{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T06:40:31Z","timestamp":1783406431189,"version":"3.54.6"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cryobiology"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.cryobiol.2021.04.003","type":"journal-article","created":{"date-parts":[[2021,4,17]],"date-time":"2021-04-17T16:20:55Z","timestamp":1618676455000},"page":"26-31","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Blastocyst transfer after extended culture of cryopreserved cleavage embryos improves in vitro fertilization cycle outcomes"],"prefix":"10.1016","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6225-3108","authenticated-orcid":false,"given":"Minh Tam","family":"Le","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thai Thanh Thi","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trung Van","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Nhan Thi","family":"Dang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quoc Huy Vu","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cryobiol.2021.04.003_bib1","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.1016\/j.jasi.2017.08.103","article-title":"Comparative study of implantation rate in cleavage embryo transfer vs blastocyst transfer among couples undergoing in vitro fertilization for treatment of infertility","volume":"66","author":"Ahuja","year":"2017","journal-title":"J. Anat. Soc. India"},{"issue":"11","key":"10.1016\/j.cryobiol.2021.04.003_bib2","doi-asserted-by":"crossref","first-page":"880","DOI":"10.3109\/09513590.2015.1056141","article-title":"Pregnancy outcome after blastocyst stage transfer comparing to early cleavage stage embryo transfer","volume":"31","author":"Aziminekoo","year":"2015","journal-title":"Gynecol. Endocrinol."},{"issue":"6","key":"10.1016\/j.cryobiol.2021.04.003_bib3","first-page":"1270","article-title":"The Istanbul consensus workshop on embryo assessment: Proceedings of an expert meeting","volume":"26","author":"Balaban","year":"2011","journal-title":"in: Hum. Reprod"},{"issue":"2","key":"10.1016\/j.cryobiol.2021.04.003_bib4","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/S0015-0282(00)00645-2","article-title":"Blastocyst quality affects the success of blastocyst-stage embryo transfer","volume":"74","author":"Balaban","year":"2000","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.cryobiol.2021.04.003_bib5","doi-asserted-by":"crossref","first-page":"e159","DOI":"10.1016\/j.fertnstert.2019.07.532","article-title":"Pregnancy outcomes of frozen thawed cleavage stage embryos with or without extended culture to blastocyst stage","volume":"112","author":"Chan","year":"2019","journal-title":"Fertil. Steril."},{"issue":"5","key":"10.1016\/j.cryobiol.2021.04.003_bib6","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1016\/j.fertnstert.2012.07.1107","article-title":"Outcomes of vitrified early cleavage-stage and blastocyst-stage embryos in a cryopreservation program: evaluation of 3,150 warming cycles","volume":"98","author":"Cobo","year":"2012","journal-title":"Fertil. Steril."},{"issue":"5","key":"10.1016\/j.cryobiol.2021.04.003_bib7","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/s10815-013-9988-y","article-title":"Chromosomal integrity of human preimplantation embryos at different days post fertilization","volume":"30","author":"Dekel-Naftali","year":"2013","journal-title":"J. Assist. Reprod. Genet."},{"key":"10.1016\/j.cryobiol.2021.04.003_bib8","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s00404-012-2303-9","article-title":"Transfer of blastocysts derived from frozen-thawed cleavage stage embryos improved ongoing pregnancy","volume":"286","author":"Eftekhar","year":"2012","journal-title":"Arch. Gynecol. Obstet."},{"key":"10.1016\/j.cryobiol.2021.04.003_bib9","doi-asserted-by":"crossref","first-page":"S174","DOI":"10.1016\/j.fertnstert.2010.07.690","article-title":"Cleavage stage versus blastocyst stage embryo transfer in frozen-thawed assisted conception cycles","volume":"94","author":"Elassar","year":"2010","journal-title":"Fertil. Steril."},{"issue":"2","key":"10.1016\/j.cryobiol.2021.04.003_bib10","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1093\/molehr\/gat073","article-title":"Morphological and cytogenetic assessment of cleavage and blastocyst stage embryos","volume":"20","author":"Fragouli","year":"2014","journal-title":"Mol. Hum. Reprod."},{"key":"10.1016\/j.cryobiol.2021.04.003_bib11","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.fertnstert.2016.06.029","article-title":"Cleavage-stage or blastocyst transfer: what are the benefits and harms?","volume":"106","author":"Glujovsky","year":"2016","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.cryobiol.2021.04.003_bib12","first-page":"CD002118","article-title":"Cleavage stage versus blastocyst stage embryo transfer in assisted reproductive technology (Review)","volume":"6","author":"Glujovsky","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.cryobiol.2021.04.003_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13048-017-0332-5","article-title":"What we learned from extended culture of \u201crejected\u201d day-3 cleavage stage embryos: a prospective cohort study","volume":"10","author":"Hershko Klement","year":"2017","journal-title":"J. Ovarian Res."},{"key":"10.1016\/j.cryobiol.2021.04.003_bib14","series-title":"How to Prepare the Endometrium to Maximize Implantation Rates and IVF Success","first-page":"91","article-title":"Cleavage stage or blastocyst transfer: which is better?","author":"Kasraie","year":"2019"},{"key":"10.1016\/j.cryobiol.2021.04.003_bib15","doi-asserted-by":"crossref","first-page":"194","DOI":"10.4103\/0974-1208.142481","article-title":"A comparative study between cleavage stage embryo transfer at day 3 and blastocyst stage transfer at day 5 in in-vitro fertilization\/intra-cytoplasmic sperm injection on clinical pregnancy rates","volume":"7","author":"Kaur","year":"2014","journal-title":"J. Hum. Reprod. Sci."