{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:22:17Z","timestamp":1791638537204,"version":"4.3.4"},"reference-count":83,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T00:00:00Z","timestamp":1710460800000},"content-version":"vor","delay-in-days":74,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM139297"],"award-info":[{"award-number":["GM139297"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["KM822"],"award-info":[{"award-number":["KM822"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["MH121453"],"award-info":[{"award-number":["MH121453"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01s DK116780"],"award-info":[{"award-number":["R01s DK116780"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Research in Physiology"],"published-print":{"date-parts":[[2024]]},"DOI":"10.1016\/j.crphys.2024.100125","type":"journal-article","created":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T17:02:50Z","timestamp":1710522170000},"page":"100125","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Allosteric modulation of serotonin and dopamine transporters: New insights from computations and experiments"],"prefix":"10.1016","volume":"7","author":[{"given":"Hoang","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Hongying","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Young","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaili","family":"Aggarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3487-8239","authenticated-orcid":false,"given":"Ole Valente","family":"Mortensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivet","family":"Bahar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.crphys.2024.100125_bib1","doi-asserted-by":"crossref","first-page":"634","DOI":"10.3390\/biomedicines9060634","article-title":"Functional characterization of the dopaminergic psychostimulant sydnocarb as an allosteric modulator of the human dopamine transporter","volume":"9","author":"Aggarwal","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.crphys.2024.100125_bib2","doi-asserted-by":"crossref","first-page":"3718","DOI":"10.1021\/acschemneuro.9b00262","article-title":"Identification of a novel allosteric modulator of the human dopamine transporter","volume":"10","author":"Aggarwal","year":"2019","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.crphys.2024.100125_bib3","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/978-3-031-21054-9_4","article-title":"Discovery and development of monoamine transporter ligands","volume":"30","author":"Aggarwal","year":"2023","journal-title":"Adv Neurobiol"},{"key":"10.1016\/j.crphys.2024.100125_bib4","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.68039","article-title":"Psychomotor impairments and therapeutic implications revealed by a mutation associated with infantile Parkinsonism-Dystonia","volume":"10","author":"Aguilar","year":"2021","journal-title":"Elife"},{"key":"10.1016\/j.crphys.2024.100125_bib5","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S1359-0278(97)00024-2","article-title":"Direct evaluation of thermal fluctuations in proteins using a single-parameter harmonic potential","volume":"2","author":"Bahar","year":"1997","journal-title":"Fold Des"},{"key":"10.1016\/j.crphys.2024.100125_bib6","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.bpj.2015.06.004","article-title":"Structure-encoded global motions and their role in mediating protein-substrate interactions","volume":"109","author":"Bahar","year":"2015","journal-title":"Biophys. J."},{"key":"10.1016\/j.crphys.2024.100125_bib7","doi-asserted-by":"crossref","first-page":"14349","DOI":"10.1073\/pnas.0904214106","article-title":"The intrinsic dynamics of enzymes plays a dominant role in determining the structural changes induced upon inhibitor binding","volume":"106","author":"Bakan","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.crphys.2024.100125_bib8","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.bpj.2013.06.032","article-title":"Coupled global and local changes direct substrate translocation by neurotransmitter-sodium symporter ortholog LeuT","volume":"105","author":"Cheng","year":"2013","journal-title":"Biophys. J."},{"key":"10.1016\/j.crphys.2024.100125_bib9","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1016\/j.str.2015.09.001","article-title":"Molecular mechanism of dopamine transport by human dopamine transporter","volume":"23","author":"Cheng","year":"2015","journal-title":"Structure"},{"key":"10.1016\/j.crphys.2024.100125_bib10","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/s41594-019-0253-7","article-title":"Monoamine transporters: structure, intrinsic dynamics and allosteric regulation","volume":"26","author":"Cheng","year":"2019","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.crphys.2024.100125_bib11","doi-asserted-by":"crossref","first-page":"134","DOI":"10.3389\/fneur.2015.00134","article-title":"Insights into the modulation of dopamine transporter function by amphetamine, orphenadrine, and cocaine Binding","volume":"6","author":"Cheng","year":"2015","journal-title":"Front. Neurol."},{"key":"10.1016\/j.crphys.2024.100125_bib13","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/s41594-018-0026-8","article-title":"Structural basis for recognition of diverse antidepressants by the human serotonin transporter","volume":"25","author":"Coleman","year":"2018","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.crphys.2024.100125_bib14","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1038\/nature17629","article-title":"X-ray structures and mechanism of the human serotonin transporter","volume":"532","author":"Coleman","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.crphys.2024.100125_bib15","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.56427","article-title":"Chemical and structural investigation of the paroxetine-human serotonin transporter complex","volume":"9","author":"Coleman","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.crphys.2024.100125_bib16","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41586-019-1135-1","article-title":"Serotonin transporter-ibogaine complexes illuminate mechanisms of inhibition and transport","volume":"569","author":"Coleman","year":"2019","journal-title":"Nature"},{"issue":"Suppl. 