{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T04:52:41Z","timestamp":1781671961870,"version":"3.54.5"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":67,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001501","name":"University Grants Commission","doi-asserted-by":"publisher","award":["31-227\/2005 (SR)"],"award-info":[{"award-number":["31-227\/2005 (SR)"]}],"id":[{"id":"10.13039\/501100001501","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Research in Toxicology"],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/j.crtox.2026.100289","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T17:17:51Z","timestamp":1773422271000},"page":"100289","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Low-dose arsenic exposure disrupts rat uterine physiology independent of generation of oxidative stress"],"prefix":"10.1016","volume":"10","author":[{"given":"Aniruddha","family":"Chatterjee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9317-5672","authenticated-orcid":false,"given":"Urmi","family":"Chatterji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.crtox.2026.100289_b0005","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0039-9140(02)00270-9","article-title":"Arsenic calamity in the Indian subcontinent what lessons have been learned?","volume":"58","author":"Chakraborti","year":"2002","journal-title":"Talanta"},{"key":"10.1016\/j.crtox.2026.100289_b0010","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/1477-7827-8-80","article-title":"Arsenic abrogates the estrogen-signaling pathway in the rat uterus","volume":"8","author":"Chatterjee","year":"2010","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.crtox.2026.100289_b0015","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.taap.2011.09.011","article-title":"All-trans retinoic acid protects against arsenic-induced uterine toxicity in female Sprague-Dawley rats","volume":"257","author":"Chatterjee","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.crtox.2026.100289_b0020","first-page":"1","article-title":"All-Trans Retinoic Acid ameliorates arsenic-induced oxidative stress and apoptosis in the rat uterus by modulating MAPK signaling proteins","volume":"9999","author":"Chatterjee","year":"2017","journal-title":"J. Cell. Biochem."},{"issue":"1","key":"10.1016\/j.crtox.2026.100289_b0025","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/jbt.20309","article-title":"The involvement of hypophyseal-gonadal and hypophyseal-adrenal axes in arsenic-mediated ovarian and uterine toxicity: modulation by hCG","volume":"24","author":"Chattopadhyay","year":"2010","journal-title":"J. Biochem. Mol. Toxicol."},{"issue":"1","key":"10.1016\/j.crtox.2026.100289_b0030","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1124\/mol.118.112268","article-title":"PI3K\/Akt\/mTOR signaling pathway and the biphasic effect of arsenic in carcinogenesis","volume":"94","author":"Chen","year":"2018","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.crtox.2026.100289_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113816","article-title":"Arsenic exposure diminishes ovarian follicular reserve and induces abnormal steroidogenesis by DNA methylation","volume":"241","author":"Chen","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"6","key":"10.1016\/j.crtox.2026.100289_b0040","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.3390\/ijms21061960","article-title":"The roles of cyclin-dependent kinases in cell-cycle progression and therapeutic strategies in human breast cancer","volume":"21","author":"Ding","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.crtox.2026.100289_b0045","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1002\/jcp.22397","article-title":"Arsenic trioxide induces apoptosis through JNK and ERK in human mesothelioma cells","volume":"226","author":"Eguchi","year":"2011","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.crtox.2026.100289_b0050","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/s41418-022-00988-z","article-title":"Cell cycle regulation: p53-p21-RB signaling","volume":"29","author":"Engeland","year":"2022","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.crtox.2026.100289_b0055","article-title":"Arsenic as an environmental and human health antagonist: a review of its toxicity and disease initiation","volume":"5","author":"Fatoki","year":"2022","journal-title":"J. Hazard. Mat. Advance."},{"key":"10.1016\/j.crtox.2026.100289_b0060","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.cell.2017.07.029","article-title":"The PI3K pathway in human disease","volume":"170","author":"Fruman","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.crtox.2026.100289_b0065","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/bs.apcsb.2019.01.001","article-title":"Estrogen receptor signaling mechanisms","volume":"116","author":"Fuentes","year":"2019","journal-title":"Adv. Protein Chem. Struct. Biol."},{"issue":"1","key":"10.1016\/j.crtox.2026.100289_b0070","doi-asserted-by":"crossref","DOI":"10.1093\/toxres\/tfad111","article-title":"Arsenic toxicity: sources, pathophysiology and mechanism","volume":"13","author":"Ganie","year":"2023","journal-title":"Toxicol. Res."