{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:27:24Z","timestamp":1792808844009,"version":"4.5.0"},"reference-count":107,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T00:00:00Z","timestamp":1688688000000},"content-version":"vor","delay-in-days":187,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Research in Pharmacology and Drug Discovery"],"published-print":{"date-parts":[[2023]]},"DOI":"10.1016\/j.crphar.2023.100161","type":"journal-article","created":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T21:21:42Z","timestamp":1689024102000},"page":"100161","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Apigenin attenuates depressive-like behavior via modulating monoamine oxidase A enzyme activity in chronically stressed mice"],"prefix":"10.1016","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5663-0015","authenticated-orcid":false,"given":"Juliet N.","family":"Olayinka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oluwole B.","family":"Akawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuela K.","family":"Ogbu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony T.","family":"Eduviere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond I.","family":"Ozolua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Soliman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.crphar.2023.100161_bib1","first-page":"3","article-title":"Endogenous antioxidants: a review of their role in oxidative stress","author":"Aguilar","year":"2016","journal-title":"A master Regul. oxidative Stress"},{"key":"10.1016\/j.crphar.2023.100161_bib2","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S1043-2760(98)00079-4","article-title":"Corticotropin releasing hormone, receptor regulation and the stress response","volume":"9","author":"Aguilera","year":"1998","journal-title":"Trends Endocrinol. Metabol."},{"key":"10.1016\/j.crphar.2023.100161_bib3","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.biopsych.2018.09.031","article-title":"The impact of stress and major depressive disorder on hippocampal and medial prefrontal cortex morphology","volume":"85","author":"Belleau","year":"2019","journal-title":"Biol. Psychiatr."},{"key":"10.1016\/j.crphar.2023.100161_bib4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0026-0495(00)80077-3","article-title":"What is oxidative stress?","volume":"49","author":"Betteridge","year":"2000","journal-title":"Metabolism"},{"key":"10.1016\/j.crphar.2023.100161_bib5","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jad.2012.07.024","article-title":"Angiotensin-(1\u20137) central administration induces anxiolytic-like effects in elevated plus maze and decreased oxidative stress in the amygdala","volume":"145","author":"Bild","year":"2013","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.crphar.2023.100161_bib6","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.psyneuen.2014.09.025","article-title":"Is depression associated with increased oxidative stress? A systematic review and meta-analysis","volume":"51","author":"Black","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.crphar.2023.100161_bib7","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.biopsych.2017.08.023","article-title":"Anhedonia following early-life adversity involves aberrant interaction of reward and anxiety circuits and is reversed by partial silencing of amygdala corticotropin-releasing hormone gene","volume":"83","author":"Bolton","year":"2018","journal-title":"Biol. Psychiatr."},{"key":"10.1016\/j.crphar.2023.100161_bib8","doi-asserted-by":"crossref","first-page":"295","DOI":"10.31887\/DCNS.2015.17.3\/mbourin","article-title":"Animal models for screening anxiolytic-like drugs: a perspective","volume":"17","author":"Bourin","year":"2022","journal-title":"Dialogues Clin. Neurosci."},{"key":"10.1016\/j.crphar.2023.100161_bib9","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.phymed.2010.08.006","article-title":"Apigenin inhibits hepatoma cell growth through alteration of gene expression patterns","volume":"18","author":"Cai","year":"2011","journal-title":"Phytomedicine"},{"key":"10.1016\/j.crphar.2023.100161_bib10","doi-asserted-by":"crossref","first-page":"18936","DOI":"10.3390\/molecules191118936","article-title":"Monoamine oxidase inhibitory constituents of propolis: kinetics and mechanism of inhibition of recombinant human MAO-A and MAO-B","volume":"19","author":"Chaurasiya","year":"2014","journal-title":"Molecules"},{"key":"10.1016\/j.crphar.2023.100161_bib11","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.jad.2011.05.057","article-title":"Hippocampal atrophy in first episode depression: a meta-analysis of magnetic resonance imaging studies","volume":"134","author":"Cole","year":"2011","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.crphar.2023.100161_bib12","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/S0006-8993(00)03000-6","article-title":"Chronic stress regulates levels of mRNA transcripts encoding \u03b2 subunits