2","key":"10.1016\/j.crphys.2024.100125_bib17","first-page":"S53","article-title":"Pharmacology of drugs used as stimulants","volume":"61","author":"Docherty","year":"2021","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.crphys.2024.100125_bib18","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/j.1527-3458.2006.00178.x","article-title":"Review of the pharmacology and clinical profile of bupropion, an antidepressant and tobacco use cessation agent","volume":"12","author":"Dwoskin","year":"2006","journal-title":"CNS Drug Rev."},{"key":"10.1016\/j.crphys.2024.100125_bib19","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.19314","article-title":"Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR","volume":"6","author":"Erlendsson","year":"2017","journal-title":"Elife"},{"key":"10.1016\/j.crphys.2024.100125_bib20","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.1007\/s12035-015-9152-z","article-title":"Revisiting the serotonin hypothesis: implications for major depressive disorders","volume":"53","author":"Fakhoury","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.crphys.2024.100125_bib21","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.neubiorev.2018.02.001","article-title":"The pharmacology of amphetamine and methylphenidate: relevance to the neurobiology of attention-deficit\/hyperactivity disorder and other psychiatric comorbidities","volume":"87","author":"Faraone","year":"2018","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.crphys.2024.100125_bib22","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.physbeh.2011.11.004","article-title":"Allostasis and addiction: role of the dopamine and corticotropin-releasing factor systems","volume":"106","author":"George","year":"2012","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.crphys.2024.100125_bib23","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/B978-0-12-420118-7.00015-9","article-title":"Bath salts, mephedrone, and methylenedioxypyrovalerone as emerging illicit drugs that will need targeted therapeutic intervention","volume":"69","author":"Glennon","year":"2014","journal-title":"Adv. Pharmacol."},{"key":"10.1016\/j.crphys.2024.100125_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.101613","article-title":"Occlusion of the human serotonin transporter is mediated by serotonin-induced conformational changes in the bundle domain","volume":"298","author":"Gradisch","year":"2022","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.crphys.2024.100125_bib25","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3389\/fphar.2015.00235","article-title":"Monoamine transporters: insights from molecular dynamics simulations","volume":"6","author":"Grouleff","year":"2015","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.crphys.2024.100125_bib26","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.sbi.2015.07.007","article-title":"Adaptability of protein structures to enable functional interactions and evolutionary implications","volume":"35","author":"Haliloglu","year":"2015","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.crphys.2024.100125_bib27","doi-asserted-by":"crossref","first-page":"3090","DOI":"10.1103\/PhysRevLett.79.3090","article-title":"Gaussian dynamics of folded proteins","volume":"79","author":"Haliloglu","year":"1997","journal-title":"Phys. Rev. Lett."},{"key":"10.1016\/j.crphys.2024.100125_bib28","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.pnpbp.2013.04.009","article-title":"Monoamine neurocircuitry in depression and strategies for new treatments","volume":"45","author":"Hamon","year":"2013","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.crphys.2024.100125_bib29","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.neuropharm.2009.08.020","article-title":"The neuropharmacology of ADHD drugs in vivo: insights on efficacy and safety","volume":"57","author":"Heal","year":"2009","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.crphys.2024.100125_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0217377","article-title":"A structural model of the human serotonin transporter in an outward-occluded state","volume":"14","author":"Hellsberg","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.crphys.2024.100125_bib31","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/B978-0-12-420118-7.00004-4","article-title":"Monoamine transporter inhibitors and substrates as treatments for stimulant abuse","volume":"69","author":"Howell","year":"2014","journal-title":"Adv. Pharmacol."},{"key":"10.1016\/j.crphys.2024.100125_bib32","doi-asserted-by":"crossref","first-page":"344","DOI":"10.3390\/ph15030344","article-title":"Two lignan glycosides from albizia julibrissin durazz. Noncompetitively inhibit serotonin transporter","volume":"15","author":"Huang","year":"2022","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.crphys.2024.100125_bib33","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.3390\/molecules27092977","article-title":"Allosteric binding of MDMA to the human serotonin transporter (hSERT) via ensemble binding space analysis with DeltaG calculations, induced fit docking and Monte Carlo simulations","volume":"27","author":"Islas","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.crphys.2024.100125_bib34","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2022110735","article-title":"Structural insights into GABA transport inhibition using an engineered neurotransmitter transporter","volume":"41","author":"Joseph","year":"2022","journal-title":"EMBO J."