{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:35:58Z","timestamp":1791275758113,"version":"4.1.0"},"reference-count":177,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,2,1]]},"DOI":"10.1016\/j.crohns.2009.12.003","type":"journal-article","created":{"date-parts":[[2010,1,16]],"date-time":"2010-01-16T09:25:14Z","timestamp":1263633914000},"page":"7-27","source":"Crossref","is-referenced-by-count":875,"title":["The second European evidence-based Consensus on the diagnosis and management of Crohn's disease: Definitions and diagnosis"],"prefix":"10.1093","volume":"4","author":[{"given":"Gert","family":"Van Assche","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Dignass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian","family":"Panes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Beaugerie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Karagiannis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Allez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Ochsenk\u00fchn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Orchard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Rogler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edouard","family":"Louis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limas","family":"Kupcinskas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerassimos","family":"Mantzaris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Travis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduard","family":"Stange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the European Crohn's and Colitis Organisation (ECCO)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,2]]},"reference":[{"key":"key\n\t\t\t\t2018110508354693800_bib1","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1136\/gut.39.5.690","article-title":"Incidence of inflammatory bowel disease across Europe: is there a difference between the north and south? Results of the European Collaborative Study on Inflammatory Bowel Disease (EC-IBD)","volume":"39","author":"Shivananda","year":"1996","journal-title":"Gut"},{"issue":"Suppl 5","key":"key\n\t\t\t\t2018110508354693800_bib2","doi-asserted-by":"crossref","first-page":"V1","DOI":"10.1136\/gut.2004.043372","article-title":"Guidelines for the management of inflammatory bowel disease in adults","volume":"53","author":"Carter","year":"2004","journal-title":"Gut"},{"key":"key\n\t\t\t\t2018110508354693800_bib3","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1055\/s-2003-36661","article-title":"Diagnostik und Therapie des M. Crohn-Ergebnisse einer evidenzbasierten Konsensuskonferenz der Deutschen Gesellschaft f\u00fcr Verdauungs- und Stoffwechselkrankheiten","volume":"41","author":"Stange","year":"2003","journal-title":"Z Gastroenterol"},{"issue":"Suppl 1","key":"key\n\t\t\t\t2018110508354693800_bib4","doi-asserted-by":"crossref","first-page":"i16","DOI":"10.1136\/gut.2005.081950b","article-title":"European evidence based consensus on the diagnosis and management of Crohn's disease: current management","author":"Travis","year":"2006","journal-title":"Gut"},{"issue":"Suppl 1","key":"key\n\t\t\t\t2018110508354693800_bib5","doi-asserted-by":"crossref","first-page":"i1","DOI":"10.1136\/gut.2005.081950a","article-title":"European evidence based consensus on the diagnosis and management of Crohn's disease: definitions and diagnosis","volume":"55","author":"Stange","year":"2006","journal-title":"Gut"},{"key":"key\n\t\t\t\t2018110508354693800_bib6","doi-asserted-by":"crossref","first-page":"979","DOI":"10.2105\/AJPH.74.9.979","article-title":"Consensus methods: characteristics and guidelines for use","volume":"74","author":"Fink","year":"1984","journal-title":"Am J Public Health"},{"key":"key\n\t\t\t\t2018110508354693800_bib7"},{"key":"key\n\t\t\t\t2018110508354693800_bib8","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1053\/j.gastro.2004.01.024","article-title":"A meta-analysis of the placebo rates of remission and response in clinical trials of active Crohn's disease","volume":"126","author":"Su","year":"2004","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t2018110508354693800_bib9","first-page":"319","article-title":"Assessing outcomes in clinical trials","author":"Irvine","year":"2003","journal-title":"Inflammatory bowel diseases"},{"key":"key\n\t\t\t\t2018110508354693800_bib10","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1053\/gast.2002.31072","article-title":"A review of activity indices and efficacy endpoints for clinical trials of medical therapy in adults with Crohn's disease","volume":"122","author":"Sandborn","year":"2002","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t2018110508354693800_bib11","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1016\/0016-5085(86)90206-4","article-title":"A laboratory index for predicting relapse in asymptomatic patients with Crohn's disease","volume":"91","author":"Brignola","year":"1986","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t2018110508354693800_bib12","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/BF01308338","article-title":"Placebo-controlled trial of oral 5-ASA in relapse prevention of Crohn's disease","volume":"37","author":"Brignola","year":"1992","journal-title":"Dig Dis Sci"},{"key":"key\n\t\t\t\t2018110508354693800_bib13","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S0016-5085(99)70332-X","article-title":"Efficacy and safety of retreatment with anti-tumor necrosis factor antibody (infliximab) to maintain remission in Crohn's disease","volume":"117","author":"Rutgeerts","year":"1999","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t2018110508354693800_bib14","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1016\/S0140-6736(02)08512-4","article-title":"Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial","volume":"359","author":"Hanauer","year":"2002","journal-title":"Lancet"},{"key":"key\n\t\t\t\t2018110508354693800_bib15","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/0016-5085(90)90613-6","article-title":"Predictability of the postoperative course of Crohn's disease","volume":"99","author":"Rutgeerts","year":"1990","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t2018110508354693800_bib16","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1365-2036.1994.tb00158.x","article-title":"Oral mesalazine (5-aminosalicylic acid; Asacol) for the prevention of post-operative recurrence of CD","volume":"8","author":"Caprilli","year":"1994","journal-title":"Aliment Pharmacol Ther"},{"key":"key\n\t\t\t\t2018110508354693800_bib17","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0002-9270(01)04037-0","article-title":"Quality of life in inflammatory bowel disease in remission: the impact of IBS-like symptoms and associated psychological factors","volume":"97","author":"Simr\u00e9n","year":"2002","journal-title":"Am J Gastroenterol"},{"issue":"6","key":"key\n\t\t\t\t2018110508354693800_bib18","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1053\/j.gastro.2004.01.063","article-title":"Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences","volume":"126","author":"Loftus","year":"2004","journal-title":"Gastroenterology"},{"issue":"6","key":"key\n\t\t\t\t2018110508354693800_bib19","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1053\/j.gastro.2004.02.072","article-title":"From symptom to diagnosis: clinical distinctions among various forms of intestinal inflammation","volume":"126","author":"Sands","year":"2004","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t2018110508354693800_bib20"},{"issue":"5","key":"key\n\t\t\t\t2018110508354693800_bib21","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.cgh.2006.03.003","article-title":"The