},{"key":"10.1016\/j.cryobiol.2021.04.003_bib16","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1017\/S0967199419000777","article-title":"Investigation of transfer results of human embryos that were vitrified and thawed at the cleavage, morula and blastocyst stages","volume":"28","author":"Korkmaz","year":"2020","journal-title":"Zygote"},{"issue":"6","key":"10.1016\/j.cryobiol.2021.04.003_bib17","doi-asserted-by":"crossref","first-page":"260","DOI":"10.4103\/2305-0500.270103","article-title":"Prolonged post-thaw culture of embryos does not improve outcomes of frozen human embryo transfer cycles: a prospective randomized study","volume":"8","author":"Le","year":"2019","journal-title":"Asian Pacific J. Reprod."},{"key":"10.1016\/j.cryobiol.2021.04.003_bib18","first-page":"6","article-title":"Cryopreservation of embryos","volume":"18","author":"Pantos","year":"2001","journal-title":"Blastocysts Pregnancy Embryos Frozen-Thawed Blastocysts"},{"issue":"11","key":"10.1016\/j.cryobiol.2021.04.003_bib19","doi-asserted-by":"crossref","first-page":"3198","DOI":"10.1093\/humrep\/dei217","article-title":"Live birth rate is significantly higher after blastocyst transfer than after cleavage-stage embryo transfer when at least four embryos are available on day 3 of embryo culture. A randomized prospective study","volume":"20","author":"Papanikolaou","year":"2005","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.cryobiol.2021.04.003_bib20","doi-asserted-by":"crossref","first-page":"52","DOI":"10.21315\/mjms2019.26.2.6","article-title":"Does overnight culture of cleaved embryos improve pregnancy rate in vitrified-warmed embryo transfer programme?","volume":"26","author":"Rahimi","year":"2019","journal-title":"Malays. J. Med. Sci."},{"key":"10.1016\/j.cryobiol.2021.04.003_bib21","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s10815-017-1063-7","article-title":"Extended culture of poor-quality supernumerary embryos improves ART outcomes","volume":"35","author":"Sallem","year":"2018","journal-title":"J. Assist. Reprod. Genet."},{"key":"10.1016\/j.cryobiol.2021.04.003_bib22","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.rbmo.2018.12.031","article-title":"Comparison of perinatal outcomes following blastocyst and cleavage-stage embryo transfer: analysis of 10 years' data from a single centre","volume":"38","author":"Shi","year":"2019","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.cryobiol.2021.04.003_bib23","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1056\/NEJMoa1705334","article-title":"Transfer of fresh versus frozen embryos in ovulatory women","volume":"378","author":"Shi","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.cryobiol.2021.04.003_bib24","doi-asserted-by":"crossref","first-page":"S289","DOI":"10.1016\/j.fertnstert.2013.07.1081","article-title":"A prospective randomised controlled study comparing the cost effectiveness of IVF-ICSI treatment: cleavage stage (day 3) embryo transfer versus extended culture (day 5\/6 blastocyst) transfer","volume":"100","author":"Singh","year":"2013","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.cryobiol.2021.04.003_bib25","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.fertnstert.2018.05.012","article-title":"Cumulative live birth rate in freeze-all cycles is comparable to that of a conventional embryo transfer policy at the cleavage stage but superior at the blastocyst stage","volume":"110","author":"Zac\u00e0","year":"2018","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.cryobiol.2021.04.003_bib26","first-page":"1","article-title":"Frozen blastocyst embryo transfer vs. frozen cleavage-stage embryo transfer in couples with recurrent implantation failure: a cohort study","author":"Zhang","year":"2019","journal-title":"Hum. Fertil."},{"key":"10.1016\/j.cryobiol.2021.04.003_bib27","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s10815-014-0361-6","article-title":"The clinical outcomes of day 3 4-cell embryos after extended in vitro culture","volume":"32","author":"Zhao","year":"2015","journal-title":"J. Assist. Reprod. Genet."},{"key":"10.1016\/j.cryobiol.2021.04.003_bib28","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.rbmo.2018.12.034","article-title":"Live birth rate and neonatal outcome following cleavage-stage embryo transfer versus blastocyst transfer using the freeze-all strategy","volume":"38","author":"Zhu","year":"2019","journal-title":"Reprod. Biomed. Online"}],"container-title":["Cryobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0011224021000754?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0011224021000754?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T00:44:57Z","timestamp":1757897097000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0011224021000754"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":28,"alternative-id":["S0011224021000754"],"URL":"https:\/\/doi.org\/10.1016\/j.cryobiol.2021.04.003","relation":{},"ISSN":["0011-2240"],"issn-type":[{"value":"0011-2240","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Blastocyst transfer after extended culture of cryopreserved cleavage embryos improves in vitro fertilization cycle outcomes","name":"articletitle","label":"Article Title"},{"value":"Cryobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cryobiol.2021.04.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}