},{"key":"10.1016\/j.crphys.2024.100125_bib35","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0063635","article-title":"Ligand induced conformational changes of the human serotonin transporter revealed by molecular dynamics simulations","volume":"8","author":"Kolds\u00f8","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.crphys.2024.100125_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1002246","article-title":"Unbiased simulations reveal the inward-facing conformation of the human serotonin transporter and Na+ ion release","volume":"7","author":"Kolds\u00f8","year":"2011","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.crphys.2024.100125_bib37","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/S2215-0366(16)00104-8","article-title":"Neurobiology of addiction: a neurocircuitry analysis","volume":"3","author":"Koob","year":"2016","journal-title":"Lancet Psychiatr."},{"key":"10.1016\/j.crphys.2024.100125_bib38","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.neuropharm.2013.04.026","article-title":"Identification of an allosteric modulator of the serotonin transporter with novel mechanism of action","volume":"72","author":"Kortagere","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.crphys.2024.100125_bib39","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/nature10737","article-title":"X-ray structures of LeuT in substrate-free outward-open and apo inward-open states","volume":"481","author":"Krishnamurthy","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.crphys.2024.100125_bib40","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1124\/pr.108.000869","article-title":"SLC6 neurotransmitter transporters: structure, function, and regulation","volume":"63","author":"Kristensen","year":"2011","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.crphys.2024.100125_bib41","doi-asserted-by":"crossref","first-page":"31069","DOI":"10.1074\/jbc.M115.688275","article-title":"Dual action of Zn2+ on the transport cycle of the dopamine transporter","volume":"290","author":"Li","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.crphys.2024.100125_bib42","article-title":"Molecular docking and biochemical validation of (-)-syringaresinol-4-O-beta-D-apiofuranosyl-(1-->2)-beta-D-glucopyranoside binding to an allosteric site in monoamine transporters","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.crphys.2024.100125_bib43","doi-asserted-by":"crossref","first-page":"36928","DOI":"10.1074\/jbc.274.52.36928","article-title":"Defining proximity relationships in the tertiary structure of the dopamine transporter. Identification of a conserved glutamic acid as a third coordinate in the endogenous Zn(2+)-binding site","volume":"274","author":"Loland","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.crphys.2024.100125_bib44","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1208\/s12248-012-9391-0","article-title":"Monoamine transporter structure, function, dynamics, and drug discovery: a computational perspective","volume":"14","author":"Manepalli","year":"2012","journal-title":"AAPS J."},{"key":"10.1016\/j.crphys.2024.100125_bib45","doi-asserted-by":"crossref","first-page":"49671","DOI":"10.1074\/jbc.M407660200","article-title":"Zinc potentiates an uncoupled anion conductance associated with the dopamine transporter","volume":"279","author":"Meinild","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.crphys.2024.100125_bib46","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1111\/j.1471-4159.2006.04060.x","article-title":"Gain of function mutants reveal sites important for the interaction of the atypical inhibitors benztropine and bupropion with monoamine transporters","volume":"98","author":"Mortensen","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.crphys.2024.100125_bib47","doi-asserted-by":"crossref","first-page":"223","DOI":"10.3389\/fphar.2015.00223","article-title":"Designing modulators of monoamine transporters using virtual screening techniques","volume":"6","author":"Mortensen","year":"2015","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.crphys.2024.100125_bib48","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.tips.2020.04.006","article-title":"Allosteric modulation of neurotransmitter transporters as a therapeutic strategy","volume":"41","author":"Niello","year":"2020","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.crphys.2024.100125_bib49","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.sbi.2010.05.007","article-title":"Substrate and drug binding sites in LeuT","volume":"20","author":"Nyola","year":"2010","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.crphys.2024.100125_bib50","doi-asserted-by":"crossref","first-page":"17837","DOI":"10.1074\/jbc.M610813200","article-title":"chi-Conotoxin and tricyclic antidepressant interactions at the norepinephrine transporter define a new transporter model","volume":"282","author":"Paczkowski","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.crphys.2024.100125_bib51","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1124\/jpet.108.139675","article-title":"Studies of the biogenic amine transporters. 