{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T15:14:03Z","timestamp":1793891643135,"version":"4.8.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T00:00:00Z","timestamp":1655683200000},"content-version":"vor","delay-in-days":170,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Research in Pharmacology and Drug Discovery"],"published-print":{"date-parts":[[2022]]},"DOI":"10.1016\/j.crphar.2022.100115","type":"journal-article","created":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T12:44:20Z","timestamp":1655901860000},"page":"100115","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["microRNAs: An opportunity to overcome significant challenges in malaria detection and control"],"prefix":"10.1016","volume":"3","author":[{"given":"Ruhi","family":"Sikka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen Kumar","family":"Bharti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1391-8358","authenticated-orcid":false,"given":"Himanshu","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"37","key":"10.1016\/j.crphar.2022.100115_bib1","doi-asserted-by":"crossref","first-page":"60723","DOI":"10.18632\/oncotarget.11032","article-title":"Role of micro-RNAs in drug resistance of multiple myeloma","volume":"7","author":"Abdi","year":"2016","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.crphar.2022.100115_bib2","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1080\/21505594.2020.1773107","article-title":"Clinical and epidemiological characterization of severe Plasmodium vivax malaria in Gujarat, India","volume":"11","author":"Anvikar","year":"2020","journal-title":"Virulence"},{"key":"10.1016\/j.crphar.2022.100115_bib3","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.3389\/fimmu.2019.02323","article-title":"Determining immune and miRNA biomarkers related to respiratory syncytial virus (RSV) vaccine types","volume":"10","author":"Atherton","year":"2019","journal-title":"Front. Immunol."},{"issue":"13","key":"10.1016\/j.crphar.2022.100115_bib4","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1056\/NEJMoa2101746","article-title":"Evidence of artemisinin-resistant malaria in Africa","volume":"385","author":"Balikagala","year":"2021","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.crphar.2022.100115_bib5","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.aca.2020.12.042","article-title":"Sensitive detection of microRNA-21 in cancer cells and human serum with Au@Si nanocomposite and lateral flow assay","volume":"1147","author":"Dong","year":"2021","journal-title":"Anal. Chim. Acta"},{"issue":"8","key":"10.1016\/j.crphar.2022.100115_bib6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0221143","article-title":"The effect of H1N1 vaccination on serum miRNA expression in children: a tale of caution for microRNA microarray studies","volume":"14","author":"Drury","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.crphar.2022.100115_bib7","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.bios.2013.10.055","article-title":"Visual detection of microRNA with lateral flow nucleic acid biosensor","volume":"54","author":"Gao","year":"2014","journal-title":"Biosens. Bioelectron."},{"issue":"1","key":"10.1016\/j.crphar.2022.100115_bib8","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.cll.2009.10.001","article-title":"Malaria","volume":"30","author":"Garcia","year":"2010","journal-title":"Clin. Lab. Med."},{"issue":"5","key":"10.1016\/j.crphar.2022.100115_bib9","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.cmi.2018.09.009","article-title":"Genetic diversity and deletion of Plasmodium falciparum histidine-rich protein 2 and 3: a threat to diagnosis of P. falciparum malaria","volume":"25","author":"Gendrot","year":"2019","journal-title":"Clin. Microbiol. Infect."},{"issue":"2","key":"10.1016\/j.crphar.2022.100115_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0167969","article-title":"Stability of circulating blood-based MicroRNAs - pre-analytic methodological considerations","volume":"12","author":"Glinge","year":"2017","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.crphar.2022.100115_bib11","doi-asserted-by":"crossref","first-page":"910","DOI":"10.3855\/jidc.6813","article-title":"Plasmodium vivax infection causes acute respiratory distress syndrome: a case report","volume":"9","author":"Gupta","year":"2015","journal-title":"J\u00a0Infect Dev Ctries"},{"issue":"4","key":"10.1016\/j.crphar.2022.100115_bib12","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1177\/0049475515624857","article-title":"Cerebral malaria in a man with Plasmodium vivax mono-infection: a case report","volume":"46","author":"Gupta","year":"2016","journal-title":"Trop. Doct."},{"issue":"2","key":"10.1016\/j.crphar.2022.100115_bib13","doi-asserted-by":"crossref","first-page":"430","DOI":"10.3201\/eid2702.191795","article-title":"Plasma MicroRNA profiling of Plasmodium falciparum biomass and association with severity of malaria disease","volume":"27","author":"Gupta","year":"2021","journal-title":"Emerg. Infect. Dis."},{"issue":"6","key":"10.1016\/j.crphar.2022.100115_bib14","doi-asserted-by":"crossref","first-page":"e396","DOI":"10.1002\/ctm2.396","article-title":"Plasma levels of hsa-miR-3158-3p microRNA on admission correlate with MRI findings and predict outcome in cerebral malaria","volume":"11","author":"Gupta","year":"2021","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.crphar.2022.100115_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.793954","article-title":"Harnessing the potential of miRNAs in malaria diagnostic and prevention","volume":"11","author":"Gupta","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.crphar.2022.100115_bib16","doi-asserted-by":"crossref","first-page":"478","DOI":"10.3389\/fgene.2019.00478","article-title":"The potential for microRNA therapeutics and clinical research","volume":"10","author":"Hanna","year":"2019","journal-title":"Front. Genet."