{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:43:28Z","timestamp":1793108608070,"version":"4.5.0"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":141,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012326","name":"International Science and Technology Cooperation Programme","doi-asserted-by":"publisher","award":["LHGJ20250391"],"award-info":[{"award-number":["LHGJ20250391"]}],"id":[{"id":"10.13039\/501100012326","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012326","name":"International Science and Technology Cooperation Programme","doi-asserted-by":"publisher","award":["252102520089"],"award-info":[{"award-number":["252102520089"]}],"id":[{"id":"10.13039\/501100012326","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004605","name":"Zhengzhou University","doi-asserted-by":"publisher","award":["YQ2024001"],"award-info":[{"award-number":["YQ2024001"]}],"id":[{"id":"10.13039\/501100004605","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004605","name":"Zhengzhou University","doi-asserted-by":"publisher","award":["LHGJ20250392"],"award-info":[{"award-number":["LHGJ20250392"]}],"id":[{"id":"10.13039\/501100004605","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Current Research in Toxicology"],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/j.crtox.2026.100301","type":"journal-article","created":{"date-parts":[[2026,5,23]],"date-time":"2026-05-23T15:49:40Z","timestamp":1779551380000},"page":"100301","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Exposure to calcium stearyl lactylate induces hepatointestinal toxicity and gut microbiota dysbiosis in mice"],"prefix":"10.1016","volume":"10","author":[{"given":"Chunjing","family":"Qiu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxu","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengya","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ihtisham","family":"Bukhari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feifei","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuexiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengyuan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Mi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.crtox.2026.100301_bb0005","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.jhep.2023.02.034","article-title":"The exposome and liver disease - how environmental factors affect liver health","volume":"79","author":"Barouki","year":"2023","journal-title":"J. Hepatol."},{"key":"10.1016\/j.crtox.2026.100301_bb0010","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1146\/annurev-food-030117-012405","article-title":"Formation, structure, and functionality of interfacial layers in food emulsions","volume":"9","author":"Berton-Carabin","year":"2018","journal-title":"Annu. Rev. Food Sci. Technol."},{"issue":"1","key":"10.1016\/j.crtox.2026.100301_bb0015","doi-asserted-by":"crossref","DOI":"10.3390\/nu17010002","article-title":"Ultra-processed food and gut microbiota: do additives affect eubiosis? A narrative review","volume":"17","author":"Bevilacqua","year":"2024","journal-title":"Nutrients"},{"issue":"12","key":"10.1016\/j.crtox.2026.100301_bb0020","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/s41574-020-00427-4","article-title":"Circadian rhythms and the gut microbiota: from the metabolic syndrome to cancer","volume":"16","author":"Bishehsari","year":"2020","journal-title":"Nat. Rev. Endocrinol."},{"issue":"5","key":"10.1016\/j.crtox.2026.100301_bb0025","doi-asserted-by":"crossref","first-page":"411","DOI":"10.3920\/BM2020.0057","article-title":"Short chain fatty acids in human gut and metabolic health","volume":"11","author":"Blaak","year":"2020","journal-title":"Benefic. Microbes"},{"issue":"11","key":"10.1016\/j.crtox.2026.100301_bb0030","doi-asserted-by":"crossref","first-page":"6022","DOI":"10.3390\/ijms25116022","article-title":"Effects of probiotics on gut microbiota: an overview","volume":"25","author":"Chandrasekaran","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.crtox.2026.100301_bb0035","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1053\/j.gastro.2021.11.006","article-title":"Randomized controlled-feeding study of dietary emulsifier carboxymethylcellulose reveals detrimental impacts on the gut microbiota and metabolome","volume":"162","author":"Chassaing","year":"2022","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.crtox.2026.100301_bb0040","doi-asserted-by":"crossref","DOI":"10.1128\/Spectrum.00483-21","article-title":"Effect of long-term and short-term imbalanced Zn manipulation on gut microbiota and screening for microbial markers sensitive to zinc status","volume":"9","author":"Chen","year":"2021","journal-title":"Microbiol. Spectrum"},{"issue":"20","key":"10.1016\/j.crtox.2026.100301_bb0045","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1042\/CS20190654","article-title":"The immune niche of the liver","volume":"135","author":"Cheng","year":"2021","journal-title":"Clin. Sci. (Lond.)"