{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T11:25:01Z","timestamp":1794137101427,"version":"4.8.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"State of Sao Paulo Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000737","name":"University of Exeter","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000737","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006507","name":"Oswaldo Cruz Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006507","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Research in Microbial Sciences"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.crmicr.2026.100645","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T05:37:42Z","timestamp":1784180262000},"page":"100645","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Qdr3 Coordinates cellular homeostasis, mitochondrial remodeling, and virulence in Candidozyma auris (Candida auris)"],"prefix":"10.1016","volume":"11","author":[{"given":"Isadora F","family":"Munhoz da Rocha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig L.","family":"Ennis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno AA","family":"Romagnoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4488-625X","authenticated-orcid":false,"given":"Kayo","family":"Schemiko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suelen A","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre T","family":"da Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5760-4209","authenticated-orcid":false,"given":"Haroldo C","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0799-6499","authenticated-orcid":false,"given":"Clarissa J","family":"Nobile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1972-2658","authenticated-orcid":false,"given":"Lysangela R","family":"Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.crmicr.2026.100645_bib0001","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1080\/21505594.2022.2026037","article-title":"From environmental adaptation to host survival: attributes that mediate pathogenicity of Candida auris","volume":"13","author":"Allert","year":"2022","journal-title":"Virulence"},{"issue":"1","key":"10.1016\/j.crmicr.2026.100645_bib0002","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1080\/21505594.2022.2026037","article-title":"From environmental adaptation to host survival: attributes that mediate pathogenicity of Candida auris","volume":"13","author":"Allert","year":"2022","journal-title":"Virulence"},{"key":"10.1016\/j.crmicr.2026.100645_bib0003","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ejim.2016.06.029","article-title":"Candidemia and invasive candidiasis in adults: a narrative review","volume":"34","author":"Antinori","year":"2016","journal-title":"Eur. J. Intern. Med."},{"issue":"7","key":"10.1016\/j.crmicr.2026.100645_bib0005","doi-asserted-by":"crossref","DOI":"10.1111\/j.1469-0691.2012.03880.x","article-title":"EUCAST technical note on the EUCAST definitive document EDef 7.2: method for the determination of broth dilution minimum inhibitory concentrations of antifungal agents for yeasts EDef 7.2 (EUCAST-AFST)","volume":"18","author":"Arendrup","year":"2012","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.crmicr.2026.100645_bib0006","doi-asserted-by":"crossref","first-page":"549","DOI":"10.2147\/CLEP.S459600","article-title":"Epidemiology of invasive candidiasis","volume":"16","author":"Bays","year":"2024","journal-title":"Clin. Epidemiol."},{"issue":"2","key":"10.1016\/j.crmicr.2026.100645_bib0007","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1574-695X.2002.tb00617.x","article-title":"Correlation between virulence of Candida albicans mutants in mice and Galleria mellonella larvae","volume":"34","author":"Brennan","year":"2002","journal-title":"FEMS Immunol. Med. Microbiol."},{"issue":"1","key":"10.1016\/j.crmicr.2026.100645_bib0008","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1186\/s12864-015-1863-z","article-title":"Draft genome of a commonly misdiagnosed multidrug resistant pathogen Candida auris","volume":"16","author":"Chatterjee","year":"2015","journal-title":"BMC Genom."