},{"issue":"18","key":"10.1016\/j.crphar.2022.100115_bib17","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1056\/NEJMoa1209026","article-title":"Treatment of HCV infection by targeting microRNA","volume":"368","author":"Janssen","year":"2013","journal-title":"N.\u00a0Engl. J. Med."},{"issue":"2","key":"10.1016\/j.crphar.2022.100115_bib18","doi-asserted-by":"crossref","first-page":"e00104","DOI":"10.1128\/CMR.00104-19","article-title":"Imported malaria in countries where malaria is not endemic: a comparison of semi-immune and nonimmune travelers","volume":"33","author":"Mischlinger","year":"2020","journal-title":"Clin. Microbiol. Rev."},{"issue":"2","key":"10.1016\/j.crphar.2022.100115_bib19","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3390\/diseases8020015","article-title":"Plasmodium falciparum histidine-rich protein 2 and 3 gene deletions and their implications in malaria control","volume":"8","author":"Nyataya","year":"2020","journal-title":"Diseases"},{"issue":"3","key":"10.1016\/j.crphar.2022.100115_bib20","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nrd.2016.246","article-title":"MicroRNA therapeutics: towards a new era for the management of cancer and other diseases","volume":"16","author":"Rupaimoole","year":"2017","journal-title":"Nat. Rev. Drug Discov."},{"issue":"6","key":"10.1016\/j.crphar.2022.100115_bib21","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.jmoldx.2013.07.005","article-title":"Quantification of circulating miRNAs in plasma: effect of preanalytical and analytical parameters on their isolation and stability","volume":"15","author":"Sourvinou","year":"2013","journal-title":"J.\u00a0Mol. Diagn."},{"key":"10.1016\/j.crphar.2022.100115_bib22","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.3389\/fmicb.2020.01197","article-title":"MicroRNA biomarkers for infectious diseases: from basic research to biosensing","volume":"11","author":"Tribolet","year":"2020","journal-title":"Front. Microbiol."},{"issue":"7","key":"10.1016\/j.crphar.2022.100115_bib23","doi-asserted-by":"crossref","first-page":"851","DOI":"10.15252\/emmm.201100899","article-title":"Development of microRNA therapeutics is coming of age","volume":"6","author":"van Rooij","year":"2014","journal-title":"EMBO Mol. Med."},{"issue":"8","key":"10.1016\/j.crphar.2022.100115_bib24","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/S1473-3099(18)30420-1","article-title":"HRP-2 deletion: a hole in the ship of malaria elimination","volume":"18","author":"Verma","year":"2018","journal-title":"Lancet Infect. Dis."},{"issue":"3 Suppl. l","key":"10.1016\/j.crphar.2022.100115_bib25","doi-asserted-by":"crossref","first-page":"42","DOI":"10.4269\/ajtmh.14-0841","article-title":"Investigating the pathogenesis of severe malaria: a multidisciplinary and cross-geographical approach","volume":"93","author":"Wassmer","year":"2015","journal-title":"Am. J. Trop. Med. Hyg."},{"issue":"8","key":"10.1016\/j.crphar.2022.100115_bib26","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1172\/JCI21682","article-title":"Antimalarial drug resistance","volume":"113","author":"White","year":"2004","journal-title":"J.\u00a0Clin. Invest."},{"issue":"1","key":"10.1016\/j.crphar.2022.100115_bib27","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/s12936-017-1731-1","article-title":"Malaria parasite clearance","volume":"16","author":"White","year":"2017","journal-title":"Malar. J."},{"key":"10.1016\/j.crphar.2022.100115_bib28","author":"WHO"},{"key":"10.1016\/j.crphar.2022.100115_bib29","author":"WHO"},{"key":"10.1016\/j.crphar.2022.100115_bib30","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.snb.2018.02.159","article-title":"Lateral flow test for visual detection of multiple MicroRNAs","volume":"264","author":"Zheng","year":"2018","journal-title":"Sensor. Actuator. B Chem."},{"issue":"8","key":"10.1016\/j.crphar.2022.100115_bib31","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.3390\/ijms17081232","article-title":"Circulating organ-specific MicroRNAs serve as biomarkers in organ-specific diseases: implications for organ allo- and xeno-transplantation","volume":"17","author":"Zhou","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.crphar.2022.100115_bib32","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/1475-2875-8-71","article-title":"Malaria transmission in non-endemic areas: case report, review of the literature and implications for public health management","volume":"8","author":"Zoller","year":"2009","journal-title":"Malar. J."}],"container-title":["Current Research in Pharmacology and Drug Discovery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590257122000359?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590257122000359?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T04:58:36Z","timestamp":1762923516000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590257122000359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":32,"alternative-id":["S2590257122000359"],"URL":"https:\/\/doi.org\/10.1016\/j.crphar.2022.100115","relation":{},"ISSN":["2590-2571"],"issn-type":[{"value":"2590-2571","type":"print"}],"subject":[],"published":{"date-parts":[[2022]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"microRNAs: An opportunity to overcome significant challenges in malaria detection and control","name":"articletitle","label":"Article Title"},{"value":"Current Research in Pharmacology and Drug Discovery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.crphar.2022.100115","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100115"}}