Manitoba Inflammatory Bowel Disease Cohort Study: prolonged symptoms before diagnosis\u2013how much is irritable bowel syndrome?","volume":"4","author":"Burgmann","year":"2006","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"12","key":"key\n\t\t\t\t2018110508354693800_bib22","doi-asserted-by":"crossref","first-page":"3458","DOI":"10.1111\/j.1572-0241.2000.03361.x","article-title":"Identification of a prodromal period in Crohn's disease but not ulcerative colitis","volume":"95","author":"Pimentel","year":"2000","journal-title":"Am J Gastroenterol"},{"issue":"4","key":"key\n\t\t\t\t2018110508354693800_bib23","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1097\/00042737-199704000-00007","article-title":"Clinical uniformity of inflammatory bowel disease a presentation and during the first year of disease in the north and south of Europe. EC-IBD Study Group","volume":"9","author":"Lennard-Jones","year":"1997","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"4 Pt 1","key":"key\n\t\t\t\t2018110508354693800_bib24","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0016-5085(75)80270-8","article-title":"Clinical patterns in Crohn's disease: a statistical study of 615 cases","volume":"68","author":"Farmer","year":"1975","journal-title":"Gastroenterology"},{"issue":"4","key":"key\n\t\t\t\t2018110508354693800_bib25","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1053\/gast.2002.32362","article-title":"The natural history of fistulizing Crohn's disease in Olmsted County, Minnesota","volume":"122","author":"Schwartz","year":"2002","journal-title":"Gastroenterology"},{"issue":"Suppl A","key":"key\n\t\t\t\t2018110508354693800_bib26","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1155\/2005\/269076","article-title":"Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology","volume":"19","author":"Silverberg","year":"2005","journal-title":"Can J Gastroenterol"},{"issue":"6","key":"key\n\t\t\t\t2018110508354693800_bib27","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1136\/jcp.31.6.567","article-title":"Overlap in the spectrum of non-specific inflammatory bowel disease\u2013'colitis indeterminate'","volume":"31","author":"Price","year":"1978","journal-title":"J Clin Pathol"},{"issue":"1","key":"key\n\t\t\t\t2018110508354693800_bib28","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1053\/gast.2003.50021","article-title":"Appendectomy is followed by increased risk of Crohn's disease","volume":"124","author":"Andersson","year":"2003","journal-title":"Gastroenterology"},{"issue":"1","key":"key\n\t\t\t\t2018110508354693800_bib29","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1136\/gut.51.1.21","article-title":"In siblings with similar genetic susceptibility for inflammatory bowel disease, smokers tend to develop Crohn's disease and non-smokers develop ulcerative colitis","volume":"51","author":"Bridger","year":"2002","journal-title":"Gut"},{"issue":"6","key":"key\n\t\t\t\t2018110508354693800_bib30","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1053\/j.gastro.2006.02.004","article-title":"Acute gastroenteritis is followed by an increased risk of inflammatory bowel disease","volume":"130","author":"Garcia Rodriguez","year":"2006","journal-title":"Gastroenterology"},{"issue":"11","key":"key\n\t\t\t\t2018110508354693800_bib31","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1046\/j.1365-2036.2003.01596.x","article-title":"An open-label trial of the selective cyclo-oxygenase-2 inhibitor, rofecoxib, in inflammatory bowel disease-associated peripheral arthritis and arthralgia","volume":"17","author":"Reinisch","year":"2003","journal-title":"Aliment Pharmacol Ther"},{"issue":"4","key":"key\n\t\t\t\t2018110508354693800_bib32","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/j.1365-2362.1982.tb02244.x","article-title":"Serum levels of C-reactive protein in Crohn's disease and ulcerative colitis","volume":"12","author":"Fagan","year":"1982","journal-title":"Eur J Clin Invest"},{"issue":"4","key":"key\n\t\t\t\t2018110508354693800_bib33","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1097\/00042737-200204000-00013","article-title":"A new, highly sensitive assay for C-reactive protein can aid the differentiation of inflammatory bowel disorders from constipation- and diarrhoea-predominant functional bowel disorders","volume":"14","author":"Poullis","year":"2002","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"5","key":"key\n\t\t\t\t2018110508354693800_bib34","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1097\/00054725-200409000-00026","article-title":"C-reactive protein as a marker for inflammatory bowel disease","volume":"10","author":"Vermeire","year":"2004","journal-title":"Inflamm Bowel Dis"},{"issue":"6","key":"key\n\t\t\t\t2018110508354693800_bib35","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1097\/00004836-199012000-00009","article-title":"Erythrocyte sedimentation as a measure of Crohn's disease activity: opposite trends in ileitis versus colitis","volume":"12","author":"Sachar","year":"1990","journal-title":"J Clin Gastroenterol"},{"issue":"4","key":"key\n\t\t\t\t2018110508354693800_bib36","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s00384-006-0159-9","article-title":"Calprotectin and lactoferrin in the assessment of intestinal inflammation and organic disease","volume":"22","author":"D'Inca","year":"2007","journal-title":"Int J Colorectal Dis"},{"issue":"6","key":"key\n\t\t\t\t2018110508354693800_bib37","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1093\/qjmed\/hci069","article-title":"Faecal calprotectin in the assessment of Crohn's disease activity","volume":"98","author":"Gaya","year":"2005","journal-title":"QJM"},{"issue":"4","key":"key\n\t\t\t\t2018110508354693800_bib38","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1136\/gut.47.4.506","article-title":"A simple method for assessing intestinal inflammation in Crohn's disease","volume":"47","author":"Tibble","year":"2000","journal-title":"Gut"},{"issue":"1","key":"key\n\t\t\t\t2018110508354693800_bib39","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1053\/gast.2000.8523","article-title":"Surrogate markers of intestinal inflammation are predictive of relapse in patients with inflammatory bowel disease","volume":"119","author":"Tibble","year":"2000","journal-title":"Gastroenterology"},{"issue":"6","key":"key\n\t\t\t\t2018110508354693800_bib40","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1111\/j.1572-0241.2003.07458.x","article-title":"Fecal lactoferrin is a sensitive and specific marker in identifying intestinal inflammation","volume":"98","author":"Kane","year":"2003","journal-title":"Am J Gastroenterol"},{"issue":"7","key":"key\n\t\t\t\t2018110508354693800_bib41","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1097\/01.ibd.0000227626.72271.91","article-title":"Fecal S100A12: a novel noninvasive marker in children with Crohn's disease","volume":"12","author":"de Jong","year":"2006","journal-title":"Inflamm Bowel Dis"},{"issue":"12","key":"key\n\t\t\t\t2018110508354693800_bib42","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1136\/gut.2006.113431","article-title":"Faecal S100A12 as a non-invasive marker distinguishing inflammatory bowel disease from irritable bowel syndrome","volume":"56","author":"Kaiser","year":"2007","journal-title":"Gut"},{"issue":"8","key":"key\n\t\t\t\t2018110508354693800_bib43","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1097\/01.meg.0000131040.38607.09","article-title":"Enteric infection in relapse of inflammatory