of the GABAA receptor in the rat stress axis","volume":"887","author":"Cullinan","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.crphar.2023.100161_bib13","doi-asserted-by":"crossref","first-page":"636","DOI":"10.2174\/1570159X13666150630175044","article-title":"Beyond monoamines-novel targets for treatment-resistant depression: a comprehensive review","volume":"13","author":"D Rosenblat","year":"2015","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.crphar.2023.100161_bib14","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.neuron.2009.04.017","article-title":"Neurogenesis-dependent and-independent effects of fluoxetine in an animal model of anxiety\/depression","volume":"62","author":"David","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.crphar.2023.100161_bib15","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ajp.2017.01.025","article-title":"The neurobiology of depression: an integrated view","volume":"27","author":"Dean","year":"2017","journal-title":"Asian J. Psychiatr."},{"key":"10.1016\/j.crphar.2023.100161_bib16","series-title":"Statistical Manual of Mental Health Disorders","author":"Diagnostic","year":"2013"},{"key":"10.1016\/j.crphar.2023.100161_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0083-6729(10)82001-1","article-title":"Models of depression","volume":"82","author":"Duman","year":"2010","journal-title":"Vitam. Horm."},{"key":"10.1016\/j.crphar.2023.100161_bib18","series-title":"Ethnobotany. Conventional and Traditional Uses of Plants","author":"Etukudo","year":"2003"},{"key":"10.1016\/j.crphar.2023.100161_bib19","doi-asserted-by":"crossref","DOI":"10.1186\/s13321-015-0067-5","article-title":"Calculating an optimal box size for ligand docking and virtual screening against experimental and predicted binding pockets","volume":"7","author":"Feinstein","year":"2015","journal-title":"J. Cheminf."},{"key":"10.1016\/j.crphar.2023.100161_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00429-016-1218-9","article-title":"Oxidative and nitrosative stress pathways in the brain of socially isolated adult male rats demonstrating depressive-and anxiety-like symptoms","volume":"222","author":"Filipovi\u0107","year":"2017","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.crphar.2023.100161_bib21","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/j.intimp.2011.03.012","article-title":"Anti-inflammatory activity of structurally related flavonoids, Apigenin, Luteolin and Fisetin","volume":"11","author":"Funakoshi-Tago","year":"2011","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.crphar.2023.100161_bib22","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/581976","article-title":"Clinical and biochemical manifestations of depression: relation to the neurobiology of stress","author":"Gold","year":"2015","journal-title":"Neural Plast."},{"key":"10.1016\/j.crphar.2023.100161_bib23","doi-asserted-by":"crossref","first-page":"24195","DOI":"10.1074\/jbc.M112.373936","article-title":"Mechanistic role for a novel glucocorticoid-KLF11 (TIEG2) protein pathway in stress-induced monoamine oxidase A expression","volume":"287","author":"Grunewald","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.crphar.2023.100161_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1758-2946-4-17","article-title":"Avogadro: an advanced semantic chemical editor, visualization, and analysis platform","volume":"4","author":"Hanwell","year":"2012","journal-title":"J. Cheminf."},{"key":"10.1016\/j.crphar.2023.100161_bib25","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1365-2826.2006.01429.x","article-title":"Do corticosteroids damage the brain?","volume":"18","author":"Herbert","year":"2006","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.crphar.2023.100161_bib26","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1159\/000126839","article-title":"Regulatory changes in neuroendocrine stress-integrative circuitry produced by a variable stress paradigm","volume":"61","author":"Herman","year":"1995","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.crphar.2023.100161_bib27","doi-asserted-by":"crossref","first-page":"604","DOI":"10.3389\/fnins.2017.00604","article-title":"Regulatory pathways of monoamine oxidase A during social stress","volume":"11","author":"Higuchi","year":"2017","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.crphar.2023.100161_bib28","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.biopsych.2017.08.005","article-title":"Elevated translocator protein in anterior cingulate in major depression and a role for inflammation in suicidal thinking: a positron emission tomography study","volume":"83","author":"Holmes","year":"2018","journal-title":"Biol. Psychiatr."