{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T16:18:36Z","timestamp":1788279516140,"version":"build-2803163510"},"reference-count":89,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:00:00Z","timestamp":1774310400000},"content-version":"vor","delay-in-days":82,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100025520","name":"Medical Research Future Fund","doi-asserted-by":"publisher","award":["GN1152556"],"award-info":[{"award-number":["GN1152556"]}],"id":[{"id":"10.13039\/501100025520","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001774","name":"University of Sydney","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001774","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001787","name":"University of South Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001787","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Research in Microbial Sciences"],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/j.crmicr.2026.100587","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T23:54:24Z","timestamp":1774396464000},"page":"100587","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["A novel self-transmissible mega plasmid from extensively drug-resistant Klebsiella oxytoca carries multiple antimicrobial resistance genes and acts as a resistance reservoir"],"prefix":"10.1016","volume":"10","author":[{"given":"Yu","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia A.","family":"Sapula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley J.","family":"Hart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5569-7755","authenticated-orcid":false,"given":"Henrietta","family":"Venter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"D1","key":"10.1016\/j.crmicr.2026.100587_bib0039","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkac920","article-title":"CARD 2023: expanded curation, support for machine learning, and resistome prediction at the Comprehensive Antibiotic Resistance Database","volume":"51","author":"Alcock","year":"2023","journal-title":"Nucleic. Acids. Res."},{"issue":"1","key":"10.1016\/j.crmicr.2026.100587_bib0067","doi-asserted-by":"crossref","first-page":"9802","DOI":"10.1038\/s41598-024-59870-2","article-title":"Genotypic analyses of IncHI2 plasmids from enteric bacteria","volume":"14","author":"Algarni","year":"2024","journal-title":"Sci. Rep."},{"issue":"14","key":"10.1016\/j.crmicr.2026.100587_bib0084","doi-asserted-by":"crossref","first-page":"4554","DOI":"10.1128\/jb.175.14.4554-4560.1993","article-title":"Sequence of a class E tetracycline resistance gene from Escherichia coli and comparison of related tetracycline efflux proteins","volume":"175","author":"Allard","year":"1993","journal-title":"J. Bacteriol."},{"issue":"3","key":"10.1016\/j.crmicr.2026.100587_bib0047","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","article-title":"Basic local alignment search tool","volume":"215","author":"Altschul","year":"1990","journal-title":"J. Mol. Biol."},{"issue":"17","key":"10.1016\/j.crmicr.2026.100587_bib0041","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","article-title":"Gapped BLAST and PSI-BLAST: a new generation of protein database search programs","volume":"25","author":"Altschul","year":"1997","journal-title":"Nucleic. Acids. Res."},{"key":"10.1016\/j.crmicr.2026.100587_bib0063","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.plasmid.2018.02.002","article-title":"Compatibility and entry exclusion of IncA and IncC plasmids revisited: incA and IncC plasmids are compatible","volume":"96-97","author":"Ambrose","year":"2018","journal-title":"Plasmid."},{"issue":"1","key":"10.1016\/j.crmicr.2026.100587_bib0060","doi-asserted-by":"crossref","DOI":"10.5812\/jjm.8691","article-title":"Effect of efflux pump inhibitor carbonyl cyanide 3-chlorophenylhydrazone on the minimum inhibitory concentration of ciprofloxacin in Acinetobacter baumannii clinical isolates","volume":"7","author":"Ardebili","year":"2014","journal-title":"Jundishapur. J. Microbiol."