12. Identification of novel partial inhibitors of amphetamine-induced dopamine release","volume":"326","author":"Pariser","year":"2008","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.crphys.2024.100125_bib52","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nature12533","article-title":"X-ray structure of dopamine transporter elucidates antidepressant mechanism","volume":"503","author":"Penmatsa","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.crphys.2024.100125_bib53","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/nsmb.3029","article-title":"X-ray structures of Drosophila dopamine transporter in complex with nisoxetine and reboxetine","volume":"22","author":"Penmatsa","year":"2015","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.crphys.2024.100125_bib54","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1038\/s41467-021-22385-9","article-title":"Structural basis of norepinephrine recognition and transport inhibition in neurotransmitter transporters","volume":"12","author":"Pidathala","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.crphys.2024.100125_bib55","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1038\/s41467-020-15292-y","article-title":"The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter","volume":"11","author":"Plenge","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.crphys.2024.100125_bib56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0014-2999(85)90314-0","article-title":"Antidepressive drugs can change the affinity of [3H]imipramine and [3H]paroxetine binding to platelet and neuronal membranes","volume":"119","author":"Plenge","year":"1985","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.crphys.2024.100125_bib57","doi-asserted-by":"crossref","first-page":"39316","DOI":"10.1074\/jbc.M112.371765","article-title":"Steric hindrance mutagenesis in the conserved extracellular vestibule impedes allosteric binding of antidepressants to the serotonin transporter","volume":"287","author":"Plenge","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.crphys.2024.100125_bib58","doi-asserted-by":"crossref","first-page":"5063","DOI":"10.1038\/s41467-021-25363-3","article-title":"The antidepressant drug vilazodone is an allosteric inhibitor of the serotonin transporter","volume":"12","author":"Plenge","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.crphys.2024.100125_bib59","doi-asserted-by":"crossref","first-page":"E7924","DOI":"10.1073\/pnas.1717444115","article-title":"The LeuT-fold neurotransmitter:sodium symporter MhsT has two substrate sites","volume":"115","author":"Quick","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.crphys.2024.100125_bib60","series-title":"Theory and Applications to Biological and Chemical Systems Math & Comp Biology Series","first-page":"41","article-title":"The Gaussian network model: theory and applications in normal mode analysis","author":"Rader","year":"2005"},{"key":"10.1016\/j.crphys.2024.100125_bib61","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1124\/molpharm.121.000400","article-title":"Allosteric modulator KM822 attenuates behavioral actions of amphetamine in Caenorhabditis elegans through interactions with the dopamine transporter DAT-1","volume":"101","author":"Refai","year":"2022","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.crphys.2024.100125_bib62","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1124\/jpet.108.149088","article-title":"Studies of the biogenic amine transporters. 13. Identification of \"agonist\" and \"antagonist\" allosteric modulators of amphetamine-induced dopamine release","volume":"329","author":"Rothman","year":"2009","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.crphys.2024.100125_bib63","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00424-013-1410-1","article-title":"The SLC6 transporters: perspectives on structure, functions, regulation, and models for transporter dysfunction","volume":"466","author":"Rudnick","year":"2014","journal-title":"Pfl\u00fcgers Archiv-European Journal of Physiology"},{"key":"10.1016\/j.crphys.2024.100125_bib64","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2304089120","article-title":"Dynamic extracellular vestibule of human SERT: unveiling druggable potential with high-affinity allosteric inhibitors","volume":"120","author":"Salomon","year":"2023","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.crphys.2024.100125_bib65","doi-asserted-by":"crossref","first-page":"21505","DOI":"10.1074\/jbc.M112265200","article-title":"The role of zinc ions in reverse transport mediated by monoamine transporters","volume":"277","author":"Scholze","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.crphys.2024.100125_bib66","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.molcel.2008.05.008","article-title":"The mechanism of a neurotransmitter:sodium symporter\u2013inward release of Na+ and substrate is triggered by substrate in a second binding site","volume":"30","author":"Shi","year":"2008","journal-title":"Mol Cell"},{"key":"10.1016\/j.crphys.2024.100125_bib67","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1016\/j.cell.2023.04.010","article-title":"Structure-based discovery of conformationally selective inhibitors of the serotonin transporter","volume":"186","author":"Singh","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.crphys.2024.100125_bib68","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/nature06038","article-title":"Antidepressant binding site in a bacterial homologue of neurotransmitter transporters","volume":"448","author":"Singh","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.crphys.2024.100125_bib69","doi-asserted-by":"crossref","first-page":"8363","DOI":"10.1074\/jbc.M109.045401","article-title":"Binding and orientation of tricyclic antidepressants within the central substrate site of the human serotonin