{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T11:51:21Z","timestamp":1774266681282,"version":"3.50.1"},"reference-count":107,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T00:00:00Z","timestamp":1618272000000},"content-version":"vor","delay-in-days":102,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012615","name":"The University of Texas Health Science Center at Houston","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012615","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Research in Pharmacology and Drug Discovery"],"published-print":{"date-parts":[[2021]]},"DOI":"10.1016\/j.crphar.2021.100025","type":"journal-article","created":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T13:15:38Z","timestamp":1620306938000},"page":"100025","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Pharmacogenomics and circadian rhythms as mediators of cardiovascular drug-drug interactions"],"prefix":"10.1016","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6835-7626","authenticated-orcid":false,"given":"Yong-Jian","family":"Geng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosalinda","family":"Madonna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8853-5901","authenticated-orcid":false,"given":"Ramon C.","family":"Hermida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael H.","family":"Smolensky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.crphar.2021.100025_bib1","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1056\/NEJMra1802337","article-title":"Circadian mechanisms in medicine","volume":"384","author":"Allada","year":"2021","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.crphar.2021.100025_bib2","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1111\/j.1365-2125.2005.02462.x","article-title":"Effects of grapefruit juice on the pharmacokinetics of pitavastatin and atorvastatin","volume":"60","author":"Ando","year":"2005","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.crphar.2021.100025_bib3","doi-asserted-by":"crossref","first-page":"345","DOI":"10.3109\/07420521003624662","article-title":"Sex differences in the administration-time-dependent effects of low-dose aspirin on ambulatory blood pressure in hypertensive subjects","volume":"27","author":"Ayala","year":"2010","journal-title":"Chronobiol. Int."},{"key":"10.1016\/j.crphar.2021.100025_bib4","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1124\/pr.116.013441","article-title":"Systems chronotherapeutics","volume":"69","author":"Ballesta","year":"2017","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.crphar.2021.100025_bib5","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1517\/17425255.4.2.175","article-title":"The influence of circadian rhythms on the kinetics of drugs in humans","volume":"4","author":"Baraldo","year":"2008","journal-title":"Expet Opin. Drug Metabol. Toxicol."},{"key":"10.1016\/j.crphar.2021.100025_bib6","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1161\/HYPERTENSIONAHA.107.087262","article-title":"Predictors of all-cause mortality in clinical ambulatory monitoring. Unique aspects of blood pressure during sleep","volume":"49","author":"Ben-Dov","year":"2007","journal-title":"Hypertension"},{"key":"10.1016\/j.crphar.2021.100025_bib7","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.pcad.2016.08.001","article-title":"The risk of hepatotoxicity, new onset diabetes and rhabdomyolysis in the era of high-intensity statin therapy: does statin type matter?","volume":"59","author":"Benes","year":"2016","journal-title":"Prog. Cardiovasc. Dis."},{"key":"10.1016\/j.crphar.2021.100025_bib8","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1160\/th14-05-0453","article-title":"Effect of aspirin intake at bedtime versus on awakening on circadian rhythm of platelet reactivity. A randomised cross-over trial","volume":"112","author":"Bonten","year":"2014","journal-title":"Thromb. Haemostasis"},{"key":"10.1016\/j.crphar.2021.100025_bib9","doi-asserted-by":"crossref","first-page":"83","DOI":"10.2165\/00003088-199835020-00001","article-title":"Chronopharmacokinetics. Current status","volume":"35","author":"Bruguerolle","year":"1998","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.crphar.2021.100025_bib10","doi-asserted-by":"crossref","first-page":"84","DOI":"10.3389\/fcvm.2019.00084","article-title":"Circadian rhythm of cardiovascular disease: the potential of chronotherapy with aspirin","volume":"6","author":"Buurma","year":"2019","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.crphar.2021.100025_bib11","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1039\/C5MB00032G","article-title":"A\u00a0metabolomic study of adipose tissue in mice with a disruption of the circadian system","volume":"11","author":"Castro","year":"2015","journal-title":"Mol. Biosyst."