},{"issue":"1","key":"10.1016\/j.crmicr.2026.100587_bib0023","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/s42003-023-04676-7","article-title":"Evidence for wastewaters as environments where mobile antibiotic resistance genes emerge","volume":"6","author":"Berglund","year":"2023","journal-title":"Commun. Biol."},{"issue":"4","key":"10.1016\/j.crmicr.2026.100587_bib0014","doi-asserted-by":"crossref","first-page":"751","DOI":"10.3390\/microorganisms12040751","article-title":"Resistome analysis of Klebsiella pneumoniae Complex from residential aged care facilities demonstrates intra-facility clonal spread of multidrug-resistant isolates","volume":"12","author":"Blaikie","year":"2024","journal-title":"Microorganisms."},{"issue":"8","key":"10.1016\/j.crmicr.2026.100587_bib0018","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1128\/JCM.00535-17","article-title":"Outbreak of NDM-1-producing Klebsiella pneumoniae in a Dutch Hospital, with interspecies transfer of the resistance plasmid and unexpected occurrence in unrelated health care centers","volume":"55","author":"Bosch","year":"2017","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.crmicr.2026.100587_bib0028","doi-asserted-by":"crossref","DOI":"10.1099\/mgen.0.001244","article-title":"Hybracter: enabling scalable, automated, complete and accurate bacterial genome assemblies","author":"Bouras","year":"2024","journal-title":"Microb. Genom."},{"issue":"8","key":"10.1016\/j.crmicr.2026.100587_bib0020","doi-asserted-by":"crossref","DOI":"10.1128\/aac.00216-22","article-title":"OXA-48-like \u03b2-lactamases: global epidemiology, treatment options, and development pipeline","volume":"66","author":"Boyd","year":"2022","journal-title":"Antimicrob. Agents Chemother"},{"key":"10.1016\/j.crmicr.2026.100587_bib0058","doi-asserted-by":"crossref","DOI":"10.1038\/srep43232","article-title":"In silico serine beta-lactamases analysis reveals a huge potential resistome in environmental and pathogenic species","volume":"7","author":"Brandt","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.crmicr.2026.100587_bib0006","doi-asserted-by":"crossref","first-page":"64","DOI":"10.12703\/P6-64","article-title":"Klebsiella: a long way to go towards understanding this enigmatic jet-setter","volume":"6","author":"Broberg","year":"2014","journal-title":"F1000Prime Rep."},{"issue":"1","key":"10.1016\/j.crmicr.2026.100587_bib0065","doi-asserted-by":"crossref","DOI":"10.1128\/genomeA.00027-15","article-title":"Complete sequences of six IncA\/C plasmids of multidrug-resistant Salmonella enterica subsp. Enterica serotype newport","volume":"3","author":"Cao","year":"2015","journal-title":"Genome Announc."},{"issue":"7","key":"10.1016\/j.crmicr.2026.100587_bib0042","doi-asserted-by":"crossref","first-page":"3895","DOI":"10.1128\/AAC.02412-14","article-title":"In silico detection and typing of plasmids using PlasmidFinder and plasmid multilocus sequence typing","volume":"58","author":"Carattoli","year":"2014","journal-title":"Antimicrob. Agents Chemother"},{"issue":"3","key":"10.1016\/j.crmicr.2026.100587_bib0072","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00853-19","article-title":"Identification of novel mobilized colistin resistance gene mcr-9 in a multidrug-resistant, colistin-susceptible Salmonella enterica serotype typhimurium isolate","volume":"10","author":"Carroll","year":"2019","journal-title":"mBio"},{"issue":"7","key":"10.1016\/j.crmicr.2026.100587_bib0017","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.3201\/eid2807.212181","article-title":"Outbreak of IncX8 plasmid-mediated KPC-3-producing enterobacterales infection","volume":"28","author":"Chen","year":"2022","journal-title":"China. Emerg Infect Dis"},{"issue":"6","key":"10.1016\/j.crmicr.2026.100587_bib0089","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.01333-22","article-title":"Identification of novel tet(X3) variants resistant to tigecycline in Acinetobacter species","volume":"10","author":"Cheng","year":"2022","journal-title":"Microbiol. Spectr."