{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T12:45:31Z","timestamp":1785242731158,"version":"3.55.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Crohn's and Colitis"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1016\/j.crohns.2012.05.002","type":"journal-article","created":{"date-parts":[[2012,5,27]],"date-time":"2012-05-27T03:12:27Z","timestamp":1338088347000},"page":"314-317","source":"Crossref","is-referenced-by-count":24,"title":["A case of EBV driven haemophagocytic lymphohistiocytosis complicating a teenage Crohn's disease patient on azathioprine, successfully treated with rituximab"],"prefix":"10.1093","volume":"7","author":[{"given":"Michael P.","family":"Fitzgerald","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"Armstrong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosie","family":"Hague","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard K.","family":"Russell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","reference":[{"issue":"4","key":"10.1016\/j.crohns.2012.05.002_bb0005","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1097\/00043426-199611000-00002","article-title":"Characteristic immune abnormalities in hemophagocytic lymphohistiocytosis","volume":"18","author":"Egeler","year":"1996","journal-title":"J Pediatr Hematol Oncol"},{"issue":"3","key":"10.1016\/j.crohns.2012.05.002_bb0010","first-page":"291","article-title":"Inflammatory cytokines in virus-associated hemophagocytic syndrome. Interferon-gamma as a sensitive indicator of disease activity","volume":"15","author":"Ohga","year":"1993","journal-title":"Am J Pediatr Hematol"},{"issue":"2","key":"10.1016\/j.crohns.2012.05.002_bb0015","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1365-2257.1994.tb00404.x","article-title":"Viral-associated haemophagocytosis and elevated serum TNF-alpha with parvovirus-B19-related pancytopenia in patients with hereditary spherocytosis","volume":"16","author":"Watanabe","year":"1994","journal-title":"Clin Lab Haematol"},{"issue":"11","key":"10.1016\/j.crohns.2012.05.002_bb0020","doi-asserted-by":"crossref","first-page":"2918","DOI":"10.1182\/blood.V78.11.2918.2918","article-title":"Hypercytokinemia in familial hemophagocytic lymphohistiocytosis","volume":"78","author":"Henter","year":"1991","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.crohns.2012.05.002_bb0025","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/BF00443367","article-title":"Familial hemophagocytic lymphohistiocytosis","volume":"140","author":"Janka","year":"1983","journal-title":"Eur J Pediatr"},{"issue":"2","key":"10.1016\/j.crohns.2012.05.002_bb0030","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/pbc.21039","article-title":"HLH-2004: diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis","volume":"48","author":"Henter","year":"2007","journal-title":"Pediatr Blood Cancer"},{"issue":"4","key":"10.1016\/j.crohns.2012.05.002_bb0035","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1182\/blood.V97.4.1131","article-title":"Hemophagocytic lymphohistiocytosis due to germline mutations in SH2D1A, the X-linked lymphoproliferative disease gene","volume":"97","author":"Arico","year":"2001","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.crohns.2012.05.002_bb0040","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1002\/pbc.22357","article-title":"Clinical presentation of Griscelli syndrome type 2 and spectrum of RAB27A mutations","volume":"54","author":"Meeths","year":"2010","journal-title":"Pediatr Blood Cancer"},{"issue":"1","key":"10.1016\/j.crohns.2012.05.002_bb0045","first-page":"53","article-title":"Chediak\u2013Higashi syndrome: a case report","volume":"26","author":"Jayaranee","year":"2004","journal-title":"Malays J Pathol"},{"issue":"4","key":"10.1016\/j.crohns.2012.05.002_bb0050","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1007\/BF00540245","article-title":"Genetic analysis of familial erythrophagocytic lymphohistiocytosis","volume":"142","author":"Gencik","year":"1984","journal-title":"Eur J Pediatr"},{"issue":"7","key":"10.1016\/j.crohns.2012.05.002_bb0055","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1182\/blood-2002-01-0172","article-title":"Treatment of hemophagocytic lymphohistiocytosis with HLH-94 immunochemotherapy and bone marrow transplantation","volume":"100","author":"Henter","year":"2002","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.crohns.2012.05.002_bb0060","first-page":"421","article-title":"Hematophagic