transporter","volume":"285","author":"Sinning","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.crphys.2024.100125_bib70","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0074-7742(09)85003-4","article-title":"Monoamine transporter as a target molecule for psychostimulants","volume":"85","author":"Sora","year":"2009","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.crphys.2024.100125_bib71","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/s41380-021-01285-w","article-title":"The relationship between dose and serotonin transporter occupancy of antidepressants-a systematic review","volume":"27","author":"Sorensen","year":"2022","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.crphys.2024.100125_bib72","doi-asserted-by":"crossref","first-page":"100430","DOI":"10.1016\/j.jbc.2021.100430","article-title":"Direct coupling of oligomerization and oligomerization-driven endocytosis of the dopamine transporter to its conformational mechanics and activity","volume":"296","author":"Sorkina","year":"2021","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.crphys.2024.100125_bib73","doi-asserted-by":"crossref","first-page":"3694","DOI":"10.1038\/s41598-017-03771-0","article-title":"Allosteric modulatory effects of SRI-20041 and SRI-30827 on cocaine and HIV-1 Tat protein binding to human dopamine transporter","volume":"7","author":"Sun","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.crphys.2024.100125_bib74","doi-asserted-by":"crossref","first-page":"L1","DOI":"10.1016\/j.bpj.2012.05.002","article-title":"LeuT conformational sampling utilizing accelerated molecular dynamics and principal component analysis","volume":"103","author":"Thomas","year":"2012","journal-title":"Biophys. J."},{"key":"10.1016\/j.crphys.2024.100125_bib75","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/nrn.2017.130","article-title":"The dopamine motive system: implications for drug and food addiction","volume":"18","author":"Volkow","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.crphys.2024.100125_bib76","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/nsmb.2215","article-title":"Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context","volume":"19","author":"Wang","year":"2012","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.crphys.2024.100125_bib77","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/embor.2012.110","article-title":"Substrate binds in the S1 site of the F253A mutant of LeuT, a neurotransmitter sodium symporter homologue","volume":"13","author":"Wang","year":"2012","journal-title":"EMBO Rep."},{"key":"10.1016\/j.crphys.2024.100125_bib78","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0014-2999(82)90333-8","article-title":"Serotonin modulates the dissociation of [3H]imipramine from human platelet recognition sites","volume":"86","author":"Wennogle","year":"1982","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.crphys.2024.100125_bib79","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1021\/acschemneuro.1c00694","article-title":"Molecular mechanism for the allosteric inhibition of the human serotonin transporter by antidepressant escitalopram","volume":"13","author":"Xue","year":"2022","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.crphys.2024.100125_bib80","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/nature03978","article-title":"Crystal structure of a bacterial homologue of Na+\/Cl\u2013dependent neurotransmitter transporters","volume":"437","author":"Yamashita","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.crphys.2024.100125_bib81","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abl3857","article-title":"Illumination of serotonin transporter mechanism and role of the allosteric site","volume":"7","author":"Yang","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.crphys.2024.100125_bib82","doi-asserted-by":"crossref","first-page":"3657","DOI":"10.1093\/bioinformatics\/btab187","article-title":"ProDy 2.0: increased scale and scope after 10 Years of protein dynamics modelling with Python","volume":"37","author":"Zhang","year":"2021","journal-title":"Bioinformatics"},{"key":"10.1016\/j.crphys.2024.100125_bib83","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1126\/science.1147614","article-title":"LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake","volume":"317","author":"Zhou","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.crphys.2024.100125_bib84","doi-asserted-by":"crossref","first-page":"109239","DOI":"10.1016\/j.neuropharm.2022.109239","article-title":"SRI-32743, a novel allosteric modulator, attenuates HIV-1 Tat protein-induced inhibition of the dopamine transporter and alleviates the potentiation of cocaine reward in HIV-1 Tat transgenic mice","volume":"220","author":"Zhu","year":"2022","journal-title":"Neuropharmacology"}],"container-title":["Current Research in Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2665944124000099?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2665944124000099?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T09:34:13Z","timestamp":1733132053000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2665944124000099"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":83,"alternative-id":["S2665944124000099"],"URL":"https:\/\/doi.org\/10.1016\/j.crphys.2024.100125","relation":{},"ISSN":["2665-9441"],"issn-type":[{"value":"2665-9441","type":"print"}],"subject":[],"published":{"date-parts":[[2024]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Allosteric modulation of serotonin and dopamine transporters: New insights from computations and experiments","name":"articletitle","label":"Article Title"},{"value":"Current Research in Physiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.crphys.2024.100125","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100125"}}