{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:29:54Z","timestamp":1787063394966,"version":"build-2736575974"},"reference-count":82,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T00:00:00Z","timestamp":1658880000000},"content-version":"vor","delay-in-days":207,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology","doi-asserted-by":"publisher","award":["CRG\/2020\/003316"],"award-info":[{"award-number":["CRG\/2020\/003316"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Research in Pharmacology and Drug Discovery"],"published-print":{"date-parts":[[2022]]},"DOI":"10.1016\/j.crphar.2022.100121","type":"journal-article","created":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T21:48:47Z","timestamp":1659390527000},"page":"100121","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Promising effects of emoxypine and its succinate derivative in the management of various diseases-with insights on recent patent applications"],"prefix":"10.1016","volume":"3","author":[{"given":"Dhruv Sanjay","family":"Gupta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddhi","family":"Bagwe Parab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5151-914X","authenticated-orcid":false,"given":"Ginpreet","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.crphar.2022.100121_bib1","first-page":"59","article-title":"\u2018Results of the sequential use of mexidol and mexidol Forte 250 in patients with chronic cerebral ischemia\u2019. Zhurnal nevrologii i psikhiatrii im. S.S","volume":"120","author":"Abramenko","year":"2020","journal-title":"Korsakova"},{"key":"10.1016\/j.crphar.2022.100121_bib2","article-title":"\u2018Mexidol in the rehabilitation of patients in the acute ischemic stroke\u2019. Zhurnal nevrologii i psikhiatrii im. S.S","volume":"77","author":"Androfagina","year":"2015","journal-title":"Korsakova"},{"issue":"4","key":"10.1016\/j.crphar.2022.100121_bib3","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.1755-3768.1989.tb01617.x","article-title":"\u2018Lipid peroxidation in open-angle glaucoma\u2019","volume":"67","author":"Babizhayev","year":"2009","journal-title":"Acta Ophthalmol."},{"issue":"3","key":"10.1016\/j.crphar.2022.100121_bib4","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nrd1330","article-title":"\u2018Neurodegenerative diseases and oxidative stress\u2019","volume":"3","author":"Barnham","year":"2004","journal-title":"Nat. Rev. Drug Discov."},{"issue":"3","key":"10.1016\/j.crphar.2022.100121_bib5","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0278-5846(03)00037-X","article-title":"\u2018The influence of anticonvulsant and antioxidant drugs on nitric oxide level and lipid peroxidation in the rat brain during penthylenetetrazole-induced epileptiform model seizures\u2019","volume":"27","author":"Bashkatova","year":"2003","journal-title":"Prog. Neuro Psychopharmacol. Biol. Psychiatr."},{"key":"10.1016\/j.crphar.2022.100121_bib6","unstructured":"Biryukov, Dmitri Valerievich and Pomytkin, Igor Anatolievich. n.d. SUBSTITUTED 3 -HYDROXYPYRIDINES AND PHARMACEUTICAL COMPOSITIONS THEREOF. https:\/\/patents.google.com\/patent\/WO2009078746A1\/en."},{"key":"10.1016\/j.crphar.2022.100121_bib80","series-title":"New sulfur derivatives of 2-ethyl-6-methyl-hydroxypyridine. RU-2706692-C1","year":"2019"},{"key":"10.1016\/j.crphar.2022.100121_bib81","series-title":"Intranasal pharmaceutical composition of 2-ethyl-6-methyl-3-oxypiridine. RU-2670609-C1","year":"2018"},{"issue":"1","key":"10.1016\/j.crphar.2022.100121_bib7","first-page":"66","article-title":"\u2018[Changes in external membrane lipids of the mouse liver mitochondria and kinetic parameters of membrane-bound monoaminoxidase in vivo and in vitro]\u2019","volume":"30","author":"Burlakova","year":"1984","journal-title":"Vopr. Med. Khim."},{"issue":"4","key":"10.1016\/j.crphar.2022.100121_bib8","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3897\/rrpharmacology.4.31594","article-title":"\u2018Pharmacological correction of metabolic disorders in experimental acute pancreatitis on the background of chronic alcohol intoxication\u2019","volume":"4","author":"Bushmina","year":"2018","journal-title":"Res. Results Pharmacol."