},{"issue":"1","key":"10.1016\/j.crmicr.2026.100587_bib0079","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1128\/IAI.02633-14","article-title":"Plasmid-encoded MCP is involved in virulence, motility, and biofilm formation of Cronobacter sakazakii ATCC 29544","volume":"83","author":"Choi","year":"2015","journal-title":"Infect. Immun"},{"issue":"4","key":"10.1016\/j.crmicr.2026.100587_bib0031","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1093\/bioinformatics\/bts723","article-title":"ALE: a generic assembly likelihood evaluation framework for assessing the accuracy of genome and metagenome assemblies","volume":"29","author":"Clark","year":"2013","journal-title":"Bioinformatics."},{"issue":"1","key":"10.1016\/j.crmicr.2026.100587_bib0075","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s44280-023-00037-5","article-title":"Prevalence and dissemination of mcr-9.1-producing non-typhoidal Salmonella strains from diarrhea patients throughout China during 2010\u20132020","volume":"2","author":"Cui","year":"2024","journal-title":"One Health Adv"},{"key":"10.1016\/j.crmicr.2026.100587_bib0044","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/978-1-4939-9877-7_19","article-title":"Identifying conjugative plasmids and integrative conjugative elements with CONJscan","volume":"2075","author":"Cury","year":"2020","journal-title":"Methods Mol. Biol."},{"issue":"6","key":"10.1016\/j.crmicr.2026.100587_bib0082","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.ijantimicag.2019.09.017","article-title":"The mobile FOX AmpC beta-lactamases originated in Aeromonas allosaccharophila","volume":"54","author":"Ebmeyer","year":"2019","journal-title":"Int. J. Antimicrob. Agents"},{"issue":"5","key":"10.1016\/j.crmicr.2026.100587_bib0083","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1093\/jac\/dkz025","article-title":"CMY-1\/MOX-family AmpC beta-lactamases MOX-1, MOX-2 and MOX-9 were mobilized independently from three Aeromonas species","volume":"74","author":"Ebmeyer","year":"2019","journal-title":"J. Antimicrob. Chemother"},{"key":"10.1016\/j.crmicr.2026.100587_bib0025","unstructured":"EUCAST, Breakpoints tables for interpretation of MICs and zone diameters. 2024."},{"key":"10.1016\/j.crmicr.2026.100587_bib0043","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/978-1-4939-9877-7_21","article-title":"MOBscan: automated annotation of MOB relaxases","volume":"2075","author":"Garcillan-Barcia","year":"2020","journal-title":"Methods Mol. Biol."},{"issue":"W1","key":"10.1016\/j.crmicr.2026.100587_bib0038","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkad326","article-title":"Proksee: in-depth characterization and visualization of bacterial genomes","volume":"51","author":"Grant","year":"2023","journal-title":"Nucleic. Acids. Res."},{"key":"10.1016\/j.crmicr.2026.100587_bib0034","first-page":"249","article-title":"Design and synthesis of benzochromene derivatives as AcrB inhibitors for the reversal of bacterial multidrug resistance","author":"Guo","year":"2023","journal-title":"Eur. J. Med. Chem."},{"issue":"8","key":"10.1016\/j.crmicr.2026.100587_bib0032","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1093\/bioinformatics\/btt086","article-title":"QUAST: quality assessment tool for genome assemblies","volume":"29","author":"Gurevich","year":"2013","journal-title":"Bioinformatics."},{"issue":"9","key":"10.1016\/j.crmicr.2026.100587_bib0056","article-title":"An analysis of the IS6\/IS26 family of insertion sequences: is it a single family?","volume":"5","author":"Harmer","year":"2019","journal-title":"Microb. Genom."