{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T18:06:27Z","timestamp":1789668387408,"version":"4.0.1"},"reference-count":163,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T00:00:00Z","timestamp":1715040000000},"content-version":"vor","delay-in-days":127,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association Inc","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Research in Physiology"],"published-print":{"date-parts":[[2024]]},"DOI":"10.1016\/j.crphys.2024.100126","type":"journal-article","created":{"date-parts":[[2024,5,7]],"date-time":"2024-05-07T15:57:35Z","timestamp":1715097455000},"page":"100126","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Urotensin II system in chronic kidney disease"],"prefix":"10.1016","volume":"7","author":[{"given":"Olugbenga S.","family":"Michael","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praghalathan","family":"Kanthakumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitesh","family":"Soni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raji","family":"Rajesh Lenin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumar","family":"Abhiram Jha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajashekhar","family":"Gangaraju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7033-1871","authenticated-orcid":false,"given":"Adebowale","family":"Adebiyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.crphys.2024.100126_bib1","doi-asserted-by":"crossref","first-page":"F1239","DOI":"10.1152\/ajprenal.90374.2008","article-title":"Enhanced renal sensitivity of the spontaneously hypertensive rat to urotensin II","volume":"295","author":"Abdel-Razik","year":"2008","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"4","key":"10.1016\/j.crphys.2024.100126_bib2","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1002\/jcp.24470","article-title":"RGS2 regulates urotensin II-induced intracellular Ca2+ elevation and contraction in glomerular mesangial cells","volume":"229","author":"Adebiyi","year":"2014","journal-title":"J. Cell. Physiol."},{"issue":"6750","key":"10.1016\/j.crphys.2024.100126_bib3","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/45809","article-title":"Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14","volume":"401","author":"Ames","year":"1999","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.crphys.2024.100126_bib4","first-page":"33","article-title":"Glomerular filtration barrier assembly: an insight","volume":"1","author":"Arif","year":"2013","journal-title":"Postdoc J."},{"issue":"4","key":"10.1016\/j.crphys.2024.100126_bib5","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/sj.ki.5001621","article-title":"Renal and vascular actions of urotensin II","volume":"70","author":"Ashton","year":"2006","journal-title":"Kidney Int."},{"issue":"Suppl. 1","key":"10.1016\/j.crphys.2024.100126_bib6","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.17305\/bjbms.2010.2643","article-title":"Kidney is in trouble with mediators","volume":"10","author":"Balat","year":"2010","journal-title":"Bosn. J. Basic Med. Sci."},{"key":"10.1016\/j.crphys.2024.100126_bib7","article-title":"Urotensin-II: more than a mediator for kidney","volume":"2012","author":"Balat","year":"2012","journal-title":"Internet J. Nephrol."},{"issue":"5","key":"10.1016\/j.crphys.2024.100126_bib8","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1080\/08860220701392108","article-title":"Urotensin-II immunoreactivity in children with chronic glomerulonephritis","volume":"29","author":"Balat","year":"2007","journal-title":"Ren. Fail."},{"issue":"1","key":"10.1016\/j.crphys.2024.100126_bib9","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s00467-004-1716-5","article-title":"Urotensin-II levels in children with minimal change nephrotic syndrome","volume":"20","author":"Balat","year":"2005","journal-title":"Pediatr. Nephrol."},{"issue":"1","key":"10.1016\/j.crphys.2024.100126_bib10","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ejogrb.2004.07.029","article-title":"Increased plasma levels of Urotensin-II in preeclampsia-eclampsia: a new mediator in pathogenesis?","volume":"120","author":"Balat","year":"2005","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"issue":"3","key":"10.1016\/j.crphys.2024.100126_bib11","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1007\/s00210-004-0873-1","article-title":"Urotensin-II: a novel systemic hypertensive factor in the cat","volume":"369","author":"Behm","year":"2004","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"issue":"3","key":"10.1016\/j.crphys.2024.100126_bib12","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/bjp.2008.266","article-title":"Palosuran inhibits binding to primate UT receptors in cell membranes but demonstrates differential activity in intact cells and vascular tissues","volume":"155","author":"Behm","year":"2008","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.crphys.2024.100126_bib13","first-page":"Suppl:xi","article-title":"A reference preparation for the study of active substances in the caudal neurosecretory system of teleosts","volume":"45","author":"Bern","year":"1969","journal-title":"J. Endocrinol."},{"issue":"2","key":"10.1016\/j.crphys.2024.100126_bib14","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1161\/HYPERTENSIONAHA.109.133777","article-title":"Protective importance of the myogenic response in the renal circulation","volume":"54","author":"Bidani","year":"2009","journal-title":"Hypertension"},{"issue":"3","key":"10.1016\/j.crphys.2024.100126_bib15","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/j.1756-185X.2011.01597.x","article-title":"Increased urotensin-II activity in patients with Raynaud's phenomenon and systemic lupus erythematosus","volume":"14","author":"Buyukhatipoglu","year":"2011","journal-title":"Int. J. Rheum. Dis."},{"issue":"8","key":"10.1016\/j.crphys.2024.100126_bib16","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/s41440-020-0460-y","article-title":"Microinjection of urotensin II into the rostral ventrolateral medulla increases sympathetic vasomotor tone via the GPR14\/ERK pathway in rats","volume":"43","author":"Cao","year":"2020","journal-title":"Hypertens. Res."},{"issue":"3","key":"10.1016\/j.crphys.2024.100126_bib17","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1097\/00041552-200305000-00008","article-title":"Diabetes and nephropathy","volume":"12","author":"Caramori","year":"2003","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"issue":"11","key":"10.1016\/j.crphys.2024.100126_bib18","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1016\/j.peptides.2005.03.043","article-title":"Urotensin II: evidence for cardiac, hepatic and renal production","volume":"26","author":"Charles","year":"2005","journal-title":"Peptides"},{"issue":"4","key":"10.1016\/j.crphys.2024.100126_bib19","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1111\/j.1365-2125.2009.03475.x","article-title":"The effects of urotensin II and urantide on forearm blood flow and systemic haemodynamics in humans","volume":"68","author":"Cheriyan","year":"2009","journal-title":"Br. J. Clin. Pharmacol."