{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T06:20:44Z","timestamp":1782886844424,"version":"3.54.5"},"reference-count":62,"publisher":"MathDoc\/Centre Mersenne","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Adrenal function and aging have been the object of intense interest recently, especially as regards dehydroepiandrosterone sulfate (DHEA-S), which is of major importance, since it is distinct from cortisol and aldosterone in declining with age. In a group of healthy old Tunisians, we investigated the association between cortisol and DHEA-S, on the one hand, and age, sex, lifestyle, physical health, including the body mass index (BMI), physical activity, and smoking indicators, on the other hand. We observed that cortisol concentrations did not change with aging, while DHEA-S concentrations decrease with age in both sexes. Cortisol\/DHEA-S ratio, however, increases with aging. Our results revealed that DHEA-S levels are affected neither by physical activity nor by weight. It appears also that current smoking could not affect the level of DHEA-S. Relationships were found between DHEA-S concentrations and BMI, then between DHEA-S levels and serum cholesterol, triglycerides and calcium. No modification in the morning serum cortisol was found to be associated with aging. Decrease in DHEA-S levels is, however, clearly associated with this phenomenon. High cortisol\/DHEA-S ratio accelerates the occurrence of some adult diseases, such as diabetes mellitus, atherosclerosis, dementia, and osteoporosis. Generally, the adrenal insufficiency marked by a cognitive impairment, immune disorders, sexual dysfunction, and scores for depression and anxiety can be corrected by a replacement of deficient DHEA-S.<\/jats:p>","DOI":"10.1016\/j.crvi.2007.08.004","type":"journal-article","created":{"date-parts":[[2007,9,12]],"date-time":"2007-09-12T07:20:22Z","timestamp":1189581622000},"page":"755-763","source":"Crossref","is-referenced-by-count":9,"title":["Hormonal status of cortisol and dehydroepiandrosterone sulfate in an elderly Tunisian population"],"prefix":"10.5802","volume":"330","author":[{"given":"Olfa","family":"Chehab","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Ouertani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamel","family":"Chaieb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faouzi","family":"Haouala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kacem","family":"Mahdouani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3842","published-online":{"date-parts":[[2007,9,11]]},"reference":[{"key":"key2025102316284176338_1","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1210\/jcem.81.9.8784058","article-title":"Dehydroepiandrosterone (DHEA): a fountain of youth?","volume":"81","author":"Baulieu, \u00c9.-\u00c9.","year":"1996","unstructured":"[1] Baulieu, \u00c9.-\u00c9. Dehydroepiandrosterone (DHEA): a fountain of youth?, J. Clin. Endocrinol. Metab., Volume 81 (1996), pp. 3147-3151","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"key2025102316284176338_2","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1210\/jcem.82.8.4161","article-title":"Physiological changes in dehydroepiandosterone are not reflected by serum levels of active androgens and estrogens but of their metabolites: intracrinology","volume":"82","author":"Labrie, F.","year":"1997","unstructured":"[2] Labrie, F.; B\u00e9langer, A.; Cusan, L.; Candas, B. Physiological changes in dehydroepiandosterone are not reflected by serum levels of active androgens and estrogens but of their metabolites: intracrinology, J. Clin. Endocrinol. Metab., Volume 82 (1997), pp. 2403-2409","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"key2025102316284176338_3","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1210\/jcem.83.6.4850","article-title":"Oral dehydroepiandrosterone for to adrenal androgen replacement: pharmacokinetics and peripheral conversion to androgens and estrogens in young healthy females after dexamethasone suppression","volume":"83","author":"Arlt, W.","year":"1998","unstructured":"[3] Arlt, W.; Justl, H.