{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:10:18Z","timestamp":1791414618902,"version":"4.3.3"},"reference-count":32,"publisher":"MathDoc\/Centre Mersenne","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>\n                    Dihydropyrimidine dehydrogenase enzyme (DPD) deficiency is a pharmacogenetic syndrome leading to severe side-effects in patients receiving therapies containing the anticancer drug 5-fluorouracil (5-FU). The aim of this population study is to evaluate gene variations in the coding region of the dihydropyrimidine dehydrogenase gene (DPYD) in the Tunisian population. One hundred and six unrelated healthy Tunisian volunteers were genotyped by denaturing HPLC (DHPLC). Twelve variants in the coding region of the DPYD were detected. Allele frequencies of DPYD*5 (A1627G), DPYD*6 (G2194A), DPYD*9A (T85C), A496G, and G1218A were 12.7%, 7.1%, 13.7%, 5.7%, and 0.5%, respectively. The DPYD alleles DPYD*2A (IVS\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" overflow=\"scroll\">\n                      <mml:mn>14<\/mml:mn>\n                      <mml:mo>+<\/mml:mo>\n                      <mml:mn>1<\/mml:mn>\n                      <mml:mtext>g<\/mml:mtext>\n                      <mml:mo>&gt;<\/mml:mo>\n                      <mml:mn>1<\/mml:mn>\n                    <\/mml:math>\n                    ), DPYD*3 (1897 del C) and DPYD*4 (G1601A) associated with DPD deficiency were absent from the examined subjects. We describe for the first time a new intronic polymorphism IVS 6\u201329 g&gt;t, found in an allelic frequency of 4.7% in the Tunisian population. Comparing our data with that obtained in Caucasian, Egyptian, Japanese and African\u2013American populations, we found that the Tunisian population resembles Egyptian and Caucasian populations with regard to their allelic frequencies of DPYD polymorphisms. This study describes for the first time the spectrum of DPYD sequence variations in the Tunisian population.\n                  <\/jats:p>","DOI":"10.1016\/j.crvi.2007.08.003","type":"journal-article","created":{"date-parts":[[2007,9,8]],"date-time":"2007-09-08T07:19:13Z","timestamp":1189235953000},"page":"764-769","source":"Crossref","is-referenced-by-count":21,"title":["Mutational spectrum of dihydropyrimidine dehydrogenase gene (DPYD) in the Tunisian population"],"prefix":"10.5802","volume":"330","author":[{"given":"Radhia","family":"Ben Fredj","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Gross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lotfi","family":"Chouchen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"B'Chir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Slim","family":"Ben Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffi","family":"Neubauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Kiechle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sa\u00e2d","family":"Saguem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3842","published-online":{"date-parts":[[2007,9,7]]},"reference":[{"key":"key2025102316284255993_1","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0165-6147(00)89065-3","article-title":"Diagnostic analysis, clinical importance and molecular basis of dihydropyrimidine dehydrogenase deficiency","volume":"16","author":"Gonzalez, F.J.","year":"1995","unstructured":"[1] Gonzalez, F.J.; Fernandez-Salguero, P. Diagnostic analysis, clinical importance and molecular basis of dihydropyrimidine dehydrogenase deficiency, Trends Pharmacol. Sci., Volume 16 (1995), pp. 325-327","journal-title":"Trends Pharmacol. Sci."