{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T22:02:39Z","timestamp":1787695359650,"version":"build-2784847793"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T00:00:00Z","timestamp":1641772800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Research in Pharmacology and Drug Discovery"],"published-print":{"date-parts":[[2022]]},"DOI":"10.1016\/j.crphar.2022.100082","type":"journal-article","created":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T01:54:47Z","timestamp":1642470887000},"page":"100082","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Variability in the serum and tissue concentrations of pre-incisional ceftriaxone for surgery in paediatric population and outcome of surgical-site infections; An open labelled, prospective, non-randomized, analytical study"],"prefix":"10.1016","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6281-9386","authenticated-orcid":false,"given":"Salim","family":"Sheikh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravinder","family":"Majoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chakra Dhar","family":"Tripathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veena","family":"Verma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak","family":"Bagga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4311-5388","authenticated-orcid":false,"given":"Bushra Ahmed","family":"Karim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Girish Gulab","family":"Meshram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.crphar.2022.100082_bib1","doi-asserted-by":"crossref","first-page":"e288","DOI":"10.1016\/S1473-3099(16)30402-9","article-title":"WHO Guidelines Development Group. New WHO recommendations on intraoperative and postoperative measures for surgical site infection prevention: an evidence-based global perspective","volume":"16","author":"Allegranzi","year":"2016","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.crphar.2022.100082_bib2","first-page":"227","article-title":"Surgical considerations of endogenous infections- sources, types, and methods of control","volume":"48","author":"Altemeier","year":"1968","journal-title":"Surg. Clin."},{"key":"10.1016\/j.crphar.2022.100082_bib3","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1086\/676022","article-title":"Strategies to prevent surgical site infections in acute care hospitals: 2014 update","volume":"35","author":"Anderson","year":"2014","journal-title":"Infect. Control Hosp. Epidemiol."},{"key":"10.1016\/j.crphar.2022.100082_bib4","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jamcollsurg.2016.10.029","article-title":"American College of Surgeons and Surgical Infection Society: surgical site infection guidelines, 2016 update","volume":"224","author":"Ban","year":"2017","journal-title":"J.\u00a0Am. Coll. Surg."},{"key":"10.1016\/j.crphar.2022.100082_bib5","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1001\/jamasurg.2017.0904","article-title":"Healthcare Infection Control Practices Advisory Committee Centers for Disease Control and Prevention guideline for the prevention of surgical site infection","volume":"152","author":"Berr\u00edos-Torres","year":"2017","journal-title":"JAMA Surg."},{"key":"10.1016\/j.crphar.2022.100082_bib6","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0022-3468(05)80177-0","article-title":"Postoperative wound infection in pediatric surgical patients: a study of 676 infants and children","volume":"25","author":"Bhattacharyya","year":"1990","journal-title":"J.\u00a0Pediatr. Surg."},{"key":"10.1016\/j.crphar.2022.100082_bib7","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/0022-3468(93)90228-D","article-title":"Nosocomial infection in pediatric surgical patients: a study of 608 infants and children","volume":"28","author":"Bhattacharyya","year":"1993","journal-title":"J.\u00a0Pediatr. Surg."},{"key":"10.1016\/j.crphar.2022.100082_bib8","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.amjsurg.2005.01.015","article-title":"Antimicrobial prophylaxis for surgery: an advisory statement from the national surgical infection prevention project","volume":"189","author":"Bratzler","year":"2005","journal-title":"Am. J. Surg."},{"key":"10.1016\/j.crphar.2022.100082_bib9","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1086\/505220","article-title":"The surgical infection prevention and surgical care improvement projects: national initiatives to improve outcomes for patients having surgery","volume":"43","author":"Bratzler","year":"2006","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.crphar.2022.100082_bib10","doi-asserted-by":"crossref","first-page":"195","DOI":"10.2146\/ajhp120568","article-title":"American Society of Health-System pharmacists; Infectious Disease Society of America; Surgical Infection Society; Society for Healthcare Epidemiology of America. Clinical practice guidelines for antimicrobial prophylaxis in surgery","volume":"70","author":"Bratzler","year":"2013","journal-title":"Am. J. Health Syst. Pharm."},{"key":"10.1016\/j.crphar.2022.100082_bib11","series-title":"The Pharmacological Basis of Therapeutics","first-page":"1023","author":"Brunton","year":"2018"},{"key":"10.1016\/j.crphar.2022.100082_bib12","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.jamcollsurg.2011.01.065","article-title":"Risk factors and outcomes of surgical site infection in children","volume":"212","author":"Bucher","year":"2011","journal-title":"J.\u00a0Am. Coll. Surg."