},{"issue":"6","key":"10.1016\/j.crmicr.2026.100587_bib0070","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01987-16","article-title":"Mechanisms of evolution in high-consequence drug resistance plasmids","volume":"7","author":"He","year":"2016","journal-title":"mBio"},{"issue":"6","key":"10.1016\/j.crmicr.2026.100587_bib0077","doi-asserted-by":"crossref","DOI":"10.1002\/mbo3.517","article-title":"mcp, aer, cheB, and cheV contribute to the regulation of Vibrio alginolyticus (ND-01) adhesion under gradients of environmental factors","volume":"6","author":"Huang","year":"2017","journal-title":"Microbiologyopen."},{"issue":"5","key":"10.1016\/j.crmicr.2026.100587_bib0008","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.00549-23","article-title":"Phylogenetic lineages and antimicrobial resistance determinants of clinical Klebsiella oxytoca spanning local to global scales","volume":"11","author":"Ikhimiukor","year":"2023","journal-title":"Microbiol. Spectr."},{"issue":"5","key":"10.1016\/j.crmicr.2026.100587_bib0045","first-page":"39","article-title":"HOTSPOT: hierarchical host prediction for assembled plasmid contigs with transformer","author":"Ji","year":"2023","journal-title":"Bioinformatics."},{"issue":"5","key":"10.1016\/j.crmicr.2026.100587_bib0062","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1093\/jac\/dkn311","article-title":"Tigecycline for the treatment of multidrug-resistant Enterobacteriaceae: a systematic review of the evidence from microbiological and clinical studies","volume":"62","author":"Kelesidis","year":"2008","journal-title":"J. Antimicrob. Chemother"},{"issue":"3","key":"10.1016\/j.crmicr.2026.100587_bib0051","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1006\/jmbi.2000.4315","article-title":"Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes","volume":"305","author":"Krogh","year":"2001","journal-title":"J. Mol. Biol."},{"issue":"12","key":"10.1016\/j.crmicr.2026.100587_bib0050","doi-asserted-by":"crossref","DOI":"10.1093\/molbev\/msae263","article-title":"MEGA12: molecular Evolutionary Genetic Analysis Version 12 for adaptive and green computing","volume":"41","author":"Kumar","year":"2024","journal-title":"Mol. Biol. Evol."},{"issue":"1","key":"10.1016\/j.crmicr.2026.100587_bib0011","article-title":"Hospital toilets and drainage systems as a reservoir for a long-term polyclonal outbreak of clinical infections with multidrug-resistant Klebsiella oxytoca species complex","volume":"7","author":"Larsen","year":"2025","journal-title":"Infect Prev Pr."},{"issue":"1","key":"10.1016\/j.crmicr.2026.100587_bib0071","doi-asserted-by":"crossref","first-page":"8113","DOI":"10.1038\/s41598-020-65106-w","article-title":"Characterization of the global distribution and diversified plasmid reservoirs of the colistin resistance gene mcr-9","volume":"10","author":"Li","year":"2020","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.crmicr.2026.100587_bib0004","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jmii.2023.10.014","article-title":"Multicenter comparative genomic study of complex reveals a highly antibiotic-resistant subspecies of michiganensis","volume":"57","author":"Li","year":"2024","journal-title":"J. Microbiol. Immunol. Infect."},{"issue":"6","key":"10.1016\/j.crmicr.2026.100587_bib0003","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.eimc.2023.04.004","article-title":"Outbreaks by Klebsiella oxytoca in neonatal intensive care units: analysis of an outbreak in a tertiary hospital and systematic review","volume":"42","author":"Li\u00e9bana-Rodr\u00edguez","year":"2024","journal-title":"Enferm. Infecc. Microbiol. Clin. (Engl. Ed)"},{"issue":"1","key":"10.1016\/j.crmicr.2026.100587_bib0090","doi-asserted-by":"crossref","first-page":"8315","DOI":"10.1038\/s41467-024-52450-y","article-title":"Prophage-encoded antibiotic resistance genes are enriched in human-impacted environments","volume":"15","author":"Liao","year":"2024","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.crmicr.2026.100587_bib0086","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1128\/AAC.02465-15","article-title":"Potential of tetracycline resistance proteins to evolve tigecycline