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Nevertheless, biological studies on the effects of mutations in the four known genes has led to the conclusion that all of these genes cause dysregulation of amyloid precursor protein processing and in particular dysregulation of the handling of a proteolytic derivative termed A\u03b2. The accumulation of A\u03b2 appears to be an early and initiating event that triggers a series of downstream processes including misprocessing of the tau protein. This cascade ultimately causes neuronal dysfunction and death, and leads to the clinical and pathological features of Alzheimer's disease. Knowledge of this biochemical cascade now provides several potential targets for the development of diagnostics and therapeutics.<\/jats:p>","DOI":"10.1016\/j.crvi.2004.10.013","type":"journal-article","created":{"date-parts":[[2005,1,5]],"date-time":"2005-01-05T07:29:50Z","timestamp":1104910190000},"page":"119-130","source":"Crossref","is-referenced-by-count":136,"title":["Molecular biology and genetics of Alzheimer's disease"],"prefix":"10.5802","volume":"328","author":[{"given":"Peter H.","family":"St George-Hyslop","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agn\u00e8s","family":"Petit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3842","published-online":{"date-parts":[[2005,1,4]]},"reference":[{"key":"key2025102316262438051_1","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1053\/scnp.2003.50006","article-title":"Dementia with Lewy bodies","volume":"8","author":"McKeith, I.G.","year":"2003","unstructured":"[1] McKeith, I.G.; Burn, D.J.; Ballard, C.G.; Collerton, D.; Jaros, E.; Morris, C.M.; McLaren, A.; Perry, E.K.; Perry, R.; Piggott, M.A.; O'Brien, J.T. 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