},{"key":"10.1016\/j.crtox.2026.100289_b0075","series-title":"Updates on Cancer Treatment","article-title":"Targeting the PI3K\/AKT\/mTOR pathway in cancer cells","author":"Guimaraes","year":"2015"},{"issue":"1","key":"10.1016\/j.crtox.2026.100289_b0080","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/s41392-021-00828-5","article-title":"Targeting PI3K\/Akt signal transduction for cancer therapy","volume":"6","author":"He","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"issue":"2","key":"10.1016\/j.crtox.2026.100289_b0085","first-page":"240","article-title":"The role of reactive oxygen species in arsenic toxicity","volume":"10","author":"Hu","year":"2020","journal-title":"Biomol"},{"key":"10.1016\/j.crtox.2026.100289_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2019.124647","article-title":"Arsenic-induced immunomodulatory effects disorient the survival-death interface by stabilizing the Hsp90\/Beclin1 interaction","volume":"238","author":"Jamal","year":"2020","journal-title":"Chemosphere"},{"key":"10.1016\/j.crtox.2026.100289_b0095","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1016\/j.cellsig.2008.03.013","article-title":"Myostatin induces p300 degradation to silence cyclin D1 expression through the PI3K\/PTEN\/Akt pathway","volume":"20","author":"Ji","year":"2008","journal-title":"Cell. Signal."},{"issue":"3","key":"10.1016\/j.crtox.2026.100289_b0100","doi-asserted-by":"crossref","first-page":"3260","DOI":"10.1002\/cam4.5068","article-title":"Arsenic compounds activate MAPK and inhibit Akt pathways to induce apoptosis in MA-10 mouse Leydig tumor cells","volume":"12","author":"Juan","year":"2023","journal-title":"Cancer Med."},{"key":"10.1016\/j.crtox.2026.100289_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2021.152768","article-title":"A review of low-dose arsenic risks and human cancers","volume":"456","author":"Lamm","year":"2021","journal-title":"Toxicol"},{"key":"10.1016\/j.crtox.2026.100289_b0110","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/nature13079","article-title":"Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus","volume":"508","author":"Liu","year":"2014","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.crtox.2026.100289_b0115","article-title":"Low-Concentration Arsenic Trioxide Inhibits Skeletal Myoblast Cell Proliferation via a Reactive Oxygen Species-Independent Pathway","volume":"10","author":"Liu","year":"2015","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.crtox.2026.100289_b0120","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1038\/s41416-023-02468-8","article-title":"The Cyclin-dependent kinase 1: more than a cell cycle regulator","volume":"129","author":"Massacci","year":"2023","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.crtox.2026.100289_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.111752","article-title":"Different mechanisms of arsenic related signaling in cellular proliferation, apoptosis and neo-plastic transformation","volume":"208","author":"Medda","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"2","key":"10.1016\/j.crtox.2026.100289_b0130","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"simple practice guide for dose conversion between animals and human","volume":"7","author":"Nair","year":"2016","journal-title":"J Basic Clin Pharm."},{"issue":"6","key":"10.1016\/j.crtox.2026.100289_b0135","first-page":"2319","article-title":"The Akt pathway in oncology therapy and beyond","volume":"53","author":"Nitulescu","year":"2018","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.crtox.2026.100289_b0140","doi-asserted-by":"crossref","unstructured":"Pellarin, I., Dall\u2019Acqua, A., Favero, A., Segatto,I., Rossi,V., Crestan, N., et al., 2025. Cyclin-dependent protein kinases and cell cycle regulation in biology and disease.Sig. Transduct. Target. Ther. 10,11.","DOI":"10.1038\/s41392-024-02080-z"},{"issue":"11","key":"10.1016\/j.crtox.2026.100289_b0145","first-page":"64","article-title":"Electrozymographic evaluation of the attenuation of arsenic induced degradation of hepatic SOD, catalase in an in vitro assay system by pectic polysaccharides ofMomordicacharantiain combination with curcumin","volume":"23","author":"Perveen","year":"2017","journal-title":"Biochem. Biophys. Rep."},{"key":"10.1016\/j.crtox.2026.100289_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijheh.2021.113883","article-title":"Is living in a region with high groundwater arsenic contamination associated with adverse reproductive health outcomes? an analysis using nationally representative data from India","volume":"239","author":"Pinchoff","year":"2022","journal-title":"Int. J. Hyg. Environ. Health"},{"issue":"6493","key":"10.1016\/j.crtox.2026.100289_b0155","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1126\/science.aba1510","article-title":"Global threat of arsenic in groundwater","volume":"20368","author":"Podgorski","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.crtox.2026.100289_b0160","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.cbi.2015.06.040","article-title":"Arsenic-induced S phase cell cycle lengthening is associated with ROS generation, p53 signaling and CDC25A expression","volume":"238","author":"Pozo-Molina","year":"2015","journal-title":"Chemico. Biol. Interact."