},{"key":"10.1016\/j.crphar.2023.100161_bib29","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.neures.2010.08.007","article-title":"Oxidative stress in anxiety and comorbid disorders","volume":"68","author":"Hovatta","year":"2010","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.crphar.2023.100161_bib30","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/j.intimp.2009.08.015","article-title":"Anti-inflammatory effects of apigenin on nicotine-and lipopolysaccharide-stimulated human periodontal ligament cells via heme oxygenase-1","volume":"9","author":"Jeong","year":"2009","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.crphar.2023.100161_bib31","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1016\/j.psyneuen.2013.03.017","article-title":"Stress and vitamin D: altered vitamin D metabolism in both the hippocampus and myocardium of chronic unpredictable mild stress exposed rats","volume":"38","author":"Jiang","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.crphar.2023.100161_bib32","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1038\/npp.2011.105","article-title":"The reduction of R1, a novel repressor protein for monoamine oxidase A, in major depressive disorder","volume":"36","author":"Johnson","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.crphar.2023.100161_bib33","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1159\/000136485","article-title":"Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite","volume":"11","author":"Jollow","year":"1974","journal-title":"Pharmacology"},{"key":"10.1016\/j.crphar.2023.100161_bib34","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.brat.2016.07.007","article-title":"Examining emotion regulation in depression: a review and future directions","volume":"86","author":"Joormann","year":"2016","journal-title":"Behav. Res. Ther."},{"key":"10.1016\/j.crphar.2023.100161_bib35","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.3892\/ijmm.2014.1666","article-title":"Protective effect of apigenin against oxidative stress-induced damage in osteoblastic cells","volume":"33","author":"Jung","year":"2014","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.crphar.2023.100161_bib36","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.3390\/antiox10091439","article-title":"Chronic stress and oxidative stress as common factors of the pathogenesis of depression and Alzheimer's disease: the role of antioxidants in prevention and treatment","volume":"10","author":"Juszczyk","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.crphar.2023.100161_bib37","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0149-7634(81)90005-1","article-title":"Acute and chronic stress effects on open field activity in the rat: implications for a model of depression","volume":"5","author":"Katz","year":"1981","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.crphar.2023.100161_bib38","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1001\/archgenpsychiatry.2011.60","article-title":"Structural neuroimaging studies in major depressive disorder: meta-analysis and comparison with bipolar disorder","volume":"68","author":"Kempton","year":"2011","journal-title":"Arch. Gen. Psychiatr."},{"key":"10.1016\/j.crphar.2023.100161_bib39","doi-asserted-by":"crossref","first-page":"D1102","DOI":"10.1093\/nar\/gky1033","article-title":"PubChem 2019 update: improved access to chemical data","volume":"47","author":"Kim","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.crphar.2023.100161_bib40","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1038\/npp.2012.252","article-title":"Using standardized fMRI protocols to identify patterns of prefrontal circuit dysregulation that are common and specific to cognitive and emotional tasks in major depressive disorder: first wave results from the iSPOT-D study","volume":"38","author":"Korgaonkar","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.crphar.2023.100161_bib41","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.cell.2007.09.018","article-title":"Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions","volume":"131","author":"Krishnan","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.crphar.2023.100161_bib42","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2174\/138620730101220118151526","article-title":"Evaluation of the antioxidant potential of natural products","volume":"1","author":"Lee","year":"1998","journal-title":"Comb. Chem. High Throughput Screen."},{"key":"10.1016\/j.crphar.2023.100161_bib43","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.neubiorev.2011.12.005","article-title":"Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression","volume":"36","author":"Leonard","year":"2012","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.crphar.2023.100161_bib44","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1016\/j.febslet.2009.05.013","article-title":"Apigenin inhibits proliferation of ovarian cancer A2780 cells through Id1","volume":"583","author":"Li","year":"2009","journal-title":"FEBS Lett."