},{"issue":"9","key":"10.1016\/j.crtox.2026.100301_bb0050","doi-asserted-by":"crossref","DOI":"10.3390\/toxics9090215","article-title":"Subacute exposure to an environmentally relevant dose of Di-(2-ethylhexyl) phthalate during gestation alters the cecal microbiome, but not pregnancy outcomes in mice","volume":"9","author":"Chiu","year":"2021","journal-title":"Toxics"},{"issue":"6","key":"10.1016\/j.crtox.2026.100301_bb0055","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1093\/nutrit\/nuaa038","article-title":"Food additive emulsifiers: a review of their role in foods, legislation and classifications, presence in food supply, dietary exposure, and safety assessment","volume":"79","author":"Cox","year":"2021","journal-title":"Nutr. Rev."},{"issue":"12","key":"10.1016\/j.crtox.2026.100301_bb0060","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1093\/eurjpc\/zwad171","article-title":"Causal relationships between the gut microbiome, blood lipids, and heart failure: a mendelian randomization analysis","volume":"30","author":"Dai","year":"2023","journal-title":"Eur. J. Prev. Cardiol."},{"issue":"5","key":"10.1016\/j.crtox.2026.100301_bb0065","doi-asserted-by":"crossref","DOI":"10.1128\/mSystems.00065-17","article-title":"Functional changes in the gut microbiome contribute to transforming growth factor \u03b2-deficient Colon Cancer","volume":"2","author":"Daniel","year":"2017","journal-title":"mSystems"},{"key":"10.1016\/j.crtox.2026.100301_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2018.12.012","article-title":"Chronic stress-induced gut dysfunction exacerbates Parkinson\u2019s disease phenotype and pathology in a rotenone-induced mouse model of Parkinson\u2019s disease","volume":"135","author":"Dodiya","year":"2020","journal-title":"Neurobiol. Dis."},{"issue":"21","key":"10.1016\/j.crtox.2026.100301_bb0075","doi-asserted-by":"crossref","first-page":"10938","DOI":"10.1039\/D1FO02255E","article-title":"Effects of oral milk extracellular vesicles on the gut microbiome and serum metabolome in mice","volume":"12","author":"Du","year":"2021","journal-title":"Food Funct."},{"key":"10.1016\/j.crtox.2026.100301_bb0080","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.662807","article-title":"Exploring the gut-brain Axis for the control of CNS inflammatory demyelination: immunomodulation by Bacteroides fragilis\u2019 polysaccharide a","volume":"12","author":"Erturk-Hasdemir","year":"2021","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.crtox.2026.100301_bb0085","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/jgh.14808","article-title":"Dietary emulsifier polysorbate-80-induced small-intestinal vulnerability to indomethacin-induced lesions via dysbiosis","volume":"35","author":"Furuhashi","year":"2020","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"2","key":"10.1016\/j.crtox.2026.100301_bb0090","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0966-842X(99)01671-6","article-title":"Pseudomonas: global bacteria","volume":"8","author":"Goldberg","year":"2000","journal-title":"Trends Microbiol."},{"issue":"12","key":"10.1016\/j.crtox.2026.100301_bb0095","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1007\/s10482-020-01474-7","article-title":"Human gut microbiota\/microbiome in health and diseases: a review","volume":"113","author":"Gomaa","year":"2020","journal-title":"Antonie Van Leeuwenhoek"},{"issue":"27","key":"10.1016\/j.crtox.2026.100301_bb0100","doi-asserted-by":"crossref","first-page":"7619","DOI":"10.1021\/acs.jafc.1c01781","article-title":"Protective effects of microbiome-derived inosine on lipopolysaccharide-induced acute liver damage and inflammation in mice via mediating the TLR4\/NF-\u03baB pathway","volume":"69","author":"Guo","year":"2021","journal-title":"J. Agric. Food Chem."},{"issue":"11","key":"10.1016\/j.crtox.2026.100301_bb0105","doi-asserted-by":"crossref","first-page":"4264","DOI":"10.1210\/jc.2015-2279","article-title":"Impact of phosphorus-based food additives on bone and mineral metabolism","volume":"100","author":"Gutierrez","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.crtox.2026.100301_bb0110","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/apt.15045","article-title":"Review article: emulsifiers in the food supply and implications for gastrointestinal disease","volume":"49","author":"Halmos","year":"2019","journal-title":"Aliment. Pharmacol. Ther."