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Genet."},{"issue":"1","key":"10.1016\/j.crphys.2025.100166_bib70","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/syn.20146","article-title":"Mice lacking the adenosine A1 receptor have normal spatial learning and plasticity in the CA1 region of the hippocampus, but they habituate more slowly","volume":"57","author":"Gim\u00e9nez-Llort","year":"2005","journal-title":"Synapse"},{"issue":"3","key":"10.1016\/j.crphys.2025.100166_bib71","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.cub.2018.12.021","article-title":"Autophagy is required for memory formation and reverses age-related memory decline","volume":"29","author":"Glatigny","year":"2019","journal-title":"Curr. 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Rev."},{"issue":"2","key":"10.1016\/j.crphys.2025.100166_bib83","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.neuron.2012.02.020","article-title":"Regulation of presynaptic neurotransmission by macroautophagy","volume":"74","author":"Hernandez","year":"2012","journal-title":"Neuron"},{"issue":"3","key":"10.1016\/j.crphys.2025.100166_bib84","doi-asserted-by":"crossref","first-page":"171","DOI":"10.5607\/en.2018.27.3.171","article-title":"LRRK2 kinase activity induces mitochondrial fission in microglia via Drp1 and modulates neuroinflammation","volume":"27","author":"Ho","year":"2018","journal-title":"Experimental Neurobiol."},{"issue":"1","key":"10.1016\/j.crphys.2025.100166_bib85","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0006-8993(01)03345-5","article-title":"Age-related changes in GluR2 and NMDAR1 glutamate receptor subunit protein immunoreactivity in corticocortically projecting neurons in macaque and patas monkeys","volume":"928","author":"Hof","year":"2002","journal-title":"Brain Res."},{"issue":"12","key":"10.1016\/j.crphys.2025.100166_bib86","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1523\/JNEUROSCI.1317-18.2019","article-title":"Light-activated ROS production induces synaptic autophagy","volume":"39","author":"Hoffmann","year":"2019","journal-title":"J. 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Neurol."},{"issue":"6","key":"10.1016\/j.crphys.2025.100166_bib89","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.stem.2016.08.002","article-title":"Functional impairment in miro degradation and mitophagy is a shared feature in familial and sporadic parkinson's disease","volume":"19","author":"Hsieh","year":"2016","journal-title":"Cell Stem Cell"},{"issue":"6","key":"10.1016\/j.crphys.2025.100166_bib90","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/j.cmet.2019.08.023","article-title":"Miro1 marks Parkinson's disease subset and Miro1 reducer rescues neuron loss in parkinson's models","volume":"30","author":"Hsieh","year":"2019","journal-title":"Cell Metab."},{"issue":"6","key":"10.1016\/j.crphys.2025.100166_bib91","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1002\/hipo.10032","article-title":"Alterations in the balance of protein kinase and phosphatase activities and age-related impairments of synaptic transmission and long-term potentiation - PubMed","volume":"12","author":"Hsu","year":"2002","journal-title":"Hippocampus"},{"issue":"7","key":"10.1016\/j.crphys.2025.100166_bib92","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1093\/brain\/awt134","article-title":"Parkinson's disease is associated with altered expression of CaV1 channels and calcium-binding proteins","volume":"136","author":"Hurley","year":"2013","journal-title":"Brain"},{"key":"10.1016\/j.crphys.2025.100166_bib93","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2022.114145","article-title":"Cognitive deficits and altered cholinergic innervation in young adult male mice carrying a Parkinson's disease Lrrk2G2019S knockin mutation","volume":"355","author":"Hussein","year":"2022","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.crphys.2025.100166_bib94","first-page":"11","article-title":"Specific reduction of calcium-binding protein (28-kilodalton calbindin-D) gene expression in aging and neurodegenerative diseases","volume":"vol. 87","author":"Iacopino","year":"1990"},{"issue":"2","key":"10.1016\/j.crphys.2025.100166_bib95","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1002\/mds.107","article-title":"Recruitment of calbindin into nigral dopamine neurons protects against MPTP-induced parkinsonism","volume":"34","author":"Inoue","year":"2019","journal-title":"Mov. Disord."},{"issue":"4","key":"10.1016\/j.crphys.2025.100166_bib96","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1002\/ana.410320410","article-title":"Calbindin-D28K in the basal ganglia of patients with parkinsonism","volume":"32","author":"Ito","year":"1992","journal-title":"Ann. Neurol."},{"issue":"1","key":"10.1016\/j.crphys.2025.100166_bib97","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1113\/jphysiol.1965.sp007742","article-title":"Heterosynaptic facilitation in neurones of the abdominal ganglion of Aplysia depilans","volume":"181","author":"Kandel","year":"1965","journal-title":"J. Physiol."