},{"key":"10.1016\/j.crphar.2023.100161_bib45","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.neulet.2015.03.040","article-title":"The effects of apigenin on lipopolysaccharide-induced depressive-like behavior in mice","volume":"594","author":"Li","year":"2015","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.crphar.2023.100161_bib46","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/BF00177912","article-title":"The use of a plus-maze to measure anxiety in the mouse","volume":"92","author":"Lister","year":"1987","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.crphar.2023.100161_bib47","doi-asserted-by":"crossref","first-page":"7785","DOI":"10.1021\/acs.jmedchem.8b00765","article-title":"Structure-guided design and development of potent and selective dual bromodomain 4 (BRD4)\/Polo-like kinase 1 (PLK1) inhibitors","volume":"61","author":"Liu","year":"2018","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.crphar.2023.100161_bib48","doi-asserted-by":"crossref","DOI":"10.1097\/00008877-199711000-00010","article-title":"The forced swimming test as a model for core and component behavioral effects of antidepressant drugs","author":"Lucki","year":"1997","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.crphar.2023.100161_bib49","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.pnpbp.2010.06.023","article-title":"An intriguing and hitherto unexplained co-occurrence: depression and chronic fatigue syndrome are manifestations of shared inflammatory, oxidative and nitrosative (IO&NS) pathways","volume":"35","author":"Maes","year":"2011","journal-title":"Prog. Neuro Psychopharmacol. Biol. Psychiatr."},{"key":"10.1016\/j.crphar.2023.100161_bib50","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.pnpbp.2010.05.004","article-title":"A review on the oxidative and nitrosative stress (O&NS) pathways in major depression and their possible contribution to the (neuro) degenerative processes in that illness","volume":"35","author":"Maes","year":"2011","journal-title":"Prog. Neuro Psychopharmacol. Biol. Psychiatr."},{"key":"10.1016\/j.crphar.2023.100161_bib51","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s10787-011-0111-7","article-title":"New drug targets in depression: inflammatory, cell-mediated immune, oxidative and nitrosative stress, mitochondrial, antioxidant, and neuroprogressive pathways. And new drug candidates\u2014nrf2 activators and GSK-3 inhibitors","volume":"20","author":"Maes","year":"2012","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.crphar.2023.100161_bib52","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.cellimm.2007.09.006","article-title":"Stress hormones and immune function","volume":"252","author":"Marketon","year":"2008","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.crphar.2023.100161_bib53","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1358\/dnp.2006.19.10.1068007","article-title":"The effects of antidepressants on the hypothalamic-pituitary-adrenal axis","volume":"19","author":"Mason","year":"2006","journal-title":"Drug News Perspect."},{"key":"10.1016\/j.crphar.2023.100161_bib54","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1176\/ajp.156.5.675","article-title":"Reciprocal limbic-cortical function and negative mood: converging PET findings in depression and normal sadness","volume":"156","author":"Mayberg","year":"1999","journal-title":"Am. J. Psychiatr."},{"key":"10.1016\/j.crphar.2023.100161_bib55","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.amepre.2005.02.009","article-title":"Assessing the burden of disease in the United States using disability-adjusted life years","volume":"28","author":"McKenna","year":"2005","journal-title":"Am. J. Prev. Med."},{"key":"10.1016\/j.crphar.2023.100161_bib56","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1139\/jpn.0905","article-title":"A meta-analysis examining clinical predictors of hippocampal volume in patients with major depressive disorder","volume":"34","author":"McKinnon","year":"2009","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.crphar.2023.100161_bib57","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1001\/archpsyc.63.11.1209","article-title":"Elevated monoamine oxidase a levels in the brain: an explanation for the monoamine imbalance of major depression","volume":"63","author":"Meyer","year":"2006","journal-title":"Arch. Gen. Psychiatr."},{"key":"10.1016\/j.crphar.2023.100161_bib58","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1001\/archgenpsychiatry.2009.156","article-title":"Brain monoamine oxidase A binding in major depressive disorder: relationship to selective serotonin reuptake inhibitor treatment, recovery, and recurrence","volume":"66","author":"Meyer","year":"2009","journal-title":"Arch. Gen. Psychiatr."