{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T19:15:24Z","timestamp":1774984524519,"version":"3.50.1"},"reference-count":34,"publisher":"MathDoc\/Centre Mersenne","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>La glucose 6-phosphate d\u00e9shydrog\u00e9nase (G6PD) catalyse la premi\u00e8re \u00e9tape de la voie des pentoses et permet, dans le globule rouge, la r\u00e9duction du NADP en NADPH, coenzyme essentiel \u00e0 la lutte contre les agressions oxydantes. \u00c0 travers le monde, le d\u00e9ficit en G6PD concerne plus de 400 millions de personnes, de sexe masculin pour plus de 90 %. Il se superpose \u00e0 la carte de l'end\u00e9mie palustre et se retrouve, bien entendu, dans toutes les populations originaires de ces r\u00e9gions. Les globules rouges d\u00e9ficitaires sont particuli\u00e8rement sensibles aux stress oxydants. Ce d\u00e9ficit prot\u00e8ge contre les formes graves de paludisme en offrant un milieu d\u00e9favorable au d\u00e9veloppement d'un parasite, lui-m\u00eame tr\u00e8s sensible aux oxydants. La contrepartie de cet avantage est un risque h\u00e9molytique accru en r\u00e9ponse \u00e0 de multiples agents oxydo-r\u00e9ducteurs. Parmi ces derniers, citons les glycosides contenus dans les f\u00e8ves (favisme) et certains m\u00e9dicaments (sulfamides, anti-palud\u00e9ens, etc.). La coexistence, dans une m\u00eame r\u00e9gion g\u00e9ographique, d'une parasitose, d'une mutation protectrice, et de traditions (alimentaires ou culturelles) pose le probl\u00e8me d'\u00e9volutions convergentes. On conna\u00eet aujourd'hui environ 150 variantes de G6PD class\u00e9es en quatre types selon leurs effets cliniques. Un petit nombre d'entre elles, comme la G6PD A\u2013 en Afrique ou la variante m\u00e9diterran\u00e9enne sont de v\u00e9ritables polymorphismes dans les r\u00e9gions impalud\u00e9es. La connaissance de la structure tridimensionnelle de la prot\u00e9ine permet de formuler des hypoth\u00e8ses expliquant les d\u00e9ficits en termes de relations structure\u2013fonction.<\/jats:p>","DOI":"10.1016\/j.crvi.2004.07.010","type":"journal-article","created":{"date-parts":[[2004,8,17]],"date-time":"2004-08-17T09:09:08Z","timestamp":1092733748000},"page":"711-720","source":"Crossref","is-referenced-by-count":30,"title":["Le d\u00e9ficit en glucose-6 phosphate d\u00e9shydrog\u00e9nase : protection contre le paludisme et risque d'accidents h\u00e9molytiques"],"prefix":"10.5802","volume":"327","author":[{"given":"Henri","family":"Wajcman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Galact\u00e9ros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3842","published-online":{"date-parts":[[2004,8,1]]},"reference":[{"key":"key2025102316253884440_1","first-page":"17","article-title":"Favism \u2013 from the \u2018avoid fava beans\u2019 of Pythagoras to the present","volume":"7","author":"Meletis, J.","year":"2004","unstructured":"[1] Meletis, J.; Konstantopoulos, K. 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