{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:19:32Z","timestamp":1791505172984,"version":"4.3.4"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970265"],"award-info":[{"award-number":["81970265"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cryobiology"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.cryobiol.2023.05.001","type":"journal-article","created":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T20:32:58Z","timestamp":1684528378000},"page":"104544","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Study on the protective effect of RNA-binding motif protein 3 in mild hypothermia oxygen-glucose deprivation\/reoxygenation cell model"],"prefix":"10.1016","volume":"112","author":[{"given":"Zhixuan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaocong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuming","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.cryobiol.2023.05.001_bib1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1186\/1477-7827-7-143","article-title":"Potential biological role of poly (ADP-ribose) polymerase (PARP) in male gametes","volume":"7","author":"Agarwal","year":"2009","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.cryobiol.2023.05.001_bib2","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.cub.2017.01.047","article-title":"RTN3 is a novel cold-induced protein and mediates neuroprotective effects of RBM3","volume":"27","author":"Bastide","year":"2017","journal-title":"Curr. Biol."},{"key":"10.1016\/j.cryobiol.2023.05.001_bib3","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/6503504","article-title":"Mild hypothermia promotes ischemic tolerance and survival of neural stem cell grafts by enhancing global SUMOylation","volume":"2022","author":"Cai","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.cryobiol.2023.05.001_bib4","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/S1474-4422(16)00114-9","article-title":"Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation","volume":"15","author":"Chamorro","year":"2016","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.cryobiol.2023.05.001_bib5","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s12031-014-0236-4","article-title":"Role of endoplasmic reticulum stress via the PERK signaling pathway in brain injury from status epilepticus","volume":"53","author":"Chen","year":"2014","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.cryobiol.2023.05.001_bib6","doi-asserted-by":"crossref","first-page":"518","DOI":"10.7150\/ijbs.17800","article-title":"Cold inducible RNA binding protein is involved in chronic hypoxia induced neuron apoptosis by down-regulating HIF-1\u03b1 expression and regulated by microRNA-23a","volume":"13","author":"Chen","year":"2017","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.cryobiol.2023.05.001_bib7","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.nbd.2011.04.010","article-title":"The RNA-binding protein RBM3 is involved in hypothermia induced neuroprotection","volume":"43","author":"Chip","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.cryobiol.2023.05.001_bib8","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/nrneurol.2012.21","article-title":"Hypothermia for acute brain injury--mechanisms and practical aspects","volume":"8","author":"Choi","year":"2012","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.cryobiol.2023.05.001_bib9","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ahj.2019.06.012","article-title":"Targeted hypothermia versus targeted Normothermia after out-of-hospital cardiac arrest (TTM2): a randomized clinical trial-Rationale and design","volume":"217","author":"Dankiewicz","year":"2019","journal-title":"Am. Heart J."},{"key":"10.1016\/j.cryobiol.2023.05.001_bib10","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.neuron.2022.01.017","article-title":"The different autophagy degradation pathways and neurodegeneration","volume":"110","author":"Fleming","year":"2022","journal-title":"Neuron"},{"key":"10.1016\/j.cryobiol.2023.05.001_bib11","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.25555","article-title":"Full length RTN3 regulates turnover of tubular endoplasmic reticulum via selective autophagy","volume":"6","author":"Grumati","year":"2017","journal-title":"Elife"},{"key":"10.1016\/j.cryobiol.2023.05.001_bib12","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/8704352","article-title":"Therapeutic hypothermia reduces oxidative damage and alters antioxidant defenses after cardiac arrest","volume":"2017","author":"Hackenhaar","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.cryobiol.2023.05.001_bib13","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1471-4159.1975.tb11881.x","article-title":"The effect of induced hypothermia upon oxygen consumption in the rat brain","volume":"24","author":"H\u00e4gerdal","year":"1975","journal-title":"J. Neurochem."},{"key":"10.1016\/j.cryobiol.2023.05.001_bib14","first-page":"325","volume":"40","author":"Jackson","year":"2018","journal-title":"Infants Uniquely Express High Levels of RBM3 and Other Cold-Adaptive Neuroprotectant Proteins in the Human Brain"},{"key":"10.1016\/j.cryobiol.2023.05.001_bib15","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1128\/jb.169.5.2092-2095.1987","article-title":"Induction of proteins in response to low temperature in Escherichia coli","volume":"169","author":"Jones","year":"1987","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.cryobiol.2023.05.001_bib16","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/bfgp\/elq028","article-title":"Deciphering the role of RNA-binding proteins in the post-transcriptional control of gene expression","volume":"9","author":"Kishore","year":"2010","journal-title":"Briefing Funct Genom"},{"key":"10.1016\/j.cryobiol.2023.05.001_bib17","doi-asserted-by":"crossref","first-page":"5430","DOI":"10.2174\/0929867326666190506124836","article-title":"Therapeutic hypothermia and neuroprotection in acute neurological disease","volume":"26","author":"Kurisu","year":"2019","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.cryobiol.2023.05.001_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci8020032","article-title":"Neuroprotective effects of bioactive compounds and MAPK pathway modulation in \"Ischemia\"-Stressed PC12 pheochromocytoma cells","volume":"8","author":"Lahiani","year":"2018","journal-title":"Brain Sci."