{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T12:20:19Z","timestamp":1789388419951,"version":"build-2803163510"},"reference-count":21,"publisher":"MathDoc\/Centre Mersenne","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p id=\"spar0005\">\n                    La toxoplasmose est une maladie n\u00e9glig\u00e9e, avec une pr\u00e9valence au niveau mondial estim\u00e9e \u00e0 un tiers de la population. Les recherches en chimie m\u00e9dicinale cherchent, depuis quelques ann\u00e9es, \u00e0 d\u00e9velopper de nouveaux m\u00e9dicaments contre la toxoplasmose, car les traitements actuels provoquent des effets secondaires graves pour les patients. L\u2019utilisation des thiosemicarbazones a \u00e9t\u00e9 propos\u00e9e, dans la litt\u00e9rature de ces derni\u00e8res ann\u00e9es, comme une alternative pour le traitement de plusieurs maladies, car elles pr\u00e9sentent des activit\u00e9s antitumorales, antimalariales, antitripanosomales, antibact\u00e9riennes et antitoxoplasmosiques, cette derni\u00e8re constituant le cadre du pr\u00e9sent travail, qui repose sur des analyses biologiques et des \u00e9tudes concernant la r\u00e9ponse de\n                    <jats:italic>Toxoplasma gondii<\/jats:italic>\n                    aux thiosemicarbazones.\n                  <\/jats:p>","DOI":"10.1016\/j.crvi.2013.03.002","type":"journal-article","created":{"date-parts":[[2013,4,23]],"date-time":"2013-04-23T15:45:20Z","timestamp":1366731920000},"page":"203-206","source":"Crossref","is-referenced-by-count":2,"title":["\u00c9tude de l\u2019effet des thiosemicarbazones sur Toxoplasma gondii"],"prefix":"10.5802","volume":"336","author":[{"given":"Marco Ant\u00f4nio G.B.","family":"Gomes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela M.","family":"Carreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela P.V.","family":"Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Marcos R.","family":"Nogueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ed\u00e9sio J.T.","family":"de Melo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmilson J.","family":"Maria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3842","published-online":{"date-parts":[[2013,4,1]]},"reference":[{"key":"key2025102316364187402_1","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.ijpara.2003.12.009","article-title":"<span class=\"italique\">Toxoplasma Gondii<\/span>: the model apicomplexan","volume":"34","author":"Kim, K.","year":"2004","unstructured":"[1] Kim, K.; Weiss, L.M. 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