},{"issue":"7","key":"10.1016\/j.crphys.2024.100126_bib20","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1097\/01.hjh.0000125452.28861.f1","article-title":"Plasma concentration of urotensin II is raised in hypertension","volume":"22","author":"Cheung","year":"2004","journal-title":"J. Hypertens."},{"issue":"4","key":"10.1016\/j.crphys.2024.100126_bib21","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1097\/SHK.0000000000001448","article-title":"Urantide improves cardiac function, modulates systemic cytokine response, and increases survival in A murine model of endotoxic shock","volume":"54","author":"Clavier","year":"2020","journal-title":"Shock"},{"issue":"3","key":"10.1016\/j.crphys.2024.100126_bib22","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1124\/jpet.105.094821","article-title":"The urotensin-II receptor antagonist palosuran improves pancreatic and renal function in diabetic rats","volume":"316","author":"Clozel","year":"2006","journal-title":"J. Pharmacol. Exp. Therapeut."},{"issue":"1\u20132","key":"10.1016\/j.crphys.2024.100126_bib23","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0014-5793(90)81500-N","article-title":"Post-translational processing of prepro-urotensin II","volume":"266","author":"Conlon","year":"1990","journal-title":"FEBS Lett."},{"issue":"26","key":"10.1016\/j.crphys.2024.100126_bib24","doi-asserted-by":"crossref","first-page":"15803","DOI":"10.1073\/pnas.95.26.15803","article-title":"Cloning of the cDNA encoding the urotensin II precursor in frog and human reveals intense expression of the urotensin II gene in motoneurons of the spinal cord","volume":"95","author":"Coulouarn","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"issue":"12","key":"10.1016\/j.crphys.2024.100126_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0083137","article-title":"Urotensin-II system in genetic control of blood pressure and renal function","volume":"8","author":"Debiec","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.crphys.2024.100126_bib26","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.tips.2003.12.005","article-title":"From 'gills to pills': urotensin-II as a regulator of mammalian cardiorenal function","volume":"25","author":"Douglas","year":"2004","journal-title":"Trends Pharmacol. Sci."},{"issue":"2","key":"10.1016\/j.crphys.2024.100126_bib27","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1471-4159.2008.05624.x","article-title":"Characterization of urotensin II, distribution of urotensin II, urotensin II-related peptide and UT receptor mRNAs in mouse: evidence of urotensin II at the neuromuscular junction","volume":"107","author":"Dubessy","year":"2008","journal-title":"J. Neurochem."},{"issue":"1","key":"10.1016\/j.crphys.2024.100126_bib28","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/sj.bjp.0704671","article-title":"Molecular and pharmacological characterization of genes encoding urotensin-II peptides and their cognate G-protein-coupled receptors from the mouse and monkey","volume":"136","author":"Elshourbagy","year":"2002","journal-title":"Br. J. Pharmacol."},{"issue":"7","key":"10.1016\/j.crphys.2024.100126_bib29","doi-asserted-by":"crossref","first-page":"506","DOI":"10.3109\/10641963.2012.758276","article-title":"Serum urotensin II levels in patients with non-dipper hypertension","volume":"35","author":"Erbay","year":"2013","journal-title":"Clin. Exp. Hypertens."},{"issue":"3","key":"10.1016\/j.crphys.2024.100126_bib30","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1113\/EP087366","article-title":"Urotensin II in the development and progression of chronic kidney disease following \u215a nephrectomy in the rat","volume":"104","author":"Eyre","year":"2019","journal-title":"Exp. Physiol."},{"issue":"8","key":"10.1016\/j.crphys.2024.100126_bib31","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1007\/s00125-008-1051-7","article-title":"The kidney in diabetes: dynamic pathways of injury and repair. The Camillo Golgi Lecture 2007","volume":"51","author":"Fioretto","year":"2008","journal-title":"Diabetologia"},{"issue":"5 Suppl. 3","key":"10.1016\/j.crphys.2024.100126_bib32","doi-asserted-by":"crossref","first-page":"S112","DOI":"10.1053\/ajkd.1998.v32.pm9820470","article-title":"Clinical epidemiology of cardiovascular disease in chronic renal disease","volume":"32","author":"Foley","year":"1998","journal-title":"Am. J. Kidney Dis."},{"issue":"10159","key":"10.1016\/j.crphys.2024.100126_bib33","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1016\/S0140-6736(18)31694-5","article-title":"Forecasting life expectancy, years of life lost, and all-cause and cause-specific mortality for 250 causes of death: reference and alternative scenarios for 2016-40 for 195 countries and territories","volume":"392","author":"Foreman","year":"2018","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.crphys.2024.100126_bib34","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1113\/expphysiol.2011.063172","article-title":"Ontogeny of the renal urotensin II system in the rat","volume":"97","author":"Forty","year":"2012","journal-title":"Exp. Physiol."},{"issue":"12","key":"10.1016\/j.crphys.2024.100126_bib35","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0083317","article-title":"The urotensin system is up-regulated in the pre-hypertensive spontaneously hypertensive rat","volume":"8","author":"Forty","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.crphys.2024.100126_bib36","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0272-6386(95)90001-2","article-title":"The link between hypertension and nephrosclerosis","volume":"25","author":"Freedman","year":"1995","journal-title":"Am. J. Kidney Dis."},{"issue":"3","key":"10.1016\/j.crphys.2024.100126_bib37","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/sj.bjp.0705954","article-title":"Bolus injection of human UII in conscious rats evokes a biphasic haemodynamic response","volume":"143","author":"Gardiner","year":"2004","journal-title":"Br. J. Pharmacol."},{"issue":"6","key":"10.1016\/j.crphys.2024.100126_bib38","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/sj.bjp.0706503","article-title":"Regional heterogeneity in the haemodynamic responses to urotensin II infusion in relation to UT receptor localisation","volume":"147","author":"Gardiner","year":"2006","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.crphys.2024.100126_bib39","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1053\/j.ajkd.2015.08.027","article-title":"Hypertension and prehypertension and prediction of development of decreased estimated GFR in the general population: a meta-analysis of cohort studies","volume":"67","author":"Garofalo","year":"2016","journal-title":"Am. J. Kidney Dis."