},{"key":"10.1016\/j.crphar.2021.100025_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/sj.ejcn.1601736","article-title":"Food-drug interaction: grapefruit juice augments drug bioavailability--mechanism, extent and relevance","volume":"58","author":"Dahan","year":"2004","journal-title":"Eur. J. Clin. Nutr."},{"key":"10.1016\/j.crphar.2021.100025_bib13","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1016\/j.jacc.2016.10.033","article-title":"Phenotypic characterization of genetically lowered human lipoprotein(a) levels","volume":"68","author":"Emdin","year":"2016","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"10.1016\/j.crphar.2021.100025_bib14","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.amjcard.2016.11.042","article-title":"Evaluation of the pooled cohort equations for prediction of cardiovascular risk in a contemporary prospective cohort","volume":"119","author":"Emdin","year":"2017","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.crphar.2021.100025_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002197","article-title":"Trans-eQTLs reveal that independent genetic variants associated with a complex phenotype converge on intermediate genes, with a major role for the HLA","volume":"7","author":"Fehrmann","year":"2011","journal-title":"PLoS Genet."},{"key":"10.1016\/j.crphar.2021.100025_bib16","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.molcel.2012.06.026","article-title":"Clocks, metabolism, and the epigenome","volume":"47","author":"Feng","year":"2012","journal-title":"Mol. Cell."},{"key":"10.1016\/j.crphar.2021.100025_bib17","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1124\/pr.113.008300","article-title":"Interaction of risk factors, comorbidities, and comedications with ischemia\/reperfusion injury and cardioprotection by preconditioning, postconditioning, and remote conditioning","volume":"66","author":"Ferdinandy","year":"2014","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.crphar.2021.100025_bib18","doi-asserted-by":"crossref","first-page":"104","DOI":"10.2174\/138920009787522179","article-title":"Cytochrome P450 and the biological clock in mammals","volume":"10","author":"Froy","year":"2009","journal-title":"Curr. Drug Metabol."},{"key":"10.1016\/j.crphar.2021.100025_bib19","article-title":"Novel alpha-actin gene mutation p.(Ala21Val) causing familial hypertrophic cardiomyopathy, myocardial noncompaction, and transmural crypts. Clinical-Pathologic Correlation","volume":"7","author":"Frustaci","year":"2018","journal-title":"J.\u00a0Am. Heart Assoc."},{"key":"10.1016\/j.crphar.2021.100025_bib20","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1517\/17425255.2011.544251","article-title":"The role of circadian timing system on drug metabolism and detoxification","volume":"7","author":"Gachon","year":"2011","journal-title":"Expet Opin. Drug Metabol. Toxicol."},{"key":"10.1016\/j.crphar.2021.100025_bib21","first-page":"76","article-title":"Regulation of programmed cell death or apoptosis in atherosclerosis","volume":"12","author":"Geng","year":"1997","journal-title":"Heart Ves."},{"key":"10.1016\/j.crphar.2021.100025_bib22","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/sj.cr.7290094","article-title":"Molecular signal transduction in vascular cell apoptosis","volume":"11","author":"Geng","year":"2001","journal-title":"Cell Res."},{"key":"10.1016\/j.crphar.2021.100025_bib23","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1196\/annals.1299.126","article-title":"Molecular mechanisms for cardiovascular stem cell apoptosis and growth in the hearts with atherosclerotic coronary disease and ischemic heart failure","volume":"1010","author":"Geng","year":"2003","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.crphar.2021.100025_bib24","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1161\/01.ATV.0000031341.84618.A4","article-title":"Progression of atheroma: a struggle between death and procreation","volume":"22","author":"Geng","year":"2002","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.crphar.2021.100025_bib25","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1146\/annurev.ph.31.030169.003331","article-title":"Chronobiology","volume":"31","author":"Halberg","year":"1969","journal-title":"Annu. Rev. Physiol."},{"issue":"3","key":"10.1016\/j.crphar.2021.100025_bib26","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1081\/CBI-100103970","article-title":"Circadian rhythm of double (rate-pressure) product in healthy normotensive young subjects","volume":"18","author":"Hermida","year":"2001","journal-title":"Chronobiol. Int."