bowel disease: importance of microbiological examination of stool","volume":"16","author":"Mylonaki","year":"2004","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"2","key":"key\n\t\t\t\t2018110508354693800_bib44","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1373\/clinchem.2005.058560","article-title":"Serologic markers in inflammatory bowel disease","volume":"52","author":"Bossuyt","year":"2006","journal-title":"Clin Chem"},{"issue":"10","key":"key\n\t\t\t\t2018110508354693800_bib45","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1111\/j.1572-0241.2006.00840.x","article-title":"Diagnostic precision of anti-Saccharomyces cerevisiae antibodies and perinuclear antineutrophil cytoplasmic antibodies in inflammatory bowel disease","volume":"101","author":"Reese","year":"2006","journal-title":"Am J Gastroenterol"},{"issue":"10","key":"key\n\t\t\t\t2018110508354693800_bib46","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.cgh.2008.04.032","article-title":"Increased immune reactivity predicts aggressive complicating Crohn's disease in children","volume":"6","author":"Dubinsky","year":"2008","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"10","key":"key\n\t\t\t\t2018110508354693800_bib47","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1136\/gut.2006.108043","article-title":"New serological markers in inflammatory bowel disease are associated with complicated disease behaviour","volume":"56","author":"Ferrante","year":"2007","journal-title":"Gut"},{"issue":"3","key":"key\n\t\t\t\t2018110508354693800_bib48","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1136\/gut.2005.069476","article-title":"Laboratory markers in IBD: useful, magic, or unnecessary toys?","volume":"55","author":"Vermeire","year":"2006","journal-title":"Gut"},{"issue":"3","key":"key\n\t\t\t\t2018110508354693800_bib49","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0016-5107(84)72358-3","article-title":"The value of ileoscopy with biopsy in the diagnosis of intestinal Crohn's disease","volume":"30","author":"Coremans","year":"1984","journal-title":"Gastrointest Endosc"},{"issue":"2","key":"key\n\t\t\t\t2018110508354693800_bib50","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1572-0241.1998.00201.x","article-title":"Is ileoscopy with biopsy worthwhile in patients presenting with symptoms of inflammatory bowel disease?","volume":"93","author":"Geboes","year":"1998","journal-title":"Am J Gastroenterol"},{"issue":"12","key":"key\n\t\t\t\t2018110508354693800_bib51","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1111\/j.1572-0241.2004.40730.x","article-title":"Is routine ileoscopy useful? An observational study of procedure times, diagnostic yield, and learning curve","volume":"99","author":"Cherian","year":"2004","journal-title":"Am J Gastroenterol"},{"issue":"4","key":"key\n\t\t\t\t2018110508354693800_bib52","first-page":"947","article-title":"Long term outcome of patients with active Crohn's disease exhibiting extensive and deep ulcerations at colonoscopy","volume":"97","author":"Allez","year":"2002","journal-title":"Am J Gastroenterol"},{"issue":"12","key":"key\n\t\t\t\t2018110508354693800_bib53","doi-asserted-by":"crossref","first-page":"3102","DOI":"10.1111\/j.1572-0241.2002.07106.x","article-title":"Colonoscopy accurately predicts the anatomical severity of colonic Crohn's disease attacks: correlation with findings from colectomy specimens","volume":"97","author":"Nahon","year":"2002","journal-title":"Am J Gastroenterol"},{"issue":"Suppl 5","key":"key\n\t\t\t\t2018110508354693800_bib54","doi-asserted-by":"crossref","first-page":"V1","DOI":"10.1136\/gut.2004.043372","article-title":"IBD Section, British Society of Gastroenterology. Guidelines for the management of inflammatory bowel disease in adults","volume":"53","author":"Carter","year":"2004","journal-title":"Gut"},{"issue":"1","key":"key\n\t\t\t\t2018110508354693800_bib55","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1148\/radiol.2471070611","article-title":"Inflammatory bowel disease diagnosed with US, MR, scintigraphy, and CT: meta-analysis of prospective studies","volume":"247","author":"Horsthuis","year":"2008","journal-title":"Radiology"},{"issue":"4","key":"key\n\t\t\t\t2018110508354693800_bib56","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s00261-007-9276-3","article-title":"Detection of inflammatory bowel disease: diagnostic performance of cross-sectional imaging modalities","volume":"33","author":"Horsthuis","year":"2008","journal-title":"Abdom Imaging"},{"issue":"7","key":"key\n\t\t\t\t2018110508354693800_bib57","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1111\/j.1572-0241.2004.30499.x","article-title":"Prospective comparison of small bowel meal with pneumocolon versus ileo-colonoscopy for the diagnosis of ileal Crohn's disease","volume":"99","author":"Marshall","year":"2004","journal-title":"Am J Gastroenterol"},{"issue":"9","key":"key\n\t\t\t\t2018110508354693800_bib58","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1002\/ibd.20466","article-title":"Correlation of magnetic resonance enteroclysis (MRE) and wireless capsule endoscopy (CE) in the diagnosis of small bowel lesions in Crohn's disease","volume":"14","author":"Tillack","year":"2008","journal-title":"Inflamm Bowel Dis"},{"issue":"6","key":"key\n\t\t\t\t2018110508354693800_bib59","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1136\/gut.49.6.777","article-title":"Behaviour of Crohn's disease according to the Vienna classification: changing pattern over the course of the disease","volume":"49","author":"Louis","year":"2001","journal-title":"Gut"},{"issue":"1","key":"key\n\t\t\t\t2018110508354693800_bib60","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1148\/radiol.2361040799","article-title":"Role of US in detection of Crohn disease: meta-analysis","volume":"236","author":"Fraquelli","year":"2005","journal-title":"Radiology"},{"issue":"6","key":"key\n\t\t\t\t2018110508354693800_bib61","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.2214\/ajr.177.6.1771325","article-title":"MR imaging evaluation of the activity of Crohn's disease","volume":"177","author":"Koh","year":"2001","journal-title":"AJR Am J Roentgenol"},{"issue":"1","key":"key\n\t\t\t\t2018110508354693800_bib62","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1148\/radiol.2291020877","article-title":"Assessment of small bowel Crohn disease: noninvasive peroral CT enterography compared with other imaging methods and endoscopy\u2013feasibility study","volume":"229","author":"Wold","year":"2003","journal-title":"Radiology"},{"issue":"9","key":"key\n\t\t\t\t2018110508354693800_bib63","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1007\/s00330-006-0248-8","article-title":"Imaging of small intestinal Crohn's disease: comparison between MR enteroclysis and conventional enteroclysis","volume":"16","author":"Gourtsoyiannis","year":"2006","journal-title":"Eur Radiol"},{"key":"key\n\t\t\t\t2018110508354693800_bib64","doi-asserted-by":"crossref","DOI":"10.1136\/gut.2008.167957","article-title":"Magnetic resonance for assessment of disease activity and severity in Crohn disease","author":"Rimola","year":"2009","journal-title":"Gut"},{"issue":"12","key":"key\n\t\t\t\t2018110508354693800_bib65","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1136\/gut.2005.069427","article-title":"Diagnosis of small bowel Crohn's disease: a prospective comparison of capsule endoscopy with magnetic resonance imaging and fluoroscopic enteroclysis","volume":"54","author":"Albert","year":"2005","journal-title":"Gut"},{"issue":"6","key":"key\n\t\t\t\t2018110508354693800_bib66","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.2214\/AJR.04.1534","article-title":"Diagnostic