},{"issue":"8","key":"10.1016\/j.crphys.2024.100126_bib40","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1016\/j.peptides.2005.03.012","article-title":"Urotensin II-induced hypotensive responses in Wistar-Kyoto (Wky) and spontaneously hypertensive (Shr) rats","volume":"26","author":"Gendron","year":"2005","journal-title":"Peptides"},{"issue":"3","key":"10.1016\/j.crphys.2024.100126_bib41","first-page":"276","article-title":"Urotensin-II as a novel therapeutic target in the clinical management of cardiorenal disease","volume":"5","author":"Gilbert","year":"2004","journal-title":"Curr. Opin. Invest. Drugs"},{"issue":"3","key":"10.1016\/j.crphys.2024.100126_bib42","first-page":"241","article-title":"Diabetic nephropathy: from mechanisms to rational therapies","volume":"97","author":"Giunti","year":"2006","journal-title":"Minerva Med."},{"issue":"10225","key":"10.1016\/j.crphys.2024.100126_bib43","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0140-6736(20)30045-3","article-title":"Global, regional, and national burden of chronic kidney disease, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"395","year":"2020","journal-title":"Lancet"},{"issue":"10053","key":"10.1016\/j.crphys.2024.100126_bib44","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/S0140-6736(16)31678-6","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015","volume":"388","year":"2016","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.crphys.2024.100126_bib45","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1161\/HYPERTENSIONAHA.117.08314","article-title":"Hypertensive kidney injury and the progression of chronic kidney disease","volume":"70","author":"Griffin","year":"2017","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.crphys.2024.100126_bib46","doi-asserted-by":"crossref","first-page":"164","DOI":"10.2337\/diacare.28.1.164","article-title":"Diabetic nephropathy: diagnosis, prevention, and treatment","volume":"28","author":"Gross","year":"2005","journal-title":"Diabetes Care"},{"issue":"8","key":"10.1016\/j.crphys.2024.100126_bib47","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1111\/j.1751-7176.2010.00336.x","article-title":"Raised plasma urotensin II in type 2 diabetes patients is associated with the metabolic syndrome phenotype","volume":"12","author":"Gruson","year":"2010","journal-title":"J. Clin. Hypertens."},{"key":"10.1016\/j.crphys.2024.100126_bib48","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/0002-9149(61)90159-X","article-title":"Physiologic regulation of arterial pressure","volume":"8","author":"Guyton","year":"1961","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.crphys.2024.100126_bib49","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1146\/annurev.ph.34.030172.000305","article-title":"Circulation: overall regulation","volume":"34","author":"Guyton","year":"1972","journal-title":"Annu. Rev. Physiol."},{"issue":"3","key":"10.1016\/j.crphys.2024.100126_bib50","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s00467-011-1939-1","article-title":"Epidemiology of chronic kidney disease in children","volume":"27","author":"Harambat","year":"2012","journal-title":"Pediatr. Nephrol."},{"issue":"2","key":"10.1016\/j.crphys.2024.100126_bib51","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1139\/y03-004","article-title":"Effect of human urotensin-II infusion on hemodynamics and cardiac function","volume":"81","author":"Hassan","year":"2003","journal-title":"Can. J. Physiol. Pharmacol."},{"issue":"3 Pt 2","key":"10.1016\/j.crphys.2024.100126_bib52","first-page":"R573","article-title":"Cardiovascular actions of dogfish urotensin II in the dogfish Scyliorhinus canicula","volume":"265","author":"Hazon","year":"1993","journal-title":"Am. J. Physiol."},{"issue":"6","key":"10.1016\/j.crphys.2024.100126_bib53","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.peptides.2009.02.009","article-title":"Increased expression of urotensin II, urotensin II-related peptide and urotensin II receptor mRNAs in the cardiovascular organs of hypertensive rats: comparison with endothelin-1","volume":"30","author":"Hirose","year":"2009","journal-title":"Peptides"},{"issue":"13","key":"10.1016\/j.crphys.2024.100126_bib54","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1056\/NEJM199809243391306","article-title":"Glomerulonephritis","volume":"339","author":"Hricik","year":"1998","journal-title":"N. Engl. J. Med."},{"issue":"2 Pt 2","key":"10.1016\/j.crphys.2024.100126_bib55","first-page":"R361","article-title":"Contraction of major artery segments of rat by fish neuropeptide urotensin II","volume":"252","author":"Itoh","year":"1987","journal-title":"Am. J. Physiol."},{"issue":"1\u20132","key":"10.1016\/j.crphys.2024.100126_bib56","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0014-2999(88)90042-8","article-title":"Functional receptors for fish neuropeptide urotensin II in major rat arteries","volume":"149","author":"Itoh","year":"1988","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.crphys.2024.100126_bib57","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.peptides.2012.12.014","article-title":"The differential extraction and immunoluminometric assay of Urotensin II and Urotensin-related peptide in heart failure","volume":"40","author":"Jani","year":"2013","journal-title":"Peptides"},{"issue":"1","key":"10.1016\/j.crphys.2024.100126_bib58","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1042\/BJ20090867","article-title":"The vasoactive peptides urotensin II and urotensin II-related peptide regulate astrocyte activity through common and distinct mechanisms: involvement in cell proliferation","volume":"428","author":"Jarry","year":"2010","journal-title":"Biochem. J."},{"issue":"10","key":"10.1016\/j.crphys.2024.100126_bib59","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1159\/000509978","article-title":"Tubular biomarkers and chronic kidney disease progression in SPRINT participants","volume":"51","author":"Jotwani","year":"2020","journal-title":"Am. J. Nephrol."},{"issue":"4","key":"10.1016\/j.crphys.2024.100126_bib60","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1080\/08820139.2021.1883647","article-title":"Role of miR-146a rs2910164 and UTS2 rs228648 genetic variants in beh\u00e7et's disease","volume":"51","author":"Kamal","year":"2022","journal-title":"Immunol. Invest."},{"issue":"5","key":"10.1016\/j.crphys.2024.100126_bib61","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nrneph.2009.44","article-title":"An update on acute postinfectious glomerulonephritis worldwide","volume":"5","author":"Kanjanabuch","year":"2009","journal-title":"Nat. Rev. Nephrol."