},{"issue":"23","key":"10.1016\/j.crtox.2026.100301_bb0115","doi-asserted-by":"crossref","DOI":"10.3390\/nu14234983","article-title":"Dietary emulsifiers exacerbate food allergy and colonic type 2 immune response through microbiota modulation","volume":"14","author":"Harusato","year":"2022","journal-title":"Nutrients"},{"issue":"4","key":"10.1016\/j.crtox.2026.100301_bb0120","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s00430-021-00702-9","article-title":"The human symbiont Mucispirillum schaedleri: causality in health and disease","volume":"210","author":"Herp","year":"2021","journal-title":"Med. Microbiol. Immunol."},{"key":"10.1016\/j.crtox.2026.100301_bb0125","doi-asserted-by":"crossref","DOI":"10.3390\/nu11071613","article-title":"Gut microbiome: profound implications for diet and disease","volume":"11","author":"Hills","year":"2019","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.crtox.2026.100301_bb0130","doi-asserted-by":"crossref","DOI":"10.1186\/s40168-016-0173-2","article-title":"Effect of postnatal low-dose exposure to environmental chemicals on the gut microbiome in a rodent model","volume":"4","author":"Hu","year":"2016","journal-title":"Microbiome"},{"issue":"1","key":"10.1016\/j.crtox.2026.100301_bb0135","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s40168-022-01227-w","article-title":"Lactobacillus murinus alleviate intestinal ischemia\/reperfusion injury through promoting the release of interleukin-10 from M2 macrophages via toll-like receptor 2 signaling","volume":"10","author":"Hu","year":"2022","journal-title":"Microbiome"},{"key":"10.1016\/j.crtox.2026.100301_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2024.105482","article-title":"Microbiome and metabolomics reveal the effect of gut microbiota on liver regeneration of fatty liver disease","volume":"111","author":"Hu","year":"2025","journal-title":"EBioMedicine"},{"key":"10.1016\/j.crtox.2026.100301_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155873","article-title":"Paeoniae decoction restores intestinal barrier dysfunction by promoting the interaction between ILC3 and gut flora","volume":"132","author":"Huang","year":"2024","journal-title":"Phytomedicine"},{"issue":"29","key":"10.1016\/j.crtox.2026.100301_bb0150","doi-asserted-by":"crossref","first-page":"8787","DOI":"10.3748\/wjg.v21.i29.8787","article-title":"Role of the normal gut microbiota","volume":"21","author":"Jandhyala","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.crtox.2026.100301_bb0155","first-page":"1","article-title":"Effects of environmental pollutants on gut microbiota","volume":"222","author":"Jin","year":"2017","journal-title":"EnvironPollut"},{"issue":"2","key":"10.1016\/j.crtox.2026.100301_bb0160","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.chom.2023.12.015","article-title":"A gut microbiota-bile acid axis promotes intestinal homeostasis upon aspirin-mediated damage","volume":"32","author":"Li","year":"2024","journal-title":"Cell Host Microbe"},{"issue":"1","key":"10.1016\/j.crtox.2026.100301_bb0165","doi-asserted-by":"crossref","DOI":"10.1186\/s12866-025-03849-0","article-title":"Full-length 16S rRNA sequencing reveals gut microbiome signatures predictive of MASLD in children with obesity","volume":"25","author":"Lin","year":"2025","journal-title":"BMC Microbiol."},{"issue":"52","key":"10.1016\/j.crtox.2026.100301_bb0170","doi-asserted-by":"crossref","first-page":"26717","DOI":"10.1073\/pnas.1915043116","article-title":"Neutralization of IL-1\u03b1 ameliorates Crohn\u2019s disease-like ileitis by functional alterations of the gut microbiome","volume":"116","author":"Menghini","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"7","key":"10.1016\/j.crtox.2026.100301_bb0175","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1016\/j.immuni.2025.05.024","article-title":"Diet-derived LPS determines intestinal IgA induction and repertoire characteristics independently of the microbiota","volume":"58","author":"Mooser","year":"2025","journal-title":"Immunity"},{"issue":"6","key":"10.1016\/j.crtox.2026.100301_bb0180","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S2468-1253(24)00390-X","article-title":"The intestinal barrier: a pivotal role in health, inflammation, and cancer","volume":"10","author":"Neurath","year":"2025","journal-title":"Lancet Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.crtox.2026.100301_bb0185","doi-asserted-by":"crossref","DOI":"10.3390\/cells12010089","article-title":"Desulfovibrio fairfieldensis-derived outer membrane vesicles damage epithelial barrier and induce inflammation and pyroptosis in macrophages","volume":"12","author":"Nie","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.crtox.2026.100301_bb0190","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jtcme.2021.09.006","article-title":"Modulation of gut microbiota by foods and herbs to prevent cardiovascular diseases","volume":"13","author":"Panyod","year":"2023","journal-title":"J. Tradit. Complement. Med."