},{"key":"10.1016\/j.cryobiol.2023.05.001_bib19","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.canlet.2009.01.035","article-title":"Over-expression of Reticulon 3 (RTN3) enhances TRAIL-mediated apoptosis via up-regulation of death receptor 5 (DR5) and down-regulation of c-FLIP","volume":"279","author":"Lee","year":"2009","journal-title":"Cancer Lett."},{"key":"10.1016\/j.cryobiol.2023.05.001_bib20","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1002\/ijc.30833","article-title":"The role of cold-inducible RNA binding protein in cell stress response","volume":"141","author":"Liao","year":"2017","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.cryobiol.2023.05.001_bib21","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.brainres.2014.11.061","article-title":"Cloning, expression, and purification of cold inducible RNA-binding protein and its neuroprotective mechanism of action","volume":"1597","author":"Liu","year":"2015","journal-title":"Brain Res."},{"key":"10.1016\/j.cryobiol.2023.05.001_bib22","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/nature14142","article-title":"RBM3 mediates structural plasticity and protective effects of cooling in neurodegeneration","volume":"518","author":"Peretti","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.cryobiol.2023.05.001_bib23","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1515\/revneuro-2016-0054","article-title":"Effects of altered RTN3 expression on BACE1 activity and Alzheimer's neuritic plaques","volume":"28","author":"Sharoar","year":"2017","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.cryobiol.2023.05.001_bib24","article-title":"Reticulon 3-mediated Chk2\/p53 activation suppresses hepatocellular carcinogenesis and is blocked by hepatitis B virus","author":"Song","year":"2020","journal-title":"Gut"},{"key":"10.1016\/j.cryobiol.2023.05.001_bib25","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/2786139","article-title":"CIRBP ameliorates neuronal amyloid toxicity via antioxidative and antiapoptotic pathways in primary cortical neurons","volume":"2020","author":"Su","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.cryobiol.2023.05.001_bib26","doi-asserted-by":"crossref","first-page":"586","DOI":"10.3389\/fnins.2019.00586","article-title":"Neuroprotection by therapeutic hypothermia","volume":"13","author":"Sun","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.cryobiol.2023.05.001_bib27","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s10495-006-0574-y","article-title":"Reticulon 3 mediates Bcl-2 accumulation in mitochondria in response to endoplasmic reticulum stress","volume":"12","author":"Wan","year":"2007","journal-title":"Apoptosis"},{"key":"10.1016\/j.cryobiol.2023.05.001_bib28","doi-asserted-by":"crossref","first-page":"3464","DOI":"10.1083\/jcb.201801143","article-title":"Cold-induced protein RBM3 orchestrates neurogenesis via modulating Yap mRNA stability in cold stress","volume":"217","author":"Xia","year":"2018","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.cryobiol.2023.05.001_bib29","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1007\/s10495-006-0082-0","article-title":"Adaptor FADD is recruited by RTN3\/HAP in ER-bound signaling complexes","volume":"11","author":"Xiang","year":"2006","journal-title":"Apoptosis"},{"key":"10.1016\/j.cryobiol.2023.05.001_bib30","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/pan.12560","article-title":"Systematic Review and Meta-Analysis of benefits and risks between normothermia and hypothermia during cardiopulmonary bypass in pediatric cardiac surgery","volume":"25","author":"Xiong","year":"2015","journal-title":"Paediatr. Anaesth."},{"key":"10.1016\/j.cryobiol.2023.05.001_bib31","doi-asserted-by":"crossref","first-page":"288","DOI":"10.3389\/fcell.2019.00288","article-title":"The RNA-binding protein RBM3 promotes neural stem cell (NSC) proliferation under hypoxia","volume":"7","author":"Yan","year":"2019","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.cryobiol.2023.05.001_bib32","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1007\/s00018-005-5338-2","article-title":"Reticulon proteins: emerging players in neurodegenerative diseases","volume":"63","author":"Yan","year":"2006","journal-title":"Cell. Mol. Life Sci. : CMLS"},{"key":"10.1016\/j.cryobiol.2023.05.001_bib33","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nrn3174","article-title":"Neuroprotective mechanisms of hypothermia in brain ischaemia","volume":"13","author":"Yenari","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.cryobiol.2023.05.001_bib34","doi-asserted-by":"crossref","first-page":"3983","DOI":"10.1038\/s41467-019-11870-x","article-title":"RBM3 promotes neurogenesis in a niche-dependent manner via IMP2-IGF2 signaling pathway after hypoxic-ischemic brain injury","volume":"10","author":"Zhu","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.cryobiol.2023.05.001_bib35","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/s12031-017-0964-3","article-title":"Cold-inducible protein RBM3 protects UV irradiation-induced apoptosis in neuroblastoma cells by affecting p38 and JNK pathways and Bcl2 family proteins","volume":"63","author":"Zhuang","year":"2017","journal-title":"J. Mol. Neurosci."}],"container-title":["Cryobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0011224023000330?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0011224023000330?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T00:46:23Z","timestamp":1757897183000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0011224023000330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":35,"alternative-id":["S0011224023000330"],"URL":"https:\/\/doi.org\/10.1016\/j.cryobiol.2023.05.001","relation":{},"ISSN":["0011-2240"],"issn-type":[{"value":"0011-2240","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Study on the protective effect of RNA-binding motif protein 3 in mild hypothermia oxygen-glucose deprivation\/reoxygenation cell model","name":"articletitle","label":"Article Title"},{"value":"Cryobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cryobiol.2023.05.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104544"}}