},{"issue":"4","key":"10.1016\/j.crphys.2024.100126_bib62","doi-asserted-by":"crossref","first-page":"G762","DOI":"10.1152\/ajpgi.00127.2009","article-title":"Urotensin II modulates hepatic fibrosis and portal hemodynamic alterations in rats","volume":"297","author":"Kemp","year":"2009","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"Suppl. 2","key":"10.1016\/j.crphys.2024.100126_bib63","first-page":"S53","article-title":"Mechanisms of progression of chronic renal damage","volume":"12","author":"Klahr","year":"1999","journal-title":"J. Nephrol."},{"issue":"1","key":"10.1016\/j.crphys.2024.100126_bib64","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1053\/ajkd.1998.v31.pm9428470","article-title":"Angiotensin II and gene expression in the kidney","volume":"31","author":"Klahr","year":"1998","journal-title":"Am. J. Kidney Dis."},{"issue":"5","key":"10.1016\/j.crphys.2024.100126_bib65","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1038\/ki.2014.143","article-title":"Endothelin and endothelin antagonists in chronic kidney disease","volume":"86","author":"Kohan","year":"2014","journal-title":"Kidney Int."},{"issue":"12","key":"10.1016\/j.crphys.2024.100126_bib66","doi-asserted-by":"crossref","first-page":"9489","DOI":"10.1007\/s11033-020-05991-6","article-title":"Association of resistin (rs3745367) and urotensin II (rs228648 and rs2890565) gene polymorphisms with risk of type 2 diabetes mellitus in Indian population","volume":"47","author":"Kumar","year":"2020","journal-title":"Mol. Biol. Rep."},{"issue":"1","key":"10.1016\/j.crphys.2024.100126_bib67","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1097\/MNH.0b013e32835b6d57","article-title":"Urotensin II and the kidney","volume":"22","author":"Langham","year":"2013","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"issue":"5","key":"10.1016\/j.crphys.2024.100126_bib68","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/S0272-6386(04)01130-8","article-title":"Increased expression of urotensin II and urotensin II receptor in human diabetic nephropathy","volume":"44","author":"Langham","year":"2004","journal-title":"Am. J. Kidney Dis."},{"issue":"5 Pt 2","key":"10.1016\/j.crphys.2024.100126_bib69","first-page":"R1335","article-title":"Cardiovascular actions of trout urotensin II in the conscious trout, Oncorhynchus mykiss","volume":"271","author":"Le Mevel","year":"1996","journal-title":"Am. J. Physiol."},{"issue":"1","key":"10.1016\/j.crphys.2024.100126_bib70","doi-asserted-by":"crossref","first-page":"31","DOI":"10.23876\/j.krcp.21.099","article-title":"Association between blood pressure and the risk of chronic kidney disease in treatment-na\u00efve hypertensive patients","volume":"41","author":"Lee","year":"2022","journal-title":"Kidney Res Clin Pract"},{"issue":"5","key":"10.1016\/j.crphys.2024.100126_bib71","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1536\/ihj.21-032","article-title":"Urotensin II induces cardiac fibrosis through the TGF-\u03b2\/smad signaling pathway during the development of cardiac hypertrophy","volume":"62","author":"Liang","year":"2021","journal-title":"Int. Heart J."},{"issue":"1","key":"10.1016\/j.crphys.2024.100126_bib72","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1097\/00004872-200301000-00026","article-title":"Central cardiovascular action of urotensin II in conscious rats","volume":"21","author":"Lin","year":"2003","journal-title":"J. Hypertens."},{"issue":"10","key":"10.1016\/j.crphys.2024.100126_bib73","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1291\/hypres.26.839","article-title":"Central cardiovascular action of urotensin II in spontaneously hypertensive rats","volume":"26","author":"Lin","year":"2003","journal-title":"Hypertens. Res."},{"issue":"6","key":"10.1016\/j.crphys.2024.100126_bib74","first-page":"953","article-title":"The urotension II antagonist SB-710411 arrests fibrosis in CCL4 cirrhotic rats","volume":"2","author":"Liu","year":"2009","journal-title":"Mol. Med. Rep."},{"issue":"11","key":"10.1016\/j.crphys.2024.100126_bib75","doi-asserted-by":"crossref","first-page":"3239","DOI":"10.3748\/wjg.v21.i11.3239","article-title":"Effects of urotensin-II on cytokines in early acute liver failure in mice","volume":"21","author":"Liu","year":"2015","journal-title":"World J. Gastroenterol."},{"issue":"9","key":"10.1016\/j.crphys.2024.100126_bib76","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1016\/S0196-9781(02)00104-3","article-title":"Cardiovascular effects of urotensin II in different brain areas","volume":"23","author":"Lu","year":"2002","journal-title":"Peptides"},{"issue":"5","key":"10.1016\/j.crphys.2024.100126_bib77","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.peptides.2007.12.015","article-title":"Urotensin II and urotensin II-related peptide activate somatostatin receptor subtypes 2 and 5","volume":"29","author":"Malagon","year":"2008","journal-title":"Peptides"},{"issue":"2","key":"10.1016\/j.crphys.2024.100126_bib78","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1006\/geno.1995.9996","article-title":"Cloning and chromosomal mapping of three novel genes, GPR9, GPR10, and GPR14, encoding receptors related to interleukin 8, neuropeptide Y, and somatostatin receptors","volume":"29","author":"Marchese","year":"1995","journal-title":"Genomics"},{"issue":"5","key":"10.1016\/j.crphys.2024.100126_bib79","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.peptides.2007.08.025","article-title":"Evidence for endogenous urotensin-II as an inhibitor of insulin secretion: study in the perfused rat pancreas","volume":"29","author":"Marco","year":"2008","journal-title":"Peptides"},{"issue":"1","key":"10.1016\/j.crphys.2024.100126_bib80","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1124\/jpet.120.265496","article-title":"Potential therapeutic value of urotensin II receptor antagonist in chronic kidney disease and associated comorbidities","volume":"374","author":"Marie-Laure","year":"2020","journal-title":"J. Pharmacol. Exp. Therapeut."},{"key":"10.1016\/j.crphys.2024.100126_bib81","doi-asserted-by":"crossref","first-page":"S67","DOI":"10.1046\/j.1523-1755.1998.06816.x","article-title":"Hypertension in end-stage renal disease","volume":"68","author":"Mart\u00ednez-Maldonado","year":"1998","journal-title":"Kidney Int. Suppl."},{"issue":"5","key":"10.1016\/j.crphys.2024.100126_bib82","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1097\/01.ASN.0000065640.77499.D7","article-title":"Extracellular matrix metabolism in diabetic nephropathy","volume":"14","author":"Mason","year":"2003","journal-title":"J. Am. Soc. Nephrol."},{"issue":"12","key":"10.1016\/j.crphys.2024.100126_bib83","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1097\/00004872-200112000-00011","article-title":"Co-expression of urotensin II and its receptor (GPR14) in human cardiovascular and renal tissues","volume":"19","author":"Matsushita","year":"2001","journal-title":"J. Hypertens."