},{"issue":"9","key":"10.1016\/j.crphar.2022.100121_bib75","doi-asserted-by":"crossref","first-page":"39","DOI":"10.17116\/jnevro201911909139","article-title":"Efficacy and safety of the drug mexidol FORTE 250 as part of sequential therapy in patients with chronic ischemia of the brain","volume":"119","author":"Chukanova","year":"2019","journal-title":"Zhurnal nevrologii i psikhiatrii im. S.S. Korsakova"},{"issue":"6","key":"10.1016\/j.crphar.2022.100121_bib9","first-page":"13","article-title":"\u2018[Metabolic effects of mexidol in complex treatment of chronic brain ischemia]\u2019","volume":"71","author":"Demchenko","year":"2008","journal-title":"Eksp. Klin. Farmakol."},{"issue":"4","key":"10.1016\/j.crphar.2022.100121_bib10","first-page":"47","article-title":"\u2018[The effect of mexidol on the process of glycolysis in rats under acute stress conditions]\u2019","volume":"67","author":"Deviatkina","year":"2004","journal-title":"Eksp. Klin. Farmakol."},{"issue":"8","key":"10.1016\/j.crphar.2022.100121_bib76","doi-asserted-by":"crossref","first-page":"52","DOI":"10.17116\/jnevro201811808152","article-title":"Mono- and combination therapy with the mexidol in young patients with cerebral angiodystonia","volume":"118","author":"Dyakonova","year":"2018","journal-title":"Zhurnal Nevrologii i Psikhiatrii Im. S.S. Korsakova"},{"issue":"2","key":"10.1016\/j.crphar.2022.100121_bib11","doi-asserted-by":"crossref","first-page":"155","DOI":"10.2174\/13816128113190990406","article-title":"\u2018Hydrogen peroxide produced by mitochondrial monoamine oxidase catalysis: biological implications\u2019","volume":"20","author":"Edmondson","year":"2014","journal-title":"Curr. Pharmaceut. Des."},{"issue":"2","key":"10.1016\/j.crphar.2022.100121_bib12","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.pharmthera.2014.02.010","article-title":"\u2018Update on the pharmacology of selective inhibitors of MAO-A and MAO-B: focus on modulation of CNS monoamine neurotransmitter release\u2019","volume":"143","author":"Finberg","year":"2014","journal-title":"Pharmacol. Ther."},{"issue":"2","key":"10.1016\/j.crphar.2022.100121_bib13","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1007\/s10517-005-0248-8","article-title":"\u2018Antihypoxic and antinecrotic effect of mexidol in skin ischemia\u2019","volume":"139","author":"Galenko-Yaroshevskii","year":"2005","journal-title":"Bull. Exp. Biol. Med."},{"issue":"11\u201312","key":"10.1016\/j.crphar.2022.100121_bib14","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1007\/BF00767648","article-title":"\u2018Cardioprotective properties of some synthetic antioxidants\u2019","volume":"26","author":"Gatsura","year":"1993","journal-title":"Pharmaceut. Chem. J."},{"issue":"10","key":"10.1016\/j.crphar.2022.100121_bib15","first-page":"97","article-title":"\u2018Experience with mexidol in neurological practice\u2019. Zhurnal nevrologii i psikhiatrii im. S.S","volume":"118","author":"Gromova","year":"2018","journal-title":"Korsakova"},{"issue":"5","key":"10.1016\/j.crphar.2022.100121_bib16","first-page":"85","article-title":"\u2018[Antiradical and antioxidant properties of nonsteroidal anti-inflammatory agents\u2013derivatives of pyridinecarboxylic acid]\u2019","volume":"71","author":"Gubski\u012d","year":"1999","journal-title":"Ukrains'kyi Biokhimichnyi Zh."},{"issue":"1","key":"10.1016\/j.crphar.2022.100121_bib17","doi-asserted-by":"crossref","DOI":"10.1098\/rsos.211239","article-title":"\u2018Theoretical insights into the antiradical activity and copper-catalysed oxidative damage of mexidol in the physiological environment\u2019","volume":"9","author":"Hoa","year":"2022","journal-title":"Royal Soc. Open Sci."