value of CT enteroclysis compared with conventional enteroclysis in patients with Crohn's disease","volume":"185","author":"Sailer","year":"2005","journal-title":"AJR Am J Roentgenol"},{"issue":"6","key":"key\n\t\t\t\t2018110508354693800_bib67","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1007\/s00330-002-1710-x","article-title":"Prospective comparison of MR enteroclysis with multidetector spiral-CT enteroclysis: interobserver agreement and sensitivity by means of \"sign-by-sign\" correlation","volume":"13","author":"Schmidt","year":"2003","journal-title":"Eur Radiol"},{"issue":"22","key":"key\n\t\t\t\t2018110508354693800_bib68","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1056\/NEJMra072149","article-title":"Computed tomography\u2013an increasing source of radiation exposure","volume":"357","author":"Brenner","year":"2007","journal-title":"N Engl J Med"},{"issue":"9","key":"key\n\t\t\t\t2018110508354693800_bib69","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1007\/s00330-007-0648-4","article-title":"A prospective randomized comparison between two MRI studies of the small bowel in Crohn's disease, the oral contrast method and MR enteroclysis","volume":"17","author":"Negaard","year":"2007","journal-title":"Eur Radiol"},{"issue":"10","key":"key\n\t\t\t\t2018110508354693800_bib70","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1002\/ibd.20199","article-title":"Wireless capsule endoscopy and small intestine contrast ultrasonography in recurrence of Crohn's disease","volume":"13","author":"Biancone","year":"2007","journal-title":"Inflamm Bowel Dis"},{"issue":"2","key":"key\n\t\t\t\t2018110508354693800_bib71","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s00261-008-9365-y","article-title":"Assessment of the extension and the inflammatory activity in Crohn's disease: comparison of ultrasound and MRI","volume":"34","author":"Martinez","year":"2009","journal-title":"Abdom Imaging"},{"issue":"2","key":"key\n\t\t\t\t2018110508354693800_bib72","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1080\/00365520310008223","article-title":"Contrast-enhanced power doppler of the intestinal wall in the evaluation of patients with Crohn disease","volume":"39","author":"Rapaccini","year":"2004","journal-title":"Scand J Gastroenterol"},{"issue":"9","key":"key\n\t\t\t\t2018110508354693800_bib73","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1023\/A:1005513723968","article-title":"Optimization of technetium-99m-HMPAO leukocyte scintigraphy in evaluation of active inflammatory bowel disease","volume":"45","author":"Sans","year":"2000","journal-title":"Dig Dis Sci"},{"issue":"2","key":"key\n\t\t\t\t2018110508354693800_bib74","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1136\/gut.2003.037085","article-title":"Magnetic resonance colonography for the detection of inflammatory diseases of the large bowel: quantifying the inflammatory activity","volume":"54","author":"Ajaj","year":"2005","journal-title":"Gut"},{"issue":"2","key":"key\n\t\t\t\t2018110508354693800_bib75","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1080\/00365520701676021","article-title":"Endoscopy and magnetic resonance imaging in patients with Crohn's disease: a retrospective single-centre comparative study","volume":"43","author":"Dinter","year":"2008","journal-title":"Scand J Gastroenterol"},{"issue":"8","key":"key\n\t\t\t\t2018110508354693800_bib76","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1002\/ibd.20140","article-title":"MR colonography without bowel purgation for the assessment of inflammatory bowel diseases: diagnostic accuracy and patient acceptance","volume":"13","author":"Langhorst","year":"2007","journal-title":"Inflamm Bowel Dis"},{"issue":"6","key":"key\n\t\t\t\t2018110508354693800_bib77","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1007\/s00261-003-0023-0","article-title":"Value of virtual computed tomographic colonography for Crohn's colitis: comparison with endoscopy and barium enema","volume":"28","author":"Ota","year":"2003","journal-title":"Abdom Imaging"},{"issue":"3","key":"key\n\t\t\t\t2018110508354693800_bib78","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0720-048X(00)00242-4","article-title":"Spiral CT colonography in inflammatory bowel disease","volume":"35","author":"Tarjan","year":"2000","journal-title":"Eur J Radiol"},{"issue":"1","key":"key\n\t\t\t\t2018110508354693800_bib79","doi-asserted-by":"crossref","first-page":"99","DOI":"10.2214\/ajr.177.1.1770099","article-title":"Hydrocolonic sonography for evaluating inflammatory bowel disease","volume":"177","author":"Bru","year":"2001","journal-title":"AJR Am J Roentgenol"},{"issue":"3","key":"key\n\t\t\t\t2018110508354693800_bib80","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1136\/gut.2004.040055","article-title":"Small bowel involvement in Crohn's disease: a prospective comparison of wireless capsule endoscopy and computed tomography enteroclysis","volume":"54","author":"Voderholzer","year":"2005","journal-title":"Gut"},{"issue":"11","key":"key\n\t\t\t\t2018110508354693800_bib81","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1080\/00365520701397867","article-title":"Double-balloon enteroscopy versus magnetic resonance enteroclysis in diagnosing suspected small-bowel Crohn's disease: results of a pilot study","volume":"42","author":"Seiderer","year":"2007","journal-title":"Scand J Gastroenterol"},{"issue":"1","key":"key\n\t\t\t\t2018110508354693800_bib82","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1148\/radiol.2381050296","article-title":"Crohn disease of the small bowel: preliminary comparison among CT enterography, capsule endoscopy, small-bowel follow-through, and ileoscopy","volume":"238","author":"Hara","year":"2006","journal-title":"Radiology"},{"issue":"6","key":"key\n\t\t\t\t2018110508354693800_bib83","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S1542-3565(04)00168-5","article-title":"Abdominal MRI after enteroclysis or with oral contrast in patients with suspected or proven Crohn's disease","volume":"2","author":"Schreyer","year":"2004","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"2","key":"key\n\t\t\t\t2018110508354693800_bib84","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1148\/radiol.2381040244","article-title":"MR imaging in patients with Crohn disease: value of T2- versus T1-weighted gadolinium-enhanced MR sequences with use of an oral superparamagnetic contrast agent","volume":"238","author":"Maccioni","year":"2006","journal-title":"Radiology"},{"issue":"4","key":"key\n\t\t\t\t2018110508354693800_bib85","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1136\/gut.50.4.490","article-title":"Bowel ultrasound in assessment of Crohn's disease and detection of related small bowel strictures: a prospective comparative study versus x ray and intraoperative findings","volume":"50","author":"Parente","year":"2002","journal-title":"Gut"},{"issue":"11","key":"key\n\t\t\t\t2018110508354693800_bib86","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.1111\/j.1572-0241.2007.01537.x","article-title":"Correlation of CT enteroclysis with surgical pathology in Crohn's disease","volume":"102","author":"Chiorean","year":"2007","journal-title":"Am J Gastroenterol"},{"issue":"3","key":"key\n\t\t\t\t2018110508354693800_bib87","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/00042737-200303000-00008","article-title":"Contrast-enhanced power Doppler ultrasound in the diagnosis and follow-up of inflammatory abdominal masses in