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Les m\u00e9canismes de l'effet d\u00e9l\u00e9t\u00e8re des progestatifs sur le sein apr\u00e8s la m\u00e9nopause et le r\u00f4le des hormones ovariennes comme agents mutag\u00e8nes initiateurs de tumeur ne sont pas d\u00e9montr\u00e9s. Les variations d'expression des r\u00e9cepteurs des estrog\u00e8nes et de la progest\u00e9rone dans les l\u00e9sions pr\u00e9canc\u00e9reuses sugg\u00e8rent une augmentation pr\u00e9coce de la sensibilit\u00e9 \u00e0 ces hormones. La canc\u00e9rogen\u00e8se partirait de pr\u00e9curseurs diff\u00e9rents et, pour les cancers n'exprimant pas de r\u00e9cepteurs des estrog\u00e8nes, d'autres cibles th\u00e9rapeutiques sont n\u00e9cessaires. La pr\u00e9vention des cancers du sein repose sur l'accentuation d'une recherche fondamentale transf\u00e9rable en clinique et d'une meilleure information des femmes sur les facteurs de risque \u00e9vitables.<\/jats:p>","DOI":"10.1016\/j.crvi.2006.07.009","type":"journal-article","created":{"date-parts":[[2006,8,29]],"date-time":"2006-08-29T08:37:22Z","timestamp":1156840642000},"page":"104-113","source":"Crossref","is-referenced-by-count":7,"title":["Canc\u00e9rogen\u00e8se hormonale chez la femme : des m\u00e9canismes \u00e0 la pr\u00e9vention"],"prefix":"10.5802","volume":"331","author":[{"given":"Henri","family":"Rochefort","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3842","published-online":{"date-parts":[[2006,8,28]]},"reference":[{"key":"key2025102316302210962_1","first-page":"7","article-title":"La fr\u00e9quence des cancers en France en 2002 et son \u00e9volution depuis 1968","volume":"93","author":"Hill, C.","year":"2006","unstructured":"[1] Hill, C.; Doyon, F. 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