},{"issue":"6","key":"10.1016\/j.crphar.2022.100121_bib18","first-page":"41","article-title":"\u2018[Comparative studies of antihypoxic, neuroprotective and analgesic action of succinate-containing drugs]\u2019","volume":"46","author":"Iasnetsov","year":"2012","journal-title":"Aviakosmicheskaia Ekologicheskaia Meditsina Aerosp. Environ. Med."},{"issue":"7","key":"10.1016\/j.crphar.2022.100121_bib19","doi-asserted-by":"crossref","first-page":"671","DOI":"10.3390\/nu9070671","article-title":"\u2018Antioxidants mediate both iron homeostasis and oxidative stress\u2019","volume":"9","author":"Imam","year":"2017","journal-title":"Nutrients"},{"issue":"11","key":"10.1016\/j.crphar.2022.100121_bib20","first-page":"59","article-title":"\u2018Effectiveness and safety of mexidol Forte 250 in the sequential therapy in patients with chronic ischemia\u2019. Zhurnal nevrologii i psikhiatrii im. S.S","volume":"120","author":"Kataeva","year":"2020","journal-title":"Korsakova"},{"issue":"2","key":"10.1016\/j.crphar.2022.100121_bib21","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1007\/s10517-017-3941-5","article-title":"\u2018Oxidative stress as a mechanisms of reduced glucose absorption under conditions of immobilization stress\u2019","volume":"164","author":"Kolesnikova","year":"2017","journal-title":"Bull. Exp. Biol. Med."},{"issue":"6","key":"10.1016\/j.crphar.2022.100121_bib22","doi-asserted-by":"crossref","first-page":"527","DOI":"10.18097\/PBMC20176306527","article-title":"\u2018Disorders in structural-functional properties of erythrocytes in experimental acute destructive pancreatitis of alcohol etiology and their correction\u2019","volume":"63","author":"Konoplja","year":"2017","journal-title":"Biomed. Khim."},{"issue":"9","key":"10.1016\/j.crphar.2022.100121_bib23","first-page":"252","article-title":"\u2018[Emoxipin in reperfusion of ischemic myocardium in dogs: effects on infarct size and plasma creatine kinase activity]\u2019","volume":"110","author":"Konorev","year":"1990","journal-title":"Biulleten Eksp. Biol. Meditsiny"},{"issue":"2","key":"10.1016\/j.crphar.2022.100121_bib24","doi-asserted-by":"crossref","first-page":"244","DOI":"10.3329\/bjms.v18i2.40693","article-title":"\u2018Features of leukocytes\u2019 apoptosis and emoxypine succinate efficacy in case of combined trauma of the chest and both thighs in rats'","volume":"18","author":"Krynytska","year":"2019","journal-title":"Bangladesh J. Med. Sci."},{"issue":"3","key":"10.1016\/j.crphar.2022.100121_bib25","first-page":"69","article-title":"\u2018Assessment of the efficacy of mexidol in the combination with hyperbaric oxygen in acute ischemic stroke\u2019. Zhurnal nevrologii i psikhiatrii im. S.S","volume":"118","author":"Kulai","year":"2018","journal-title":"Korsakova"},{"issue":"2","key":"10.1016\/j.crphar.2022.100121_bib77","first-page":"33","article-title":"The effect of mexidol in the combination with antidepressants on sleep disturbance in young patients with panic disorder","volume":"113","author":"Kursakov","year":"2013","journal-title":"Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova"},{"issue":"12","key":"10.1016\/j.crphar.2022.100121_bib78","doi-asserted-by":"crossref","first-page":"89","DOI":"10.17116\/jnevro201911912289","article-title":"The study of the efficacy and safety of Mexidol and Mexidol Forte 250 in patients with chronic cerebral ischemia","volume":"119","author":"Kutashov","year":"2019","journal-title":"Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova"},{"issue":"1","key":"10.1016\/j.crphar.2022.100121_bib26","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/geronj\/35.1.45","article-title":"\u2018Aspects of free radical reactions in biological systems: aging\u2019","volume":"35","author":"Leibovitz","year":"1980","journal-title":"J.\u00a0Gerontol."},{"issue":"4","key":"10.1016\/j.crphar.2022.100121_bib27","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s11055-019-00746-8","article-title":"\u2018Current concepts in the pathogenesis of neurodegenerative diseases and treatment strategies\u2019","volume":"49","author":"Litvinenko","year":"2019","journal-title":"Neurosci. Behav. Physiol."