},{"key":"10.1016\/j.crphar.2022.100082_bib13","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1086\/504938","article-title":"Risk factors for surgical site infection in children","volume":"27","author":"Casanova","year":"2006","journal-title":"Infect. Control Hosp. Epidemiol."},{"key":"10.1016\/j.crphar.2022.100082_bib14","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1086\/504938","article-title":"Risk factors for surgical site infection in children","volume":"27","author":"Casanova","year":"2006","journal-title":"Infect. Control Hosp. Epidemiol."},{"key":"10.1016\/j.crphar.2022.100082_bib15","first-page":"1171","article-title":"Risk factors for surgical site infection in a teaching hospital: a prospective study of 1,138 patients","volume":"14","author":"Cheng","year":"2015","journal-title":"Patient Prefer. Adherence"},{"key":"10.1016\/j.crphar.2022.100082_bib16","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1056\/NEJM199201303260501","article-title":"The timing of prophylactic administration of antibiotics and the risk of surgical-wound infection","volume":"326","author":"Classen","year":"1992","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.crphar.2022.100082_bib17","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S0022-3468(05)80348-3","article-title":"Wound infection in pediatric surgery: a study of 1,094 neonates","volume":"28","author":"Davenport","year":"1993","journal-title":"J.\u00a0Pediatr. Surg."},{"key":"10.1016\/j.crphar.2022.100082_bib18","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1097\/00006454-198403000-00006","article-title":"Postoperative wound infections in a children's hospital","volume":"3","author":"Davis","year":"1984","journal-title":"Pediatr. Infect. Dis."},{"key":"10.1016\/j.crphar.2022.100082_bib19","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1002\/bjs.1800630822","article-title":"Wound infection in a children's hospital","volume":"63","author":"Doig","year":"1976","journal-title":"Br. J. Surg."},{"key":"10.1016\/j.crphar.2022.100082_bib20","doi-asserted-by":"crossref","first-page":"158S","DOI":"10.1016\/0002-9343(91)90362-2","article-title":"Risk factors for postoperative infection","volume":"91","author":"Garibaldi","year":"1991","journal-title":"Am. J. Med."},{"key":"10.1016\/j.crphar.2022.100082_bib21","doi-asserted-by":"crossref","first-page":"S69","DOI":"10.1086\/321860","article-title":"Surgical site infection (SSI) rates in the United States, 1992\u20131998: the National Nosocomial Infections Surveillance System basic SSI risk index","volume":"33","author":"Gaynes","year":"2001","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.crphar.2022.100082_bib22","first-page":"Doc18","article-title":"Incidence and clinical implication of nosocomial infections associated with implantable biomaterials - catheters, ventilator-associated pneumonia, urinary tract infections","volume":"6","author":"Guggenbichler","year":"2011","journal-title":"GMS Krankenhhyg Interdiszip"},{"key":"10.1016\/j.crphar.2022.100082_bib23","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1093\/oxfordjournals.aje.a113991","article-title":"Identifying patients at high risk of surgical wound infection. A simple multivariate index of patient susceptibility and wound contamination","volume":"121","author":"Haley","year":"1985","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.crphar.2022.100082_bib24","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1001\/jamasurg.2013.134","article-title":"Timing of surgical antibiotic prophylaxis and the risk of surgical site infection","volume":"148","author":"Hawn","year":"2013","journal-title":"JAMA Surg"},{"key":"10.1016\/j.crphar.2022.100082_bib25","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1097\/00000658-199804000-00017","article-title":"Pediatric wound infections. A prospective multicenter study","volume":"227","author":"Horwitz","year":"1998","journal-title":"Ann. Surg."},{"key":"10.1016\/j.crphar.2022.100082_bib26","doi-asserted-by":"crossref","first-page":"314","DOI":"10.4103\/joacp.JOACP_28_18","article-title":"Ceftriaxone concentration at the surgical site following systemic and isolated upper limb injection","volume":"34","author":"Kundra","year":"2018","journal-title":"J.\u00a0Anaesthesiol. Clin. Pharmacol."},{"key":"10.1016\/j.crphar.2022.100082_bib27","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1179\/joc.2003.15.2.139","article-title":"Ceftriaxone (1 g intravenously) penetration into abdominal tissues when administered as antibiotic prophylaxis during nephrectomy","volume":"15","author":"Leone","year":"2003","journal-title":"J.\u00a0Chemother."},{"key":"10.1016\/j.crphar.2022.100082_bib28","first-page":"599","article-title":"Antimicrobial tissue concentrations","volume":"17","author":"Liu","year":"2003","journal-title":"Infect. Dis. Clin."},{"key":"10.1016\/j.crphar.2022.100082_bib29","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1128\/AAC.36.12.2804","article-title":"Pharmacokinetics and tissue penetration of a single dose of ceftriaxone (1,000 milligrams intravenously) for antibiotic prophylaxis in thoracic surgery","volume":"36","author":"Martin","year":"1992","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.crphar.2022.100082_bib30","first-page":"21","article-title":"Tissue penetration of antibiotics. Introduction. Focus on some problems involved in the treatment of infectious diseases","volume":"S14","author":"Nordbring","year":"1978","journal-title":"Scand. J. Infect. Dis."