{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:48:23Z","timestamp":1760888903105},"reference-count":43,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2014,6,1]],"date-time":"2014-06-01T00:00:00Z","timestamp":1401580800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cryobiology"],"published-print":{"date-parts":[[2014,6]]},"DOI":"10.1016\/j.cryobiol.2014.03.003","type":"journal-article","created":{"date-parts":[[2014,3,21]],"date-time":"2014-03-21T11:52:13Z","timestamp":1395402733000},"page":"436-445","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Preservation of high phenylalanine ammonia lyase activities in roots of Japanese Striped corn: A potential oral therapeutic to treat phenylketonuria"],"prefix":"10.1016","volume":"68","author":[{"given":"Arturo","family":"L\u00f3pez-Villalobos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joost","family":"L\u00fccker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Angela","family":"L\u00f3pez-Quir\u00f3z","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward C.","family":"Yeung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristoffer","family":"Palma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison R.","family":"Kermode","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cryobiol.2014.03.003_b0005","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/jxb\/46.4.433","article-title":"Development of white spruce (Picea glauca (Moench) Voss) somatic embryos during culture with abscisic-acid and osmoticum, and their tolerance to drying and frozen storage","volume":"46","author":"Attree","year":"1995","journal-title":"J. Exp. Bot."},{"key":"10.1016\/j.cryobiol.2014.03.003_b0010","article-title":"The chemical composition of maple syrup","volume":"84","author":"Ball","year":"2007","journal-title":"J. Chem. Educ."},{"key":"10.1016\/j.cryobiol.2014.03.003_b0015","series-title":"Plant Cryopreservation: A Practical Guide","first-page":"15","article-title":"Cryopreservation theory","author":"Benson","year":"2008"},{"issue":"2002","key":"10.1016\/j.cryobiol.2014.03.003_b0020","first-page":"304","article-title":"High frequency of tetrahydrobiopterin-responsiveness among hyperphenylalaninemias: a study of, patients observed from 1988 to 2002","volume":"77","author":"Bernegger","year":"1919","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.cryobiol.2014.03.003_b0025","series-title":"Seeds: physiology of development and germination","author":"Bewley","year":"1994"},{"key":"10.1016\/j.cryobiol.2014.03.003_b0030","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/S0140-6736(10)60961-0","article-title":"Phenylketonuria","volume":"376","author":"Blau","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/j.cryobiol.2014.03.003_b0035","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cryobiol.2004.02.011","article-title":"Glass formation in plant anhydrobiotes: survival in the dry state","volume":"48","author":"Buitink","year":"2004","journal-title":"Cryobiology"},{"key":"10.1016\/j.cryobiol.2014.03.003_b0040","series-title":"Current Frontiers in Cryopreservation","first-page":"415","article-title":"Proline and the cryopreservation of plant tissues: functions and practical applications","author":"Burritt","year":"2012"},{"key":"10.1016\/j.cryobiol.2014.03.003_b0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/10731199509117665","article-title":"A new theory of enterorecirculation of amino-acids and its use for depleting unwanted amino-acids using oral enzyme artificial cells, as in removing phenylalanine in phenylketonuria","volume":"23","author":"Chang","year":"1995","journal-title":"Artif. Cell. Blood Sub."},{"key":"10.1016\/j.cryobiol.2014.03.003_b0050","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1152\/physrev.1982.62.4.1193","article-title":"Interorgan amino-acid nutrition","volume":"62","author":"Christensen","year":"1982","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.cryobiol.2014.03.003_b0055","first-page":"375","article-title":"Cryoprotectants: the essential antifreezes to protect life in the frozen state","volume":"25","author":"Fuller","year":"2004","journal-title":"Cryoletters"},{"key":"10.1016\/j.cryobiol.2014.03.003_b0060","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.ymthe.2005.02.013","article-title":"Development of pegylated forms of recombinant Rhodosporidium toruloides phenylalanine ammonia-lyase for the treatment of classical phenylketonuria","volume":"11","author":"Gamez","year":"2005","journal-title":"Mol. Ther."},{"key":"10.1016\/j.cryobiol.2014.03.003_b0065","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.ymgme.2007.04.015","article-title":"Structure-based epitope and PEGylation sites mapping of phenylalanine ammonia-lyase for enzyme substitution treatment of phenylketonuria","volume":"91","author":"Gamez","year":"2007","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.cryobiol.2014.03.003_b0070","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1743-7075-9-7","article-title":"Phenylketonuria: nutritional advances and challenges","volume":"9","author":"Giovannini","year":"2012","journal-title":"Nutr. Metab."