},{"key":"10.1016\/j.crtox.2026.100289_b0165","doi-asserted-by":"crossref","unstructured":"Redondo-Mu\u00f1oz, J., Escobar-D\u00edaz, E., Hern\u00e1ndez, Del Cerro. M., Pandiella. A., Terol, M.J., Garc\u00eda-Marco, J.A., and Garc\u00eda-Pardo, A., 2010. Induction of B-chronic lymphocytic leukemia cell apoptosis by arsenic trioxide involves suppression of the phosphoinositide 3-kinase\/Akt survival pathway via c-jun-NH2 terminal kinase activation and PTEN upregulation. Clin. Cancer. Res.16,4382\u20134391.","DOI":"10.1158\/1078-0432.CCR-10-0072"},{"issue":"1","key":"10.1016\/j.crtox.2026.100289_b0170","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1289\/ehp.1002114","article-title":"An Emerging Role for Epigenetic Dysregulation in Arsenic Toxicity and Carcinogenesis","volume":"119","author":"Ren","year":"2011","journal-title":"Environ. Health Perspect."},{"issue":"10","key":"10.1016\/j.crtox.2026.100289_b0180","doi-asserted-by":"crossref","first-page":"7769","DOI":"10.1021\/cr300015c","article-title":"Arsenic Binding to Proteins","volume":"113","author":"Shen","year":"2013","journal-title":"Chem. Rev."},{"issue":"1\u20132","key":"10.1016\/j.crtox.2026.100289_b0185","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1023\/B:MCBI.0000007262.26044.e8","article-title":"Oxidative mechanism of arsenic toxicity and carcinogenesis","volume":"255","author":"Shi","year":"2004","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.crtox.2026.100289_b0190","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/817693","article-title":"In Vivo effect of Arsenic Trioxide on Keap1-p62-Nrf2 Signaling Pathway in Mouse Liver: Expression of Antioxidant Responsive Element-Driven Genes Related to Glutathione Metabolism","volume":"2013","author":"Srivastava","year":"2013","journal-title":"ISRN. Hepatol."},{"issue":"10","key":"10.1016\/j.crtox.2026.100289_b0195","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1289\/ehp.1103441","article-title":"Arsenic toxicology: translating between experimental models and human pathology","volume":"119","author":"States","year":"2011","journal-title":"Environ. Health Perspect."},{"issue":"2","key":"10.1016\/j.crtox.2026.100289_b0200","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1080\/15384101.2019.1706903","article-title":"The double dealing of cyclin D1","volume":"19","author":"Tchakarska","year":"2020","journal-title":"Cell Cycle"},{"issue":"5","key":"10.1016\/j.crtox.2026.100289_b0205","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1080\/10915810600840776","article-title":"Reproductive and Developmental Toxicity of Arsenic in Rodents: a Review","volume":"25","author":"Wang","year":"2006","journal-title":"Int. J. Toxicol."},{"key":"10.1016\/j.crtox.2026.100289_b0210","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1002\/jcb.20329","article-title":"Diarsenic and tetraarsenic oxide inhibit cell cycle progression and FGF- and VEGF-induced proliferation of human endothelial cells","volume":"95","author":"Woo","year":"2005","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.crtox.2026.100289_b0215","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/951724","article-title":"Akt: a double-edged sword in cell proliferation and genome stability","volume":"2012","author":"Xu","year":"2012","journal-title":"J. Oncol."},{"issue":"6","key":"10.1016\/j.crtox.2026.100289_b0220","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.01921-23","article-title":"Forsythoside a inhibits apoptosis and autophagy induced by infectious bronchitis virus through regulation of the PI3K\/Akt\/NF-\u03baB pathway","volume":"11","author":"Xu","year":"2023","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.crtox.2026.100289_b0225","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1007\/s00204-012-0864-9","article-title":"Arsenic induces apoptosis in myoblasts through a reactive oxygen species-induced endoplasmic reticulum stress and mitochondrial dysfunction pathway","volume":"86","author":"Yen","year":"2012","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.crtox.2026.100289_b0230","first-page":"6346","article-title":"Arsenite induces p53 accumulation through an ATM-dependent pathway in human fibroblasts","volume":"60","author":"Yih","year":"2000","journal-title":"Cancer Res."}],"container-title":["Current Research in Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666027X26000101?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666027X26000101?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T04:03:34Z","timestamp":1781669014000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666027X26000101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":45,"alternative-id":["S2666027X26000101"],"URL":"https:\/\/doi.org\/10.1016\/j.crtox.2026.100289","relation":{},"ISSN":["2666-027X"],"issn-type":[{"value":"2666-027X","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Low-dose arsenic exposure disrupts rat uterine physiology independent of generation of oxidative stress","name":"articletitle","label":"Article Title"},{"value":"Current Research in Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.crtox.2026.100289","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100289"}}