},{"issue":"4","key":"10.1016\/j.crmicr.2026.100645_bib0009","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1093\/jac\/dkx480","article-title":"A multicentre study of antifungal susceptibility patterns among 350 Candida auris isolates (2009\u201317) in India: role of the ERG11 and FKS1 genes in azole and echinocandin resistance","volume":"73","author":"Chowdhary","year":"2018","journal-title":"J. Antimicrob. Chemother."},{"issue":"1","key":"10.1016\/j.crmicr.2026.100645_bib0010","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s40560-018-0342-4","article-title":"Epidemiology, clinical characteristics, resistance, and treatment of infections by Candida auris","volume":"6","author":"Cortegiani","year":"2018","journal-title":"J. Intensive Care"},{"key":"10.1016\/j.crmicr.2026.100645_bib0011","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2014.00197","article-title":"MFS multidrug transporters in pathogenic fungi: do they have real clinical impact?","volume":"5","author":"Costa","year":"2014","journal-title":"Front. Physiol."},{"key":"10.1016\/j.crmicr.2026.100645_bib0012","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.micpath.2018.09.014","article-title":"Candida auris: epidemiology, risk factors, virulence, resistance, and therapeutic options","volume":"125","author":"De C\u00e1ssia Orlandi Sardi","year":"2018","journal-title":"Microb. Pathog."},{"issue":"5","key":"10.1016\/j.crmicr.2026.100645_bib0013","doi-asserted-by":"crossref","first-page":"927","DOI":"10.3390\/microorganisms12050927","article-title":"Candida auris Outbreaks: current status and future perspectives","volume":"12","author":"De Gaetano","year":"2024","journal-title":"Microorganisms"},{"key":"10.1016\/j.crmicr.2026.100645_bib0014","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2014.00180","article-title":"MFS transporters required for multidrug\/multixenobiotic (MD\/MX) resistance in the model yeast: understanding their physiological function through post-genomic approaches","volume":"5","author":"Dos Santos","year":"2014","journal-title":"Front. Physiol."},{"issue":"10","key":"10.1016\/j.crmicr.2026.100645_bib0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1008921","article-title":"Candida auris: epidemiology, biology, antifungal resistance, and virulence","volume":"16","author":"Du","year":"2020","journal-title":"PLoS Pathog."},{"issue":"2","key":"10.1016\/j.crmicr.2026.100645_bib0016","doi-asserted-by":"crossref","DOI":"10.1128\/jcm.01530-25","article-title":"Beyond candidiasis: should infections caused by Candidozyma auris be renamed?","volume":"64","author":"Ekeno\u011flu Merdan","year":"2026","journal-title":"J. Clin. Microbiol."},{"issue":"3","key":"10.1016\/j.crmicr.2026.100645_bib0017","doi-asserted-by":"crossref","DOI":"10.1128\/Spectrum.01820-21","article-title":"A markerless CRISPR-mediated system for genome editing in Candida auris reveals a conserved role for Cas5 in the Caspofungin response","volume":"9","author":"Ennis","year":"2021","journal-title":"Microbiol. Spectr."},{"issue":"3","key":"10.1016\/j.crmicr.2026.100645_bib0018","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/j.1742-4658.2009.07485.x","article-title":"Multidrug efflux pumps: substrate selection in ATP-binding cassette multidrug efflux pumps \u2013 first come, first served?","volume":"277","author":"Ernst","year":"2010","journal-title":"FEBS J."},{"issue":"1","key":"10.1016\/j.crmicr.2026.100645_bib0019","doi-asserted-by":"crossref","DOI":"10.1128\/Spectrum.00013-21","article-title":"Characterization of the differential pathogenicity of Candida auris in a Galleria mellonella infection model","volume":"9","author":"Garcia-Bustos","year":"2021","journal-title":"Microbiol. Spectr."},{"issue":"1\u20132","key":"10.1016\/j.crmicr.2026.100645_bib0020","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.fbr.2010.04.001","article-title":"Galleria mellonella larvae as models for studying fungal virulence","volume":"24","author":"Kavanagh","year":"2010","journal-title":"Fungal Biol. Rev."},{"issue":"3","key":"10.1016\/j.crmicr.2026.100645_bib0021","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3390\/jof4030113","article-title":"The use of galleria mellonella larvae to identify novel antimicrobial agents against fungal species of medical interest","volume":"4","author":"Kavanagh","year":"2018","journal-title":"J. Fungi"},{"issue":"2","key":"10.1016\/j.crmicr.2026.100645_bib0022","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1093\/cid\/ciw691","article-title":"Simultaneous emergence of multidrug-resistant Candida auris on 3 continents confirmed by whole-genome sequencing and epidemiological analyses","volume":"64","author":"Lockhart","year":"2017","journal-title":"Clin. Infect. Dis."