},{"issue":"1","key":"10.1016\/j.crtox.2026.100301_bb0195","doi-asserted-by":"crossref","DOI":"10.1038\/s42003-024-06224-3","article-title":"Common dietary emulsifiers promote metabolic disorders and intestinal microbiota dysbiosis in mice","volume":"7","author":"Panyod","year":"2024","journal-title":"Commun. Biol."},{"issue":"1","key":"10.1016\/j.crtox.2026.100301_bb0200","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0015-6264(81)90296-0","article-title":"Studies on the metabolism of calcium stearoyl-2-lactylate in the rat, mouse, guinea-pig and man","volume":"19","author":"Phillips","year":"1981","journal-title":"Food Cosmet. Toxicol."},{"issue":"5","key":"10.1016\/j.crtox.2026.100301_bb0205","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1177\/10915818241255885","article-title":"Exploring greater flexibility for chronic toxicity study designs to support human safety assessment while balancing 3Rs considerations","volume":"43","author":"Prior","year":"2024","journal-title":"Int. J. Toxicol."},{"issue":"Suppl. 1","key":"10.1016\/j.crtox.2026.100301_bb0210","article-title":"Review - Helicobacter, inflammation, immunology and vaccines","volume":"25","author":"Robinson","year":"2020","journal-title":"Helicobacter"},{"issue":"10","key":"10.1016\/j.crtox.2026.100301_bb0215","doi-asserted-by":"crossref","DOI":"10.3390\/nu13103565","article-title":"The emulsifier carboxymethylcellulose induces more aggressive colitis in humanized mice with inflammatory bowel disease microbiota than Polysorbate-80","volume":"13","author":"Rousta","year":"2021","journal-title":"Nutrients"},{"issue":"5","key":"10.1016\/j.crtox.2026.100301_bb0220","doi-asserted-by":"crossref","first-page":"54003","DOI":"10.1289\/EHP14923","article-title":"Nanosized additives: silicon dioxide's potential role in development of food sensitivities in mice","volume":"132","author":"Schmidt","year":"2024","journal-title":"Environ. Health Perspect."},{"issue":"13","key":"10.1016\/j.crtox.2026.100301_bb0225","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202500737R","article-title":"Food additives: emerging detrimental roles on gut health","volume":"39","author":"Seto","year":"2025","journal-title":"FASEB J."},{"issue":"13","key":"10.1016\/j.crtox.2026.100301_bb0230","doi-asserted-by":"crossref","DOI":"10.3390\/nu17132120","article-title":"Industrial bread composition: potential implications for patients with inflammatory bowel disease","volume":"17","author":"Shakhman","year":"2025","journal-title":"Nutrients"},{"issue":"8","key":"10.1016\/j.crtox.2026.100301_bb0235","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/j.chom.2024.06.008","article-title":"Dietary fiber alleviates alcoholic liver injury via Bacteroides acidifaciens and subsequent ammonia detoxification","volume":"32","author":"Shen","year":"2024","journal-title":"Cell Host Microbe"},{"issue":"7","key":"10.1016\/j.crtox.2026.100301_bb0240","doi-asserted-by":"crossref","DOI":"10.1007\/s00284-024-03694-w","article-title":"Microbiota and gut-liver axis: an unbreakable bond?","volume":"81","author":"Sivaprasadan","year":"2024","journal-title":"Curr. Microbiol."},{"issue":"6","key":"10.1016\/j.crtox.2026.100301_bb0245","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1016\/j.jhep.2023.07.005","article-title":"Bifidobacterium pseudolongum-generated acetate suppresses non-alcoholic fatty liver disease-associated hepatocellular carcinoma","volume":"79","author":"Song","year":"2023","journal-title":"J. Hepatol."},{"issue":"14","key":"10.1016\/j.crtox.2026.100301_bb0250","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.2174\/1568026623666230117122433","article-title":"Food color additives in hazardous consequences of human health: an overview","volume":"23","author":"Sultana","year":"2023","journal-title":"Curr. Top. Med. Chem."},{"issue":"2","key":"10.1016\/j.crtox.2026.100301_bb0255","doi-asserted-by":"crossref","DOI":"10.1128\/msystems.00100-22","article-title":"Bifidobacterium lactis Probio-M8 adjuvant treatment confers added benefits to patients with coronary artery disease via target modulation of the gut-heart\/-brain axes","volume":"7","author":"Sun","year":"2022","journal-title":"mSystems"},{"issue":"2","key":"10.1016\/j.crtox.2026.100301_bb0260","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.chom.2018.06.017","article-title":"\u03b1-Toxin induces platelet aggregation and liver injury during Staphylococcus aureus sepsis","volume":"24","author":"Surewaard","year":"2018","journal-title":"Cell Host