{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T18:46:18Z","timestamp":1770144378913,"version":"3.49.0"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T00:00:00Z","timestamp":1744848000000},"content-version":"vor","delay-in-days":106,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011132","name":"Rutgers The State University of New Jersey","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011132","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Research in Pharmacology and Drug Discovery"],"published-print":{"date-parts":[[2025]]},"DOI":"10.1016\/j.crphar.2025.100220","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T19:45:43Z","timestamp":1744919143000},"page":"100220","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Tissue distribution pharmacokinetics of intrathecal U1 adaptor oligonucleotide in mice"],"prefix":"10.1016","volume":"8","author":[{"given":"Medha","family":"Satti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kavita","family":"Prasad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yash","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Demi","family":"Poulathas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence","family":"Walker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esha","family":"Paghdal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Gunderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4339-3951","authenticated-orcid":false,"given":"Lei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.crphar.2025.100220_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2023.1244016","article-title":"Determination of spinal tracer dispersion after intrathecal injection in a deformable CNS model","volume":"14","author":"Ayansiji","year":"2023","journal-title":"Front. Physiol."},{"issue":"9","key":"10.1016\/j.crphar.2025.100220_bib2","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1002\/psp4.12323","article-title":"A semi-mechanistic population pharmacokinetic model of nusinersen: an antisense oligonucleotide for the treatment of spinal muscular atrophy","volume":"7","author":"Biliouris","year":"2018","journal-title":"CPT Pharmacometrics Syst. Pharmacol."},{"issue":"6","key":"10.1016\/j.crphar.2025.100220_bib3","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1093\/nar\/gkad067","article-title":"Chemistry, structure and function of approved oligonucleotide therapeutics","volume":"51","author":"Egli","year":"2023","journal-title":"Nucleic Acids Res."},{"issue":"3","key":"10.1016\/j.crphar.2025.100220_bib4","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/BF02255467","article-title":"Spinal plasticity of acute opioid tolerance","volume":"7","author":"Fairbanks","year":"2000","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.crphar.2025.100220_bib5","series-title":"Spinraza (Nusinersen) Injection, for Intrathecal Use","year":"2016"},{"key":"10.1016\/j.crphar.2025.100220_bib6","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.addr.2020.02.006","article-title":"Intrathecal drug delivery in the era of nanomedicine","volume":"165\u2013166","author":"Fowler","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.crphar.2025.100220_bib7","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.addr.2015.01.008","article-title":"Pharmacokinetics, biodistribution and cell uptake of antisense oligonucleotides","volume":"87","author":"Geary","year":"2015","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"3","key":"10.1016\/j.crphar.2025.100220_bib8","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/nbt.1525","article-title":"Gene silencing by synthetic U1 adaptors","volume":"27","author":"Goraczniak","year":"2009","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.crphar.2025.100220_bib9","doi-asserted-by":"crossref","first-page":"e92","DOI":"10.1038\/mtna.2013.24","article-title":"U1 adaptor oligonucleotides targeting BCL2 and GRM1 suppress growth of human melanoma xenografts in vivo","volume":"2","author":"Goraczniak","year":"2013","journal-title":"Mol. Ther. Nucleic Acids"},{"issue":"1","key":"10.1016\/j.crphar.2025.100220_bib10","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/bdd.2338","article-title":"Biodistribution and delivery of oligonucleotide therapeutics to the central nervous system: advances, challenges, and future perspectives","volume":"44","author":"Goto","year":"2023","journal-title":"Biopharm Drug Dispos."},{"issue":"2\u20133","key":"10.1016\/j.crphar.2025.100220_bib11","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0014-2999(80)90515-4","article-title":"Intrathecal morphine in mice: a new technique","volume":"67","author":"Hylden","year":"1980","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.crphar.2025.100220_bib12","doi-asserted-by":"crossref","first-page":"192","DOI":"10.4161\/rna.7.2.11207","article-title":"Spliceosomal snRNA modifications and their function","volume":"7","author":"Karijolich","year":"2010","journal-title":"RNA Biol."