},{"key":"10.1016\/j.crphar.2023.100161_bib59","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1080\/13547500500216546","article-title":"F2-isoprostanes as markers of oxidative stress in vivo: an overview","volume":"10","author":"Milne","year":"2005","journal-title":"Biomarkers"},{"key":"10.1016\/j.crphar.2023.100161_bib60","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1016\/S0021-9258(19)45228-9","article-title":"The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase","volume":"247","author":"Misra","year":"1972","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.crphar.2023.100161_bib61","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1017\/S1461145704004080","article-title":"Antidepressants and brain monoaminergic systems: a dimensional approach to understanding their behavioural effects in depression and anxiety disorders","volume":"7","author":"Morilak","year":"2004","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.crphar.2023.100161_bib62","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1159\/000356540","article-title":"Immunology of major depression","volume":"21","author":"M\u00fcller","year":"2014","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.crphar.2023.100161_bib63","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/978-1-60327-029-8_10","article-title":"Assessment of antioxidant activity of eugenol in vitro and in vivo","volume":"610","author":"Nagababu","year":"2010","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.crphar.2023.100161_bib64","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1248\/bpb.26.474","article-title":"Antidepressant-like effects of apigenin and 2, 4, 5-trimethoxycinnamic acid from Perilla frutescens in the forced swimming test","volume":"26","author":"Nakazawa","year":"2003","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.crphar.2023.100161_bib65","first-page":"5","article-title":"The neurobiology of depression: inroads to treatment and new drug discovery","volume":"66","author":"Nemeroff","year":"2005","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.crphar.2023.100161_bib66","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0031-6997(25)06673-6","article-title":"Physiology and pharmacology of corticotropin-releasing factor","volume":"43","author":"Owens","year":"1991","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.crphar.2023.100161_bib67","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1097\/00004850-200403000-00006","article-title":"Antioxidant enzyme activities and oxidative stress in affective disorders","volume":"19","author":"Ozcan","year":"2004","journal-title":"Int. Clin. Psychopharmacol."},{"key":"10.1016\/j.crphar.2023.100161_bib68","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0014-2999(95)00697-4","article-title":"Pharmacological validation of the chronic mild stress model of depression","volume":"296","author":"Papp","year":"1996","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.crphar.2023.100161_bib69","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.bbr.2019.04.002","article-title":"The neural systems of emotion regulation and abnormalities in major depressive disorder","volume":"367","author":"Park","year":"2019","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.crphar.2023.100161_bib70","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera\u2014a visualization system for exploratory research and analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.crphar.2023.100161_bib71","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera--a visualization system for exploratory research and analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.crphar.2023.100161_bib72","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/s11033-019-05129-3","article-title":"The cellular and molecular basis of major depressive disorder: towards a unified model for understanding clinical depression","volume":"47","author":"Pitsillou","year":"2020","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.crphar.2023.100161_bib73","series-title":"Antidepressants: Neurochemical, Behavioural and Clinical Perspectives","article-title":"Behavioural despair","author":"Porsolt","year":"1981"},{"key":"10.1016\/j.crphar.2023.100161_bib74","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0014-2999(78)90118-8","article-title":"Behavioural despair in rats: a new model sensitive to antidepressant treatments","volume":"47","author":"Porsolt","year":"1978","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.crphar.2023.100161_bib75","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0014-2999(79)90366-2","article-title":"Immobility induced by forced swimming in rats: effects of agents which modify central catecholamine and serotonin activity","volume":"57","author":"Porsolt","year":"1979","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.crphar.2023.100161_bib76","doi-asserted-by":"crossref","first-page":"188","DOI":"10.3389\/fnins.2019.00188","article-title":"Chronic glucocorticoid exposure induces depression-like phenotype in rhesus macaque (Macaca Mulatta)","volume":"13","author":"Qin","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.crphar.2023.100161_bib77","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.it.2005.11.006","article-title":"Cytokines sing the blues: inflammation and the pathogenesis of depression","volume":"27","author":"Raison","year":"2006","journal-title":"Trends Immunol."