},{"key":"10.1016\/j.cryobiol.2014.03.003_b0075","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1002\/jsfa.3126","article-title":"Screening of phenylalanine ammonia lyase in plant tissues, and retention of activity during dehydration","volume":"88","author":"Goldson","year":"2008","journal-title":"J. Sci. Food Agric."},{"key":"10.1016\/j.cryobiol.2014.03.003_b0080","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1023\/A:1025008117046","article-title":"Proteases associated with programmed cell death of megagametophyte cells after germination of white spruce (Picea glauca) seeds","volume":"52","author":"He","year":"2003","journal-title":"Plant Mol. Biol."},{"key":"10.1016\/j.cryobiol.2014.03.003_b0085","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1128\/JB.161.3.963-966.1985","article-title":"Regulation of phenylalanine ammonia-lyase in Rhodotorula glutinis","volume":"161","author":"Kane","year":"1985","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.cryobiol.2014.03.003_b0090","series-title":"Plant Cryopreservation: A Practical Guide","first-page":"281","article-title":"Cryopreservation of herbaceous dicots","author":"Keller","year":"2008"},{"key":"10.1016\/j.cryobiol.2014.03.003_b0095","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/pbi.12008","article-title":"Oral delivery of bioencapsulated exendin-4 expressed in chloroplasts lowers blood glucose level in mice and stimulates insulin secretion in beta-TC6 cells","volume":"11","author":"Kwon","year":"2013","journal-title":"Plant Biotechnol. J."},{"key":"10.1016\/j.cryobiol.2014.03.003_b0100","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.addr.2012.10.005","article-title":"Oral delivery of human biopharmaceuticals, autoantigens and vaccine antigens bioencapsulated in plant cells","volume":"65","author":"Kwon","year":"2013","journal-title":"Adv. Drug Delivery Rev."},{"key":"10.1016\/j.cryobiol.2014.03.003_b0105","doi-asserted-by":"crossref","first-page":"11407","DOI":"10.1021\/jf8021942","article-title":"Retention of phenylalanine ammonia-lyase activity in wheat seedlings during storage and in vitro digestion","volume":"56","author":"Lam","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.cryobiol.2014.03.003_b0110","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s00299-008-0650-6","article-title":"The ornamental variety, Japanese striped corn, contains high anthocyanin levels and PAL specific activity: establishing the potential for development of an oral therapeutic","volume":"28","author":"McInnis","year":"2009","journal-title":"Plant Cell Rep."},{"key":"10.1016\/j.cryobiol.2014.03.003_b0115","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1093\/pcp\/pcs038","article-title":"High-throughput cryopreservation of plant cell cultures for functional genomics","volume":"53","author":"Ogawa","year":"2012","journal-title":"Plant Cell Physiol."},{"key":"10.1016\/j.cryobiol.2014.03.003_b0120","series-title":"Plant Cryopreservation: A Practical Guide","first-page":"241","article-title":"Cryopreservation of monocots","author":"Panis","year":"2008"},{"key":"10.1016\/j.cryobiol.2014.03.003_b0125","doi-asserted-by":"crossref","first-page":"374","DOI":"10.3945\/ajcn.110.009456","article-title":"Maternal phenylketonuria and hyperphenylalaninemia in pregnancy: pregnancy complications and neonatal sequelae in untreated and treated pregnancies","volume":"95","author":"Prick","year":"2012","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.cryobiol.2014.03.003_b0130","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.cryobiol.2011.01.015","article-title":"Addition of oligosaccharide decreases the freezing lesions on human red blood cell membrane in the presence of dextran and glucose","volume":"62","author":"Quan","year":"2011","journal-title":"Cryobiology"},{"key":"10.1016\/j.cryobiol.2014.03.003_b0135","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.cryobiol.2010.02.004","article-title":"In vivo circulation of mouse red blood cells frozen in the presence of dextran and glucose","volume":"61","author":"Quan","year":"2010","journal-title":"Cryobiology"},{"key":"10.1016\/j.cryobiol.2014.03.003_b0140","doi-asserted-by":"crossref","first-page":"3426","DOI":"10.1105\/tpc.104.025288","article-title":"Structural basis for the entrance into the phenylpropanoid metabolism catalyzed by phenylalanine ammonia-lyase","volume":"16","author":"Ritter","year":"2004","journal-title":"Plant Cell"},{"key":"10.1016\/j.cryobiol.2014.03.003_b0145","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1104\/pp.113.1.175","article-title":"Maize phenylalanine ammonia-lyase has tyrosine ammonia-lyase activity","volume":"113","author":"R\u00f6sler","year":"1997","journal-title":"Plant Physiol."