},{"key":"10.1016\/j.crphys.2025.100166_bib98","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.neuropharm.2017.08.015","article-title":"Metformin lowers \u03b1-synuclein phosphorylation and upregulates neurotrophic factor in the MPTP mouse model of Parkinson's disease","volume":"125","author":"Katila","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.crphys.2025.100166_bib99","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.114193","article-title":"Activation of AMPK\/aPKC\u03b6\/CREB pathway by metformin is associated with upregulation of GDNF and dopamine","volume":"180","author":"Katila","year":"2020","journal-title":"Biochem. 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A."},{"issue":"1","key":"10.1016\/j.crphys.2025.100166_bib109","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1152\/jn.00835.2009","article-title":"Specific roles of AMPA receptor subunit GluR1 (GluA1) phosphorylation sites in regulating synaptic plasticity in the CA1 region of Hippocampus","volume":"103","author":"Lee","year":"2010","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.crphys.2025.100166_bib110","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/978-90-481-8622-8_19","article-title":"Cholesterol and ion channels","volume":"51","author":"Levitan","year":"2010","journal-title":"Subcell. Biochem."},{"key":"10.1016\/j.crphys.2025.100166_bib111","doi-asserted-by":"crossref","DOI":"10.1016\/j.parkreldis.2024.107186","article-title":"Clinical progression of Parkinson's disease in the early 21st century: insights from the accelerating medicine partnership (AMP-PD) data","volume":"130","author":"Lewis","year":"2025","journal-title":"Park. Relat. Disord."},{"issue":"1","key":"10.1016\/j.crphys.2025.100166_bib112","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41583-021-00535-8","article-title":"Energy matters: presynaptic metabolism and the maintenance of synaptic transmission","volume":"23","author":"Li","year":"2022","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.crphys.2025.100166_bib113","article-title":"Proteomic profile of mouse brain aging contributions to mitochondrial dysfunction, DNA oxidative damage, loss of neurotrophic factor, and synaptic and ribosomal proteins","volume":"2020","author":"Li","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.crphys.2025.100166_bib114","article-title":"Post-Translational modification of Cav1.2 and its role in neurodegenerative diseases","volume":"12","author":"Li","year":"2022","journal-title":"Front. 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Neurosci."},{"issue":"5","key":"10.1016\/j.crphys.2025.100166_bib118","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/0896-6273(93)90119-C","article-title":"Multiple calcium channel types control glutamatergic synaptic transmission in the hippocampus","volume":"11","author":"Luebke","year":"1993","journal-title":"Neuron"},{"issue":"12","key":"10.1016\/j.crphys.2025.100166_bib119","doi-asserted-by":"crossref","first-page":"3825","DOI":"10.1021\/bi952250b","article-title":"Membrane stiffness and channel function","volume":"35","author":"Lundbaek","year":"1996","journal-title":"Biochemistry"},{"issue":"6","key":"10.1016\/j.crphys.2025.100166_bib120","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a005710","article-title":"NMDA receptor-dependent long-term potentiation and long-term depression (LTP\/LTD)","volume":"4","author":"L\u00fcscher","year":"2012","journal-title":"Cold Spring Harbor Perspect. 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Neurosci."},{"issue":"3","key":"10.1016\/j.crphys.2025.100166_bib124","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0047-6374(95)01658-9","article-title":"Differential effects of aging on binding sites of the activated NMDA receptor complex in mice","volume":"84","author":"Magnusson","year":"1995","journal-title":"Mech. Ageing Dev."},{"issue":"5","key":"10.1016\/j.crphys.2025.100166_bib125","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1523\/JNEUROSCI.20-05-01666.2000","article-title":"Declines in mRNA expression of different subunits may account for differential effects of aging on agonist and antagonist binding to the NMDA receptor","volume":"20","author":"Magnusson","year":"2000","journal-title":"J. Neurosci."},{"issue":"9","key":"10.1016\/j.crphys.2025.100166_bib126","doi-asserted-by":"crossref","first-page":"B448","DOI":"10.1093\/gerona\/55.9.B448","article-title":"Changes in anesthetic sensitivity and glutamate receptors in the aging canine brain","volume":"55","author":"Magnusson","year":"2000","journal-title":"J. Gerontol.: Series A"},{"issue":"1","key":"10.1016\/j.crphys.2025.100166_bib127","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0169-328X(01)00344-8","article-title":"Age-related changes in the protein expression of subunits of the NMDA receptor","volume":"99","author":"Magnusson","year":"2002","journal-title":"Mol. Brain Res."},{"key":"10.1016\/j.crphys.2025.100166_bib128","first-page":"11","article-title":"Selective vulnerabilities of N-methyl-D-aspartate (NMDA) receptors during brain aging","volume":"2","author":"Magnusson","year":"2010","journal-title":"Front. 