{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T19:52:56Z","timestamp":1781898776264,"version":"3.54.5"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T00:00:00Z","timestamp":1754265600000},"content-version":"vor","delay-in-days":215,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Research in Toxicology"],"published-print":{"date-parts":[[2025]]},"DOI":"10.1016\/j.crtox.2025.100253","type":"journal-article","created":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T08:11:33Z","timestamp":1755245493000},"page":"100253","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Evaluation of the impact of a 8\u00a0week exposure to a portable light therapy device, Luminette\u00ae, on retinal function assessed by ElectroRetinoGraphy"],"prefix":"10.1016","volume":"9","author":[{"given":"Marie","family":"de Deus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Petit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eve","family":"Cosker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amandine","family":"Luc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9dric","family":"Baumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Schwitzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.crtox.2025.100253_b0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.mbs.2023.109053","article-title":"A multi-scale simulation of retinal physiology","volume":"363","author":"Abuelnasr","year":"2023","journal-title":"Math. Biosci."},{"key":"10.1016\/j.crtox.2025.100253_b0010","series-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"2013"},{"key":"10.1016\/j.crtox.2025.100253_b0015","doi-asserted-by":"crossref","first-page":"5998","DOI":"10.3390\/ijms24065998","article-title":"Blue Light\u2014Ocular and Systemic Damaging Effects: a Narrative Review","volume":"24","author":"Antemie","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.crtox.2025.100253_b0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10633-012-9353-y","article-title":"ISCEV standard for clinical pattern electroretinography (PERG): 2012 update","volume":"126","author":"Bach","year":"2013","journal-title":"Doc. Ophthalmol."},{"key":"10.1016\/j.crtox.2025.100253_b0025","article-title":"Ocular toxicity of psychotropic medications in a tertiary hospital in Lagos","volume":"68","author":"Balogun","year":"2024","journal-title":"Nigeria. RJO"},{"key":"10.1016\/j.crtox.2025.100253_b0030","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1111\/j.1751-1097.2009.00590.x","article-title":"Photochemical reactions involved in the phototoxicity of the anticonvulsant and antidepressant drug lamotrigine (Lamictal\u00d2)","volume":"85","author":"Bilski","year":"2009","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.crtox.2025.100253_b0035","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1111\/acps.12785","article-title":"Light therapy: is it safe for the eyes?","volume":"136","author":"Brouwer","year":"2017","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.crtox.2025.100253_b0040","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/nrn3475","article-title":"Power failure: why small sample size undermines the reliability of neuroscience","volume":"14","author":"Button","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.crtox.2025.100253_b0045","first-page":"E13","article-title":"Bright light therapy: seasonal affective disorder and beyond","volume":"32","author":"Campbell","year":"2017","journal-title":"EinsteinJBiolMed"},{"key":"10.1016\/j.crtox.2025.100253_b0050","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2024.1509434","article-title":"Blue light-induced phototoxicity in retinal cells: implications in age-related macular degeneration","volume":"16","author":"Chakravarthy","year":"2024","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.crtox.2025.100253_b0060","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2021-049331","article-title":"Portable light therapy in the treatment of unipolar non-seasonal major depressive disorder: study protocol for the LUMIDEP randomised controlled trial","volume":"11","author":"Cosker","year":"2021","journal-title":"BMJ Open"},{"key":"10.1016\/j.crtox.2025.100253_b0075","doi-asserted-by":"crossref","first-page":"e101","DOI":"10.1192\/bjo.2021.59","article-title":"A retrospective examination of care pathways in individuals with treatment-resistant depression","volume":"7","author":"Day","year":"2021","journal-title":"Bjpsych Open"},{"key":"10.1016\/j.crtox.2025.100253_b0085","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/j.1440-1819.1998.tb01058.x","article-title":"Effects of short duration morning bright light in healthy elderly subjects. I:Subjective feeling and ophthalmological examinations","volume":"52","author":"Fukuda","year":"1998","journal-title":"Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.crtox.2025.100253_b0090","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.psychres.2006.09.004","article-title":"Impact of light therapy on rod and cone functions in healthy subjects","volume":"151","author":"Gagn\u00e9","year":"2007","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.crtox.2025.100253_b0095","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.pnpbp.2010.11.009","article-title":"Impact of blue vs red light on retinal response of patients with seasonal affective disorder and healthy controls","volume":"35","author":"Gagn\u00e9","year":"2011","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.crtox.2025.100253_b0100","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/S0002-9394(14)73874-7","article-title":"Ophthalmologic examination of patients with seasonal affective disorder, before and after bright light therapy","volume":"119","author":"Gallin","year":"1995","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.crtox.2025.100253_b0105","first-page":"137","article-title":"Mental Disorders Collaborators, 2022. Global, regional, and national burden of 12 mental disorders in 204 countries and territories, 1990\u20132019: a systematic analysis for the Global Burden of Disease Study 2019","volume":"9","year":"2019","journal-title":"Lancet Psych"},{"key":"10.1016\/j.crtox.2025.100253_b0120","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1080\/02713683.2017.1420198","article-title":"Effects of selective serotonin reuptake inhibitors on macular ganglion cell complex thickness and peripapillary retinal nerve fiber layer thickness","volume":"43","author":"Guclu","year":"2018","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.crtox.2025.100253_b0130","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s10633-020-09812-w","article-title":"ISCEV standard for clinical multifocal electroretinography (mfERG) (2021 update)","volume":"142","author":"Hoffmann","year":"2021","journal-title":"Doc. Ophthalmol."