ajtmh.16-0672","article-title":"Oropouche Virus: clinical, epidemiological, and molecular aspects of a neglected orthobunyavirus","volume":"96","author":"Travassos da Rosa","year":"2017","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.crmicr.2023.100217_bib0065","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.crmicr.2023.100217_bib0066","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1128\/AAC.42.3.487","article-title":"Inhibition of acute-, latent-, and chronic-phase human immunodeficiency virus type 1 (HIV-1) replication by a bistriazoloacridone analog that selectively inhibits HIV-1 transcription","volume":"42","author":"Turpin","year":"1998","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.crmicr.2023.100217_bib0067","doi-asserted-by":"crossref","first-page":"6281","DOI":"10.1021\/acs.jctc.1c00645","article-title":"gmx_MMPBSA: a new tool to perform end-state free energy calculations with GROMACS","volume":"17","author":"Vald\u00e9s-Tresanco","year":"2021","journal-title":"J. Chem. Theory Comput."},{"key":"10.1016\/j.crmicr.2023.100217_bib0068","doi-asserted-by":"crossref","first-page":"5059","DOI":"10.1128\/JVI.80.10.5059-5064.2006","article-title":"Double-stranded RNA is produced by positive-strand RNA viruses and DNA viruses but not in detectable amounts by negative-strand RNA viruses","volume":"80","author":"Weber","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.crmicr.2023.100217_bib0069","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/pro.3330","article-title":"MolProbity: more and better reference data for improved all-atom structure validation: PROTEIN SCIENCE.ORG","volume":"27","author":"Williams","year":"2018","journal-title":". Protein Sci."},{"key":"10.1016\/j.crmicr.2023.100217_bib0070","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0166-3542(89)90065-X","article-title":"Anti-herpesvirus activity of citrusinine-I, a new acridone alkaloid, and related compounds","volume":"12","author":"Yamamoto","year":"1989","journal-title":"Antiviral Res."}],"container-title":["Current Research in Microbial Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S266651742300038X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S266651742300038X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T19:48:56Z","timestamp":1730922536000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S266651742300038X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":70,"alternative-id":["S266651742300038X"],"URL":"https:\/\/doi.org\/10.1016\/j.crmicr.2023.100217","relation":{},"ISSN":["2666-5174"],"issn-type":[{"value":"2666-5174","type":"print"}],"subject":[],"published":{"date-parts":[[2024]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acridones as promising drug candidates against Oropouche virus","name":"articletitle","label":"Article Title"},{"value":"Current Research in Microbial Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.crmicr.2023.100217","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100217"}}