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Neurosci."},{"issue":"6","key":"10.1016\/j.crphys.2025.100166_bib134","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/j.neuron.2012.08.022","article-title":"LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis","volume":"75","author":"Matta","year":"2012","journal-title":"Neuron"},{"issue":"3","key":"10.1016\/j.crphys.2025.100166_bib135","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0197-4580(03)00116-7","article-title":"Sulindac improves memory and increases NMDA receptor subunits in aged fischer 344 rats","volume":"25","author":"Mesches","year":"2004","journal-title":"Neurobiol. 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Int."},{"issue":"6","key":"10.1016\/j.crphys.2025.100166_bib217","doi-asserted-by":"crossref","first-page":"605","DOI":"10.4062\/biomolther.2021.012","article-title":"Neuronal autophagy: characteristic features and roles in neuronal pathophysiology","volume":"29","author":"Valencia","year":"2021","journal-title":"Biomol Ther. (Seoul)."},{"issue":"10","key":"10.1016\/j.crphys.2025.100166_bib218","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.15252\/embj.201695773","article-title":"The SAC1 domain in synaptojanin is required for autophagosome maturation at presynaptic terminals","volume":"36","author":"Vanhauwaert","year":"2017","journal-title":"EMBO J."},{"issue":"2","key":"10.1016\/j.crphys.2025.100166_bib219","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/S0169-328X(02)00453-9","article-title":"Regionally selective alterations in expression of the \u03b11D subunit (Cav1.3) of L-type calcium channels in the hippocampus of aged rats","volume":"107","author":"Veng","year":"2002","journal-title":"Mol. 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Sci."},{"key":"10.1016\/j.crphys.2025.100166_bib225","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.28377","article-title":"Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in mice","volume":"6","author":"Volta","year":"2017","journal-title":"eLife"},{"issue":"11","key":"10.1016\/j.crphys.2025.100166_bib226","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1152\/jn.00213.2012","article-title":"Regulation of presynaptic calcium in a Mammalian synaptic terminal","volume":"108","author":"Wan","year":"2012","journal-title":"J. Neurophysiol."},{"issue":"9","key":"10.1016\/j.crphys.2025.100166_bib227","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1093\/hmg\/dds003","article-title":"LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1","volume":"21","author":"Wang","year":"2012","journal-title":"Hum. Mol. Genet."},{"issue":"3","key":"10.1016\/j.crphys.2025.100166_bib228","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1002\/jnr.10427","article-title":"Age-related deficits in long-term potentiation are insensitive to hydrogen peroxide: coincidence with enhanced autophosphorylation of Ca2+\/calmodulin-dependent protein kinase II","volume":"70","author":"Watson","year":"2002","journal-title":"J. Neurosci. Res."},{"issue":"6","key":"10.1016\/j.crphys.2025.100166_bib229","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1083\/jcb.201003122","article-title":"\u03b1-Synuclein impairs macroautophagy: implications for Parkinson's disease","volume":"190","author":"Winslow","year":"2010","journal-title":"J. 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Rep."},{"issue":"5","key":"10.1016\/j.crphys.2025.100166_bib233","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.neuron.2021.12.031","article-title":"Presynaptic autophagy is coupled to the synaptic vesicle cycle via ATG-9","volume":"110","author":"Yang","year":"2022","journal-title":"Neuron"},{"issue":"4","key":"10.1016\/j.crphys.2025.100166_bib234","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1124\/pr.114.009654","article-title":"The physiology, pathology, and pharmacology of voltage-gated calcium channels and their future therapeutic potential","volume":"67","author":"Zamponi","year":"2015","journal-title":"Pharmacol. Rev."},{"issue":"1","key":"10.1016\/j.crphys.2025.100166_bib235","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41514-023-00102-8","article-title":"Aging reduces calreticulin expression and alters spontaneous calcium signals in astrocytic endfeet of the mouse dorsolateral striatum","volume":"9","author":"Zarate","year":"2023","journal-title":"npj Aging."},{"issue":"4","key":"10.1016\/j.crphys.2025.100166_bib236","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.neuroscience.2009.05.018","article-title":"The effects of aging on N-methyl-d-aspartate receptor subunits in the synaptic membrane and relationships to long-term spatial memory","volume":"162","author":"Zhao","year":"2009","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.crphys.2025.100166_bib237","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41392-024-01931-z","article-title":"Glucagon-like peptide-1 receptor: mechanisms and advances in therapy","volume":"9","author":"Zheng","year":"2024","journal-title":"Signal Transduct. 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