},{"key":"key2025102316284255993_2","first-page":"149","author":"Grem, J.L.","year":"1996","unstructured":"[2] Grem, J.L. 5-Fluoropyrimidines (Chabner, B.A.; Long, D.L., eds.), Cancer Chemotherapy and Biotherapy, Lippincott-Raven, Philadelphia, 1996, pp. 149-197","journal-title":"5-Fluoropyrimidines"},{"key":"key2025102316284255993_3","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1007\/s10147-003-0330-z","article-title":"Clinical implications of dihydropyrimidine dehydrogenase (DPD) activity in 5-FU-based chemotherapy mutations in the DPD gene, and DPD inhibitory fluoropyrimidines","volume":"8","author":"Omura, K.","year":"2003","unstructured":"[3] Omura, K. Clinical implications of dihydropyrimidine dehydrogenase (DPD) activity in 5-FU-based chemotherapy mutations in the DPD gene, and DPD inhibitory fluoropyrimidines, Int. J. Clin. Oncol., Volume 8 (2003), pp. 132-138","journal-title":"Int. J. Clin. Oncol."},{"key":"key2025102316284255993_4","first-page":"4705","article-title":"Clinical implication of dihydropyrimidine dehydrogenase (DPD) deficiency in patients with severe 5-fluorouracil-associated toxicity: identification of new mutation in the DPD gene","volume":"6","author":"Van Kuilenburg, A.B.P.","year":"2000","unstructured":"[4] Van Kuilenburg, A.B.P.; Haasjes, J.; Richel, D.J.; Zoetekouw, L.; Van Lenthe, H.; De Abrau, R.A.; Maring, J.G.; Vreken, P.; Van Gennip, A.H. Clinical implication of dihydropyrimidine dehydrogenase (DPD) deficiency in patients with severe 5-fluorouracil-associated toxicity: identification of new mutation in the DPD gene, Clin. Cancer Res., Volume 6 (2000), pp. 4705-4712","journal-title":"Clin. Cancer Res."},{"key":"key2025102316284255993_5","first-page":"2203","article-title":"Clinical pharmacokinetic of 5-fluorouracil and its metabolites in plasma, urine and bile","volume":"47","author":"Heggie, G.D.","year":"1987","unstructured":"[5] Heggie, G.D.; Sommadossi, J.P.; Cross, D.S.; Huster, W.J.; Diasio, R.B. Clinical pharmacokinetic of 5-fluorouracil and its metabolites in plasma, urine and bile, Cancer Res., Volume 47 (1987), pp. 2203-2206","journal-title":"Cancer Res."},{"key":"key2025102316284255993_6","first-page":"17","article-title":"Known variant DPYD alleles do not explain DPD deficiency in cancer patients","volume":"10","author":"Collie-Duguid, E.S.K.","year":"2000","unstructured":"[6] Collie-Duguid, E.S.K.; Etienne, M.C.; Milano, G.; Mc Leod, H.L. Known variant DPYD alleles do not explain DPD deficiency in cancer patients, Pharmacogenetics, Volume 10 (2000), pp. 17-223","journal-title":"Pharmacogenetics"},{"key":"key2025102316284255993_7","first-page":"2006","article-title":"Life threatening toxicity in a dihydropyrimidine dehydrogenase deficient patient after treatment with topical 5-Fluorouracil","volume":"5","author":"Johnson, M.R.","year":"1999","unstructured":"[7] Johnson, M.R.; Hageboutros, A.; Wang, K.L.; High, L.; Smith, J.B.; Diasio, R.B. Life threatening toxicity in a dihydropyrimidine dehydrogenase deficient patient after treatment with topical 5-Fluorouracil, Clin. Cancer Res., Volume 5 (1999), pp. 2006-2011","journal-title":"Clin. Cancer Res."},{"key":"key2025102316284255993_8","first-page":"2999","article-title":"Identification of novel mutations in the dihydropyrimidine dehydrogenase gene in a Japanese patient with 5-fluorouracil toxicity","volume":"4","author":"Kouwaki, M.","year":"1998","unstructured":"[8] Kouwaki, M.; Hamajima, N.; Sumi, S.; Nonaka, M.; Sasaki, M.; Dobashi, K.; Kiduchi, K.H.; Togari, Y.; Wada, Y. Identification of novel mutations in the dihydropyrimidine dehydrogenase gene in a Japanese patient with 5-fluorouracil toxicity, Clin. Cancer Res., Volume 4 (1998), pp. 2999-3004","journal-title":"Clin. Cancer Res."