},{"key":"10.1016\/j.crphar.2021.100025_bib27","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.addr.2006.09.021","article-title":"Chronotherapy of hypertension: administration-time-dependent effects of treatment on the circadian pattern of blood pressure","volume":"59","author":"Hermida","year":"2007","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.crphar.2021.100025_bib28","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.3109\/07420528.2010.489167","article-title":"Chronotherapy with valsartan\/amlodipine fixed combination: improved blood pressure control of essential hypertension with bedtime dosing","volume":"27","author":"Hermida","year":"2010","journal-title":"Chronobiol. Int."},{"issue":"8","key":"10.1016\/j.crphar.2021.100025_bib29","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.3109\/07420528.2010.510230","article-title":"Influence of circadian time of hypertension treatment on cardiovascular risk: results of the MAPEC study","volume":"27","author":"Hermida","year":"2010","journal-title":"Chronobiol. Int."},{"key":"10.1016\/j.crphar.2021.100025_bib30","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/j.jacc.2011.04.043","article-title":"Decreasing sleep-time blood pressure determined by ambulatory monitoring reduces cardiovascular risk","volume":"58","author":"Hermida","year":"2011","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"10.1016\/j.crphar.2021.100025_bib31","doi-asserted-by":"crossref","first-page":"280","DOI":"10.3109\/07420528.2012.709448","article-title":"Administration-time differences in effects of hypertension medications on ambulatory blood pressure regulation","volume":"30","author":"Hermida","year":"2013","journal-title":"Chronobiol. Int."},{"key":"10.1016\/j.crphar.2021.100025_bib32","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.3109\/07420528.2015.1113804","article-title":"Ambulatory Blood Pressure Monitoring (ABPM) as the reference standard for diagnosis of hypertension and assessment of vascular risk in adults","volume":"32","author":"Hermida","year":"2015","journal-title":"Chronobiol. Int."},{"key":"10.1016\/j.crphar.2021.100025_bib33","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/hr.2015.142","article-title":"Chronotherapy with conventional blood pressure medications improves management of hypertension and reduces cardiovascular and stroke risks","volume":"39","author":"Hermida","year":"2016","journal-title":"Hypertens. Res."},{"key":"10.1016\/j.crphar.2021.100025_bib34","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.smrv.2016.04.001","article-title":"Sleep-time blood pressure: unique sensitive prognostic marker of vascular risk and therapeutic target for prevention","volume":"33","author":"Hermida","year":"2017","journal-title":"Sleep Med. Rev."},{"key":"10.1016\/j.crphar.2021.100025_bib35","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.hfc.2017.05.010","article-title":"Bedtime blood pressure chronotherapy significantly improves hypertension management","volume":"13","author":"Hermida","year":"2017","journal-title":"Heart Fail. Clin."},{"key":"10.1016\/j.crphar.2021.100025_bib36","doi-asserted-by":"crossref","first-page":"4159","DOI":"10.1093\/eurheartj\/ehy475","article-title":"For the Hygia Project Investigators. Asleep blood pressure: significant prognostic marker of vascular risk and therapeutic target for prevention","volume":"39","author":"Hermida","year":"2018","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.crphar.2021.100025_bib37","doi-asserted-by":"crossref","DOI":"10.1111\/eci.12909","article-title":"Hypertension: new perspective on its definition and clinical management by bedtime therapy substantially reduces cardiovascular disease risk","volume":"48","author":"Hermida","year":"2018","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.crphar.2021.100025_bib38","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1080\/17425255.2020.1825681","article-title":"Ingestion-time - relative to circadian rhythms - differences in the pharmacokinetics and pharmacodynamics of hypertension medications","volume":"16","author":"Hermida","year":"2020","journal-title":"Expet Opin. Drug Metabol. Toxicol."},{"key":"10.1016\/j.crphar.2021.100025_bib39","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/s11886-020-01353-7","article-title":"Does timing of antihypertensive medication dosing matter?","volume":"22","author":"Hermida","year":"2020","journal-title":"Curr. Cardiol. Rep."