},{"issue":"6","key":"10.1016\/j.crphys.2024.100126_bib84","doi-asserted-by":"crossref","first-page":"e273","DOI":"10.3928\/19382359-20200519-01","article-title":"Postinfectious glomerulonephritis","volume":"49","author":"Mohammad","year":"2020","journal-title":"Pediatr. Ann."},{"issue":"3\u20134","key":"10.1016\/j.crphys.2024.100126_bib85","first-page":"115","article-title":"Glomerulonephritis for the generalist","volume":"32","author":"Mookerje","year":"2001","journal-title":"J. Med."},{"issue":"2","key":"10.1016\/j.crphys.2024.100126_bib86","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.peptides.2008.09.021","article-title":"Increased expression of urotensin II-related peptide and its receptor in kidney with hypertension or renal failure","volume":"30","author":"Mori","year":"2009","journal-title":"Peptides"},{"issue":"3","key":"10.1016\/j.crphys.2024.100126_bib87","doi-asserted-by":"crossref","first-page":"F243","DOI":"10.1152\/ajprenal.00224.2014","article-title":"Chronic kidney disease: targeting prostaglandin E2 receptors","volume":"307","author":"Nasrallah","year":"2014","journal-title":"Am. J. Physiol. Ren. Physiol."},{"issue":"1","key":"10.1016\/j.crphys.2024.100126_bib88","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1097\/FJC.0000000000000618","article-title":"A novel and highly potent urotensin II receptor antagonist inhibits urotensin II-induced pressure response in mice","volume":"73","author":"Nishi","year":"2019","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"2","key":"10.1016\/j.crphys.2024.100126_bib89","doi-asserted-by":"crossref","first-page":"R437","DOI":"10.1152\/ajpregu.00629.2010","article-title":"Potent cardiovascular effects of homologous urotensin II (UII)-related peptide and UII in unanesthetized eels after peripheral and central injections","volume":"300","author":"Nobata","year":"2011","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"6","key":"10.1016\/j.crphys.2024.100126_bib90","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/14081","article-title":"Identification of the natural ligand of an orphan G-protein-coupled receptor involved in the regulation of vasoconstriction","volume":"1","author":"Nothacker","year":"1999","journal-title":"Nat. Cell Biol."},{"issue":"10","key":"10.1016\/j.crphys.2024.100126_bib91","doi-asserted-by":"crossref","first-page":"921","DOI":"10.3109\/02713683.2012.688181","article-title":"Association between Thr21Met and Ser89Asn polymorphisms of the urotensin-II (UTS2) gene, diabetes mellitus, and diabetic retinopathy","volume":"37","author":"Okumus","year":"2012","journal-title":"Curr. Eye Res."},{"issue":"7","key":"10.1016\/j.crphys.2024.100126_bib92","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1016\/j.peptides.2006.02.008","article-title":"Haplotypes in the urotensin II gene and urotensin II receptor gene are associated with insulin resistance and impaired glucose tolerance","volume":"27","author":"Ong","year":"2006","journal-title":"Peptides"},{"issue":"5","key":"10.1016\/j.crphys.2024.100126_bib93","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1093\/ndt\/gfk049","article-title":"Renal effects of human urotensin-II in rats with experimental congestive heart failure","volume":"21","author":"Ovcharenko","year":"2006","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.crphys.2024.100126_bib94","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.peptides.2012.12.013","article-title":"Thr21Met (T21M) but not Ser89Asn (S89N) polymorphisms of the urotensin-II (UTS-II) gene are associated with Behcet's disease (BD)","volume":"42","author":"Oztuzcu","year":"2013","journal-title":"Peptides"},{"issue":"4","key":"10.1016\/j.crphys.2024.100126_bib95","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1159\/000443445","article-title":"Urotensin II induces ER stress and EMT and increase extracellular matrix production in renal tubular epithelial cell in early diabetic mice","volume":"41","author":"Pang","year":"2016","journal-title":"Kidney Blood Press. Res."},{"issue":"8","key":"10.1016\/j.crphys.2024.100126_bib96","doi-asserted-by":"crossref","first-page":"5021","DOI":"10.1073\/pnas.77.8.5021","article-title":"Urotensin II: a somatostatin-like peptide in the caudal neurosecretory system of fishes","volume":"77","author":"Pearson","year":"1980","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"issue":"1","key":"10.1016\/j.crphys.2024.100126_bib97","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3899\/jrheum.110509","article-title":"Association between Thr21Met and Ser89Asn polymorphisms of the urotensin II gene and systemic sclerosis","volume":"39","author":"Pehlivan","year":"2012","journal-title":"J. Rheumatol."},{"issue":"3","key":"10.1016\/j.crphys.2024.100126_bib98","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1530\/JME-21-0199","article-title":"Loss of urotensin II receptor diminishes hyperglycemia and kidney injury in streptozotocin-treated mice","volume":"68","author":"Peixoto-Neves","year":"2022","journal-title":"J. Mol. Endocrinol."},{"issue":"12","key":"10.1016\/j.crphys.2024.100126_bib99","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0081764","article-title":"Association between human urotensin II and essential hypertension--a 1:1 matched case-control study","volume":"8","author":"Peng","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.crphys.2024.100126_bib100","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1006\/gcen.1997.7030","article-title":"Cardiovascular actions of dogfish urotensin I in the dogfish, Scyliorhinus canicula","volume":"109","author":"Platzack","year":"1998","journal-title":"Gen. Comp. Endocrinol."},{"issue":"12","key":"10.1016\/j.crphys.2024.100126_bib101","doi-asserted-by":"crossref","first-page":"3261","DOI":"10.1016\/j.peptides.2006.09.012","article-title":"Cardiovascular effects of native and non-native urotensin II and urotensin II-related peptide on rat and salmon hearts","volume":"27","author":"Prosser","year":"2006","journal-title":"Peptides"},{"issue":"6","key":"10.1016\/j.crphys.2024.100126_bib102","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1681\/ASN.V661666","article-title":"Urinary excretion of beta 2-microglobulin predicts renal outcome in patients with idiopathic membranous nephropathy","volume":"6","author":"Reichert","year":"1995","journal-title":"J. Am. Soc. Nephrol."},{"issue":"4","key":"10.1016\/j.crphys.2024.100126_bib103","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s12079-022-00672-4","article-title":"The network map of urotensin-II mediated signaling pathway in physiological and pathological conditions","volume":"16","author":"Rex","year":"2022","journal-title":"J. Cell Commun. Signal."