},{"key":"key2025102316284255993_9","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1016\/S0959-8049(97)00261-X","article-title":"Heterozygosity for a point mutation in an invariant splice donor site of dihydropyrimidine dehydrogenase and severe 5-fluorouracil-related toxicity","volume":"33","author":"Van Kuilenburg, A.B.P.","year":"1997","unstructured":"[9] Van Kuilenburg, A.B.P.; Vreken, P.; Beex, L.V.A.M.; Meinsma, R.; Van Lenthe, H.; De Abrau, R.A.; Van Gennip, A.H. Heterozygosity for a point mutation in an invariant splice donor site of dihydropyrimidine dehydrogenase and severe 5-fluorouracil-related toxicity, Eur. J. Cancer, Volume 33 (1997), pp. 2258-2264","journal-title":"Eur. J. Cancer"},{"key":"key2025102316284255993_10","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1172\/JCI118830","article-title":"Molecular basis of the human dihydropyrimidine dehydropyrimidine deficiency and 5-fluorouracil toxicity","volume":"3","author":"Wei, X.","year":"1996","unstructured":"[10] Wei, X.; McLeod, H.L.; Murrough, M.C. Jr.; Gonzalez, F.J.; Salguero, P.F. Molecular basis of the human dihydropyrimidine dehydropyrimidine deficiency and 5-fluorouracil toxicity, J. Clin. Invest., Volume 3 (1996), pp. 610-615","journal-title":"J. Clin. Invest."},{"key":"key2025102316284255993_11","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1006\/geno.1994.1680","article-title":"Assignment of the human dihydropyrimidine dehydrogenase (DPYD) to chromosome region 1p22 by fluorescence in situ hybridation","volume":"24","author":"Takai, S.","year":"1994","unstructured":"[11] Takai, S.; Fernandez-Salguero, P.; Kimura, S.; Gonzalez, F.G.; Yamada, K. Assignment of the human dihydropyrimidine dehydrogenase (DPYD) to chromosome region 1p22 by fluorescence in situ hybridation, Genomics, Volume 24 (1994), pp. 613-614","journal-title":"Genomics"},{"key":"key2025102316284255993_12","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1006\/geno.1998.5379","article-title":"Characterization of the human dihydropyrimidine dehydrogenase gene","volume":"51","author":"Wei, X.","year":"1998","unstructured":"[12] Wei, X.; Elizondo, G.; Sapone, A.; Mc Leod, H.L.; Raunio, H.; Fernandez-Salguero, P.; Gonzalez, F.J. Characterization of the human dihydropyrimidine dehydrogenase gene, Genomics, Volume 51 (1998), pp. 391-400","journal-title":"Genomics"},{"key":"key2025102316284255993_13","first-page":"2832","article-title":"Prevalence of a common point mutation in the dihydropyrimidine dehydrogenase (DPD) gene within the 5\u2032-splice donor site of intron 14 in patients with severe 5-fluorouracil (5-FU)-related toxicity compared with controls","volume":"7","author":"Raida, M.","year":"2001","unstructured":"[13] Raida, M.; Schwabe, W.; Hausler, P.; Van Kuilenburg, A.B.P.; Van Gennip, A.H.; Behnke, D.; H\u00f6ffken, K. Prevalence of a common point mutation in the dihydropyrimidine dehydrogenase (DPD) gene within the 5\u2032-splice donor site of intron 14 in patients with severe 5-fluorouracil (5-FU)-related toxicity compared with controls, Clin. Cancer Res., Volume 7 (2001), pp. 2832-2839","journal-title":"Clin. Cancer Res."},{"key":"key2025102316284255993_14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/PL00008711","article-title":"Genotype and phenotype in patients with dihydropyrimidine dehydrogenase deficiency","volume":"104","author":"Van Kuilenburg, A.B.P.","year":"1999","unstructured":"[14] Van Kuilenburg, A.B.P.; Vreken, P.; Abeling, N.G.G.M.; Bakker, H.D.; Meinsma, R.; Van Lenthe, H.; De Abreu, R.A.; Smeitink, J.A.M.; Kayserili, H.; Apak, M.Y.; Christensen, E.; Holopainen, I.; Pulkki, K.; Riva, D.; Botteon, G.; Holme, E.; Tulinius, M.; Kleijer, W.J.; Beemer, F.A.; Duran, M.; Niezen-Koning, K.E.; Smit, G.P.A.; Jakobs, C.; Smit, L.M.E.; Moog, U.; Spaapen, L.J.M.; Van Gennip, A.H. Genotype and phenotype in patients with dihydropyrimidine dehydrogenase deficiency, Hum. Genet., Volume 104 (1999), pp. 1-9","journal-title":"Hum. Genet."