resistance","volume":"60","author":"Linkevicius","year":"2016","journal-title":"Antimicrob. Agents Chemother"},{"issue":"3","key":"10.1016\/j.crmicr.2026.100587_bib0005","doi-asserted-by":"crossref","DOI":"10.1128\/aac.02183-21","article-title":"Genome analysis of Klebsiella oxytoca complex for antimicrobial resistance and virulence genes","volume":"66","author":"Long","year":"2022","journal-title":"Antimicrob. Agents. Chemother"},{"issue":"7","key":"10.1016\/j.crmicr.2026.100587_bib0012","article-title":"Sharing of carbapenemase-encoding plasmids between Enterobacteriaceae in UK sewage uncovered by MinION sequencing","volume":"3","author":"Ludden","year":"2017","journal-title":"Microb. Genom."},{"issue":"12","key":"10.1016\/j.crmicr.2026.100587_bib0073","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmi.2021.04.020","article-title":"Silent spread of mobile colistin resistance gene mcr-9.1 on IncHI2 'superplasmids' in clinical carbapenem-resistant enterobacterales","volume":"27","author":"Macesic","year":"2021","journal-title":"Clin. Microbiol. Infect."},{"issue":"W1","key":"10.1016\/j.crmicr.2026.100587_bib0036","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkac240","article-title":"Search and sequence analysis tools services from EMBL-EBI in 2022","volume":"50","author":"Madeira","year":"2022","journal-title":"Nucleic. Acids. Res."},{"issue":"3","key":"10.1016\/j.crmicr.2026.100587_bib0010","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1469-0691.2011.03570.x","article-title":"Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance","volume":"18","author":"Magiorakos","year":"2012","journal-title":"Clin. Microbiol. Infect."},{"issue":"11","key":"10.1016\/j.crmicr.2026.100587_bib0081","doi-asserted-by":"crossref","DOI":"10.3390\/pathogens13110921","article-title":"Aeromonas and mcr-3: a critical juncture for transferable polymyxin resistance in gram-negative bacteria","volume":"13","author":"McDonald","year":"2024","journal-title":"Pathogens."},{"issue":"3","key":"10.1016\/j.crmicr.2026.100587_bib0007","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1093\/gbe\/evx019","article-title":"Population structure of multidrug-resistant Klebsiella oxytoca within hospitals across the United Kingdom and Ireland identifies sharing of virulence and resistance genes with K. pneumoniae","volume":"9","author":"Moradigaravand","year":"2017","journal-title":"Genome. Biol. Evol."},{"issue":"1","key":"10.1016\/j.crmicr.2026.100587_bib0026","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0086669","article-title":"Evaluation of epidemiological cut-off values indicates that biocide resistant subpopulations are uncommon in natural isolates of clinically-relevant microorganisms","volume":"9","author":"Morrissey","year":"2014","journal-title":"PLoS. One"},{"issue":"1","key":"10.1016\/j.crmicr.2026.100587_bib0049","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1080\/14756366.2017.1344235","article-title":"Beta-lactamase database (BLDB) \u2013 structure and function","volume":"32","author":"Naas","year":"2017","journal-title":"J. Enzyme Inhib. Med. Chem."},{"issue":"4","key":"10.1016\/j.crmicr.2026.100587_bib0002","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1007\/s00284-021-02402-2","article-title":"Klebsiella oxytoca and emerging nosocomial infections","volume":"78","author":"Neog","year":"2021","journal-title":"Curr. Microbiol."},{"issue":"1","key":"10.1016\/j.crmicr.2026.100587_bib0015","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s10661-019-7952-8","article-title":"Occurrence of antibiotics residues in hospital wastewater, wastewater treatment plant, and in surface water in Nairobi County","volume":"192","author":"Ngigi","year":"2019","journal-title":"Kenya. Env. Monit Assess"},{"issue":"1","key":"10.1016\/j.crmicr.2026.100587_bib0068","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1038\/s41598-023-29530-y","article-title":"Factors associated with plasmid antibiotic resistance gene carriage revealed using large-scale multivariable analysis","volume":"13","author":"Orlek","year":"2023","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.crmicr.2026.100587_bib0019","doi-asserted-by":"crossref","DOI":"10.1128\/CMR.00088-17","article-title":"Mobile genetic elements associated with antimicrobial resistance","volume":"31","author":"Partridge","year":"2018","journal-title":"Clin. Microbiol. Rev."