},{"key":"10.1016\/j.crphar.2023.100161_bib78","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0306-4530(02)00017-3","article-title":"Body weight gain and diurnal differences of corticosterone changes in response to acute and chronic stress in rats","volume":"28","author":"Retana-Marquez","year":"2003","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.crphar.2023.100161_bib79","first-page":"104","article-title":"Study of antioxidant effect of apigenin, luteolin and quercetin by DNA protective method","volume":"48","author":"Romanova","year":"2001","journal-title":"Neoplasma"},{"key":"10.1016\/j.crphar.2023.100161_bib80","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.2147\/NDT.S177973","article-title":"Neuroprogression: the hidden mechanism of depression","volume":"14","author":"Ruiz","year":"2018","journal-title":"Neuropsychiatric Dis. Treat."},{"key":"10.1016\/j.crphar.2023.100161_bib81","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1007\/s00018-014-1568-5","article-title":"Stress, glucocorticoid receptors, and adult neurogenesis: a balance between excitation and inhibition?","volume":"71","author":"Saaltink","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.crphar.2023.100161_bib82","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1001\/archgenpsychiatry.2010.32","article-title":"Elevated brain monoamine oxidase A binding in the early postpartum period","volume":"67","author":"Sacher","year":"2010","journal-title":"Arch. Gen. Psychiatr."},{"key":"10.1016\/j.crphar.2023.100161_bib83","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.physbeh.2016.05.017","article-title":"Adolescent voluntary exercise attenuated hippocampal innate immunity responses and depressive-like behaviors following maternal separation stress in male rats","volume":"163","author":"Sadeghi","year":"2016","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.crphar.2023.100161_bib84","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/B978-0-12-398314-5.00001-5","article-title":"Inflammation in anxiety","volume":"88","author":"Salim","year":"2012","journal-title":"Adv. Protein Chem. Struct. Biol."},{"key":"10.1016\/j.crphar.2023.100161_bib85","doi-asserted-by":"crossref","first-page":"477","DOI":"10.2165\/11633190-000000000-00000","article-title":"Antioxidants as antidepressants","volume":"26","author":"Scapagnini","year":"2012","journal-title":"CNS Drugs"},{"key":"10.1016\/j.crphar.2023.100161_bib86","article-title":"Oxidative stress","author":"Sies","year":"2017","journal-title":"Annu. Rev."},{"key":"10.1016\/j.crphar.2023.100161_bib87","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1078\/0944711041495254","article-title":"Protective role of Apigenin on the status of lipid peroxidation and antioxidant defense against hepatocarcinogenesis in Wistar albino rats","volume":"11","author":"Singh","year":"2004","journal-title":"Phytomedicine"},{"key":"10.1016\/j.crphar.2023.100161_bib88","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1037\/a0035302","article-title":"From stress to inflammation and major depressive disorder: a social signal transduction theory of depression","volume":"140","author":"Slavich","year":"2014","journal-title":"Psychol. Bull."},{"key":"10.1016\/j.crphar.2023.100161_bib89","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.bbi.2017.09.011","article-title":"Nested positive feedback loops in the maintenance of major depression: an integration and extension of previous models","volume":"67","author":"Smith","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.crphar.2023.100161_bib90","doi-asserted-by":"crossref","first-page":"5739","DOI":"10.1073\/pnas.0710626105","article-title":"Structure of human monoamine oxidase A at 2.2-\u00c5 resolution: the control of opening the entry for substrates\/inhibitors","volume":"105","author":"Son","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.crphar.2023.100161_bib91","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1038\/mp.2011.48","article-title":"Antidepressants recruit new neurons to improve stress response regulation","volume":"16","author":"Surget","year":"2011","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.crphar.2023.100161_bib92","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S0006-8993(02)03273-0","article-title":"Neurochemical and behavioral alterations elicited by a chronic intermittent stressor regimen: implications for allostatic load","volume":"953","author":"Tannenbaum","year":"2002","journal-title":"Brain Res."