},{"key":"key2025102316284255993_15","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/00008571-199704000-00012","article-title":"Lack of correlation between phenotype and genotype for polymorphically expressed dihydropyrimidine dehydrogenase in a family of Pakistani origin","volume":"7","author":"Fernanduez-Sanguero, P.","year":"1997","unstructured":"[15] Fernanduez-Sanguero, P.; Sapone, A.; Wei, X.; Holt, J.R.; Jones, S.; Idle, J.R.; Gonzalez, F.J.L. Lack of correlation between phenotype and genotype for polymorphically expressed dihydropyrimidine dehydrogenase in a family of Pakistani origin, Pharmacogenetics, Volume 7 (1997), pp. 161-163","journal-title":"Pharmacogenetics"},{"key":"key2025102316284255993_16","first-page":"1149","article-title":"Lethal outcome of a patient with a complete dihydropyrimidine dehydrogenase (DPD) deficiency after administration of 5-fluorouracil: frequency of the common IVS <span class=\"mathjax-formula\" data-tex=\"$ 14+1\\mathrm{G}\\to \\mathbf{A}$\"><math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" overflow=\"scroll\"><mn>14<\/mn><mo>+<\/mo><mn>1<\/mn><mi mathvariant=\"normal\">G<\/mi><mo>\u2192<\/mo><mi mathvariant=\"bold\">A<\/mi><\/math><\/span> mutation causing DPD deficiency","volume":"7","author":"Van Kuilenburg, A.B.P.","year":"2001","unstructured":"[16] Van Kuilenburg, A.B.P.; Muller, E.W.; Haasjes, J.; Meinsma, R.; Zoetekouw, L.; Waterham, H.R.; Baas, F.; Richel, D.J.; Van Gennip, A.H. Lethal outcome of a patient with a complete dihydropyrimidine dehydrogenase (DPD) deficiency after administration of 5-fluorouracil: frequency of the common IVS 14+1G\u2192A mutation causing DPD deficiency, Clin. Cancer Res., Volume 7 (2001), pp. 1149-1153","journal-title":"Clin. Cancer Res."},{"key":"key2025102316284255993_17","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1046\/j.1365-2125.2002.01604.x","article-title":"Allele and genotype frequencies of polymorphic cytochromes P450 (CYP2C9, CYP2C19, CYP2E1) and dihydropyrimidine dehydrogenase (DPYD) in the Egyptian population","volume":"6","author":"Hamdy, S.I.","year":"2002","unstructured":"[17] Hamdy, S.I.; Hiratsuka, M.; Narahara, K.; El-Enany, M.; Moursi, N.; Ahmed, M.S.E.; Mizugaki, M. Allele and genotype frequencies of polymorphic cytochromes P450 (CYP2C9, CYP2C19, CYP2E1) and dihydropyrimidine dehydrogenase (DPYD) in the Egyptian population, Br. J. Clin. Pharmacol., Volume 6 (2002), pp. 596-603","journal-title":"Br. J. Clin. Pharmacol."},{"key":"key2025102316284255993_18","doi-asserted-by":"crossref","first-page":"5886","DOI":"10.1158\/1078-0432.CCR-04-1784","article-title":"Analysis of the DPYD gene implicated in 5-fluorouracil catabolism in a cohort of Caucasian individuals","volume":"11","author":"Seck, K.","year":"2005","unstructured":"[18] Seck, K.; Riemer, S.; Kates, R.; Ullrich, T.; Lutz, V.; Harbeck, N.; Schmitt, M.; Kiechle, M.; Diasio, R.B.; Gross, E. Analysis of the DPYD gene implicated in 5-fluorouracil catabolism in a cohort of Caucasian individuals, Clin. Cancer Res., Volume 11 (2005), pp. 5886-5892","journal-title":"Clin. Cancer Res."},{"key":"key2025102316284255993_19","first-page":"325","article-title":"High-throughput genotyping by DHPLC of the dihydropyrimidine dehydrogenase gene implicated in (fluoro) pyrimidine catabolism","volume":"22","author":"Gross, E.","year":"2003","unstructured":"[19] Gross, E.; Seck, K.; Neubauer, S.; Mayr, J.; Hellebrand, H.; Ratanaphan, A.; Lutz, V.; Stockinger, H.; Kiechle, M. High-throughput genotyping by DHPLC of the dihydropyrimidine dehydrogenase gene implicated in (fluoro) pyrimidine catabolism, Int. J. Oncol., Volume 22 (2003), pp. 325-332","journal-title":"Int. J. Oncol."},{"key":"key2025102316284255993_20","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1093\/clinchem\/45.8.1133","article-title":"Optimal temperature selection for mutation detection by denaturing HPLC and comparison to single-stranded conformation polymorphism and heteroduplex analysis","volume":"45","author":"Jones, A.C.","year":"1999","unstructured":"[20] Jones, A.C.; Austin, J.; Hansen, N.; Hoogendoorn, B.; Oefner, P.; Cheadle, J.P.; O'Donovan, M.C. Optimal temperature selection for mutation detection by denaturing HPLC and comparison to single-stranded conformation polymorphism and heteroduplex analysis, Clin. Chem., Volume 45 (1999), pp. 1133-1140","journal-title":"Clin. Chem."