},{"issue":"2","key":"10.1016\/j.crphar.2025.100220_bib13","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1097\/00000542-200402000-00021","article-title":"Pharmacokinetics of intrathecal oligodeoxynucleotides","volume":"100","author":"Krupp","year":"2004","journal-title":"Anesthesiology"},{"key":"10.1016\/j.crphar.2025.100220_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2023.1130925","article-title":"A mechanistic pharmacokinetic model for intrathecal administration of antisense oligonucleotides","volume":"14","author":"Linninger","year":"2023","journal-title":"Front. Physiol."},{"issue":"20","key":"10.1016\/j.crphar.2025.100220_bib15","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.129240","article-title":"Brain pharmacology of intrathecal antisense oligonucleotides revealed through multimodal imaging","volume":"4","author":"Mazur","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.crphar.2025.100220_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2023.1250276","article-title":"Nucleic acid-based therapeutics for the treatment of central nervous system disorders","volume":"14","author":"McCartan","year":"2023","journal-title":"Front. Genet."},{"issue":"5","key":"10.1016\/j.crphar.2025.100220_bib17","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s10928-021-09761-0","article-title":"A physiologically-based pharmacokinetic model to describe antisense oligonucleotide distribution after intrathecal administration","volume":"48","author":"Monine","year":"2021","journal-title":"J. Pharmacokinet. Pharmacodyn."},{"key":"10.1016\/j.crphar.2025.100220_bib18","series-title":"Guide for the Care and Use of Laboratory Animals","year":"1996"},{"issue":"72","key":"10.1016\/j.crphar.2025.100220_bib19","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3001777","article-title":"Antisense oligonucleotides delivered to the mouse CNS ameliorate symptoms of severe spinal muscular atrophy","volume":"3","author":"Passini","year":"2011","journal-title":"Sci. Transl. Med."},{"issue":"5","key":"10.1016\/j.crphar.2025.100220_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11051413","article-title":"Epidural and intrathecal drug delivery in rats and mice for experimental research: fundamental concepts, techniques, precaution, and application","volume":"11","author":"Rahman","year":"2023","journal-title":"Biomedicines"},{"issue":"1","key":"10.1016\/j.crphar.2025.100220_bib21","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1124\/jpet.113.212407","article-title":"Pharmacology of a central nervous system delivered 2'-O-methoxyethyl-modified survival of motor neuron splicing oligonucleotide in mice and nonhuman primates","volume":"350","author":"Rigo","year":"2014","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.crphar.2025.100220_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2023.1248271","article-title":"Pre-clinical delivery of gene therapy products to the cerebrospinal fluid: challenges and considerations for clinical translation","volume":"16","author":"Salegio","year":"2023","journal-title":"Front. Mol. Neurosci."},{"issue":"4","key":"10.1016\/j.crphar.2025.100220_bib23","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1109\/TBME.2019.2930451","article-title":"In vivo intrathecal tracer dispersion in cynomolgus monkey validates wide biodistribution along neuraxis","volume":"67","author":"Tangen","year":"2020","journal-title":"IEEE Trans. Biomed. Eng."},{"issue":"8","key":"10.1016\/j.crphar.2025.100220_bib24","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1158\/1535-7163.MCT-16-0867","article-title":"U1 adaptors suppress the KRAS-MYC oncogenic Axis in human pancreatic cancer xenografts","volume":"16","author":"Tsang","year":"2017","journal-title":"Mol. Cancer Therapeut."}],"container-title":["Current Research in Pharmacology and Drug Discovery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590257125000082?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590257125000082?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T21:03:09Z","timestamp":1762635789000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590257125000082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":24,"alternative-id":["S2590257125000082"],"URL":"https:\/\/doi.org\/10.1016\/j.crphar.2025.100220","relation":{},"ISSN":["2590-2571"],"issn-type":[{"value":"2590-2571","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tissue distribution pharmacokinetics of intrathecal U1 adaptor oligonucleotide in mice","name":"articletitle","label":"Article Title"},{"value":"Current Research in Pharmacology and Drug Discovery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.crphar.2025.100220","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100220"}}