},{"issue":"10","key":"10.1016\/j.crphar.2022.100121_bib28","first-page":"22","article-title":"\u2018The trial of the efficacy and safety of sequential therapy with mexidol Forte 250 in acute and early recovery stages of hemispheric ischemic stroke\u2019. Zhurnal nevrologii i psikhiatrii im. S.S","volume":"120","author":"Loskutnikov","year":"2020","journal-title":"Korsakova"},{"issue":"6","key":"10.1016\/j.crphar.2022.100121_bib29","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1134\/S0006350914060098","article-title":"\u2018The effects of magnesium, acetylsalicylic acid, and emoxypine on platelet aggregation\u2019","volume":"59","author":"Loznikova","year":"2014","journal-title":"Biophysics"},{"key":"10.1016\/j.crphar.2022.100121_bib30","author":"Lukyanova"},{"issue":"4","key":"10.1016\/j.crphar.2022.100121_bib31","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s10517-010-0771-0","article-title":"\u2018Energotropic effect of succinate-containing derivatives of 3-hydroxypyridine\u2019","volume":"148","author":"Lukyanova","year":"2009","journal-title":"Bull. Exp. Biol. Med."},{"issue":"8","key":"10.1016\/j.crphar.2022.100121_bib32","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1007\/BF00766466","article-title":"\u2018Features of the antihypoxic action of mexidol associated with its specific effect on energy metabolism\u2019","volume":"24","author":"Luk\u2019yanova","year":"1990","journal-title":"Pharmaceut. Chem. J."},{"issue":"4","key":"10.1016\/j.crphar.2022.100121_bib33","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1007\/BF00850908","article-title":"\u2018Antihypoxic effects of some 3-hydroxypyridine derivatives in isolated rat myocardium\u2019","volume":"115","author":"Luk\u2019yanova","year":"1993","journal-title":"Bull. Exp. Biol. Med."},{"key":"10.1016\/j.crphar.2022.100121_bib82","series-title":"Method of treating encephalopathy. RU2709614C1","year":"2019"},{"issue":"7","key":"10.1016\/j.crphar.2022.100121_bib34","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1107\/S2053229618007386","article-title":"\u2018Pharmaceutical salts of emoxypine with dicarboxylic acids\u2019","volume":"74","author":"Manin","year":"2018","journal-title":"Acta Crystallogr. C Struct. Chem."},{"issue":"1","key":"10.1016\/j.crphar.2022.100121_bib35","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jalz.2018.06.3063","article-title":"\u2018Racial and ethnic estimates of Alzheimer's disease and related dementias in the United States (2015-2060) in adults aged \u226565 Years'","volume":"15","author":"Matthews","year":"2019","journal-title":"Alzheimer's Dementia"},{"issue":"3","key":"10.1016\/j.crphar.2022.100121_bib36","first-page":"3","article-title":"\u2018[Cerebrovascular pharmacology of separate and combined vascular pathology of brain and heart]\u2019","volume":"77","author":"Mirzoian","year":"2014","journal-title":"Eksp. Klin. Farmakol."},{"issue":"1","key":"10.1016\/j.crphar.2022.100121_bib37","first-page":"3","article-title":"\u2018[Electrophysiological study of the mechanism of mexidol action]\u2019","volume":"75","author":"Motin","year":"2012","journal-title":"Eksp. Klin. Farmakol."},{"key":"10.1016\/j.crphar.2022.100121_bib38","volume":"vol. 7","author":"Pereira","year":"2012"},{"key":"10.1016\/j.crphar.2022.100121_bib39","volume":"2","author":"Pharmaceuticals","year":"2019"},{"issue":"71","key":"10.1016\/j.crphar.2022.100121_bib40","article-title":"\u2018Preventive therapy with mexidol in toxic damage to the heart\u2019","volume":"4","author":"Polozova","year":"2018","journal-title":"Khirurgiya. Zhurnal Im. N.I. Pirogova"},{"issue":"2","key":"10.1016\/j.crphar.2022.100121_bib41","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s10517-017-3951-3","article-title":"\u2018Comparison of the pharmacological effects of dimeric dipeptide nerve growth factor mimetic GK-2 and mexidol on the model of ischemic stroke in rats\u2019","volume":"164","author":"Povarnina","year":"2017","journal-title":"Bull. Exp. Biol. Med."