},{"key":"10.1016\/j.crphar.2021.100025_bib40","doi-asserted-by":"crossref","first-page":"4565","DOI":"10.1093\/eurheartj\/ehz754","article-title":"Bedtime hypertension treatment improves cardiovascular risk reduction: the Hygia Chronotherapy Trial","volume":"41","author":"Hermida","year":"2020","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.crphar.2021.100025_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/07420528.2020.1850468","article-title":"Guidelines for the design and conduct of human clinical trials on ingestion-time differences - chronopharmacology and chronotherapy - of hypertension medications","volume":"38","author":"Hermida","year":"2021","journal-title":"Chronobiol. Int."},{"key":"10.1016\/j.crphar.2021.100025_bib42","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.addr.2021.01.013","article-title":"Ingestion-time differences in the pharmacodynamics of hypertension medications: systematic review of human chronopharmacology trials","volume":"170","author":"Hermida","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.crphar.2021.100025_bib43","doi-asserted-by":"crossref","first-page":"101454","DOI":"10.1016\/j.smrv.2021.101454","article-title":"Extent of asleep blood pressure reduction by hypertension medications is ingestion-time dependent: systematic review and meta-analysis of published human trials","volume":"59","author":"Hermida","year":"2021","journal-title":"Sleep Med. Rev."},{"key":"10.1016\/j.crphar.2021.100025_bib44","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1592\/phco.26.11.1601","article-title":"Role of P-glycoprotein in statin drug interactions","volume":"26","author":"Holtzman","year":"2006","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.crphar.2021.100025_bib45","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/nature10405","article-title":"Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk","volume":"478","author":"International Consortium for Blood Pressure Genome-Wide Association","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.crphar.2021.100025_bib46","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1038\/nature14618","article-title":"Directional dominance on stature and cognition in diverse human populations","volume":"523","author":"Joshi","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.crphar.2021.100025_bib47","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0009-9236(98)90034-0","article-title":"Grapefruit juice greatly increases serum concentrations of lovastatin and lovastatin acid","volume":"63","author":"Kantola","year":"1998","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.crphar.2021.100025_bib48","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1056\/NEJMoa1605086","article-title":"Genetic Risk, Adherence to a healthy lifestyle, and coronary disease","volume":"375","author":"Khera","year":"2016","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.crphar.2021.100025_bib49","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.1016\/j.jacc.2016.03.520","article-title":"Diagnostic yield and clinical utility of sequencing familial hypercholesterolemia genes in patients with severe hypercholesterolemia","volume":"67","author":"Khera","year":"2016","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"10.1016\/j.crphar.2021.100025_bib50","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1475-2891-6-33","article-title":"Medicinal importance of grapefruit juice and its interaction with various drugs","volume":"6","author":"Kiani","year":"2007","journal-title":"Nutr. J."},{"key":"10.1016\/j.crphar.2021.100025_bib51","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1517\/17425255.2015.1069274","article-title":"Role of organic cation transporters in drug-drug interaction","volume":"11","author":"Koepsell","year":"2015","journal-title":"Expet Opin. Drug Metabol. Toxicol."},{"key":"10.1016\/j.crphar.2021.100025_bib52","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/iub.1160","article-title":"Circadian events in human diseases and in cytochrome P450-related drug metabolism and therapy","volume":"65","author":"Kosir","year":"2013","journal-title":"IUBMB Life"},{"key":"10.1016\/j.crphar.2021.100025_bib53","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ijcard.2014.11.176","article-title":"Comparison of a morning polypill, evening polypill and individual pills on LDL-cholesterol, ambulatory blood pressure and adherence in high-risk patients; a randomized crossover trial","volume":"181","author":"Lafeber","year":"2015","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.crphar.2021.100025_bib54","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1001\/jama.1995.03530010049034","article-title":"Systems analysis of adverse drug events. ADE Prevention Study Group","volume":"274","author":"Leape","year":"1995","journal-title":"J.\u00a0Am. Med. Assoc."