{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T01:56:58Z","timestamp":1791079018057,"version":"4.1.0"},"reference-count":13,"publisher":"MathDoc\/Centre Mersenne","issue":"6-7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Teeth form as epithelial appendages and the mechanisms regulating their development share similarities with other organs such as hairs, glands, and gut. However, the regenerative potential of mammalian teeth is generally limited. Stem cells have been identified in the epithelium of continuously growing incisors of mice. We have identified a network of signalling molecules that regulates the proliferation and differentiation of these stem cells, and that thereby influences the incisors' growth and enamel formation. The signals, including FGFs, BMPs, and Activin, mediate interactions between the mesenchymal and epithelial cells within the stem cell niche and form an integrated network. Follistatin antagonizes the functions of BMPs and Activin, and is a key regulator of the asymmetry of the incisor structure. The evolutionary variation in the growth capacity of teeth and the extent of enamel deposition may have resulted from fine-tuning of this signal network. In addition, subtle variations in this or in related regulatory networks may explain the different regenerative capacities of various organs and animal species.<\/jats:p>","DOI":"10.1016\/j.crvi.2007.03.005","type":"journal-article","created":{"date-parts":[[2007,5,10]],"date-time":"2007-05-10T07:35:04Z","timestamp":1178782504000},"page":"561-564","source":"Crossref","is-referenced-by-count":36,"title":["Regulation of epithelial stem cells in tooth regeneration"],"prefix":"10.5802","volume":"330","author":[{"given":"Irma","family":"Thesleff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu-Ping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marika","family":"Suomalainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3842","published-online":{"date-parts":[[2007,5,9]]},"reference":[{"key":"key2025102316293611963_1","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S0092-8674(04)00255-7","article-title":"Socializing with the neighbors: stem cells and their niche","volume":"116","author":"Fuchs, E.","year":"2004","unstructured":"[1] Fuchs, E.; Tumbar, T.; Guasch, G. Socializing with the neighbors: stem cells and their niche, Cell, Volume 116 (2004), pp. 769-778","journal-title":"Cell"},{"key":"key2025102316293611963_2","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.ceb.2004.09.003","article-title":"The stem cell niche: theme and variations","volume":"16","author":"Ohlstein, B.","year":"2004","unstructured":"[2] Ohlstein, B.; Kai, T.; Decotto, E.; Spradling, A. The stem cell niche: theme and variations, Curr. Opin. Cell Biol., Volume 16 (2004), pp. 693-699","journal-title":"Curr. Opin. Cell Biol."},{"key":"key2025102316293611963_3","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1126\/science.1110542","article-title":"Stem cells and their niches","volume":"311","author":"Moore, K.A.","year":"2006","unstructured":"[3] Moore, K.A.; Lemischka, I.R. Stem cells and their niches, Science, Volume 311 (2006), pp. 1880-1885","journal-title":"Science"},{"key":"key2025102316293611963_4","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1083\/jcb.147.1.105","article-title":"Localization of putative stem cells in dental epithelium and their association with Notch and FGF signalling","volume":"147","author":"Harada, H.","year":"1999","unstructured":"[4] Harada, H.; Kettunen, P.; Jung, H.S.; Mustonen, T.; Wang, Y.A.; Thesleff, I. Localization of putative stem cells in dental epithelium and their association with Notch and FGF signalling, J. Cell Biol., Volume 147 (1999), pp. 105-120","journal-title":"J. Cell Biol."},{"key":"key2025102316293611963_5","first-page":"265","volume":"vol. 1","author":"Tummers, M.","year":"2004","unstructured":"[5] Tummers, M.; Thesleff, I. Epithelial stem cell niche in the tooth (Lanza, R.P., ed.), Handbook of Stem Cells, vol. 1, Academic Press, Boston, MA, USA, 2004, pp. 265-271","journal-title":"Epithelial stem cell niche in the tooth"},{"key":"key2025102316293611963_6","first-page":"143","article-title":"The migration and renewal of tritium labelled cells in the developing enamel organ of rabbits","volume":"115","author":"Starkey, W.E.","year":"1963","unstructured":"[6] Starkey, W.E. The migration and renewal of tritium labelled cells in the developing enamel organ of rabbits, Br. Dent. J., Volume 115 (1963), pp. 143-153","journal-title":"Br. Dent. J."},{"key":"key2025102316293611963_7","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1080\/03008200290000989","article-title":"FGF10 maintains stem cell population during mouse incisor development","volume":"43","author":"Harada, H.","year":"2002","unstructured":"[7] Harada, H.; Toyono, T.; Toyoshima, K.; Yamasaki, M.; Itoh, N.; Kato, S.; Sekine, K.; Ohuchi, H. FGF10 maintains stem cell population during mouse incisor development, Connect Tissue Res., Volume 43 (2002), pp. 201-204","journal-title":"Connect Tissue Res."},{"key":"key2025102316293611963_8","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.devcel.2004.09.012","article-title":"Follistatin regulates enamel patterning in mouse incisors by asymmetrically inhibiting BMP signalling and ameloblast differentiation","volume":"7","author":"Wang, X.-P.","year":"2004","unstructured":"[8] Wang, X.-P.; Suomalainen, M.; Jorgez, C.J.; Matzuk, M.M.; Werner, S.; Thesleff, I. Follistatin regulates enamel patterning in mouse incisors by asymmetrically inhibiting BMP signalling and ameloblast differentiation, Dev. Cell, Volume 7 (2004), pp. 719-730","journal-title":"Dev. Cell"},{"key":"key2025102316293611963_9","doi-asserted-by":"crossref","unstructured":"[9] X.-P. Wang, M. Suomalainen, S. Felszeghy, L.C. Zelarayan, M.T. Alonso, M.V. Plikus, R. Maas, C.-M. Chuong, T. Schimmang, I. Thesleff, An integrated gene regulatory network controls epithelial stem cell proliferation in teeth, PLoS Biol. (2007), in press","DOI":"10.1371\/journal.pbio.0050159"},{"key":"key2025102316293611963_10","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1006\/dbio.2002.0779","article-title":"Extracellular regulation of BMP signalling in vertebrates: a cocktail of modulators","volume":"250","author":"Balemans, W.","year":"2002","unstructured":"[10] Balemans, W.; Van Hul, W. Extracellular regulation of BMP signalling in vertebrates: a cocktail of modulators, Dev. Biol., Volume 250 (2002), pp. 231-250","journal-title":"Dev. 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Meyers, Mast R.B., Lemurs of Madagascar, Conservation International, Washington, DC, USA, 1994"},{"key":"key2025102316293611963_13","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1242\/dev.00332","article-title":"Root or crown: a developmental choice orchestrated by the differential regulation of the epithelial stem cell niche in the tooth of two rodent species","volume":"130","author":"Tummers, M.","year":"2003","unstructured":"[13] Tummers, M.; Thesleff, I. Root or crown: a developmental choice orchestrated by the differential regulation of the epithelial stem cell niche in the tooth of two rodent species, Development, Volume 130 (2003), pp. 1049-1057","journal-title":"Development"}],"container-title":["Comptes Rendus. 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