},{"issue":"6","key":"10.1016\/j.crphys.2024.100126_bib104","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1681\/ASN.2006111199","article-title":"A population-based, prospective study of blood pressure and risk for end-stage renal disease in China","volume":"18","author":"Reynolds","year":"2007","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.crphys.2024.100126_bib105","article-title":"Chronic kidney disease","volume":"3","author":"Romagnani","year":"2017","journal-title":"Nat. Rev. Dis. Prim."},{"issue":"5","key":"10.1016\/j.crphys.2024.100126_bib106","doi-asserted-by":"crossref","first-page":"R1156","DOI":"10.1152\/ajpregu.00706.2009","article-title":"Role of urotensin II in health and disease","volume":"298","author":"Ross","year":"2010","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"4","key":"10.1016\/j.crphys.2024.100126_bib107","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0019327","article-title":"Association analysis of urotensin II gene (UTS2) and flanking regions with biochemical parameters related to insulin resistance","volume":"6","author":"S\u00e1ez","year":"2011","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.crphys.2024.100126_bib108","doi-asserted-by":"crossref","first-page":"901","DOI":"10.4049\/jimmunol.179.2.901","article-title":"Urotensin II is a new chemotactic factor for UT receptor-expressing monocytes","volume":"179","author":"Segain","year":"2007","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.crphys.2024.100126_bib109","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/ndt\/gfy220","article-title":"Standardized classification and reporting of glomerulonephritis","volume":"34","author":"Sethi","year":"2019","journal-title":"Nephrol. Dial. Transplant."},{"issue":"7","key":"10.1016\/j.crphys.2024.100126_bib110","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1177\/002215540205000702","article-title":"Localization of urotensin-II immunoreactivity in normal human kidneys and renal carcinoma","volume":"50","author":"Shenouda","year":"2002","journal-title":"J. Histochem. Cytochem."},{"issue":"5","key":"10.1016\/j.crphys.2024.100126_bib111","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.peptides.2008.02.015","article-title":"Hemodynamic-independent anti-natriuretic effect of urotensin II in spontaneously hypertensive rats","volume":"29","author":"Shi","year":"2008","journal-title":"Peptides"},{"issue":"4","key":"10.1016\/j.crphys.2024.100126_bib112","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1111\/j.1365-2125.2009.03480.x","article-title":"Effect of the urotensin-II receptor antagonist palosuran on secretion of and sensitivity to insulin in patients with Type 2 diabetes mellitus","volume":"68","author":"Sidharta","year":"2009","journal-title":"Br. J. Clin. Pharmacol."},{"issue":"3","key":"10.1016\/j.crphys.2024.100126_bib113","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.clpt.2006.05.013","article-title":"Pharmacodynamics and pharmacokinetics of the urotensin II receptor antagonist palosuran in macroalbuminuric, diabetic patients","volume":"80","author":"Sidharta","year":"2006","journal-title":"Clin. Pharmacol. Ther."},{"issue":"6","key":"10.1016\/j.crphys.2024.100126_bib115","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1530\/eje.0.1510803","article-title":"Urotensin-II is present in pancreatic extracts and inhibits insulin release in the perfused rat pancreas","volume":"151","author":"Silvestre","year":"2004","journal-title":"Eur. J. Endocrinol."},{"issue":"1","key":"10.1016\/j.crphys.2024.100126_bib116","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.regpep.2008.11.008","article-title":"Characterization of the insulinostatic effect of urotensin II: a study in the perfused rat pancreas","volume":"153","author":"Silvestre","year":"2009","journal-title":"Regul. Pept."},{"issue":"2","key":"10.1016\/j.crphys.2024.100126_bib117","doi-asserted-by":"crossref","first-page":"204","DOI":"10.3390\/children9020204","article-title":"The role of urotensin-II in obesity and metabolic syndrome in pediatric population","volume":"9","author":"Simunovic","year":"2022","journal-title":"Children"},{"issue":"8","key":"10.1016\/j.crphys.2024.100126_bib118","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1038\/sj.ki.5000290","article-title":"Urotensin II and renal function in the rat","volume":"69","author":"Song","year":"2006","journal-title":"Kidney Int."},{"issue":"3","key":"10.1016\/j.crphys.2024.100126_bib164","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1530\/JOE-12-0556","article-title":"Pressor and renal regional hemodynamic effects of urotensin II in neonatal pigs","volume":"217","author":"Soni","year":"2013","journal-title":"J. Endocrinol."},{"issue":"1","key":"10.1016\/j.crphys.2024.100126_bib119","doi-asserted-by":"crossref","first-page":"18049","DOI":"10.1038\/s41598-017-18143-x","article-title":"Urotensin II-induced store-operated Ca2+ entry contributes to glomerular mesangial cell proliferation and extracellular matrix protein production under high glucose conditions","volume":"7","author":"Soni","year":"2017","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.crphys.2024.100126_bib120","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.2337\/diab.38.9.1077","article-title":"Mesangial expansion as a central mechanism for loss of kidney function in diabetic patients","volume":"38","author":"Steffes","year":"1989","journal-title":"Diabetes"},{"issue":"2","key":"10.1016\/j.crphys.2024.100126_bib121","doi-asserted-by":"crossref","first-page":"H925","DOI":"10.1152\/ajpheart.2001.280.2.H925","article-title":"Potent vasodilator responses to human urotensin-II in human pulmonary and abdominal resistance arteries","volume":"280","author":"Stirrat","year":"2001","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"3","key":"10.1016\/j.crphys.2024.100126_bib122","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.bbrc.2003.09.102","article-title":"Identification of urotensin II-related peptide as the urotensin II-immunoreactive molecule in the rat brain","volume":"310","author":"Sugo","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"11","key":"10.1016\/j.crphys.2024.100126_bib123","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1042\/CS20080014","article-title":"Increased plasma urotensin-II levels are associated with diabetic retinopathy and carotid atherosclerosis in Type 2 diabetes","volume":"115","author":"Suguro","year":"2008","journal-title":"Clin. Sci."},{"issue":"3","key":"10.1016\/j.crphys.2024.100126_bib124","first-page":"223","article-title":"[The association of two single nucleotide polymorphisms in PRKCZ and UTS2 respectively with type 2 diabetes in Han people of northern China]","volume":"24","author":"Sun","year":"2002","journal-title":"Zhongguo Yi Xue Ke Xue Yuan Xue Bao"},{"key":"10.1016\/j.crphys.2024.100126_bib125","article-title":"Urotensin II: an inflammatory cytokine","author":"Sun","year":"2019","journal-title":"J. Endocrinol. 