},{"key":"10.1016\/j.crphar.2021.100025_bib55","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1161\/CIRCRESAHA.117.310782","article-title":"Emerging role of precision medicine in cardiovascular disease","volume":"122","author":"Leopold","year":"2018","journal-title":"Circ. Res."},{"key":"10.1016\/j.crphar.2021.100025_bib56","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.cell.2014.10.020","article-title":"Time in motion: the molecular clock meets the microbiome","volume":"159","author":"Liang","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.crphar.2021.100025_bib57","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s13059-016-1138-2","article-title":"iRegNet3D: three-dimensional integrated regulatory network for the genomic analysis of coding and non-coding disease mutations","volume":"18","author":"Liang","year":"2017","journal-title":"Genome Biol."},{"key":"10.1016\/j.crphar.2021.100025_bib58","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nature14177","article-title":"Genetic studies of body mass index yield new insights for obesity biology","volume":"518","author":"Locke","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.crphar.2021.100025_bib59","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1146\/annurev.genom.5.061903.175925","article-title":"Mammalian circadian biology: elucidating genome-wide levels of temporal organization","volume":"5","author":"Lowrey","year":"2004","journal-title":"Annu. Rev. Genom. Hum. Genet."},{"key":"10.1016\/j.crphar.2021.100025_bib60","doi-asserted-by":"crossref","first-page":"168","DOI":"10.3389\/fphar.2018.00168","article-title":"Pharmacogenomics of hypertension and preeclampsia: focus on gene-gene Interactions","volume":"9","author":"Luizon","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.crphar.2021.100025_bib61","doi-asserted-by":"crossref","first-page":"13503","DOI":"10.1074\/jbc.M411859200","article-title":"Simvastatin attenuates expression of cytokine-inducible nitric-oxide synthase in embryonic cardiac myoblasts","volume":"280","author":"Madonna","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.crphar.2021.100025_bib62","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1093\/eurheartj\/ehw113","article-title":"Position Paper of the European Society of Cardiology Working Group Cellular Biology of the Heart: cell-based therapies for myocardial repair and regeneration in ischemic heart disease and heart failure","volume":"37","author":"Madonna","year":"2016","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.crphar.2021.100025_bib63","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1073\/pnas.1314066111","article-title":"Circadian clock-dependent and -independent rhythmic proteomes implement distinct diurnal functions in mouse liver","volume":"111","author":"Mauvoisin","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.crphar.2021.100025_bib64","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1002\/pmic.201400187","article-title":"Proteomics and circadian rhythms: it's all about signaling!","volume":"15","author":"Mauvoisin","year":"2015","journal-title":"Proteomics"},{"key":"10.1016\/j.crphar.2021.100025_bib65","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1086\/514346","article-title":"Mendelian Inheritance in man and its online version, OMIM","volume":"80","author":"McKusick","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.crphar.2021.100025_bib66","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0140-6736(02)11203-7","article-title":"Clinical importance of the cytochromes P450","volume":"360","author":"Nebert","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.crphar.2021.100025_bib67","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1097\/00004872-200211000-00017","article-title":"Prognostic significance of the nocturnal decline in blood pressure in individuals with and without high 24-h blood pressure: the Ohasama study","volume":"20","author":"Ohkubo","year":"2002","journal-title":"J.\u00a0Hypertens."},{"key":"10.1016\/j.crphar.2021.100025_bib68","first-page":"601","article-title":"Pharmacokinetic drug-drug interaction and their implication in clinical management","volume":"18","author":"Palleria","year":"2013","journal-title":"J.\u00a0Res. Med. Sci."},{"key":"10.1016\/j.crphar.2021.100025_bib69","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1172\/JCI111495","article-title":"Plasma mevalonate as a measure of cholesterol synthesis in man","volume":"74","author":"Parker","year":"1984","journal-title":"J.\u00a0Clin. Invest."},{"issue":"9","key":"10.1016\/j.crphar.2021.100025_bib70","doi-asserted-by":"crossref","first-page":"833","DOI":"10.2174\/1389200216666151015113828","article-title":"Association of flavonoid-rich foods and statins in the management of hypercholesterolemia: a dangerous or helpful combination?","volume":"16","author":"Peluso","year":"2015","journal-title":"Curr. Drug Metabol."