Crohn's disease","volume":"15","author":"Esteban","year":"2003","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"2","key":"key\n\t\t\t\t2018110508354693800_bib88","doi-asserted-by":"crossref","first-page":"149","DOI":"10.7863\/jum.2002.21.2.149","article-title":"Contrast-enhanced power Doppler sonography of the intestinal wall in the differentiation of hypervascularized and hypovascularized intestinal obstructions in patients with Crohn's disease","volume":"21","author":"Kratzer","year":"2002","journal-title":"J Ultrasound Med"},{"issue":"3","key":"key\n\t\t\t\t2018110508354693800_bib89","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1148\/radiology.217.3.r00dc19787","article-title":"Doppler US in patients with crohn disease: vessel density in the diseased bowel reflects disease activity","volume":"217","author":"Spalinger","year":"2000","journal-title":"Radiology"},{"issue":"12","key":"key\n\t\t\t\t2018110508354693800_bib90","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1007\/s00330-006-0338-7","article-title":"Assessment of Crohn's disease in the small bowel: Prospective comparison of magnetic resonance enteroclysis with conventional enteroclysis","volume":"16","author":"Masselli","year":"2006","journal-title":"Eur Radiol"},{"issue":"2","key":"key\n\t\t\t\t2018110508354693800_bib91","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1080\/00365520500265075","article-title":"The \"star-sign\" in magnetic resonance enteroclysis: a characteristic finding of internal fistulae in Crohn's disease","volume":"41","author":"Herrmann","year":"2006","journal-title":"Scand J Gastroenterol"},{"issue":"6","key":"key\n\t\t\t\t2018110508354693800_bib92","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/s00261-005-0400-y","article-title":"Internal fistulas in Crohn disease: magnetic resonance enteroclysis","volume":"31","author":"Herrmann","year":"2006","journal-title":"Abdom Imaging"},{"issue":"1","key":"key\n\t\t\t\t2018110508354693800_bib93","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1136\/gut.44.1.112","article-title":"Transabdominal bowel sonography for the detection of intestinal complications in Crohn's disease","volume":"44","author":"Gasche","year":"1999","journal-title":"Gut"},{"issue":"7","key":"key\n\t\t\t\t2018110508354693800_bib94","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1111\/j.1572-0241.2003.07521.x","article-title":"Contrast radiology, computed tomography and ultrasonography in detecting internal fistulas and intra-abdominal abscesses in Crohn's disease: a prospective comparative study","volume":"98","author":"Maconi","year":"2003","journal-title":"Am J Gastroenterol"},{"issue":"6","key":"key\n\t\t\t\t2018110508354693800_bib95","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1055\/s-2007-1021762","article-title":"Crohn's disease of the stomach and duodenum: A clinical study with emphasis on the value of endoscopy and endoscopic biopsies","volume":"12","author":"Rutgeerts","year":"1980","journal-title":"Endoscopy"},{"issue":"2","key":"key\n\t\t\t\t2018110508354693800_bib96","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/S0300-2977(96)00063-0","article-title":"Crohn's disease of the upper gastrointestinal tract","volume":"50","author":"Wagtmans","year":"1997","journal-title":"Neth J Med"},{"key":"key\n\t\t\t\t2018110508354693800_bib97","first-page":"100","article-title":"Crohn's disease of the upper gastrointestinal tract: the value of endoscopic examination","volume":"100-5","author":"Witte","year":"1998","journal-title":"Scand J Gastroenterol Suppl"},{"issue":"2","key":"key\n\t\t\t\t2018110508354693800_bib98","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0016-5107(04)02571-4","article-title":"Capsule endoscopy vs. push enteroscopy and enteroclysis in suspected small-bowel Crohn's disease","volume":"61","author":"Chong","year":"2005","journal-title":"Gastrointest Endosc"},{"issue":"4","key":"key\n\t\t\t\t2018110508354693800_bib99","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1053\/gast.2002.35988","article-title":"A prospective trial comparing small bowel radiographs and video capsule endoscopy for suspected small bowel disease","volume":"123","author":"Costamagna","year":"2002","journal-title":"Gastroenterology"},{"issue":"8","key":"key\n\t\t\t\t2018110508354693800_bib100","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.dld.2004.03.011","article-title":"Wireless capsule video endoscopy compared to barium follow-through and computerised tomography in patients with suspected Crohn's disease\u2013final report","volume":"36","author":"Eliakim","year":"2004","journal-title":"Dig Liver Dis"},{"issue":"3","key":"key\n\t\t\t\t2018110508354693800_bib101","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1136\/gut.52.3.390","article-title":"Diagnosing small bowel Crohn's disease with wireless capsule endoscopy","volume":"52","author":"Fireman","year":"2003","journal-title":"Gut"},{"issue":"2","key":"key\n\t\t\t\t2018110508354693800_bib102","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00384-005-0755-0","article-title":"Comparison of capsule endoscopy and magnetic resonance (MR) enteroclysis in suspected small bowel disease","volume":"21","author":"Golder","year":"2006","journal-title":"Int J Colorectal Dis"},{"issue":"1","key":"key\n\t\t\t\t2018110508354693800_bib103","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S1542-3565(03)00289-1","article-title":"Initial experience with wireless capsule enteroscopy in the diagnosis and management of inflammatory bowel disease","volume":"2","author":"Mow","year":"2004","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"5","key":"key\n\t\t\t\t2018110508354693800_bib104","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1111\/j.1572-0241.2006.00506.x","article-title":"A meta-analysis of the yield of capsule endoscopy compared to other diagnostic modalities in patients with non-stricturing small bowel Crohn's disease","volume":"101","author":"Triester","year":"2006","journal-title":"Am J Gastroenterol"},{"issue":"6","key":"key\n\t\t\t\t2018110508354693800_bib105","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1053\/j.gastro.2004.03.023","article-title":"Endoscopy in inflammatory bowel diseases","volume":"126","author":"Hommes","year":"2004","journal-title":"Gastroenterology"},{"issue":"3","key":"key\n\t\t\t\t2018110508354693800_bib106","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/ibd.20058","article-title":"Role of capsule endoscopy in inflammatory bowel disease: where we are and where we are going","volume":"13","author":"Leighton","year":"2007","journal-title":"Inflamm Bowel Dis"},{"key":"key\n\t\t\t\t2018110508354693800_bib107","article-title":"Crohn's disease clinical issues and treatment: what the radiologist needs to know and what the gastroenterologist wants to know","author":"Bruining","year":"2008","journal-title":"Abdom Imaging"},{"issue":"7","key":"key\n\t\t\t\t2018110508354693800_bib108","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1111\/j.1572-0241.2006.00648.x","article-title":"Evaluation of deep small bowel involvement by double-balloon enteroscopy in Crohn's disease","volume":"101","author":"Oshitani","year":"2006","journal-title":"Am J Gastroenterol"},{"issue":"5","key":"key\n\t\t\t\t2018110508354693800_bib109","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1136\/gut.34.5.647","article-title":"Perioperative endoscopy of the whole small bowel in Crohn's disease","volume":"34","author":"Lescut","year":"1993","journal-title":"Gut"},{"issue":"6","key":"key\n\t\t\t\t2018110508354693800_bib110","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1016\/0016-5085(85)90007-1","article-title":"Recurrence