},{"issue":"5","key":"10.1016\/j.crphar.2022.100121_bib42","first-page":"84","article-title":"\u2018Efficacy of mexidol in patients with type 2 diabetes mellitus with neurological complications\u2019. Zhurnal nevrologii i psikhiatrii im. S.S","volume":"122","author":"Pugacheva","year":"2022","journal-title":"Korsakova"},{"issue":"4","key":"10.1016\/j.crphar.2022.100121_bib43","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/nrneph.2013.282","article-title":"\u2018Acute kidney injury\u2014epidemiology, outcomes and economics\u2019","volume":"10","author":"Rewa","year":"2014","journal-title":"Nat. Rev. Nephrol."},{"issue":"2","key":"10.1016\/j.crphar.2022.100121_bib44","first-page":"186","article-title":"\u2018[Antioxidant and prooxidant properties of the ascorbic acid, dihydroquercetine and mexidol in the radical reactions induced by the ionizing radiation and chemical reagents]\u2019","volume":"50","author":"Riabchenko","year":"2010","journal-title":"Radiatsionnaia Biol. Radioecologiia"},{"issue":"8","key":"10.1016\/j.crphar.2022.100121_bib45","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1007\/s11055-012-9646-3","article-title":"\u2018Antioxidant treatment of ischemic brain lesions\u2019","volume":"42","author":"Rumyantseva","year":"2012","journal-title":"Neurosci. Behav. Physiol."},{"issue":"5","key":"10.1016\/j.crphar.2022.100121_bib46","first-page":"160","article-title":"\u2018Possibilities of using mexidol in the complex therapy of mental disorders\u2019. Zhurnal nevrologii i psikhiatrii im. S.S","volume":"120","author":"Shamrey","year":"2020","journal-title":"Korsakova"},{"issue":"10","key":"10.1016\/j.crphar.2022.100121_bib47","first-page":"32","article-title":"\u2018The efficacy and safety study of mexidol and mexidol FORTE 250 in patients with chronic cerebral ischemia\u2019. Zhurnal nevrologii i psikhiatrii im. S.S","volume":"121","author":"Shchepankevich","year":"2021","journal-title":"Korsakova"},{"issue":"8","key":"10.1016\/j.crphar.2022.100121_bib48","first-page":"221","article-title":"\u2018Evaluation of A renoprotective potential of organospecific peptides under the conditions of acute kidney injury of different etiology\u2019","volume":"31","author":"Shchudrova","year":"2018","journal-title":"J.\u00a0Educ. Health Sport"},{"issue":"12","key":"10.1016\/j.crphar.2022.100121_bib49","first-page":"87","article-title":"\u2018A modern concept of antihypoxic and antioxidant effects of mexidol\u2019. Zhurnal nevrologii i psikhiatrii im. S.S","volume":"118","author":"Shchulkin","year":"2018","journal-title":"Korsakova"},{"issue":"12","key":"10.1016\/j.crphar.2022.100121_bib50","first-page":"87","article-title":"\u2018A modern concept of antihypoxic and antioxidant effects of mexidol\u2019. Zhurnal nevrologii i psikhiatrii im. S.S","volume":"118","author":"Shchulkin","year":"2018","journal-title":"Korsakova"},{"issue":"12. Vyp. 2","key":"10.1016\/j.crphar.2022.100121_bib51","doi-asserted-by":"crossref","first-page":"87","DOI":"10.17116\/jnevro201811812287","article-title":"\u2018[A modern concept of antihypoxic and antioxidant effects of mexidol]\u2019","volume":"118","author":"Shchulkin","year":"2018","journal-title":"Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova"},{"key":"10.1016\/j.crphar.2022.100121_bib52","first-page":"6","article-title":"\u2018Influence of 2-ethyl-6-methyl-3-hydroxypyridine on the functional state of rat liver mitochondria","volume":"vol. 55","author":"Sinitskii","year":"2021"},{"issue":"8","key":"10.1016\/j.crphar.2022.100121_bib53","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1007\/s10593-005-0270-9","article-title":"\u2018Synthesis of 3-hydroxy-6-methyl- and 3-hydroxy-2-(2-Phenylethyl)Pyridines and their sulfur-containing amino and hydroxymethyl derivatives\u2019","volume":"41","author":"Smirnov","year":"2005","journal-title":"Chem. Heterocycl. Compd."