histiocytosis: a clinicopathologic analysis of 23 cases with special reference to the association with peripheral T-cell lymphoma","volume":"93","author":"Chang","year":"1994","journal-title":"J Formos Med Assoc"},{"issue":"4","key":"10.1016\/j.crohns.2012.05.002_bb0065","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1128\/JCM.02052-08","article-title":"Fatal Epstein\u2013Barr virus primo infection in a 25-year-old man treated with azathioprine for Crohn's disease","volume":"47","author":"N'guyen","year":"2009","journal-title":"J Clin Microbiol"},{"issue":"12","key":"10.1016\/j.crohns.2012.05.002_bb0070","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/S1473-3099(07)70290-6","article-title":"Infections associated with haemophagocytic syndrome","volume":"7","author":"Rouphael","year":"2007","journal-title":"Lancet Infect Dis"},{"issue":"1","key":"10.1016\/j.crohns.2012.05.002_bb0075","first-page":"7","article-title":"Fatal infectious mononucleosis during azathioprine treatment in Crohn's disease","volume":"23","author":"Serrano","year":"2000","journal-title":"Gastroenterol Hepatol"},{"issue":"2","key":"10.1016\/j.crohns.2012.05.002_bb0080","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1097\/MPG.0b013e31816a30b9","article-title":"Hemophagocytic syndrome in an adolescent with Crohn disease receiving azathioprine and infliximab","volume":"47","author":"Francolla","year":"2008","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"4","key":"10.1016\/j.crohns.2012.05.002_bb0085","doi-asserted-by":"crossref","first-page":"e977","DOI":"10.1542\/peds.2010-0486","article-title":"Natural killer cell lymphoma in a pediatric patient with inflammatory bowel disease","volume":"126","author":"Deneau","year":"2010","journal-title":"Pediatrics"},{"issue":"5","key":"10.1016\/j.crohns.2012.05.002_bb0090","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.jpeds.2011.04.045","article-title":"Association of Crohn's disease, thiopurines, and primary Epstein\u2013Barr virus infection with hemophagocytic lymphohistiocytosis","volume":"159","author":"Biank","year":"2011","journal-title":"J Pediatr"},{"issue":"9","key":"10.1016\/j.crohns.2012.05.002_bb0095","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1097\/01.mib.0000232470.00703.67","article-title":"Azathioprine maintains first remission in newly diagnosed pediatric Crohn's disease","volume":"12","author":"Jaspers","year":"2006","journal-title":"Inflamm Bowel Dis"},{"issue":"4","key":"10.1016\/j.crohns.2012.05.002_bb0100","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1053\/gast.2000.18144","article-title":"A multicenter trial of 6-mercaptopurine and prednisone in children with newly diagnosed Crohn's disease","volume":"119","author":"Markowitz","year":"2000","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.crohns.2012.05.002_bb0105","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1136\/gut.36.2.311","article-title":"Fatal infectious mononucleosis: a severe complication in the treatment of Crohn's disease with azathioprine","volume":"36","author":"Posthuma","year":"1995","journal-title":"Gut"},{"issue":"9701","key":"10.1016\/j.crohns.2012.05.002_bb0110","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1016\/S0140-6736(09)61302-7","article-title":"Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study","volume":"374","author":"Beaugerie","year":"2009","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.crohns.2012.05.002_bb0115","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1097\/MPG.0b013e3181d893c6","article-title":"Epstein\u2013Barr virus-associated lymphoproliferative disorder in Crohn disease treated with azathioprine","volume":"51","author":"Ross","year":"2010","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"13","key":"10.1016\/j.crohns.2012.05.002_bb0120","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1056\/NEJM199409293311321","article-title":"Reversible lymphoma in the setting of azathioprine therapy for Crohn's disease","volume":"331","author":"Larvol","year":"1994","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.crohns.2012.05.002_bb0125","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1532\/IJH97.07012","article-title":"Nationwide survey of hemophagocytic lymphohistiocytosis in Japan","volume":"86","author":"Ishii","year":"2007","journal-title":"Int J