after surgery in Crohn's disease. Relationship to location of disease (clinical pattern) and surgical indication","volume":"88","author":"Whelan","year":"1985","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t2018110508354693800_bib111","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1136\/jcp.55.12.955","article-title":"How could pathologists improve the initial diagnosis of colitis? Evidence from an international workshop","volume":"55","author":"Bentley","year":"2002","journal-title":"J Clin Pathol"},{"key":"key\n\t\t\t\t2018110508354693800_bib112","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1055\/s-2003-44593","article-title":"Diagnosing colitis: a prospective study on essential parameters for reaching a diagnosis","volume":"35","author":"Dejaco","year":"2003","journal-title":"Endoscopy"},{"key":"key\n\t\t\t\t2018110508354693800_bib113","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1080\/00365529950172844","article-title":"Morphologic criteria applicable to biopsy specimens for effective distinction of inflammatory bowel disease from other forms of colitis and of Crohn's disease from ulcerative colitis","volume":"34","author":"Tanaka","year":"1999","journal-title":"Scan J Gastroenterol"},{"key":"key\n\t\t\t\t2018110508354693800_bib114","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1572-0241.1998.00201.x","article-title":"Is ileoscopy with biopsy worthwhile in patients presenting with symptoms of IBD","volume":"93","author":"Geboes","year":"1998","journal-title":"Am J Gastroenterol"},{"key":"key\n\t\t\t\t2018110508354693800_bib115","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1136\/jcp.50.2.93","article-title":"Guidelines for the initial biopsy diagnosis of suspected chronic idiopathic inflammatory bowel disease. The British Society of Gastroenterology Initiative","volume":"50","author":"Jenkins","year":"1997","journal-title":"J Clin Pathol"},{"key":"key\n\t\t\t\t2018110508354693800_bib116","doi-asserted-by":"crossref","first-page":"318","DOI":"10.3109\/00365529409094843","article-title":"A prospective study of first attacks of inflammatory bowel disease and infectious colitis. Histologic course during the 1st year after presentation","volume":"29","author":"Schumacher","year":"1994","journal-title":"Scand J Gastroenterol"},{"key":"key\n\t\t\t\t2018110508354693800_bib117","doi-asserted-by":"crossref","first-page":"151420","DOI":"10.1136\/gut.32.12.1514","article-title":"Histopathological evaluation of colonic mucosal biopsy specimens in chronic inflammatory bowel disease: diagnostic implications","volume":"32","author":"Seldenrijk","year":"1991","journal-title":"Gut"},{"key":"key\n\t\t\t\t2018110508354693800_bib118","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1136\/gut.35.7.961","article-title":"Observer variation and discriminatory value of biopsy features in inflammatory bowel disease","volume":"35","author":"Theodossi","year":"1994","journal-title":"Gut"},{"key":"key\n\t\t\t\t2018110508354693800_bib119","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1007\/BF01295652","article-title":"Serial sectioning of a portion of a rectal biopsy detects more focal abnormalities. A prospective study of patients with inflammatory bowel disease","volume":"27","author":"Surawicz","year":"1982","journal-title":"Dig Dis Sci"},{"key":"key\n\t\t\t\t2018110508354693800_bib120","first-page":"3","article-title":"Colonic mucosal biopsy in inflammatory bowel disease","volume":"4","author":"Goldman","year":"1991","journal-title":"Surgical Pathology"},{"key":"key\n\t\t\t\t2018110508354693800_bib121","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1055\/s-2003-36663","article-title":"Evidenz-basierte Leitlinien der DGVS f\u00fcr Diagnostik und Therapie beim Morbus Crohn","volume":"41","author":"Von Herbay","year":"2003","journal-title":"Germany Z Gastroenterol"},{"key":"key\n\t\t\t\t2018110508354693800_bib122","first-page":"37","article-title":"Diagnosis in chronic inflammatory bowel diseases \u2013 report of the Austrian Chronic Inflammatory Bowel Disease Study Group","volume":"25","author":"Petritsch","year":"1998","journal-title":"Acta Med Austriaca"},{"key":"key\n\t\t\t\t2018110508354693800_bib123","first-page":"2023","article-title":"Inflammatory bowel diseases: diagnosis (including new procedures for small intestine examination)","volume":"91","author":"Hahne","year":"2002","journal-title":"Schweiz Rundsch Med Prax"},{"issue":"suppl I","key":"key\n\t\t\t\t2018110508354693800_bib124","first-page":"173","article-title":"Crohn's disease: definition, pathogenesis, aetiology","author":"Lennard-Jones","year":"1980","journal-title":"Clin Gastroenterol"},{"key":"key\n\t\t\t\t2018110508354693800_bib125","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1080\/003655200750024155","article-title":"Simple mucosal biopsy criteria differentiating among Crohn's disease, ulcerative colitis, and other forms of colitis Measurement of validity","volume":"35","author":"Tanaka","year":"2000","journal-title":"Scand J Gastroenterol"},{"key":"key\n\t\t\t\t2018110508354693800_bib126","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1046\/j.1365-2559.2002.01416.x","article-title":"Granulomatous ulcerative colitis: a re-appraisal of the mucosal granuloma in the distinction of Crohn's disease from ulcerative colitis","volume":"41","author":"Mahadeva","year":"2002","journal-title":"Histopathology"},{"key":"key\n\t\t\t\t2018110508354693800_bib127","first-page":"1047","article-title":"Proposition d'un syst\u00e8me de crit\u00e8res pour le diagnostic des ent\u00e9rocolite inflammatoires cryptog\u00e9n\u00e9tiques (maladie de Crohn et Rectocolite H\u00e9morragique)","volume":"2","author":"Bernades","year":"1978","journal-title":"Gastroent\u00e9rol Clin Biol"},{"key":"key\n\t\t\t\t2018110508354693800_bib128","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1136\/jcp.41.1.72","article-title":"What is colitis? Statistical approach to distinguishing clinically important inflammatory change in rectal biopsy specimens","volume":"41","author":"Jenkins","year":"1988","journal-title":"J Clin Pathol"},{"key":"key\n\t\t\t\t2018110508354693800_bib129","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1097\/00000478-199808000-00008","article-title":"Ulcerative colitis: patterns of involvement in colorectal biopsies and changes with time","volume":"22","author":"Kleer","year":"1998","journal-title":"Am J Surg Pathol"},{"key":"key\n\t\t\t\t2018110508354693800_bib130","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/S0016-5107(95)70097-8","article-title":"Patchiness of mucosal inflammation in treated ulcerative colitis : a prospective study","volume":"42","author":"Bernstein","year":"1995","journal-title":"Gastrointest Endosc"},{"key":"key\n\t\t\t\t2018110508354693800_bib131","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1046\/j.1463-1318.2001.00187.x","article-title":"Pathology of inflammatory bowel diseases (IBD): variability with time and treatment","volume":"3","author":"Geboes","year":"2001","journal-title":"Colorectal disease"},{"key":"key\n\t\t\t\t2018110508354693800_bib132","first-page":"2034","article-title":"Atypical rectosigmoid histology in children with newly diagnosed ulcerative colitis","volume":"88","author":"Markowitz","year":"1993","journal-title":"Am J Gastroenterol"},{"key":"key\n\t\t\t\t2018110508354693800_bib133","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1097\/00000478-200402000-00005","article-title":"Patterns of inflammation in mucosal biopsies of ulcerative