{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T17:11:06Z","timestamp":1789924266683,"version":"4.0.1"},"reference-count":37,"publisher":"MathDoc\/Centre Mersenne","issue":"10-11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    Dans le but d'\u00e9valuer les effets toxiques de faibles doses de lithium, des rats blancs de souche Wistar, m\u00e2les et femelles, ont \u00e9t\u00e9 aliment\u00e9s pendant un mois avec une nourriture suppl\u00e9ment\u00e9e en Li\n                    <jats:sub>2<\/jats:sub>\n                    CO\n                    <jats:sub>3<\/jats:sub>\n                    aux concentrations de 2000 mg (groupe Li1) et 4000 mg (groupe Li2) par kilogramme. Si l'on tient compte des poids corporels des rats et de la quantit\u00e9 de nourritures qu'ils ing\u00e8rent chaque jour, on peut estimer que les quantit\u00e9s de carbonates de lithium ing\u00e9r\u00e9es par jour et par kg PC sont respectivement, chez les groupes Li1 et Li2, de 212 mg (5,738 mmol Li) et de 323 mg (8,742 mmol Li) chez les m\u00e2les, et de l'ordre de 190 mg (5,142 mmol Li) et 289 mg (7,822 mmol Li) chez les femelles. Nous avons analys\u00e9 la croissance pond\u00e9rale, la lith\u00e9mie, la cr\u00e9atinin\u00e9mie et les concentrations s\u00e9riques d'hormones thyro\u00efdiennes libres et sexuelles ainsi que l'aspect histologique des testicules et la cytologie vaginale. Nos r\u00e9sultats montrent que le lithium entra\u00eene une diminution de la consommation de nourriture et une perte de poids dose d\u00e9pendantes. Des ph\u00e9nom\u00e8nes de polyurie, polydipsie, diarrh\u00e9e ont \u00e9galement \u00e9t\u00e9 observ\u00e9s. Bien que la quantit\u00e9 de nourriture ing\u00e9r\u00e9e et donc la consommation de Li\n                    <jats:sub>2<\/jats:sub>\n                    CO\n                    <jats:sub>3<\/jats:sub>\n                    aient diminu\u00e9 en fonction du temps de traitement, la lith\u00e9mie a augment\u00e9 chez les rats Li1 comme chez les rats Li2, pour lesquels une forte mortalit\u00e9 a \u00e9t\u00e9 not\u00e9e d\u00e8s le 14\n                    <jats:sup>e<\/jats:sup>\n                    jour. Cette augmentation de la lith\u00e9mie est certainement en relation avec l'apparition d'une insuffisance r\u00e9nale, mise en \u00e9vidence par une augmentation de la cr\u00e9atinin\u00e9mie. Le lithium a induit une diminution dose-d\u00e9pendante des taux s\u00e9riques de triiodothyronine (FT3) et, \u00e0 un moindre degr\u00e9, de thyroxine (FT4), sugg\u00e9rant un d\u00e9faut de conversion de FT4 en FT3. Pour des lith\u00e9mies \u00e9quivalentes, une baisse de la testost\u00e9rone s\u00e9rique, associ\u00e9e \u00e0 une inhibition de la spermatogen\u00e8se, a \u00e9t\u00e9 not\u00e9e chez les m\u00e2les. Chez les femelles, une augmentation de l'oestradiol s\u00e9rique et des perturbations du cycle oestral ont \u00e9t\u00e9 observ\u00e9es. Ces r\u00e9sultats montrent que la toxicit\u00e9 du lithium se manifeste chez le rat \u00e0 des concentrations couramment utilis\u00e9es en th\u00e9rapeutique humaine.\n                  <\/jats:p>","DOI":"10.1016\/j.crvi.2005.08.005","type":"journal-article","created":{"date-parts":[[2005,9,27]],"date-time":"2005-09-27T10:19:28Z","timestamp":1127816368000},"page":"900-911","source":"Crossref","is-referenced-by-count":22,"title":["Effets secondaires de faibles concentrations de lithium sur les fonctions r\u00e9nales, thyro\u00efdiennes et sexuelles chez des rats matures m\u00e2les et femelles"],"prefix":"10.5802","volume":"328","author":[{"given":"Mohamed Salah","family":"Allagui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nejla","family":"Hfaiedh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Croute","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadhel","family":"Guermazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chritian","family":"Vincent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Soleilhavoup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelfettah","family":"El Feki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3842","published-online":{"date-parts":[[2005,9,26]]},"reference":[{"key":"key2025102316260798018_1","author":"Beliles, R.P.","year":"1994","unstructured":"[1] Beliles, R.P.; Clayton, G.D.; Clayton, F.E. 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