},{"issue":"2","key":"10.1016\/j.crphar.2021.100025_bib71","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1093\/cvr\/cvaa155","article-title":"Improving translational research in sex-specific effects of comorbidities and risk factors in ischemic heart disease and cardioprotection: position paper and recommendations of the ESC working group on cellular biology of the heart","volume":"117","author":"Perrino","year":"2021","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.crphar.2021.100025_bib72","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1208\/s12248-013-9470-x","article-title":"Drug-drug interaction studies: regulatory guidance and an industry perspective","volume":"15","author":"Prueksaritanont","year":"2013","journal-title":"AAPS J."},{"key":"10.1016\/j.crphar.2021.100025_bib73","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1007\/s002280050582","article-title":"Suspected adverse drug events requiring emergency department visits or hospital admissions","volume":"54","author":"Raschetti","year":"1999","journal-title":"Eur. J. Clin. Pharmacol."},{"issue":"Suppl. 1","key":"10.1016\/j.crphar.2021.100025_bib74","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1177\/03331024830030S108","article-title":"Aspects of clinical chronopharmacology","volume":"3","author":"Reinberg","year":"1983","journal-title":"Cephalalgia"},{"key":"10.1016\/j.crphar.2021.100025_bib75","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1097\/01.pap.0000131825.77317.ee","article-title":"Pharmacogenomics","volume":"11","author":"Ross","year":"2004","journal-title":"Adv. Anat. Pathol."},{"key":"10.1016\/j.crphar.2021.100025_bib76","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1097\/HJH.0000000000000355","article-title":"Prognostic impact from clinic, daytime, and nighttime systolic blood pressure in 9 cohorts on 13,844 patients with hypertension","volume":"32","author":"Roush","year":"2014","journal-title":"J.\u00a0Hypertens."},{"key":"10.1016\/j.crphar.2021.100025_bib77","doi-asserted-by":"crossref","first-page":"106651","DOI":"10.1016\/j.vph.2020.106651","article-title":"Differential expression of microRNA and arachidonic acid metabolism in aspirin-treated human cardiac and peri-cardiac fat-derived mesenchymal stem cells","volume":"127","author":"Ruan","year":"2020","journal-title":"Vasc. Pharmacol."},{"key":"10.1016\/j.crphar.2021.100025_bib78","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.atherosclerosis.2020.12.023","article-title":"Combination of bempedoic acid, ezetimibe, and atorvastatin in patients with hypercholesterolemia: a randomized clinical trial","volume":"320","author":"Rubino","year":"2021","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.crphar.2021.100025_bib79","doi-asserted-by":"crossref","first-page":"688","DOI":"10.3390\/ijms19030688","article-title":"Advances in the genetics of hypertension: the effect of rare variants","volume":"19","author":"Russo","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.crphar.2021.100025_bib80","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1161\/HYPERTENSIONAHA.115.06981","article-title":"Prognostic impact of the nocturnal blood pressure fall in hypertensive patients: the ambulatory blood pressure collaboration in patients with hypertension (ABC-H) meta-analysis","volume":"67","author":"Salles","year":"2016","journal-title":"Hypertension"},{"key":"10.1016\/j.crphar.2021.100025_bib81","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.3390\/nu11071439","article-title":"Diurnal variation of markers for cholesterol synthesis, cholesterol absorption, and bile acid synthesis: a systematic review and the Bispebjerg study of diurnal variations","volume":"11","author":"Schroor","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.crphar.2021.100025_bib82","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1254\/jphs.08R01FM","article-title":"Pharmacogenomics of cardiovascular pharmacology: molecular network analysis in pleiotropic effects of statin -- an experimental elucidation of the pharmacologic action from protein-protein interaction analysis","volume":"107","author":"Shiota","year":"2008","journal-title":"J.\u00a0Pharmacol. Sci."},{"key":"10.1016\/j.crphar.2021.100025_bib83","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/nature14132","article-title":"New genetic loci link adipose and insulin biology to body fat distribution","volume":"518","author":"Shungin","year":"2015","journal-title":"Nature"},{"issue":"4 Pt 2","key":"10.1016\/j.crphar.2021.100025_bib84","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1016\/S0002-8703(99)70392-3","article-title":"Chronopharmacology and chronotherapy of cardiovascular medications: relevance to prevention and treatment of coronary heart disease","volume":"137","author":"Smolensky","year":"1999","journal-title":"Am. Heart J."