colitis. Perceived differences in pediatric populations are limited to children younger than 10 years","volume":"28","author":"Robert","year":"2004","journal-title":"Am J Surg Pathol"},{"key":"key\n\t\t\t\t2018110508354693800_bib134","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1097\/00000478-200402000-00006","article-title":"Pediatric patients with untreated ulcerative colitis may present initially with unusual morphologic findings","volume":"28","author":"Glickman","year":"2004","journal-title":"Am J Surg Pathol"},{"key":"key\n\t\t\t\t2018110508354693800_bib135","first-page":"18","article-title":"The pathological diagnosis and differential diagnosis of Crohn's disease","volume":"37","author":"Tanaka","year":"1990","journal-title":"Hepatogastroenterol"},{"key":"key\n\t\t\t\t2018110508354693800_bib136","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1136\/gut.14.4.255","article-title":"An analysis of the reliability of detection and diagnostic value of various pathological features in Crohn's disease and ulcerative colitis","volume":"14","author":"Cook","year":"1973","journal-title":"Gut"},{"key":"key\n\t\t\t\t2018110508354693800_bib137","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1365-2559.1993.tb01183.x","article-title":"Granulomatous gastritis : a morphological and diagnostic approach","volume":"23","author":"Ectors","year":"1993","journal-title":"Histopathology"},{"key":"key\n\t\t\t\t2018110508354693800_bib138","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1097\/00000478-199604000-00009","article-title":"A clinicopathologic study of 42 patients with granulomatous gastritis. Is there really an idiopathic granulomatous gastritis","volume":"20","author":"Shapiro","year":"1996","journal-title":"Am J Surg Pathol"},{"key":"key\n\t\t\t\t2018110508354693800_bib139","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1053\/gast.1997.v112.pm9041230","article-title":"Focally enhanced gastritis: a frequent type of gastritis in patients with Crohn's disease","volume":"112","author":"Oberhuber","year":"1997","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t2018110508354693800_bib140","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1097\/00000478-199804000-00001","article-title":"Histology of the stomach and duodenum in Crohn's disease","volume":"22","author":"Wright","year":"1998","journal-title":"Am J Surg Pathol"},{"key":"key\n\t\t\t\t2018110508354693800_bib141","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1111\/j.1572-0241.2000.01851.x","article-title":"Focal gastric inflammatory infiltrates in inflammatory bowel diseases: prevalence, immunohistochemical characteristics and diagnostic role","volume":"95","author":"Parente","year":"2000","journal-title":"Am J Gastroenterol"},{"key":"key\n\t\t\t\t2018110508354693800_bib142","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/S0016-5107(91)70726-8","article-title":"Endoscopic biopsy technique for acquiring larger mucosal samples","volume":"37","author":"Levine","year":"1991","journal-title":"Gastrointest Endosc"},{"key":"key\n\t\t\t\t2018110508354693800_bib143","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1016\/0016-5085(95)90683-5","article-title":"Low incidence of significant dysplasia in a successful endoscopic surveillance program of patients with ulcerative colitis","volume":"108","author":"Rozen","year":"1995","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t2018110508354693800_bib144","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/S0046-8177(83)80175-0","article-title":"Dysplasia in inflammatory bowel disease: Standardized classification with provisional clinical applications","volume":"14","author":"Riddell","year":"1983","journal-title":"Hum Pathol"},{"key":"key\n\t\t\t\t2018110508354693800_bib145","doi-asserted-by":"crossref","first-page":"3184","DOI":"10.1111\/j.1572-0241.2000.03199.x","article-title":"The importance of diagnostic accuracy in colonic inflammatory bowel disease","volume":"95","author":"Farmer","year":"2000","journal-title":"Am J Gastroenterol"},{"key":"key\n\t\t\t\t2018110508354693800_bib146","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1002\/bjs.1800790934","article-title":"Fat-wrapping in Crohn's disease: pathological basis and relevance to surgical practice","volume":"79","author":"Sheehan","year":"1992","journal-title":"Br J Surg"},{"key":"key\n\t\t\t\t2018110508354693800_bib147","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/(SICI)1096-9896(200002)190:2<196::AID-PATH513>3.0.CO;2-5","article-title":"The relationship between inflammatory and serosal connective tissue change in ileal Crohn's disease: evidence for a possible causative link","volume":"190","author":"Borley","year":"2000","journal-title":"J Pathol"},{"key":"key\n\t\t\t\t2018110508354693800_bib148","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/BF02233941","article-title":"Serial rectal biopsy in ulcerative colitis during the course of a controlled therapeutic trial of various diets","volume":"11","author":"Wright","year":"1964","journal-title":"Am J Dig Dis"},{"key":"key\n\t\t\t\t2018110508354693800_bib149","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1097\/00000478-199309000-00002","article-title":"Effect of topical 5-amino-salicylic acid (5-ASA) therapy on rectal mucosal biopsy morphology in chronic ulcerative colitis","volume":"17","author":"Odze","year":"1993","journal-title":"Am J Surg Pathol"},{"key":"key\n\t\t\t\t2018110508354693800_bib150","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1136\/gut.32.2.174","article-title":"Microscopic activity in ulcerative colitis: what does it mean?","volume":"32","author":"Riley","year":"1991","journal-title":"Gut"},{"key":"key\n\t\t\t\t2018110508354693800_bib151","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1053\/gast.2001.20912","article-title":"Clinical, biological and histologic parameters as predictors of relapse in ulcerative colitis","volume":"120","author":"Bitton","year":"2001","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t2018110508354693800_bib152","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/00004836-198404000-00005","article-title":"Response to drug therapy in Crohn's disease: Evaluation by rectal biopsy and mucosal cell counts","volume":"6","author":"Korelitz","year":"1984","journal-title":"J Clin Gastroenterol"},{"key":"key\n\t\t\t\t2018110508354693800_bib153","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/S0016-5085(97)70027-1","article-title":"Healing of severe recurrent ileitis with azathioprine therapy in patients with Crohn's disease","volume":"112","author":"D'Haens","year":"1997","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t2018110508354693800_bib154","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/S0016-5085(99)70005-3","article-title":"Endoscopic and histological healing with infliximab anti-tumor necrosis factor antibodies in Crohn's diseas: a European multicenter trial","volume":"116","author":"D'Haens","year":"1999","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t2018110508354693800_bib155","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1136\/adc.71.3.243","article-title":"Cyclosporin as initial treatment for Crohn's disease","volume":"71","author":"Nicholls","year":"1994","journal-title":"Arch Dis Child"},{"key":"key\n\t\t\t\t2018110508354693800_bib156","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/j.1365-2036.1994.tb00338.x","article-title":"Polymeric nutrition as the primary therapy in children with small bowel Crohn's disease","volume":"8","author":"Beattie","year":"1994","journal-title":"Aliment Pharmacol