{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T20:41:23Z","timestamp":1768336883667,"version":"3.49.0"},"reference-count":42,"publisher":"MathDoc\/Centre Mersenne","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>Dopamine receptors play a critical role in the cell signalling process responsible for information transfer in neurons functioning in the nervous system. Development of improved therapeutics for disorders like Parkinson's disease and schizophrenia would be significantly enhanced with the availability of the 3D structure for the dopamine receptors. Scorpion neurotoxins are unique source of structural templates from which new therapeutic agents might be developed. We report here the 3D structure of the human D1 dopamine receptor, predicted from primary sequence using computational techniques. The predicted structure of the human D1 dopamine receptor is used to understand the mechanism of interactions between scorpion neurotoxins through the protein\u2013protein docking method. CHARMM force field was used for the energy minimization step before applying the docking method.<\/jats:p>","DOI":"10.1016\/j.crvi.2008.04.007","type":"journal-article","created":{"date-parts":[[2008,5,28]],"date-time":"2008-05-28T13:53:39Z","timestamp":1211982819000},"page":"489-499","source":"Crossref","is-referenced-by-count":3,"title":["Investigations on the interactions of scorpion neurotoxins with the predicted structure of D1 dopamine receptor by protein\u2013protein docking method. A bioinformatics approach"],"prefix":"10.5802","volume":"331","author":[{"given":"C.","family":"Sudandiradoss","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. George","family":"Priya Doss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Rajasekaran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Ramanathan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rituraj","family":"Purohit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rao","family":"Sethumadhavan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3842","published-online":{"date-parts":[[2008,5,27]]},"reference":[{"key":"key2025102316305247654_1","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S0092-8674(01)00483-4","article-title":"A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons","volume":"106","author":"Dong, X.","year":"2001","unstructured":"[1] Dong, X.; Han, S.K.; Zylka, M.J.; Simon, M.I.; Anderson, D.J. 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Multiple receptors for dopamine, Nature, Volume 277 (1979), pp. 93-96","journal-title":"Nature"},{"key":"key2025102316305247654_11","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0163-7258(99)00029-7","article-title":"Dopamine receptors: Physiological understanding to therapeutic intervention potential","volume":"84","author":"Emilien, G.","year":"1999","unstructured":"[11] Emilien, G.; Maloteaux, J.M.; Geurts, K.; Hoogenberg, K.; Cragg, S. Dopamine receptors: Physiological understanding to therapeutic intervention potential, Pharmacol. Ther., Volume 84 (1999), pp. 133-156","journal-title":"Pharmacol. Ther."},{"key":"key2025102316305247654_12","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1254\/jjp.60.263","article-title":"Application of physiologically active substances isolated from natural resources to pharmacological studies","volume":"73","author":"Ohizumi, Y.","year":"1997","unstructured":"[12] Ohizumi, Y. 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Three-dimensional structure of a neurotoxin from red scorpion (Buthus tamulus) at 2.2-\u00c5 resolution http:\/\/www.rcsb.org\/pdb\/cgi\/explore.cgi (submitted for publication pid=275071047101552&amp;pdbId=1DQ7)"},{"key":"key2025102316305247654_20","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1006\/jmbi.1994.1270","article-title":"Crystal structure of toxin II from the scorpion <span class=\"italique\">Androctonus australis<\/span> Hector refined at 1.3 A resolution","volume":"238","author":"Housset, D.","year":"1994","unstructured":"[20] Housset, D.; Habersetzer-Rochat, C.; Astier, J.-P.; Fontecilla-Camps, J.-C. Crystal structure of toxin II from the scorpion Androctonus australis Hector refined at 1.3 A resolution, J. Mol. Biol., Volume 238 (1994), pp. 88-103","journal-title":"J. Mol. 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