{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T22:17:40Z","timestamp":1790979460620,"version":"4.1.0"},"reference-count":15,"publisher":"MathDoc\/Centre Mersenne","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>The development of new therapeutic approaches against colorectal cancer requires preclinical studies in mice. In vivo imaging could greatly facilitate these trials, but the small size of the animals is a major limitation for the direct visualization of intestinal tissue. Here we report a method of in vivo imaging of the mouse intestine based on X-ray micro-computed tomography using multiple contrast agents. This method was validated in the model of non-cancerous polyp-like heteroplasia that spontaneously develops in the caecum area of Cdx2+\/\u2013 mutant mice and in the model of colon adenocarcinoma induced by administration of the chemical carcinogen azoxymethane. As a simple and non-invasive method, multiple-contrast X-ray micro-computed tomography is appropriate for pre-clinical studies of intestinal diseases in living mice.<\/jats:p>","DOI":"10.1016\/j.crvi.2007.08.002","type":"journal-article","created":{"date-parts":[[2007,9,8]],"date-time":"2007-09-08T07:19:13Z","timestamp":1189235953000},"page":"821-827","source":"Crossref","is-referenced-by-count":16,"title":["Multiple-contrast X-ray micro-CT visualization of colon malformations and tumours in situ in living mice"],"prefix":"10.5802","volume":"330","author":[{"given":"Philippe","family":"Choquet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Calon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9lodie","family":"Breton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Beck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Domon-Dell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-No\u00ebl","family":"Freund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Constantinesco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3842","published-online":{"date-parts":[[2007,9,7]]},"reference":[{"key":"key2025102316284786071_1","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1053\/gast.2003.50094","article-title":"Pathology of mouse models of intestinal cancer: consensus report and recommendations","volume":"124","author":"Boivin, G.P.","year":"2003","unstructured":"[1] Boivin, G.P.; Washington, K.; Yang, K.; Ward, J.M.; Pretlow, T.P.; Russell, R.; Besselsen, D.G.; Godfrey, V.L.; Doetschman, T.; Dove, W.F.; Pitot, H.C.; Halberg, R.B.; Itzkowitz, S.H.; Groden, J.; Coffey, R.J. Pathology of mouse models of intestinal cancer: consensus report and recommendations, Gastroenterology, Volume 124 (2003), pp. 762-777","journal-title":"Gastroenterology"},{"key":"key2025102316284786071_2","first-page":"391","article-title":"From animal models to prevention of colon cancer. Systematic review of chemoprevention in min mice and choice of the model system","volume":"12","author":"Corpet, D.E.","year":"2003","unstructured":"[2] Corpet, D.E.; Pierre, F. From animal models to prevention of colon cancer. Systematic review of chemoprevention in min mice and choice of the model system, Cancer Epidemiol. Biomark. Prev., Volume 12 (2003), pp. 391-400","journal-title":"Cancer Epidemiol. Biomark. Prev."},{"key":"key2025102316284786071_3","doi-asserted-by":"crossref","first-page":"S34","DOI":"10.1016\/S0167-7799(02)02004-8","article-title":"Micro-CT in small animal and specimen imaging","volume":"20","author":"Holdsworth, D.W.","year":"2002","unstructured":"[3] Holdsworth, D.W.; Thornton, M.M. Micro-CT in small animal and specimen imaging, Trends Biotechnol., Volume 20 (2002), p. S34-S39","journal-title":"Trends Biotechnol."},{"key":"key2025102316284786071_4","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/jcb.10415","article-title":"Molecular imaging in small animals-roles for micro-CT","volume":"39","author":"Ritman, E.L.","year":"2002","unstructured":"[4] Ritman, E.L. Molecular imaging in small animals-roles for micro-CT, J. Cell Biochem. (Suppl.), Volume 39 (2002), pp. 116-124","journal-title":"J. Cell Biochem. 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The Cdx2 homeobox gene has a tumour suppressor function in the distal colon in addition to a homeotic role during gut development, Gut, Volume 52 (2003), pp. 1465-1471","journal-title":"Gut"},{"key":"key2025102316284786071_8","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/386084a0","article-title":"Homeosis and intestinal tumours in Cdx2 mutant mice","volume":"385","author":"Chawengsaksophak, K.","year":"1997","unstructured":"[8] Chawengsaksophak, K.; James, R.; Hammond, V.E.; Kontgen, F.; Beck, F. Homeosis and intestinal tumours in Cdx2 mutant mice, Nature, Volume 385 (1997), pp. 84-87","journal-title":"Nature"},{"key":"key2025102316284786071_9","doi-asserted-by":"crossref","first-page":"779","DOI":"10.3748\/wjg.v9.i4.779","article-title":"Relative efficacy of some prokinetic drugs in morphine-induced gastrointestinal transit delay in mice","volume":"9","author":"Suchitra, A.D.","year":"2003","unstructured":"[9] Suchitra, A.D.; Dkhar, S.A.; Shewade, D.G.; Shashindran, C.H. Relative efficacy of some prokinetic drugs in morphine-induced gastrointestinal transit delay in mice, World J. Gastroenterol., Volume 9 (2003), pp. 779-783","journal-title":"World J. Gastroenterol."},{"key":"key2025102316284786071_10","first-page":"20","article-title":"Intraperitoneal administration of an iodine-based contrast agent to improve abdominal micro-computed tomography imaging in mice","volume":"44","author":"Johnson, E.M.","year":"2005","unstructured":"[10] Johnson, E.M.; Price, R.E.; Rivera, B.; Cody, D.D. Intraperitoneal administration of an iodine-based contrast agent to improve abdominal micro-computed tomography imaging in mice, Contemp. Top. Lab. Anim. Sci., Volume 44 (2005), pp. 20-27","journal-title":"Contemp. Top. Lab. Anim. Sci."},{"key":"key2025102316284786071_11","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1097\/00054725-200606000-00006","article-title":"Magnetic resonance imaging of experimental mouse colitis and association with inflammatory activity","volume":"12","author":"Larsson, A.E.","year":"2006","unstructured":"[11] Larsson, A.E.; Melgar, S.; Rehnstrom, E.; Michaelsson, E.; Svensson, L.; Hockings, P.; Olsson, L.E. 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Technol."},{"key":"key2025102316284786071_13","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.immuni.2004.07.020","article-title":"TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling","volume":"21","author":"Becker, C.","year":"2004","unstructured":"[13] Becker, C.; Fantini, M.C.; Schramm, C.; Lehr, H.A.; Wirtz, S.; Nikolaev, A.; Burg, J.; Strand, S.; Kiesslich, R.; Huber, S.; Ito, H.; Nishimoto, N.; Yoshizaki, K.; Kishimoto, T.; Galle, P.R.; Blessing, M.; Rose-John, S.; Neurath, M.F. 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