},{"key":"10.1016\/j.crphar.2022.100082_bib32","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s11135-006-9018-6","article-title":"A\u00a0caution regarding rules of thumb for variance inflation factors","volume":"41","author":"O\u2019brien","year":"2007","journal-title":"Qual. Quantity"},{"key":"10.1016\/j.crphar.2022.100082_bib33","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/S0895-4356(96)00236-3","article-title":"A\u00a0simulation study of the number of events per variable in logistic regression analysis","volume":"49","author":"Peduzzi","year":"1996","journal-title":"J.\u00a0Clin. Epidemiol."},{"key":"10.1016\/j.crphar.2022.100082_bib35","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1067\/mic.2003.85","article-title":"A\u00a0prospective study of surgical site infections in a pediatric hospital in Mexico City","volume":"31","author":"Porras-Hern\u00e1ndez","year":"2003","journal-title":"Am. J. Infect. Control"},{"key":"10.1016\/j.crphar.2022.100082_bib47","series-title":"R: A Language and environment for statistical computing version 4.0","year":"2021"},{"key":"10.1016\/j.crphar.2022.100082_bib36","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1007\/s00228-021-03093-1","article-title":"Pharmacological evaluation of prophylactic anti-microbial use in laparoscopic cholecystectomy; an open labelled study evaluating the concentrations of single dose intravenous ceftriaxone at serum and tissue level","volume":"77","author":"Salim","year":"2021","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"10.1016\/j.crphar.2022.100082_bib37","first-page":"585","article-title":"Antiobiotic prophylaxis to prevent surgical site infections","volume":"83","author":"Salkind","year":"2011","journal-title":"Am. Fam. Physician"},{"key":"10.1016\/j.crphar.2022.100082_bib39","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S0022-3468(86)80016-1","article-title":"Postoperative wound infection in a pediatric surgical service","volume":"21","author":"Sharma","year":"1986","journal-title":"J.\u00a0Pediatr. Surg."},{"key":"10.1016\/j.crphar.2022.100082_bib40","first-page":"524","article-title":"Comparative pharmacokinetics of ceftriaxone, cefmetazole and moxalactam during abdominal surgery","volume":"1","author":"Shinagawa","year":"1989","journal-title":"J.\u00a0Chemother."},{"key":"10.1016\/j.crphar.2022.100082_bib41","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1097\/SLA.0b013e3181ad5fca","article-title":"Trial to reduce antimicrobial prophylaxis Errors (TRAPE) study group timing of antimicrobial prophylaxis and the risk of surgical site infections: results from the trial to reduce antimicrobial prophylaxis Errors","volume":"250","author":"Steinberg","year":"2009","journal-title":"Ann. Surg."},{"key":"10.1016\/j.crphar.2022.100082_bib42","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1001\/jama.2010.841","article-title":"Adherence to surgical care improvement project measures and the association with postoperative infections","volume":"303","author":"Stulberg","year":"2010","journal-title":"JAMA"},{"key":"10.1016\/j.crphar.2022.100082_bib43","doi-asserted-by":"crossref","first-page":"S112","DOI":"10.1093\/cid\/cix087","article-title":"Antimicrobial stewardship in surgery: challenges and opportunities","volume":"64","author":"Tarchini","year":"2017","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.crphar.2022.100082_bib45","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s003830000389","article-title":"Incidence of surgical site infections in pediatric patients: a 3-month prospective study in an academic pediatric surgical unit","volume":"16","author":"Uludag","year":"2000","journal-title":"Pediatr. Surg. Int."},{"key":"10.1016\/j.crphar.2022.100082_bib46","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1086\/512192","article-title":"Antibiotic prophylaxis and the risk of surgical site infections following total hip arthroplasty: timely administration is the most important factor","volume":"44","author":"van Kasteren","year":"2007","journal-title":"Clin. Infect. Dis."}],"updated-by":[{"DOI":"10.1016\/j.crphar.2024.100211","type":"expression_of_concern","label":"Expression of concern","source":"publisher","updated":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000}}],"container-title":["Current Research in Pharmacology and Drug Discovery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590257122000025?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590257122000025?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,29]],"date-time":"2024-06-29T00:27:22Z","timestamp":1719620842000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590257122000025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":43,"alternative-id":["S2590257122000025"],"URL":"https:\/\/doi.org\/10.1016\/j.crphar.2022.100082","relation":{"expression_of_concern":[{"id-type":"doi","id":"10.1016\/j.crphar.2024.100211","asserted-by":"object"}]},"ISSN":["2590-2571"],"issn-type":[{"value":"2590-2571","type":"print"}],"subject":[],"published":{"date-parts":[[2022]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Variability in the serum and tissue concentrations of pre-incisional ceftriaxone for surgery in paediatric population and outcome of surgical-site infections; An open labelled, prospective, non-randomized, analytical study","name":"articletitle","label":"Article Title"},{"value":"Current Research in Pharmacology and Drug Discovery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.crphar.2022.100082","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100082"}}