Ther"},{"key":"key\n\t\t\t\t2018110508354693800_bib157","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1016\/0016-5085(94)90398-0","article-title":"Tumor necrosis factor alpha producing cells in the intestinal mucosa of children with inflammatory bowel disease","volume":"106","author":"Breese","year":"1994","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t2018110508354693800_bib158","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1046\/j.1365-2036.2000.00707.x","article-title":"Mucosal healing and a fall in mucosal pro-inflammatory cytokine mRNA induced by a specific oral polymeric diet in paediatric Crohn's disease","volume":"14","author":"Fell","year":"2000","journal-title":"Aliment Pharmacol Ther"},{"key":"key\n\t\t\t\t2018110508354693800_bib159","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s00428-003-0863-6","article-title":"Histopathological parameters as predictors for the course of Crohn's disease","volume":"443","author":"Bataille","year":"2003","journal-title":"Virchows Arch"},{"key":"key\n\t\t\t\t2018110508354693800_bib160","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1136\/gut.2005.082909","article-title":"The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications","volume":"55","author":"Satsangi","year":"2006","journal-title":"Gut"},{"issue":"Suppl A","key":"key\n\t\t\t\t2018110508354693800_bib161","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1155\/2005\/269076","article-title":"Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology","volume":"19","author":"Silverberg","year":"2005","journal-title":"Can J Gastroenterol"},{"key":"key\n\t\t\t\t2018110508354693800_bib162","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/00054725-200002000-00002","article-title":"A simple classification of Crohn's disease: report of the Working Party for the World Congresses of Gastroenterology, Vienna 1998","volume":"6","author":"Gasche","year":"2000","journal-title":"Inflamm Bowel Dis"},{"key":"key\n\t\t\t\t2018110508354693800_bib163","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1136\/gut.49.6.777","article-title":"Behaviour of Crohn's disease according to the Vienna classification: changing pattern over the course of the disease","volume":"49","author":"Louis","year":"2001","journal-title":"Gut"},{"key":"key\n\t\t\t\t2018110508354693800_bib164","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1097\/00054725-200207000-00002","article-title":"Long-term evolution of disease behavior of Crohn's disease","volume":"8","author":"Cosnes","year":"2002","journal-title":"Inflamm Bowel Dis"},{"key":"key\n\t\t\t\t2018110508354693800_bib165","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1002\/ibd.20335","article-title":"Changes in Crohn's disease phenotype over time in the Chinese population: validation of the Montreal classification system","volume":"14","author":"Chow","year":"2008","journal-title":"Inflamm Bowel Dis"},{"key":"key\n\t\t\t\t2018110508354693800_bib166","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1053\/gast.2000.18144","article-title":"A multicenter trial of 6-mercaptopurine and prednisone in children with newly diagnosed Crohn's disease","volume":"119","author":"Markowitz","year":"2000","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t2018110508354693800_bib167","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/S0140-6736(08)60304-9","article-title":"Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn's disease: an open randomised trial","volume":"371","author":"D'Haens","year":"2008","journal-title":"Lancet"},{"key":"key\n\t\t\t\t2018110508354693800_bib168","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1053\/j.gastro.2005.12.019","article-title":"Predictors of Crohn's disease","volume":"130","author":"Beaugerie","year":"2006","journal-title":"Gastroenterology"},{"issue":"8","key":"key\n\t\t\t\t2018110508354693800_bib169","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1080\/00365520801957149","article-title":"Predictors of severe Crohn's disease","volume":"43","author":"Loly","year":"2008","journal-title":"Scand J Gastroenterol"},{"key":"key\n\t\t\t\t2018110508354693800_bib170","first-page":"A17","article-title":"Validation of predictors of 5-year disabling CD in a population-based cohort from Olmsted County, Minnesota, 1983-1996","volume":"132","author":"Seksik","year":"2007","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t2018110508354693800_bib171","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1016\/j.cgh.2008.06.010","article-title":"Relationships between disease activity and serum and fecal biomarkers in patients with Crohn's disease","volume":"6","author":"Jones","year":"2008","journal-title":"Clin Gastroenterol Hepatol"},{"key":"key\n\t\t\t\t2018110508354693800_bib172","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1053\/j.gastro.2003.11.014","article-title":"Comparison of scheduled and episodic treatment strategies of infliximab in Crohn's disease","volume":"126","author":"Rutgeerts","year":"2004","journal-title":"Gastroenterology"},{"key":"key\n\t\t\t\t2018110508354693800_bib173","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/ibd.20312","article-title":"Crohn's disease activity assessed by fecal calprotectin and lactoferrin: correlation with Crohn's disease activity index and endoscopic findings","volume":"14","author":"Sipponen","year":"2008","journal-title":"Inflamm Bowel Dis"},{"issue":"10","key":"key\n\t\t\t\t2018110508354693800_bib174","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1002\/ibd.20490","article-title":"Fecal calprotectin, lactoferrin, and endoscopic disease activity in monitoring anti-TNF-alpha therapy for Crohn's disease","volume":"14","author":"Sipponen","year":"2008","journal-title":"Inflamm Bowel Dis"},{"key":"key\n\t\t\t\t2018110508354693800_bib175","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1038\/ng.175","article-title":"Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease","volume":"40","author":"Barrett","year":"2008","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t2018110508354693800_bib176","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.cgh.2008.04.032","article-title":"Increased immune reactivity predicts aggressive complicating Crohn's disease in children","volume":"6","author":"Dubinsky","year":"2008","journal-title":"Clin Gastroenterol Hepatol"},{"key":"key\n\t\t\t\t2018110508354693800_bib177","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1136\/gut.52.8.1133","article-title":"Genotype-phenotype analysis of the Crohn's disease susceptibility haplotype on chromosome 5q31","volume":"52","author":"Armuzzi","year":"2003","journal-title":"Gut"}],"container-title":["Journal of Crohn's and Colitis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S1873994609001469?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S1873994609001469?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/ecco-jcc\/article-pdf\/4\/1\/7\/26359608\/4-1-7.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T20:52:58Z","timestamp":1590526378000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ecco-jcc\/article\/4\/1\/7\/402141"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2,1]]},"references-count":177,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2010,2]]},"published-print":{"date-parts":[[2010,2,1]]}},"URL":"https:\/\/doi.org\/10.1016\/j.crohns.2009.12.003","relation":{},"ISSN":["1876-4479","1873-9946"],"issn-type":[{"value":"1876-4479","type":"electronic"},{"value":"1873-9946","type":"print"}],"subject":[],"published-other":{"date-parts":[[2010,2]]},"published":{"date-parts":[[2010,2,1]]}}}