},{"key":"10.1016\/j.crtox.2025.100253_b0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10633-011-9296-8","article-title":"ISCEV standard for clinical multifocal electroretinography (mfERG)","volume":"124","author":"Hood","year":"2012","journal-title":"Doc. Ophthalmol."},{"key":"10.1016\/j.crtox.2025.100253_b0140","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.seizure.2022.01.011","article-title":"Eye disorders associated with newer antiepileptic drugs: a real-world disproportionality analysis of FDA adverse event reporting system","volume":"96","author":"Hu","year":"2022","journal-title":"Seizure"},{"key":"10.1016\/j.crtox.2025.100253_b0145","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1007\/s12264-023-01089-8","article-title":"A comprehensive overview of the neural mechanisms of light therapy","volume":"40","author":"Huang","year":"2024","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.crtox.2025.100253_b0160","doi-asserted-by":"crossref","first-page":"e30","DOI":"10.1017\/S2045796019000180","article-title":"The excess costs of depression: a systematic review and meta-analysis","volume":"29","author":"K\u00f6nig","year":"2019","journal-title":"Epidemiol. Psychiatr. Sci."},{"key":"10.1016\/j.crtox.2025.100253_b0165","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.neuroscience.2016.10.015","article-title":"Light-induced retinal damage using different light sources, protocols and rat strains reveals LED phototoxicity","volume":"339","author":"Krigel","year":"2016","journal-title":"Neuroscience"},{"key":"10.1016\/j.crtox.2025.100253_b0170","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1001\/jamapsychiatry.2015.2235","article-title":"Efficacy of bright light treatment, fluoxetine, and the combination in patients with nonseasonal major depressive disorder: a randomized clinical trial","volume":"73","author":"Lam","year":"2016","journal-title":"JAMA Psychiat."},{"key":"10.1016\/j.crtox.2025.100253_b0185","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.biopsych.2008.11.020","article-title":"Evidence of a biological effect of light therapy on the retina of patients with seasonal affective disorder","volume":"66","author":"Lavoie","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.crtox.2025.100253_b0190","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s12264-018-0210-1","article-title":"The antidepressant effect of light therapy from retinal projections","volume":"34","author":"Li","year":"2018","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.crtox.2025.100253_b0195","article-title":"Blue Light from cell phones can cause chronic retinal light injury: the evidence from a clinical observational study and a SD rat model","volume":"2021","author":"Li","year":"2021","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.crtox.2025.100253_b0205","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1016\/S0140-6736(18)31948-2","article-title":"Depression","volume":"392","author":"Malhi","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.crtox.2025.100253_b0210","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.1021\/acschemneuro.2c00420","article-title":"Schizophrenia, bipolar and major depressive disorders: overview of clinical features, neurotransmitter alterations, pharmacological interventions, and impact of oxidative stress in the disease process","volume":"13","author":"Mandal","year":"2022","journal-title":"ACS Chem. Nerosci."},{"key":"10.1016\/j.crtox.2025.100253_b0215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10633-014-9473-7","article-title":"ISCEV Standard for full-field clinical electroretinography (2015 update)","volume":"130","author":"McCulloch","year":"2015","journal-title":"Doc. Ophthalmol."},{"key":"10.1016\/j.crtox.2025.100253_b0220","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1001\/jamapsychiatry.2024.2871","article-title":"Bright light therapy for nonseasonal depressive disorders","volume":"82","author":"Menegaz de Almeida","year":"2025","journal-title":"JAMA Psychiat."},{"key":"10.1016\/j.crtox.2025.100253_b0230","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1177\/0706743720936470","article-title":"Quality of life impacts of bright light treatment, fluoxetine, and the combination in patients with nonseasonal major depressive disorder: a randomized clinical trial","volume":"66","author":"Morton","year":"2021","journal-title":"Can. J. Psychiatry"},{"key":"10.1016\/j.crtox.2025.100253_b0235","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jpsychires.2022.07.022","article-title":"Retinal markers of therapeutic responses in major depressive disorder: Effects of antidepressants on retinal function","volume":"154","author":"Moulard","year":"2022","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.crtox.2025.100253_b0240","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1016\/j.jcrs.2015.01.017","article-title":"Prevention of increased abnormal fundus autofluorescence with blue light\u2013filtering intraocular lenses","volume":"41","author":"Nagai","year":"2015","journal-title":"J. Cataract. Refract. Surg."