{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T12:19:41Z","timestamp":1789388381567,"version":"build-2803163510"},"reference-count":67,"publisher":"MathDoc\/Centre Mersenne","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p id=\"spar0005\">\n                    La musaraigne musette\n                    <jats:italic>Crocidura russula<\/jats:italic>\n                    a une dur\u00e9e de vie courte et la phase de s\u00e9nescence est consid\u00e9rablement allong\u00e9e en captivit\u00e9. La perte de rythmicit\u00e9 des fonctions biologiques qui accompagne ce vieillissement est, par ailleurs, bien document\u00e9e.\n                    <jats:italic>C.\u00a0russula<\/jats:italic>\n                    constitue ainsi un excellent mod\u00e8le pour tester les cons\u00e9quences de la s\u00e9nescence sur les horloges biologiques. La m\u00e9latonine est une hormone clef dans la synchronisation des comportements, m\u00e9tabolismes et r\u00e9gulations physiologiques avec les facteurs du milieu. Dans ce travail, nous avons cherch\u00e9 \u00e0 savoir si la perte de la rythmicit\u00e9 circadienne et, en particulier, celle de la s\u00e9cr\u00e9tion de m\u00e9latonine (MLT) observ\u00e9es d\u00e8s la deuxi\u00e8me ann\u00e9e de vie chez cette esp\u00e8ce pouvaient \u00eatre associ\u00e9es \u00e0 des modifications de structure du parenchyme pin\u00e9al, lieu de synth\u00e8se de l\u2019hormone. Des pin\u00e9ales d\u2019individus jeunes (1\u20134\u00a0mois) et s\u00e9nescents (25\u201328\u00a0mois) ont \u00e9t\u00e9 analys\u00e9es au microscope \u00e9lectronique \u00e0 transmission (MET). Dans les pin\u00e9alocytes de musaraignes \u00e2g\u00e9es, les alt\u00e9rations touchent le noyau, les mitochondries et les citernes de r\u00e9ticulum avec un accroissement du nombre de corps denses et la formation de corps concr\u00e9tiques. Les produits de s\u00e9cr\u00e9tion se rar\u00e9fient. Ces modifications \u00e9voquent un ralentissement du m\u00e9tabolisme pin\u00e9alocytaire, ce qui expliquerait la r\u00e9duction des taux de MLT enregistr\u00e9s chez l\u2019esp\u00e8ce au cours de l\u2019\u00e2ge.\n                  <\/jats:p>","DOI":"10.1016\/j.crvi.2011.11.001","type":"journal-article","created":{"date-parts":[[2011,12,28]],"date-time":"2011-12-28T07:22:47Z","timestamp":1325056967000},"page":"9-18","source":"Crossref","is-referenced-by-count":4,"title":["Aspects cellulaires du vieillissement de la glande pin\u00e9ale chez la musaraigne, Crocidura\u00a0russula"],"prefix":"10.5802","volume":"335","author":[{"given":"Aicha","family":"Dekar-Madoui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Besseau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9lodie","family":"Magnanou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Fons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saliha","family":"Ouali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mounira","family":"Bendjelloul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Falcon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3842","published-online":{"date-parts":[[2011,12,28]]},"reference":[{"key":"key2025102316351003021_1","first-page":"246","author":"Zucker, I.","year":"1991","unstructured":"[1] Zucker, I.; Lee, T.M.; Dark, J. 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