},{"issue":"10","key":"10.1016\/j.crmicr.2026.100645_bib0023","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.3390\/jof8101009","article-title":"The drug H+ antiporter FgQdr2 is essential for multiple drug resistance, ion homeostasis, and pathogenicity in fusarium graminearum","volume":"8","author":"Ma","year":"2022","journal-title":"J. Fungi"},{"issue":"1","key":"10.1016\/j.crmicr.2026.100645_bib0024","doi-asserted-by":"crossref","first-page":"5346","DOI":"10.1038\/s41467-018-07779-6","article-title":"Genomic insights into multidrug-resistance, mating and virulence in Candida auris and related emerging species","volume":"9","author":"Mu\u00f1oz","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.crmicr.2026.100645_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.fgb.2022.103713","article-title":"Quinidine drug resistance transporter knockout Candida cells modulate glucose transporter expression and accumulate metabolites leading to enhanced azole drug resistance","volume":"161","author":"Qadri","year":"2022","journal-title":"Fungal Genet. Biol."},{"key":"10.1016\/j.crmicr.2026.100645_bib0026","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.3389\/fmicb.2018.03081","article-title":"Candida auris: what have we learned about its mechanisms of pathogenicity?","volume":"9","author":"Rossato","year":"2018","journal-title":"Front. Microbiol."},{"issue":"1","key":"10.1016\/j.crmicr.2026.100645_bib0027","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00430-024-00795-y","article-title":"Alteration of \u03b2-glucan in the emerging fungal pathogen Candida auris leads to immune evasion and increased virulence","volume":"213","author":"Selisana","year":"2024","journal-title":"Med. Microbiol. Immunol."},{"issue":"2","key":"10.1016\/j.crmicr.2026.100645_bib0028","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1042\/BJ20140010","article-title":"Novel role of a family of major facilitator transporters in biofilm development and virulence of Candida albicans","volume":"460","author":"Shah","year":"2014","journal-title":"Biochem. J."},{"issue":"6","key":"10.1016\/j.crmicr.2026.100645_bib0029","doi-asserted-by":"crossref","DOI":"10.1093\/femsyr\/foaa045","article-title":"A detailed lipidomic study of human pathogenic fungi Candida auris","volume":"20","author":"Shahi","year":"2020","journal-title":"FEMS Yeast Res."},{"key":"10.1016\/j.crmicr.2026.100645_bib0030","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.nmni.2016.07.003","article-title":"Whole genome sequencing of emerging multidrug resistant Candida auris isolates in India demonstrates low genetic variation","volume":"13","author":"Sharma","year":"2016","journal-title":"New Microbes New Infect."},{"issue":"3","key":"10.1016\/j.crmicr.2026.100645_bib0031","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1080\/21505594.2015.1135289","article-title":"Galleria mellonella infection models for the study of bacterial diseases and for antimicrobial drug testing","volume":"7","author":"Tsai","year":"2016","journal-title":"Virulence"}],"container-title":["Current Research in Microbial Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S266651742600101X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S266651742600101X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,8]],"date-time":"2026-11-08T10:49:47Z","timestamp":1794134987000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S266651742600101X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":30,"alternative-id":["S266651742600101X"],"URL":"https:\/\/doi.org\/10.1016\/j.crmicr.2026.100645","relation":{},"ISSN":["2666-5174"],"issn-type":[{"value":"2666-5174","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Qdr3 Coordinates cellular homeostasis, mitochondrial remodeling, and virulence in Candidozyma auris (Candida auris)","name":"articletitle","label":"Article Title"},{"value":"Current Research in Microbial Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.crmicr.2026.100645","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100645"}}