-G.; Callies, F.; Reincke, M.; Hubler, D.; Oettel, M.; Ernst, M.; Schulte, H.M.; Allolio, B. Oral dehydroepiandrosterone for to adrenal androgen replacement: pharmacokinetics and peripheral conversion to androgens and estrogens in young healthy females after dexamethasone suppression, J. Clin. Endocrinol. Metab., Volume 83 (1998), pp. 1928-1934","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"key2025102316284176338_4","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1093\/ageing\/27.6.745","article-title":"Physical activity and dehydroepiandrosterone sulfate, insulin-like growth factor I and testosterone in healthy active elderly people","volume":"27","author":"Bonnefoy, M.","year":"1998","unstructured":"[4] Bonnefoy, M.; Kostka, T.; Patricot, M.-C.; Berthouse, S.E.; Mathian, B.; Lacour, J.-R. Physical activity and dehydroepiandrosterone sulfate, insulin-like growth factor I and testosterone in healthy active elderly people, Age Ageing, Volume 27 (1998), pp. 745-751","journal-title":"Age Ageing"},{"key":"key2025102316284176338_5","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0169-328X(99)00002-9","article-title":"Dehydroepiandosterone (DHEA) protects hippocampal cells from oxidative stress-induced damage","volume":"20","author":"Bastianetto, S.","year":"1999","unstructured":"[5] Bastianetto, S.; Ramassamy, C.; Poirier, J.; Quirion, R. Dehydroepiandosterone (DHEA) protects hippocampal cells from oxidative stress-induced damage, Brain Res. Mol. Brain Res., Volume 20 (1999), pp. 35-41","journal-title":"Brain Res. Mol. 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Med., Volume 341 (1999), pp. 1073-1074","journal-title":"N. Engl. J. Med."},{"key":"key2025102316284176338_22","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1749-6632.1995.tb17376.x","article-title":"Dehydroepiandosterone sulfate, and aging","volume":"774","author":"Vermeulen, A.","year":"1995","unstructured":"[22] Vermeulen, A. Dehydroepiandosterone sulfate, and aging, Ann. N. Y. Acad. Sci., Volume 774 (1995), pp. 121-125","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"key2025102316284176338_23","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1126\/science.1071851","article-title":"Biomarkers of caloric restriction may predict longevity in humans","volume":"297","author":"Roth, G.S.","year":"2002","unstructured":"[23] Roth, G.S.; Lane, M.A.; Ingram, D.K.; Mattison, J.A.; Elahi, D.; Tobin, J.D.; Muller, D.; Metter, E.J. Biomarkers of caloric restriction may predict longevity in humans, Science, Volume 297 (2002), p. 811","journal-title":"Science"},{"key":"key2025102316284176338_24","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S0531-5565(99)00047-9","article-title":"Glucocorticoids, stress, and their adverse neurological effects: relevance to aging","volume":"34","author":"Sapolsky, R.M.","year":"1999","unstructured":"[24] Sapolsky, R.M. Glucocorticoids, stress, and their adverse neurological effects: relevance to aging, Exp. Gerontol., Volume 34 (1999), pp. 721-732","journal-title":"Exp. 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Metab., Volume 12 (1998), pp. 441-451","journal-title":"Balliere's Clin. Endocrinol. Metab."},{"key":"key2025102316284176338_27","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1081\/CBI-100101052","article-title":"Alteration with aging of the endocrine and neuroendocrine circadian system in humans","volume":"17","author":"Touitou, Y.","year":"2000","unstructured":"[27] Touitou, Y.; Haus, E. Alteration with aging of the endocrine and neuroendocrine circadian system in humans, Chronobiol. Int., Volume 17 (2000), pp. 369-390","journal-title":"Chronobiol. 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Cortisol and dehydroepiandosterone sulfate plasma levels and their relationship to aging, cognitive function, and dementia, Brain Cognition, Volume 50 (2002), pp. 316-323","journal-title":"Brain Cognition"},{"key":"key2025102316284176338_34","first-page":"1173","article-title":"The relationship of dehydroepiandrosterone sulfate (DHEAS) to endocrine-metabolic parameters and functional status in the oldest-old. Results from an Italian study on healthy free-living over-ninety-year-olds","volume":"81","author":"Ravaglia, G.","year":"1996","unstructured":"[34] Ravaglia, G.; Forti, P.; Maioli, F.; Boschi, F.; Bernardi, M.; Pratelli, L.; Pizzoferrato, A.; Gasbarrini, G. The relationship of dehydroepiandrosterone sulfate (DHEAS) to endocrine-metabolic parameters and functional status in the oldest-old. Results from an Italian study on healthy free-living over-ninety-year-olds, J. Clin. Endocrinol. Metab., Volume 81 (1996), pp. 1173-1178","journal-title":"J. Clin. Endocrinol. 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