Hematol"},{"issue":"8","key":"10.1016\/j.crohns.2012.05.002_bb0130","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1182\/blood.V84.8.2457.2457","article-title":"Phase I clinical trial using escalating single-dose infusion of chimeric anti-CD20 monoclonal antibody (IDEC-C2B8) in patients with recurrent B-cell lymphoma","volume":"84","author":"Maloney","year":"1994","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.crohns.2012.05.002_bb0135","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1002\/ibd.20823","article-title":"Epstein\u2013Barr virus-associated lymphoproliferation awareness in hemophagocytic syndrome complicating thiopurine treatment for Crohn's disease","volume":"15","author":"Serrate","year":"2009","journal-title":"Inflamm Bowel Dis"},{"issue":"1","key":"10.1016\/j.crohns.2012.05.002_bb0140","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1053\/gast.2002.30328","article-title":"Epstein\u2013Barr virus-positive lymphoma in patients with inflammatory bowel disease treated with azathioprine or 6-mercaptopurine","volume":"122","author":"Dayharsh","year":"2002","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.crohns.2012.05.002_bb0145","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1182\/blood-2004-07-2965","article-title":"Treatment of primary Epstein\u2013Barr virus infection in patients with X-linked lymphoproliferative disease using B-cell-directed therapy","volume":"105","author":"Milone","year":"2005","journal-title":"Blood"},{"issue":"Suppl. 1","key":"10.1016\/j.crohns.2012.05.002_bb0150","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1093\/annonc\/11.suppl_1.S113","article-title":"Humanized anti-CD20 monoclonal antibody (rituximab) in post transplant B-lymphoproliferative disorder: a retrospective analysis on 32 patients","volume":"11","author":"Milpied","year":"2000","journal-title":"Ann Oncol"},{"issue":"6","key":"10.1016\/j.crohns.2012.05.002_bb0155","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1182\/blood-2004-02-0733","article-title":"A91V is a polymorphism in the perforin gene not causative of an FHLH phenotype","volume":"104","author":"zur Stadt","year":"2004","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.crohns.2012.05.002_bb0160","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1136\/jmg.2003.011528","article-title":"Characterisation of diverse PRF1 mutations leading to decreased natural killer cell activity in North American families with haemophagocytic lymphohistiocytosis","volume":"41","author":"Lee","year":"2004","journal-title":"J Med Genet"},{"issue":"1","key":"10.1016\/j.crohns.2012.05.002_bb0165","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/j.1440-1711.2005.01409.x","article-title":"Addressing the mysteries of perforin function","volume":"84","author":"Voskoboinik","year":"2006","journal-title":"Immunol Cell Biol"},{"key":"10.1016\/j.crohns.2012.05.002_bb0170","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.crohns.2009.02.010","article-title":"European evidence-based consensus on the prevention, diagnosis and management of opportunistic infection in inflammatory bowel disease","volume":"3","author":"Rahier","year":"2009","journal-title":"J Crohns Colitis"},{"issue":"9","key":"10.1016\/j.crohns.2012.05.002_bb0175","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1182\/blood.V83.9.2715.2715","article-title":"Direct correlation between the load of Epstein\u2013Barr virus-infected lymphocytes in the peripheral blood of pediatric transplant patients and risk of lymphoproliferative disease","volume":"83","author":"Savoie","year":"1994","journal-title":"Blood"}],"container-title":["Journal of Crohn's and Colitis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S1873994612002188?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S1873994612002188?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/ecco-jcc\/article-pdf\/7\/4\/314\/1092365\/7-4-314.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,16]],"date-time":"2022-01-16T10:30:02Z","timestamp":1642329002000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/ecco-jcc\/article-lookup\/doi\/10.1016\/j.crohns.2012.05.002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["S1873994612002188"],"URL":"https:\/\/doi.org\/10.1016\/j.crohns.2012.05.002","relation":{},"ISSN":["1873-9946"],"issn-type":[{"value":"1873-9946","type":"print"}],"subject":[],"published":{"date-parts":[[2013,5]]}}}