},{"key":"key2025102316284255993_21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/dna.1995.14.1","article-title":"Human polymorphism in drug metabolism: mutation in the dihydropyrimidine dehydrogenase gene results in exon skipping and thymine Uracilurea","volume":"14","author":"Meinsma, R.","year":"1995","unstructured":"[21] Meinsma, R.; Fernandez-Salguero, P.; Van Kuilenburg, A.B.P.; Van Gennip, A.H.; Gonzalez, F.J. Human polymorphism in drug metabolism: mutation in the dihydropyrimidine dehydrogenase gene results in exon skipping and thymine Uracilurea, DNA Cell Biol., Volume 14 (1995), pp. 1-6","journal-title":"DNA Cell Biol."},{"key":"key2025102316284255993_22","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s004390050502","article-title":"Identification of a four-base deletion (del TCAT<sub>296\u2013299<\/sub>) in the dihydropyrimidine dehydrogenase gene with variable clinical expression","volume":"100","author":"Vreken, P.","year":"1997","unstructured":"[22] Vreken, P.; Van Kuilenburg, A.B.P.; Meinsma, R.; De Abreu, R.A.; Van Gennip, A.H.; Van Kuilenburg, A.B.P. Identification of a four-base deletion (del TCAT296\u2013299) in the dihydropyrimidine dehydrogenase gene with variable clinical expression, Hum. Genet., Volume 100 (1997), pp. 263-265","journal-title":"Hum. Genet."},{"key":"key2025102316284255993_23","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1023\/A:1005470524203","article-title":"Clinical and biochemical abnormalities in a patient with dihydropyrimidine dehydrogenase deficiency due to homozygosity for the C29R mutation","volume":"22","author":"Van Kuilenburg, A.B.P.","year":"1999","unstructured":"[23] Van Kuilenburg, A.B.P.; Vreken, P.; Riva, D.; Botteon, G.; Abeling, N.G.G.M.; Bakker, H.D. Clinical and biochemical abnormalities in a patient with dihydropyrimidine dehydrogenase deficiency due to homozygosity for the C29R mutation, J. Inherit. Metab. Dis., Volume 22 (1999), pp. 191-192","journal-title":"J. Inherit. Metab. Dis."},{"key":"key2025102316284255993_24","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s004390050637","article-title":"Dihydropyrimidine dehydrogenase (DPD) deficiency: identification and expression of missense mutations C29R, R886H and R235W","volume":"101","author":"Vreken, P.","year":"1997","unstructured":"[24] Vreken, P.; Van Kuilenburg, A.B.P.; Meinsma, R.; Van Gennip, A.H. Dihydropyrimidine dehydrogenase (DPD) deficiency: identification and expression of missense mutations C29R, R886H and R235W, Hum. Genet., Volume 101 (1997), pp. 333-338","journal-title":"Hum. Genet."},{"key":"key2025102316284255993_25","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1056\/NEJMra020526","article-title":"Pharmacogenomics-drug disposition, drug targets, and side effects","volume":"348","author":"Evans, W.E.","year":"2003","unstructured":"[25] Evans, W.E.; McLeod, H.L. Pharmacogenomics-drug disposition, drug targets, and side effects, N. Engl. J. Med., Volume 348 (2003), pp. 538-549","journal-title":"N. Engl. J. Med."},{"key":"key2025102316284255993_26","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1006\/abio.2002.5666","article-title":"A high-throughput denaturing high-performance liquid chromatographymethod for the identification of variant alleles associated with dihydropyrimidine dehydrogenase deficiency","volume":"306","author":"Ezzeldin, H.","year":"2002","unstructured":"[26] Ezzeldin, H.; Okamoto, Y.; Johnson, M.R.; Diasio, R.B. A high-throughput denaturing high-performance liquid chromatographymethod for the identification of variant alleles associated with dihydropyrimidine dehydrogenase deficiency, Anal. Biochem., Volume 306 (2002), pp. 63-73","journal-title":"Anal. Biochem."