},{"issue":"4","key":"10.1016\/j.crmicr.2026.100587_bib0085","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1128\/mr.60.4.575-608.1996","article-title":"Proton-dependent multidrug efflux systems","volume":"60","author":"Paulsen","year":"1996","journal-title":"Microbiol. Rev."},{"issue":"3","key":"10.1016\/j.crmicr.2026.100587_bib0080","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s13213-014-0911-2","article-title":"The prevalence of antibiotic resistance genes among Aeromonas species in aquatic environments","volume":"64","author":"Piotrowska","year":"2014","journal-title":"Ann. Microbiol"},{"issue":"21","key":"10.1016\/j.crmicr.2026.100587_bib0027","doi-asserted-by":"crossref","first-page":"4207","DOI":"10.1093\/bioinformatics\/btz220","article-title":"TORMES: an automated pipeline for whole bacterial genome analysis","volume":"35","author":"Quijada","year":"2019","journal-title":"Bioinformatics."},{"issue":"12","key":"10.1016\/j.crmicr.2026.100587_bib0078","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1012327","article-title":"MCP5, a methyl-accepting chemotaxis protein regulated by both the Hk1-Rrp1 and Rrp2-RpoN-RpoS pathways, is required for the immune evasion of Borrelia burgdorferi","volume":"20","author":"Raghunandanan","year":"2025","journal-title":"PLoS. Pathog."},{"key":"10.1016\/j.crmicr.2026.100587_bib0037","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gku316","article-title":"Deciphering key features in protein structures with the new ENDscript server","volume":"42","author":"Robert","year":"2014","journal-title":"Nucleic. Acids. Res."},{"issue":"5","key":"10.1016\/j.crmicr.2026.100587_bib0066","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1093\/jac\/dkx488","article-title":"Plasmids carrying antimicrobial resistance genes in Enterobacteriaceae","volume":"73","author":"Rozwandowicz","year":"2018","journal-title":"J. Antimicrob. Chemother"},{"issue":"18","key":"10.1016\/j.crmicr.2026.100587_bib0076","doi-asserted-by":"crossref","first-page":"3293","DOI":"10.1007\/s00018-017-2514-0","article-title":"Methyl-accepting chemotaxis proteins: a core sensing element in prokaryotes and archaea","volume":"74","author":"Salah Ud-Din","year":"2017","journal-title":"Cell Mol. Life Sci."},{"issue":"1","key":"10.1016\/j.crmicr.2026.100587_bib0052","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01260-17","article-title":"Dissemination and characteristics of a novel plasmid-encoded carbapenem-hydrolyzing class D \u03b2-lactamase, OXA-436, found in isolates from four patients at six different hospitals in Denmark","volume":"62","author":"Samuelsen","year":"2018","journal-title":"Antimicrob. Agents Chemother"},{"issue":"3","key":"10.1016\/j.crmicr.2026.100587_bib0013","doi-asserted-by":"crossref","DOI":"10.1002\/mbo3.1409","article-title":"Multidrug-resistant Stenotrophomonas maltophilia in residential aged care facilities: an emerging threat","volume":"13","author":"Sapula","year":"2024","journal-title":"Microbiologyopen."},{"issue":"14","key":"10.1016\/j.crmicr.2026.100587_bib0033","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1093\/bioinformatics\/btu153","article-title":"Prokka: rapid prokaryotic genome annotation","volume":"30","author":"Seemann","year":"2014","journal-title":"Bioinformatics."