240 (3), R107\u2013R117"},{"issue":"10","key":"10.1016\/j.crphys.2024.100126_bib126","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1016\/j.peptides.2004.03.030","article-title":"Genetic variations at urotensin II and urotensin II receptor genes and risk of type 2 diabetes mellitus in Japanese","volume":"25","author":"Suzuki","year":"2004","journal-title":"Peptides"},{"issue":"8","key":"10.1016\/j.crphys.2024.100126_bib127","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1016\/j.peptides.2009.05.018","article-title":"The renin-angiotensin system, adrenomedullins and urotensin II in the kidney: possible renoprotection via the kidney peptide systems","volume":"30","author":"Takahashi","year":"2009","journal-title":"Peptides"},{"issue":"11","key":"10.1016\/j.crphys.2024.100126_bib128","first-page":"732","article-title":"[Role of urotensin II gene in the genetic susceptibility to gestational diabetes mellitus in northern Chinese women]","volume":"41","author":"Tan","year":"2006","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"key":"10.1016\/j.crphys.2024.100126_bib129","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173391","article-title":"Identification of novel Urotensin-II receptor antagonists with potent inhibition of U-II induced pressor response in mice","volume":"886","author":"Tandon","year":"2020","journal-title":"Eur. J. Pharmacol."},{"issue":"5","key":"10.1016\/j.crphys.2024.100126_bib130","doi-asserted-by":"crossref","first-page":"E1234","DOI":"10.1152\/ajpendo.90672.2008","article-title":"Diabetes-induced upregulation of urotensin II and its receptor plays an important role in TGF-beta1-mediated renal fibrosis and dysfunction","volume":"295","author":"Tian","year":"2008","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"5","key":"10.1016\/j.crphys.2024.100126_bib131","doi-asserted-by":"crossref","first-page":"E1234","DOI":"10.1152\/ajpendo.90672.2008","article-title":"Diabetes-induced upregulation of urotensin II and its receptor plays an important role in TGF-beta1-mediated renal fibrosis and dysfunction","volume":"295","author":"Tian","year":"2008","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"5","key":"10.1016\/j.crphys.2024.100126_bib132","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.peptides.2007.08.029","article-title":"Cardiorenovascular effects of urotensin II and the relevance of the UT receptor","volume":"29","author":"T\u00f6lle","year":"2008","journal-title":"Peptides"},{"key":"10.1016\/j.crphys.2024.100126_bib133","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ygcen.2015.04.009","article-title":"Urotensin II upregulates migration and cytokine gene expression in leukocytes of the African clawed frog, Xenopus laevis","volume":"216","author":"Tomiyama","year":"2015","journal-title":"Gen. Comp. Endocrinol."},{"issue":"7","key":"10.1016\/j.crphys.2024.100126_bib134","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1073\/pnas.0510700103","article-title":"Comparative genomics provides evidence for close evolutionary relationships between the urotensin II and somatostatin gene families","volume":"103","author":"Tostivint","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.crphys.2024.100126_bib135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/cs1040001","article-title":"Increased plasma urotensin II levels in patients with diabetes mellitus","volume":"104","author":"Totsune","year":"2003","journal-title":"Clin. Sci."},{"issue":"10","key":"10.1016\/j.crphys.2024.100126_bib136","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1016\/j.peptides.2004.06.024","article-title":"Elevated plasma levels of immunoreactive urotensin II and its increased urinary excretion in patients with Type 2 diabetes mellitus: association with progress of diabetic nephropathy","volume":"25","author":"Totsune","year":"2004","journal-title":"Peptides"},{"issue":"4","key":"10.1016\/j.crphys.2024.100126_bib137","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/cvr\/cvy023","article-title":"Vascular smooth muscle contraction in hypertension","volume":"114","author":"Touyz","year":"2018","journal-title":"Cardiovasc. Res."},{"issue":"4","key":"10.1016\/j.crphys.2024.100126_bib138","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1002\/hep.22170","article-title":"Hemodynamic effects of urotensin II and its specific receptor antagonist palosuran in cirrhotic rats","volume":"47","author":"Trebicka","year":"2008","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.crphys.2024.100126_bib139","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1161\/HYPERTENSIONAHA.117.10546","article-title":"Hypertension and diabetes mellitus: coprediction and time trajectories","volume":"71","author":"Tsimihodimos","year":"2018","journal-title":"Hypertension"},{"issue":"1","key":"10.1016\/j.crphys.2024.100126_bib140","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrneph.2010.154","article-title":"Epidemiology of hypertensive kidney disease","volume":"7","author":"Udani","year":"2011","journal-title":"Nat. Rev. Nephrol."},{"issue":"1","key":"10.1016\/j.crphys.2024.100126_bib141","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1124\/pr.114.009480","article-title":"International Union of Basic and Clinical Pharmacology. XCII. Urotensin II, urotensin II-related peptide, and their receptor: from structure to function","volume":"67","author":"Vaudry","year":"2015","journal-title":"Pharmacol. Rev."},{"issue":"5","key":"10.1016\/j.crphys.2024.100126_bib142","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1161\/HYPERTENSIONAHA.109.149559","article-title":"Effect of the urotensin receptor antagonist palosuran in hypertensive patients with type 2 diabetic nephropathy","volume":"55","author":"Vogt","year":"2010","journal-title":"Hypertension"},{"issue":"10","key":"10.1016\/j.crphys.2024.100126_bib143","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1038\/nrneph.2012.191","article-title":"The role of the kidney in regulating arterial blood pressure","volume":"8","author":"Wadei","year":"2012","journal-title":"Nat. Rev. Nephrol."},{"issue":"10","key":"10.1016\/j.crphys.2024.100126_bib144","article-title":"Urotensin II inhibits skeletal muscle glucose transport signaling pathways via the NADPH oxidase pathway","volume":"8","author":"Wang","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.crphys.2024.100126_bib145","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.regpep.2009.01.004","article-title":"Elevated expression of urotensin II and its receptor in skeletal muscle of diabetic mouse","volume":"154","author":"Wang","year":"2009","journal-title":"Regul. Pept."