},{"key":"10.1016\/j.crphar.2021.100025_bib85","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/MBP.0b013e32833c7308","article-title":"Administration-time-dependent effects of blood pressure-lowering medications: basis for the chronotherapy of hypertension","volume":"15","author":"Smolensky","year":"2010","journal-title":"Blood Pres. Monit."},{"key":"10.1016\/j.crphar.2021.100025_bib86","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.3109\/07420528.2015.1082106","article-title":"Ambulatory blood pressure monitoring (ABPM) as the reference standard to confirm diagnosis of hypertension in adults: recommendation of the 2015 U.S. Preventive services task force (USPSTF)","volume":"32","author":"Smolensky","year":"2015","journal-title":"Chronobiol. Int."},{"key":"10.1016\/j.crphar.2021.100025_bib87","doi-asserted-by":"crossref","first-page":"773","DOI":"10.2174\/1381612820666141024150542","article-title":"Bedtime hypertension chronotherapy: concepts and patient outcomes","volume":"21","author":"Smolensky","year":"2015","journal-title":"Curr. Pharmaceut. Des."},{"key":"10.1016\/j.crphar.2021.100025_bib88","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1080\/07420528.2016.1184678","article-title":"Circadian disruption: new clinical perspective of disease pathology and basis for chronotherapeutic intervention","volume":"33","author":"Smolensky","year":"2016","journal-title":"Chronobiol. Int."},{"key":"10.1016\/j.crphar.2021.100025_bib89","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.smrv.2016.02.003","article-title":"Circadian mechanisms of 24-hour blood pressure regulation and patterning","volume":"33","author":"Smolensky","year":"2017","journal-title":"Sleep Med. Rev."},{"key":"10.1016\/j.crphar.2021.100025_bib90","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.hfc.2017.05.011","article-title":"Bedtime chronotherapy with conventional hypertension medications to target increased asleep blood pressure results in markedly better chronoprevention of cardiovascular and other risks than customary on-awakening therapy","volume":"13","author":"Smolensky","year":"2017","journal-title":"Heart Fail. Clin."},{"key":"10.1016\/j.crphar.2021.100025_bib91","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.coph.2020.10.014","article-title":"Chronotherapy of cardiac and vascular disease: timing medications to circadian rhythms to optimize treatment effects and outcomes","volume":"57","author":"Smolensky","year":"2020","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.crphar.2021.100025_bib92","article-title":"Atorvastatin enhance efficacy of mesenchymal stem cells treatment for swine myocardial infarction via activation of nitric oxide synthase","volume":"8","author":"Song","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.crphar.2021.100025_bib93","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s00439-017-1779-6","article-title":"The Human Gene Mutation Database: towards a comprehensive repository of inherited mutation data for medical research, genetic diagnosis and next-generation sequencing studies","volume":"136","author":"Stenson","year":"2017","journal-title":"Hum. Genet."},{"key":"10.1016\/j.crphar.2021.100025_bib94","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1159\/000375373","article-title":"The role of rare variants in systolic blood pressure: analysis of ExomeChip data in HyperGEN African Americans","volume":"79","author":"Sung","year":"2015","journal-title":"Hum. Hered."},{"key":"10.1016\/j.crphar.2021.100025_bib95","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/nrg.2016.150","article-title":"Transcriptional architecture of the mammalian circadian clock","volume":"18","author":"Takahashi","year":"2017","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.crphar.2021.100025_bib96","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1186\/s12916-020-01827-z","article-title":"Multimorbidity, polypharmacy, and drug-drug-gene interactions following a non-ST elevation acute coronary syndrome: analysis of a multicentre observational study","volume":"18","author":"Turner","year":"2020","journal-title":"BMC Med."