},{"key":"10.1016\/j.cryobiol.2014.03.003_b0150","series-title":"Molecular Cloning: A laboratory manual","author":"Sambrook","year":"1989"},{"key":"10.1016\/j.cryobiol.2014.03.003_b0155","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1006\/mgme.2000.2974","article-title":"A heteroallelic mutant mouse model: a new orthologue for human hyperphenylalaninemia","volume":"69","author":"Sarkissian","year":"2000","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.cryobiol.2014.03.003_b0160","doi-asserted-by":"crossref","first-page":"S22","DOI":"10.1016\/j.ymgme.2005.06.016","article-title":"Phenylalanine ammonia lyase, enzyme substitution therapy for phenylketonuria, where are we now?","volume":"86","author":"Sarkissian","year":"2005","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.cryobiol.2014.03.003_b0165","doi-asserted-by":"crossref","first-page":"20894","DOI":"10.1073\/pnas.0808421105","article-title":"Preclinical evaluation of multiple species of PEGylated recombinant phenylalanine ammonia lyase for the treatment of phenylketonuria","volume":"105","author":"Sarkissian","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cryobiol.2014.03.003_b0170","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.ymgme.2011.06.016","article-title":"Evaluation of orally administered PEGylated phenylalanine ammonia lyase in mice for the treatment of phenylketonuria","volume":"104","author":"Sarkissian","year":"2011","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.cryobiol.2014.03.003_b0175","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1002\/jms.1218","article-title":"Quantitation of phenylalanine and its trans-cinnamic, benzoic and hippuric acid metabolites in biological fluids in a single GC-MS analysis","volume":"42","author":"Sarkissian","year":"2007","journal-title":"J. Mass Spectrom."},{"key":"10.1016\/j.cryobiol.2014.03.003_b0180","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1073\/pnas.96.5.2339","article-title":"A different approach to treatment of phenylketonuria: phenylalanine degradation with recombinant phenylalanine ammonia lyase","volume":"96","author":"Sarkissian","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.cryobiol.2014.03.003_b0185","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0031-9422(03)00151-1","article-title":"Phenylpropanoid compounds and disease resistance in transgenic tobacco with altered expression of L-phenylalanine ammonia-lyase","volume":"64","author":"Shadle","year":"2003","journal-title":"Phytochemistry"},{"key":"10.1016\/j.cryobiol.2014.03.003_b0190","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3181\/00379727-44-11346","article-title":"Cinnamic acid metabolism in man","volume":"44","author":"Snapper","year":"1940","journal-title":"Proc. Soc. Exp. Biol. Med."},{"key":"10.1016\/j.cryobiol.2014.03.003_b0195","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S1096-7192(02)00229-9","article-title":"Tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency, state of the art","volume":"78","author":"Spaapen","year":"2003","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.cryobiol.2014.03.003_b0200","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cryobiol.2009.05.007","article-title":"Thermodynamic aspects of vitrification","volume":"60","author":"Wowk","year":"2010","journal-title":"Cryobiology"},{"key":"10.1016\/j.cryobiol.2014.03.003_b0205","series-title":"Cell Culture and Somatic Cell Genetics of Plants","first-page":"689","article-title":"Histological and histochemical staining procedures","author":"Yeung","year":"1984"},{"key":"10.1016\/j.cryobiol.2014.03.003_b0210","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s11627-999-0023-z","article-title":"The use of histology in the study of plant tissue culture systems \u2013 some practical comments","volume":"35","author":"Yeung","year":"1999","journal-title":"In vitro Cell. Develop. Biol. Plant"},{"key":"10.1016\/j.cryobiol.2014.03.003_b0215","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1007\/s10545-012-9458-1","article-title":"Tetrahydrobiopterin (BH4) in PKU: effect on dietary treatment, metabolic control, and quality of life","volume":"35","author":"Ziesch","year":"2012","journal-title":"J. Inherit. Metab. Dis."}],"container-title":["Cryobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0011224014000480?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0011224014000480?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,16]],"date-time":"2020-08-16T16:32:04Z","timestamp":1597595524000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0011224014000480"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["S0011224014000480"],"URL":"https:\/\/doi.org\/10.1016\/j.cryobiol.2014.03.003","relation":{},"ISSN":["0011-2240"],"issn-type":[{"value":"0011-2240","type":"print"}],"subject":[],"published":{"date-parts":[[2014,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Preservation of high phenylalanine ammonia lyase activities in roots of Japanese Striped corn: A potential oral therapeutic to treat phenylketonuria","name":"articletitle","label":"Article Title"},{"value":"Cryobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cryobiol.2014.03.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}