},{"issue":"11","key":"10.1016\/j.crmicr.2026.100587_bib0057","doi-asserted-by":"crossref","first-page":"6781","DOI":"10.1021\/acs.est.0c01272","article-title":"Novel transposon Tn6433 variants accelerate the dissemination of tet(E) in Aeromonas in an aerobic biofilm reactor under oxytetracycline stresses","volume":"54","author":"Shi","year":"2020","journal-title":"Env. Sci Technol"},{"key":"10.1016\/j.crmicr.2026.100587_bib0054","doi-asserted-by":"crossref","DOI":"10.1016\/j.micres.2024.127867","article-title":"Enterobacter adelaidei sp. nov. Isolation of an extensively drug resistant strain from hospital wastewater in Australia and the global distribution of the species","volume":"288","author":"Siderius","year":"2024","journal-title":"Microbiol. Res."},{"key":"10.1016\/j.crmicr.2026.100587_bib0046","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkj014","article-title":"ISfinder: the reference centre for bacterial insertion sequences","volume":"34","author":"Siguier","year":"2006","journal-title":"Nucleic. Acids. Res."},{"issue":"5","key":"10.1016\/j.crmicr.2026.100587_bib0055","article-title":"The highly diverse plasmid population found in Escherichia coli colonizing travellers to Laos and its role in antimicrobial resistance gene carriage","volume":"9","author":"Snaith","year":"2023","journal-title":"Microb. Genom."},{"key":"10.1016\/j.crmicr.2026.100587_bib0074","first-page":"108","article-title":"Decoding the origins, spread, and global risks of mcr-9 gene","author":"Song","year":"2024","journal-title":"EBioMedicine"},{"issue":"12","key":"10.1016\/j.crmicr.2026.100587_bib0040","doi-asserted-by":"crossref","first-page":"3882","DOI":"10.1093\/bioinformatics\/btaa250","article-title":"Phigaro: high-throughput prophage sequence annotation","volume":"36","author":"Starikova","year":"2020","journal-title":"Bioinformatics."},{"issue":"1","key":"10.1016\/j.crmicr.2026.100587_bib0009","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1186\/s12879-022-07687-7","article-title":"Epidemiology and genomic analysis of Klebsiella oxytoca from a single hospital network in Australia","volume":"22","author":"Stewart","year":"2022","journal-title":"BMC. Infect. Dis."},{"issue":"7","key":"10.1016\/j.crmicr.2026.100587_bib0048","doi-asserted-by":"crossref","DOI":"10.1038\/s41587-021-01156-3","article-title":"SignalP 6.0 predicts all five types of signal peptides using protein language models","volume":"40","author":"Teufel","year":"2022","journal-title":"Nat. Biotechnol."},{"issue":"1","key":"10.1016\/j.crmicr.2026.100587_bib0021","doi-asserted-by":"crossref","DOI":"10.1111\/1751-7915.14408","article-title":"Microbial evolution through horizontal gene transfer by mobile genetic elements","volume":"17","author":"Tokuda","year":"2024","journal-title":"Microb. Biotechnol."},{"issue":"3\u20134","key":"10.1016\/j.crmicr.2026.100587_bib0035","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1574-6968.1986.tb01189.x","article-title":"Plasmid curing in bacteria","volume":"32","author":"Trevors","year":"1986","journal-title":"FEMS Microbiol. Lett"},{"issue":"5","key":"10.1016\/j.crmicr.2026.100587_bib0069","doi-asserted-by":"crossref","DOI":"10.1128\/aac.01672-24","article-title":"Impact of porin deletions on cefepime-taniborbactam activity against Klebsiella pneumoniae","volume":"69","author":"Uehara","year":"2025","journal-title":"Antimicrob. Agents Chemother"},{"key":"10.1016\/j.crmicr.2026.100587_bib0059","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.3389\/fmicb.2015.00377","article-title":"RND-type drug efflux pumps from gram-negative bacteria: molecular mechanism and inhibition","volume":"Volume 6","author":"Venter","year":"2015","journal-title":"Front. Microbiol."},{"issue":"1","key":"10.1016\/j.crmicr.2026.100587_bib0016","doi-asserted-by":"crossref","first-page":"e159","DOI":"10.1093\/infdis\/jiae019","article-title":"Integrated analysis of patient networks and plasmid genomes to investigate a regional, multispecies outbreak of carbapenemase-producing enterobacterales carrying both blaIMP and mcr-9 genes","volume":"230","author":"Wan","year":"2024","journal-title":"J. Infect. Dis."