},{"key":"10.1016\/j.crphar.2021.100025_bib97","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1093\/bioinformatics\/btr323","article-title":"MixupMapper: correcting sample mix-ups in genome-wide datasets increases power to detect small genetic effects","volume":"27","author":"Westra","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.crphar.2021.100025_bib98","doi-asserted-by":"crossref","first-page":"e468","DOI":"10.1161\/CIR.0000000000000456","article-title":"Recommendations for management of clinically significant drug-drug interactions with statins and select agents used in patients with cardiovascular disease: a scientific statement from the American heart association","volume":"134","author":"Wiggins","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.crphar.2021.100025_bib99","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.2217\/rme-2019-0024","article-title":"Transplantation efficacy of autologous bone marrow mesenchymal stem cells combined with atorvastatin for acute myocardial infarction (TEAM-AMI): rationale and design of a randomized, double-blind, placebo-controlled, multi-center, Phase II TEAM-AMI trial","volume":"14","author":"Xu","year":"2019","journal-title":"Regen. Med."},{"key":"10.1016\/j.crphar.2021.100025_bib100","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1093\/eurheartj\/ehn167","article-title":"Atorvastatin treatment improves survival and effects of implanted mesenchymal stem cells in post-infarct swine hearts","volume":"29","author":"Yang","year":"2008","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.crphar.2021.100025_bib101","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1161\/ATVBAHA.109.189662","article-title":"Combined therapy with simvastatin and bone marrow-derived mesenchymal stem cells increases benefits in infarcted swine hearts","volume":"29","author":"Yang","year":"2009","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.crphar.2021.100025_bib102","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.vph.2013.10.004","article-title":"Simvastatin-enhanced expression of promyogenic nuclear factors and cardiomyogenesis of murine embryonic stem cells","volume":"60","author":"Yang","year":"2014","journal-title":"Vasc. Pharmacol."},{"issue":"1","key":"10.1016\/j.crphar.2021.100025_bib103","doi-asserted-by":"crossref","first-page":"e001139","DOI":"10.1136\/openhrt-2019-001139","article-title":"Strengthening effects of bone marrow mononuclear cells with intensive atorvastatin in acute myocardial infarction","volume":"7","author":"Yang","year":"2020","journal-title":"Open Heart"},{"key":"10.1016\/j.crphar.2021.100025_bib104","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.thromres.2006.10.021","article-title":"Warfarin dose and the pharmacogenomics of CYP2C9 and VKORC1 - rationale and perspectives","volume":"120","author":"Yin","year":"2007","journal-title":"Thromb. Res."},{"key":"10.1016\/j.crphar.2021.100025_bib105","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/00498254.2019.1672120","article-title":"Circadian clock-controlled drug metabolism and transport","volume":"50","author":"Zhao","year":"2020","journal-title":"Xenobiotica"},{"key":"10.1016\/j.crphar.2021.100025_bib106","doi-asserted-by":"crossref","first-page":"628705","DOI":"10.3389\/fphar.2021.628705","article-title":"Drug-drug interactions at organic cation transporter 1","volume":"12","author":"Zhou","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.crphar.2021.100025_bib107","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1124\/dmd.110.037861","article-title":"Role of intestinal cytochrome P450 (P450) in modulating the bioavailability of oral lovastatin: insights from studies on the intestinal epithelium-specific P450 reductase knockout mouse","volume":"39","author":"Zhu","year":"2011","journal-title":"Drug Metab. Dispos."}],"updated-by":[{"DOI":"10.1016\/j.crphar.2021.100032","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000}}],"container-title":["Current Research in Pharmacology and Drug Discovery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590257121000122?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590257121000122?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T04:47:49Z","timestamp":1762922869000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590257121000122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":107,"alternative-id":["S2590257121000122"],"URL":"https:\/\/doi.org\/10.1016\/j.crphar.2021.100025","relation":{},"ISSN":["2590-2571"],"issn-type":[{"value":"2590-2571","type":"print"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pharmacogenomics and circadian rhythms as mediators of cardiovascular drug-drug interactions","name":"articletitle","label":"Article Title"},{"value":"Current Research in Pharmacology and Drug Discovery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.crphar.2021.100025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100025"}}