},{"key":"10.1016\/j.crphar.2023.100161_bib93","series-title":"Advances in Protein Chemistry and Structural Biology","doi-asserted-by":"crossref","DOI":"10.1016\/bs.apcsb.2017.01.007","article-title":"A computational approach to identify the biophysical and structural aspects of methylenetetrahydrofolate reductase (MTHFR) mutations (A222V, E429A, and R594Q) leading to schizophrenia","author":"Tanwar","year":"2017"},{"key":"10.1016\/j.crphar.2023.100161_bib94","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1007\/s11064-007-9518-3","article-title":"Innovative approaches for the treatment of depression: targeting the HPA axis","volume":"33","author":"Thomson","year":"2008","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.crphar.2023.100161_bib95","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1177\/35.1.3025289","article-title":"Immunocytochemical localization of monoamine oxidases A and B in human peripheral tissues and brain","volume":"35","author":"Thorpe","year":"1987","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.crphar.2023.100161_bib96","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1001\/archgenpsychiatry.2010.121","article-title":"Regional brain volume in depression and anxiety disorders","volume":"67","author":"van Tol","year":"2010","journal-title":"Arch. Gen. Psychiatr."},{"key":"10.1016\/j.crphar.2023.100161_bib97","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.biopsych.2014.06.018","article-title":"Illness progression, recent stress, and morphometry of hippocampal subfields and medial prefrontal cortex in major depression","volume":"77","author":"Treadway","year":"2015","journal-title":"Biol. Psychiatr."},{"key":"10.1016\/j.crphar.2023.100161_bib98","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"Autodock vina: improving the speed and accuracy of docking","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.crphar.2023.100161_bib99","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/898393","article-title":"Markers of oxidative stress and neuroprogression in depression disorder","author":"Vav\u00e1kov\u00e1","year":"2015","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.crphar.2023.100161_bib100","first-page":"88","article-title":"Animal models of depression and schizophrenia","author":"Weiss","year":"1998","journal-title":"Textb. Psychopharmacol."},{"key":"10.1016\/j.crphar.2023.100161_bib101","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s002130050456","article-title":"Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation","volume":"134","author":"Willner","year":"1997","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.crphar.2023.100161_bib102","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/BF00187257","article-title":"Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant","volume":"93","author":"Willner","year":"1987","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.crphar.2023.100161_bib103","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1038\/mp.2016.72","article-title":"Common and distinct patterns of grey-matter volume alteration in major depression and bipolar disorder: evidence from voxel-based meta-analysis","volume":"22","author":"Wise","year":"2017","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.crphar.2023.100161_bib104","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/6435861","article-title":"Oxidant\/antioxidant imbalance in Alzheimer's disease: therapeutic and diagnostic prospects","author":"Wojsiat","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.crphar.2023.100161_bib106","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0029169","article-title":"Synergistic effects of apigenin and paclitaxel on apoptosis of cancer cells","volume":"6","author":"Xu","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.crphar.2023.100161_bib107","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.lfs.2008.01.007","article-title":"Antidepressant-like behavioral and neurochemical effects of the citrus-associated chemical apigenin","volume":"82","author":"Yi","year":"2008","journal-title":"Life Sci."},{"key":"10.1016\/j.crphar.2023.100161_bib108","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nrn1883","article-title":"The therapeutic potential of monoamine oxidase inhibitors","volume":"7","author":"Youdim","year":"2006","journal-title":"Nat. Rev. Neurosci."}],"container-title":["Current Research in Pharmacology and Drug Discovery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590257123000093?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590257123000093?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T04:46:47Z","timestamp":1762922807000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590257123000093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":107,"alternative-id":["S2590257123000093"],"URL":"https:\/\/doi.org\/10.1016\/j.crphar.2023.100161","relation":{},"ISSN":["2590-2571"],"issn-type":[{"value":"2590-2571","type":"print"}],"subject":[],"published":{"date-parts":[[2023]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Apigenin attenuates depressive-like behavior via modulating monoamine oxidase A enzyme activity in chronically stressed mice","name":"articletitle","label":"Article Title"},{"value":"Current Research in Pharmacology and Drug Discovery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.crphar.2023.100161","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100161"}}