},{"key":"key2025102316284255993_27","first-page":"3021","article-title":"Denaturing high-performance chromatography analysis of the DPYD gene in patients with lethal 5-fluorouracil toxicity","volume":"9","author":"Ezzeldin, H.","year":"2003","unstructured":"[27] Ezzeldin, H.; Johnson, M.R.; Okamoto, Y.; Diasio, R.B. Denaturing high-performance chromatography analysis of the DPYD gene in patients with lethal 5-fluorouracil toxicity, Clin. Cancer Res., Volume 9 (2003), pp. 3021-3028","journal-title":"Clin. Cancer Res."},{"key":"key2025102316284255993_28","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1373\/49.10.1661","article-title":"Use of pyrosequencing to detect clinically relevant polymorphisms in dihydropyrimidine dehydrogenase","volume":"49","author":"Ahluwalia, R.","year":"2003","unstructured":"[28] Ahluwalia, R.; Freimuth, R.; McLeod, L.H.; Marsh, S. Use of pyrosequencing to detect clinically relevant polymorphisms in dihydropyrimidine dehydrogenase, Clin. Chem., Volume 49 (2003), pp. 1661-1664","journal-title":"Clin. Chem."},{"key":"key2025102316284255993_29","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1046\/j.1365-2125.1998.00751.x","article-title":"Dihydropyrimidine dehydrogenase pharmacogenetics in Caucasian subjects","volume":"46","author":"Ridge, S.A.","year":"1998","unstructured":"[29] Ridge, S.A.; Sludden, J.; Brown, O.; Robertson, L.; Wei, X.; Sapone, A.; Fernandez-Salguero, P.M.; Gonzalez, F.J.; Vreken, P.; Van Kuilenburg, A.B.P.; Van Gennip, A.H.; McLeod, H.L. Dihydropyrimidine dehydrogenase pharmacogenetics in Caucasian subjects, Br. J. Clin. Pharmacol., Volume 46 (1998), pp. 151-156","journal-title":"Br. J. Clin. Pharmacol."},{"key":"key2025102316284255993_30","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1002\/humu.9201","article-title":"Detailed analysis of five mutations in dihydropyrimidine dehydrogenase detected in cancer patients with 5-fluorouracil-related side effects","volume":"22","author":"Gross, E.","year":"2003","unstructured":"[30] Gross, E.; Ullrich, T.; Seck, K.; Mueller, V.; de Wit, M.; Von Schlling, C.; Meindl, A.; Schmitt, M.; Kiechle, M. Detailed analysis of five mutations in dihydropyrimidine dehydrogenase detected in cancer patients with 5-fluorouracil-related side effects, Hum. Mutat., Volume 22 (2003), p. 498","journal-title":"Hum. Mutat."},{"issue":"2","key":"key2025102316284255993_31","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1097\/FTD.0b013e318040b1fe","article-title":"Thymidylate synthase (TYMS) and dihydropyrimidine dehydrogenase (DPYD) polymorphisms in the Korean population for prediction of 5-fluorouracil-associated toxicity","volume":"29","author":"Cho, H.J.","year":"2007","unstructured":"[31] Cho, H.J.; Park, Y.S.; Kang, W.K.; Kim, J.W.; Lee, S.Y. Thymidylate synthase (TYMS) and dihydropyrimidine dehydrogenase (DPYD) polymorphisms in the Korean population for prediction of 5-fluorouracil-associated toxicity, Ther. Drug Monit., Volume 29 (2007) no. 2, pp. 190-196","journal-title":"Ther. Drug Monit."},{"key":"key2025102316284255993_32","first-page":"768","article-title":"Profound dihydropyrimidine dehydrogenase (DPD) deficiency resulting from a novel compound heterozygote genotype","volume":"8","author":"Johnson, M.R.","year":"2002","unstructured":"[32] Johnson, M.R.; Wang, K.; Diasio, R.B. Profound dihydropyrimidine dehydrogenase (DPD) deficiency resulting from a novel compound heterozygote genotype, Clin. Cancer Res., Volume 8 (2002), pp. 768-774","journal-title":"Clin. Cancer Res."}],"container-title":["Comptes Rendus. 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