},{"issue":"3","key":"10.1016\/j.crmicr.2026.100587_bib0064","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.ijantimicag.2014.10.021","article-title":"IncA\/C plasmids harboured in serious multidrug-resistant ibrio cholerae serogroup O139 strains in China","volume":"45","author":"Wang","year":"2015","journal-title":"Int. J. Antimicrob. Agents"},{"issue":"1","key":"10.1016\/j.crmicr.2026.100587_bib0087","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1093\/jac\/dkab375","article-title":"Identification of a novel plasmid-mediated tigecycline resistance-related gene, tet(Y), in Acinetobacter baumannii","volume":"77","author":"Wang","year":"2021","journal-title":"J. Antimicrob. Chemother"},{"issue":"3","key":"10.1016\/j.crmicr.2026.100587_bib0088","doi-asserted-by":"crossref","DOI":"10.1128\/Spectrum.01310-21","article-title":"Novel Tet(L) efflux pump variants conferring resistance to tigecycline and eravacycline in Staphylococcus spp","volume":"9","author":"Wang","year":"2021","journal-title":"Microbiol. Spectr."},{"issue":"1","key":"10.1016\/j.crmicr.2026.100587_bib0022","doi-asserted-by":"crossref","DOI":"10.1093\/ismejo\/wrad032","article-title":"Inter-plasmid transfer of antibiotic resistance genes accelerates antibiotic resistance in bacterial pathogens","volume":"18","author":"Wang","year":"2024","journal-title":"ISMe J."},{"issue":"1","key":"10.1016\/j.crmicr.2026.100587_bib0024","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/s42003-024-05940-0","article-title":"Identification and characterization of CIM-1, a carbapenemase that adds to the family of resistance factors against last resort antibiotics","volume":"7","author":"Wang","year":"2024","journal-title":"Commun. Biol."},{"issue":"1","key":"10.1016\/j.crmicr.2026.100587_bib0029","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1009802","article-title":"Polypolish: short-read polishing of long-read bacterial genome assemblies","volume":"18","author":"Wick","year":"2022","journal-title":"PLoS. Comput. Biol."},{"issue":"1","key":"10.1016\/j.crmicr.2026.100587_bib0001","doi-asserted-by":"crossref","DOI":"10.1128\/CMR.00006-21","article-title":"Klebsiella oxytoca complex: update on taxonomy, antimicrobial resistance, and virulence","volume":"35","author":"Yang","year":"2022","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.crmicr.2026.100587_bib0053","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.960892","article-title":"Co-occurrence of dual carbapenemases KPC-2 and OXA-48 with the mobile colistin resistance gene mcr-9.1 in Enterobacter xiangfangensis","volume":"12","author":"Yao","year":"2022","journal-title":"Front. Cell Infect. Microbiol."},{"issue":"6","key":"10.1016\/j.crmicr.2026.100587_bib0030","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1007981","article-title":"The genome polishing tool POLCA makes fast and accurate corrections in genome assemblies","volume":"16","author":"Zimin","year":"2020","journal-title":"PLoS. Comput. Biol."}],"container-title":["Current Research in Microbial Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666517426000428?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666517426000428?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T15:33:17Z","timestamp":1788276797000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666517426000428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":89,"alternative-id":["S2666517426000428"],"URL":"https:\/\/doi.org\/10.1016\/j.crmicr.2026.100587","relation":{},"ISSN":["2666-5174"],"issn-type":[{"value":"2666-5174","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel self-transmissible mega plasmid from extensively drug-resistant Klebsiella oxytoca carries multiple antimicrobial resistance genes and acts as a resistance reservoir","name":"articletitle","label":"Article Title"},{"value":"Current Research in Microbial Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.crmicr.2026.100587","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100587"}}