},{"issue":"18","key":"10.1016\/j.crphar.2022.100121_bib54","doi-asserted-by":"crossref","first-page":"9866","DOI":"10.1073\/pnas.94.18.9866","article-title":"\u2018Iron accumulation in alzheimer disease is a source of redox-generated free radicals\u2019","volume":"94","author":"Smith","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"12","key":"10.1016\/j.crphar.2022.100121_bib55","first-page":"620","article-title":"Emoxipine as an inhibitor of angiogenesis","volume":"114","author":"Sologub","year":"1992","journal-title":"Biulleten Eksp. Biol. Meditsiny"},{"key":"10.1016\/j.crphar.2022.100121_bib56","first-page":"49","volume":"vol. 120","author":"Stakhovskaya","year":"2020"},{"issue":"3","key":"10.1016\/j.crphar.2022.100121_bib79","doi-asserted-by":"crossref","first-page":"54","DOI":"10.17116\/jnevro202012003254","article-title":"The efficacy and safety of mexidol Forte 250 as part of long-term sequential therapy in patients with carotid stroke","volume":"120","author":"Strelnikova","year":"2020","journal-title":"Zhurnal Nevrologii i Psikhiatrii Im. S.S. Korsakova"},{"issue":"12","key":"10.1016\/j.crphar.2022.100121_bib57","doi-asserted-by":"crossref","first-page":"9179","DOI":"10.1002\/jcp.26954","article-title":"\u2018Ferritinophagy\/Ferroptosis: iron-related newcomers in human diseases\u2019","volume":"233","author":"Tang","year":"2018","journal-title":"J.\u00a0Cell. Physiol."},{"issue":"1. Vyp. 2","key":"10.1016\/j.crphar.2022.100121_bib58","first-page":"75","article-title":"\u2018A comparative chemoreactome analysis of mexidol\u2019. Zhurnal nevrologii i psikhiatrii im. S.S","volume":"117","author":"Torshin","year":"2017","journal-title":"Korsakova"},{"issue":"2","key":"10.1016\/j.crphar.2022.100121_bib59","doi-asserted-by":"crossref","first-page":"45","DOI":"10.17116\/stomat20209902145","article-title":"\u2018Toothpastes of the \u00abmexidol dent\u00bb line \u2014 parapharmaceuticals with stable Antioxidative activity\u2019","volume":"99","author":"Udyanskaya","year":"2020","journal-title":"Stomatologiya (Mosc.)"},{"issue":"3","key":"10.1016\/j.crphar.2022.100121_bib60","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s10517-011-1134-1","article-title":"\u2018Effect of pro- and antioxidants on insulin sensitivity and glucose tolerance\u2019","volume":"150","author":"Volchegorskii","year":"2011","journal-title":"Bull. Exp. Biol. Med."},{"issue":"3","key":"10.1016\/j.crphar.2022.100121_bib61","first-page":"13","article-title":"\u2018[Effect of 3-oxypyridine and succinic acid derivatives on endometrial leucocyte infiltration and lipid peroxidation in recrudescence of inflammatory diseases of the uterus and its appendages]\u2019","volume":"76","author":"Volchegorski\u012d","year":"2013","journal-title":"Eksp. Klin. Farmakol."},{"issue":"5","key":"10.1016\/j.crphar.2022.100121_bib62","first-page":"6","article-title":"\u2018[Insulin potentiating and antidepressant effects of 3-oxypyridine and succinic acid derivatives]\u2019","volume":"77","author":"Volchegorski\u012d","year":"2014","journal-title":"Eksp. Klin. Farmakol."},{"issue":"6","key":"10.1016\/j.crphar.2022.100121_bib63","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s11055-016-0296-8","article-title":"\u2018The antidepressant actions of 3-hydroxypyridine and succinic acid derivatives in experimental studies\u2019","volume":"46","author":"Volchegorskii","year":"2016","journal-title":"Neurosci. Behav. Physiol."},{"key":"10.1016\/j.crphar.2022.100121_bib64","first-page":"26","article-title":"\u2018Effects of 3-hydroxypyridine and succinic acid derivatives on monoamine oxidase activity","volume":"vol. 52","author":"Volchegorskii","year":"2018"},{"issue":"4","key":"10.1016\/j.crphar.2022.100121_bib65","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s11055-019-00761-9","article-title":"\u2018Acute antidepressant effects of derivatives of 3-hydroxypyridine and succinic acid in experiments on rats\u2019","volume":"49","author":"Volchegorskii","year":"2019","journal-title":"Neurosci. Behav. Physiol."