},{"issue":"1","key":"10.1016\/j.crphys.2024.100126_bib146","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.neuroscience.2008.05.032","article-title":"Effect of central urotensin II on heart rate, blood pressure and brain Fos immunoreactivity in conscious rats","volume":"155","author":"Watson","year":"2008","journal-title":"Neuroscience"},{"issue":"10075","key":"10.1016\/j.crphys.2024.100126_bib147","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/S0140-6736(16)32064-5","article-title":"Chronic kidney disease","volume":"389","author":"Webster","year":"2017","journal-title":"Lancet"},{"issue":"7","key":"10.1016\/j.crphys.2024.100126_bib148","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1007\/s00125-003-1145-1","article-title":"Role of urotensin II gene in genetic susceptibility to Type 2 diabetes mellitus in Japanese subjects","volume":"46","author":"Wenyi","year":"2003","journal-title":"Diabetologia"},{"issue":"4","key":"10.1016\/j.crphys.2024.100126_bib149","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.kint.2016.04.026","article-title":"The incidence, prevalence, and outcomes of glomerulonephritis derived from a large retrospective analysis","volume":"90","author":"Wetmore","year":"2016","journal-title":"Kidney Int."},{"issue":"2","key":"10.1016\/j.crphys.2024.100126_bib150","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0008-6363(01)00485-0","article-title":"High plasma concentrations of human urotensin II do not alter local or systemic hemodynamics in man","volume":"53","author":"Wilkinson","year":"2002","journal-title":"Cardiovasc. Res."},{"issue":"9","key":"10.1016\/j.crphys.2024.100126_bib151","doi-asserted-by":"crossref","first-page":"705","DOI":"10.47102\/annals-acadmedsg.V39N9p705","article-title":"Urotensin 2 and retinoic acid receptor alpha (RARA) gene expression in IgA nephropathy","volume":"39","author":"Woo","year":"2010","journal-title":"Ann. Acad. Med. Singapore"},{"issue":"6","key":"10.1016\/j.crphys.2024.100126_bib152","first-page":"656","article-title":"[Relationship between polymorphism of urotensin II gene and type 2 diabetes in pedigrees]","volume":"24","author":"Wu","year":"2007","journal-title":"Zhonghua Yi Xue Yi Chuan Xue Za Zhi"},{"issue":"1","key":"10.1016\/j.crphys.2024.100126_bib153","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1006\/gcen.1995.1010","article-title":"Cardiovascular actions of frog urotensin II in the frog, Rana catesbeiana","volume":"97","author":"Yano","year":"1995","journal-title":"Gen. Comp. Endocrinol."},{"issue":"1","key":"10.1016\/j.crphys.2024.100126_bib154","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.peptides.2012.03.001","article-title":"Intracerebroventricular administration of urotensin II regulates food intake and sympathetic nerve activity in brown adipose tissue","volume":"35","author":"Yasuda","year":"2012","journal-title":"Peptides"},{"issue":"3","key":"10.1016\/j.crphys.2024.100126_bib155","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1177\/147323000603400306","article-title":"Association of ACE, ACE2 and UTS2 polymorphisms with essential hypertension in Han and Dongxiang populations from north-western China","volume":"34","author":"Yi","year":"2006","journal-title":"J. Int. Med. Res."},{"issue":"8","key":"10.1016\/j.crphys.2024.100126_bib156","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1161\/ATVBAHA.112.252973","article-title":"Genetic and pharmacological manipulation of urotensin II ameliorate the metabolic and atherosclerosis sequalae in mice","volume":"32","author":"You","year":"2012","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"1","key":"10.1016\/j.crphys.2024.100126_bib157","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/j.1745-7254.2007.00485.x","article-title":"Urotensin II accelerates cardiac fibrosis and hypertrophy of rats induced by isoproterenol","volume":"28","author":"Zhang","year":"2007","journal-title":"Acta Pharmacol. Sin."},{"issue":"6","key":"10.1016\/j.crphys.2024.100126_bib158","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20181275","article-title":"Urotensin-II gene rs228648 polymorphism associated with the risk of diabetes mellitus","volume":"38","author":"Zhao","year":"2018","journal-title":"Biosci. Rep."},{"issue":"21","key":"10.1016\/j.crphys.2024.100126_bib159","first-page":"1473","article-title":"[The role of urotensin II gene in the genetic susceptibility to type 2 diabetes in Chinese population]","volume":"82","author":"Zhu","year":"2002","journal-title":"Zhonghua Yixue Zazhi"},{"issue":"7","key":"10.1016\/j.crphys.2024.100126_bib160","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1038\/sj.bjp.0706800","article-title":"The role of urotensin II in cardiovascular and renal physiology and diseases","volume":"148","author":"Zhu","year":"2006","journal-title":"Br. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.crphys.2024.100126_bib161","doi-asserted-by":"crossref","first-page":"H830","DOI":"10.1152\/ajpheart.00406.2003","article-title":"Urotensin II causes fatal circulatory collapse in anesthesized monkeys in vivo: a \"vasoconstrictor\" with a unique hemodynamic profile","volume":"286","author":"Zhu","year":"2004","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"2","key":"10.1016\/j.crphys.2024.100126_bib162","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1097\/MNH.0b013e3282f49566","article-title":"Urotensin II: a cardiovascular and renal update","volume":"17","author":"Zoccali","year":"2008","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"issue":"10","key":"10.1016\/j.crphys.2024.100126_bib163","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1111\/j.1440-1681.2008.04960.x","article-title":"Effect of urotensin II on skin microvessel tone in diabetic patients without heart failure or essential hypertension","volume":"35","author":"Zomer","year":"2008","journal-title":"Clin. Exp. Pharmacol. Physiol."}],"container-title":["Current Research in Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2665944124000105?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2665944124000105?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T09:34:43Z","timestamp":1733132083000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2665944124000105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":163,"alternative-id":["S2665944124000105"],"URL":"https:\/\/doi.org\/10.1016\/j.crphys.2024.100126","relation":{},"ISSN":["2665-9441"],"issn-type":[{"value":"2665-9441","type":"print"}],"subject":[],"published":{"date-parts":[[2024]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Urotensin II system in chronic kidney disease","name":"articletitle","label":"Article Title"},{"value":"Current Research in Physiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.crphys.2024.100126","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100126"}}