},{"key":"10.1016\/j.crtox.2025.100253_b0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110577","article-title":"Mechanisms of blue light-induced eye hazard and protective measures: a review","volume":"130","author":"Ouyang","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.crtox.2025.100253_b0250","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0165-1781(93)90098-2","article-title":"Effects of phototherapy on electrooculographic ratio in winter seasonal affective disorder","volume":"49","author":"Ozaki","year":"1993","journal-title":"Psych. Res."},{"key":"10.1016\/j.crtox.2025.100253_b0260","article-title":"Ocular adverse effects of common psychotropic agents","volume":"501\u201326","author":"Richa","year":"2010","journal-title":"CNS Drugs"},{"key":"10.1016\/j.crtox.2025.100253_b0265","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s10633-022-09872-0","article-title":"ISCEV Standard for full-field clinical electroretinography (2022 update)","volume":"144","author":"Robson","year":"2022","journal-title":"Doc. Ophthalmol."},{"key":"10.1016\/j.crtox.2025.100253_b0270","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10633-017-9621-y","article-title":"ISCEV guide to visual electrodiagnostic procedures","volume":"136","author":"Robson","year":"2018","journal-title":"Doc. Ophthalmol."},{"key":"10.1016\/j.crtox.2025.100253_b0275","first-page":"876","article-title":"Influence of blue light on photoreceptors in a live retinal explant system","volume":"17","author":"Roehlecke","year":"2011","journal-title":"Mol. Vis."},{"key":"10.1016\/j.crtox.2025.100253_b0280","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1001\/archpsyc.1984.01790120076010","article-title":"Seasonal affective disorder: a description of the syndrome and preliminary findings with light therapy","volume":"41","author":"Rosenthal","year":"1984","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.crtox.2025.100253_b0285","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1001\/jamapsychiatry.2015.2688","article-title":"Association of mental disorders with subsequent chronic physical conditions: world mental health surveys from 17 countries","volume":"73","author":"Scott","year":"2016","journal-title":"JAMA Psychiat."},{"key":"10.1016\/j.crtox.2025.100253_b0290","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1177\/1477153513517255","article-title":"Effect of home-based light treatment on persons with dementia and their caregivers","volume":"47","author":"Sloane","year":"2015","journal-title":"Light. Res. Technol."},{"key":"10.1016\/j.crtox.2025.100253_b0300","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s10633-024-09970-1","article-title":"ISCEV standard for clinical pattern electroretinography (2024 update)","volume":"148","author":"Thompson","year":"2024","journal-title":"Doc. Ophthalmol."},{"key":"10.1016\/j.crtox.2025.100253_b0305","doi-asserted-by":"crossref","DOI":"10.63500\/mv_v22_61","article-title":"Effects of blue light on the circadian system and eye physiology","author":"Tosini","year":"2016","journal-title":"Mol. Vis."},{"key":"10.1016\/j.crtox.2025.100253_b0315","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/acps.13385","article-title":"Functional and cognitive impairment in the first episode of depression: a systematic review","volume":"145","author":"Varghese","year":"2022","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.crtox.2025.100253_b0325","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1038\/s41380-019-0595-x","article-title":"Depression and anxiety in relation to cancer incidence and mortality: a systematic review and meta-analysis of cohort studies","volume":"25","author":"Wang","year":"2020","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.crtox.2025.100253_b0330","doi-asserted-by":"crossref","first-page":"901","DOI":"10.2165\/00023210-200721110-00003","article-title":"Long-term and preventative treatment for seasonal affective disorder","volume":"21","author":"Westrin","year":"2007","journal-title":"CNS Drugs"},{"key":"10.1016\/j.crtox.2025.100253_b0335","unstructured":"World Health Organization, 2023. Depressive disorder (depression). Available at: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/depression (Accessed January 22, 2024)."},{"key":"10.1016\/j.crtox.2025.100253_b0340","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/nyas.15045","article-title":"REG1A protects retinal photoreceptors from blue light damage","volume":"1527","author":"Xu","year":"2023","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.crtox.2025.100253_b0345","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.37011","article-title":"Depressive symptoms and mortality among US adults","volume":"6","author":"Zhang","year":"2023","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.crtox.2025.100253_b0350","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1167\/iovs.17-23526","article-title":"A novel visual psychometric test for light-induced discomfort using red and blue light stimuli under binocular and monocular viewing conditions","volume":"59","author":"Zivcevska","year":"2018","journal-title":"Invest. Ophthalmol. vis. Sci."}],"container-title":["Current Research in Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666027X25000398?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666027X25000398?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T21:02:20Z","timestamp":1772917340000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666027X25000398"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":53,"alternative-id":["S2666027X25000398"],"URL":"https:\/\/doi.org\/10.1016\/j.crtox.2025.100253","relation":{},"ISSN":["2666-027X"],"issn-type":[{"value":"2666-027X","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of the impact of a 8\u00a0week exposure to a portable light therapy device, Luminette\u00ae, on retinal function assessed by ElectroRetinoGraphy","name":"articletitle","label":"Article Title"},{"value":"Current Research in Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.crtox.2025.100253","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100253"}}