Microbe"},{"issue":"1","key":"10.1016\/j.crtox.2026.100301_bb0265","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s12929-021-00711-z","article-title":"Gut microbiota-mediated lysophosphatidylcholine generation promotes colitis in intestinal epithelium-specific Fut2 deficiency","volume":"28","author":"Tang","year":"2021","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.crtox.2026.100301_bb0270","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2019.00221","article-title":"Lactobacillus plantarum TW1-1 alleviates Diethylhexyl-phthalate induced testicular damage in mice by modulating gut microbiota and decreasing Inflam mation","volume":"9","author":"Tian","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"1","key":"10.1016\/j.crtox.2026.100301_bb0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108229","article-title":"Dietary emulsifiers directly impact adherent-invasive E. coli gene expression to drive chronic intestinal inflammation","volume":"33","author":"Viennois","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.crtox.2026.100301_bb0280","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/s41430-021-00991-6","article-title":"Role of the gut microbiome in chronic diseases: a narrative review","volume":"76","author":"Vijay","year":"2022","journal-title":"Eur. J. Clin. Nutr."},{"issue":"2","key":"10.1016\/j.crtox.2026.100301_bb0285","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00889-14","article-title":"Revealing the bacterial butyrate synthesis pathways by analyzing (meta)genomic data","volume":"5","author":"Vital","year":"2014","journal-title":"mBio"},{"issue":"6","key":"10.1016\/j.crtox.2026.100301_bb0290","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/s41575-024-00893-5","article-title":"Ultra-processed foods and food additives in gut health and disease","volume":"21","author":"Whelan","year":"2024","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.crtox.2026.100301_bb0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.anaerobe.2024.102918","article-title":"Butyricimonas paravirosa bacteremia associated with acute terminal ileitis: case report and literature review","volume":"90","author":"Whitehill","year":"2024","journal-title":"Anaerobe"},{"issue":"1","key":"10.1016\/j.crtox.2026.100301_bb0300","doi-asserted-by":"crossref","DOI":"10.1186\/s12967-023-04335-9","article-title":"Identification of host gene-microbiome associations in colorectal cancer patients using mendelian randomization","volume":"21","author":"Xiang","year":"2023","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.crtox.2026.100301_bb0305","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2020.127959","article-title":"DEHP induce cholesterol imbalance via disturbing bile acid metabolism by altering the composition of gut microbiota in rats","volume":"263","author":"Yu","year":"2021","journal-title":"Chemosphere"},{"issue":"71","key":"10.1016\/j.crtox.2026.100301_bb0310","doi-asserted-by":"crossref","first-page":"43619","DOI":"10.1039\/D0RA07502G","article-title":"Gut microbiota-mediated tributyltin-induced metabolic disorder in rats","volume":"10","author":"Yuan","year":"2020","journal-title":"RSC Adv."},{"issue":"48","key":"10.1016\/j.crtox.2026.100301_bb0315","doi-asserted-by":"crossref","first-page":"12706","DOI":"10.1021\/acs.jafc.8b05036","article-title":"Effects of dietary Fiber supplementation on fatty acid metabolism and intestinal microbiota diversity in C57BL\/6J mice fed with a high-fat diet","volume":"66","author":"Zhai","year":"2018","journal-title":"J. Agric. Food Chem."},{"issue":"34","key":"10.1016\/j.crtox.2026.100301_bb0320","article-title":"Melatonin ameliorates depressive-like Behaviors in ovariectomized mice by improving tryptophan metabolism via inhibition of gut microbe Alistipes Inops","volume":"11","author":"Zheng","year":"2024","journal-title":"Adv. Sci. (Weinh)."}],"container-title":["Current Research in Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666027X26000228?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666027X26000228?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T06:16:46Z","timestamp":1783059406000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666027X26000228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":64,"alternative-id":["S2666027X26000228"],"URL":"https:\/\/doi.org\/10.1016\/j.crtox.2026.100301","relation":{},"ISSN":["2666-027X"],"issn-type":[{"value":"2666-027X","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exposure to calcium stearyl lactylate induces hepatointestinal toxicity and gut microbiota dysbiosis in mice","name":"articletitle","label":"Article Title"},{"value":"Current Research in Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.crtox.2026.100301","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100301"}}