},{"issue":"1","key":"10.1016\/j.crphar.2022.100121_bib66","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/s11055-018-0706-1","article-title":"\u2018Anxiolytic and antidepressant actions of emoxypine, reamberin, and mexidol in experimental diabetes mellitus\u2019","volume":"49","author":"Volchegorskii","year":"2019","journal-title":"Neurosci. Behav. Physiol."},{"issue":"12","key":"10.1016\/j.crphar.2022.100121_bib67","first-page":"86","article-title":"\u2018[Mexidol: the spectrum of pharmacological effects]\u2019","volume":"112","author":"Voronina","year":"2012","journal-title":"Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova"},{"issue":"4","key":"10.1016\/j.crphar.2022.100121_bib68","first-page":"115","article-title":"\u2018Combined administration of mexidol with known medicines\u2019. Zhurnal nevrologii i psikhiatrii im. S.S","volume":"119","author":"Voronina","year":"2019","journal-title":"Korsakova"},{"issue":"1","key":"10.1016\/j.crphar.2022.100121_bib69","first-page":"42","article-title":"\u2018[Mexidol effects in extreme conditions (experiments with animals)]\u2019","volume":"41","author":"Voronina","year":"2007","journal-title":"Aviakosmicheskaia Ekologicheskaia Meditsina Aerosp. Environ. Med."},{"issue":"5","key":"10.1016\/j.crphar.2022.100121_bib70","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/BF00784176","article-title":"\u2018Effect of low-dose emoxypine and pyridoxine hydrochloride on human Cataract and glaucoma\u2019","volume":"115","author":"Yanovskaya","year":"1993","journal-title":"Bull. Exp. Biol. Med."},{"issue":"1","key":"10.1016\/j.crphar.2022.100121_bib71","doi-asserted-by":"crossref","DOI":"10.1042\/bj1210020Pa","article-title":"\u2018Rat liver mitochondrial monoamine oxidase, a flavin-containing enzyme\u2019","volume":"121","author":"Youdim","year":"1971","journal-title":"Biochem. J."},{"issue":"11","key":"10.1016\/j.crphar.2022.100121_bib72","first-page":"82","article-title":"\u2018Effect of mexidol on physical working capacity and level of lactate in the blood of rats in conditions of light deprivation\u2019. Zhurnal nevrologii i psikhiatrii im. S.S","volume":"118","author":"Zamoshchina","year":"2018","journal-title":"Korsakova"},{"issue":"5","key":"10.1016\/j.crphar.2022.100121_bib73","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/BF02471877","article-title":"\u2018Antioxidant and hypolipidemic properties of mexidol and emoxypine during prolonged immobilization stress\u2019","volume":"32","author":"Zor\u2019kina","year":"1998","journal-title":"Pharmaceut. Chem. J."},{"issue":"5","key":"10.1016\/j.crphar.2022.100121_bib74","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/BF02471877","article-title":"\u2018Antioxidant and hypolipidemic properties of mexidol and emoxypine during prolonged immobilization stress\u2019","volume":"32","author":"Zor\u2019kina","year":"1998","journal-title":"Pharmaceut. Chem. J."}],"container-title":["Current Research in Pharmacology and Drug Discovery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590257122000414?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590257122000414?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T04:52:33Z","timestamp":1762923153000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590257122000414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":82,"alternative-id":["S2590257122000414"],"URL":"https:\/\/doi.org\/10.1016\/j.crphar.2022.100121","relation":{},"ISSN":["2590-2571"],"issn-type":[{"value":"2590-2571","type":"print"}],"subject":[],"published":{"date-parts":[[2022]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Promising effects of emoxypine and its succinate derivative in the management of various diseases-with insights on recent patent applications","name":"articletitle","label":"Article Title"},{"value":"Current Research in Pharmacology and Drug Discovery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.crphar.2022.100121","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100121"}}