{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T20:41:13Z","timestamp":1768336873971,"version":"3.49.0"},"reference-count":46,"publisher":"MathDoc\/Centre Mersenne","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    Cette \u00e9tude a \u00e9t\u00e9 r\u00e9alis\u00e9e dans le but d'\u00e9valuer, chez le rat Wistar, les effets oxydants d'un traitement chronique par le vanadium et le r\u00f4le antioxydant du th\u00e9 vert, connu pour sa richesse en polyph\u00e9nols, pi\u00e9geurs de radicaux libres. Des rats m\u00e2les (V) ont re\u00e7u pendant 10 jours des injections intrap\u00e9riton\u00e9ales journali\u00e8res de m\u00e9tavanadate d'ammonium (5 mg NH\n                    <jats:sub>4<\/jats:sub>\n                    VO\n                    <jats:sub>3<\/jats:sub>\n                    par kilogramme de poids corporel) et les rats t\u00e9moins (T) des injections de NaCl \u00e0 0,9%. Parall\u00e8lement, des rats buvant du th\u00e9 vert depuis un mois ont \u00e9t\u00e9 r\u00e9partis en deux groupes, recevant respectivement des injections de NaCl 0,9% (TH) ou de m\u00e9tavanadate d'ammonium (TH + V). Le vanadate a induit une augmentation des TBARS d\u00e9pendante du temps dans les tissus h\u00e9patiques, r\u00e9naux et testiculaires des rats (V), qui \u00e9tait plus mod\u00e9r\u00e9e ou absente chez les rats TH + V. Le th\u00e9 n'a pas modifi\u00e9 significativement les taux de TBARS dans le foie et les testicules, mais a induit une diminution des TBARS dans les tissus r\u00e9naux. Chez les rats (V), le vanadium a \u00e9galement induit une chute des concentrations s\u00e9riques de vitamine E pendant toute la dur\u00e9e du traitement (1\u201310 j) et une baisse de la vitamine A, uniquement en fin de traitement (10 j). Chez les rats (TH + V), les concentrations de vitamine E ont \u00e9t\u00e9 diminu\u00e9es de fa\u00e7on plus mod\u00e9r\u00e9e en d\u00e9but de traitement (1\u20133 j) et augment\u00e9e \u00e0 J10. De m\u00eame, les concentrations en vitamine A ont \u00e9t\u00e9 augment\u00e9e \u00e0 J10 chez les rats (TH + V). Le th\u00e9 seul n'a pas eu d'effet significatif. Les activit\u00e9s de la catalase et de la superoxydismutase (SOD) ont \u00e9t\u00e9 augment\u00e9es de J1 \u00e0 J3 et inversement inhib\u00e9es de J5 \u00e0 J10 chez les rats (V). En revanche, aucune modification significative de ces deux activit\u00e9s enzymatiques n'a \u00e9t\u00e9 mise en \u00e9vidence chez les rats (TH + V) et (TH). Ces r\u00e9sultats montrent que le m\u00e9tavanadate d'ammonium a g\u00e9n\u00e9r\u00e9 chez les rats (V) un stress oxydant d\u00e8s le premier jour de traitement, qui a induit une augmentation de la peroxydation lipidique, une chute des concentrations s\u00e9riques de vitamine E et une induction de l'activit\u00e9 de la catalase et de la SOD. Bien que le th\u00e9 seul n'ait pas eu d'effet sur ces marqueurs du statut oxydant, il a nettement diminu\u00e9 les effets oxydants du vanadium. Ceci met nettement en \u00e9vidence le r\u00f4le protecteur des divers compos\u00e9s du th\u00e9 (polyph\u00e9nols, flavono\u00efdes, tanins) vis-\u00e0-vis des esp\u00e8ces r\u00e9actives de l'oxyg\u00e8ne g\u00e9n\u00e9r\u00e9es au cours du traitement par le m\u00e9tavanadate d'ammonium.\n                  <\/jats:p>","DOI":"10.1016\/j.crvi.2006.07.004","type":"journal-article","created":{"date-parts":[[2006,9,21]],"date-time":"2006-09-21T07:47:11Z","timestamp":1158824831000},"page":"775-784","source":"Crossref","is-referenced-by-count":18,"title":["Impact du th\u00e9 vert sur l'effet oxydatif du m\u00e9tavanadate d'ammonium chez le rat male pub\u00e8re"],"prefix":"10.5802","volume":"329","author":[{"given":"Ahlem","family":"Soussi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7oise","family":"Croute","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Pierre","family":"Soleilhavoup","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdelaziz","family":"Kammoun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdelfattah","family":"El Feki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3842","published-online":{"date-parts":[[2006,9,20]]},"reference":[{"key":"key2025102316272176161_1","first-page":"1","author":"Nriagu, J.O.","year":"1998","unstructured":"[1] Nriagu, J.O. 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