{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T20:24:54Z","timestamp":1780950294638,"version":"3.54.1"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cryobiology"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.cryobiol.2024.105164","type":"journal-article","created":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T05:06:11Z","timestamp":1731733571000},"page":"105164","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["KCl enhances the cryoablation-induced antitumor immune response: A hepatocellular carcinoma murine model research"],"prefix":"10.1016","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9463-6741","authenticated-orcid":false,"given":"Mu","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4392-4863","authenticated-orcid":false,"given":"Baolin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.cryobiol.2024.105164_bib1","article-title":"Challenges in liver cancer and possible treatment approaches","volume":"1873","author":"Anwanwan","year":"2020","journal-title":"Biochim. Biophys. Acta Rev. Canc"},{"issue":"3","key":"10.1016\/j.cryobiol.2024.105164_bib2","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1158\/0008-5472.CAN-09-3566","article-title":"Tumor cell death and ATP release prime dendritic cells and efficient anticancer immunity","volume":"70","author":"Aymeric","year":"2010","journal-title":"Cancer Res."},{"issue":"3","key":"10.1016\/j.cryobiol.2024.105164_bib3","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0014-5793(98)00172-0","article-title":"Pro- and anti-apoptotic effects of K+ in HeLa cells","volume":"424","author":"Bilney","year":"1998","journal-title":"FEBS Lett."},{"issue":"1","key":"10.1016\/j.cryobiol.2024.105164_bib4","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1006\/cryo.1996.1978","article-title":"Cryosurgery of dunning AT-1 rat prostate tumor: thermal, biophysical, and viability response at the cellular and tissue level","volume":"34","author":"Bischof","year":"1997","journal-title":"Cryobiology"},{"issue":"18","key":"10.1016\/j.cryobiol.2024.105164_bib5","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1056\/NEJM200005043421807","article-title":"Role of transforming growth factor beta in human disease","volume":"342","author":"Blobe","year":"2000","journal-title":"N. Engl. J. Med."},{"issue":"5","key":"10.1016\/j.cryobiol.2024.105164_bib6","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1097\/00000658-200005000-00016","article-title":"Hepatic cryoablation, but not radiofrequency ablation, results in lung inflammation","volume":"231","author":"Chapman","year":"2000","journal-title":"Ann. Surg."},{"key":"10.1016\/j.cryobiol.2024.105164_bib7","doi-asserted-by":"crossref","DOI":"10.1007\/s10439-024-03512-1","article-title":"Cryoablation with KCl solution enhances necrosis and apoptosis of HepG2 liver cancer cells","author":"Chen","year":"2024","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.cryobiol.2024.105164_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2019.114428","article-title":"Targeted therapy for hepatocellular carcinoma: challenges and opportunities","volume":"460","author":"Chen","year":"2019","journal-title":"Cancer Lett."},{"issue":"2","key":"10.1016\/j.cryobiol.2024.105164_bib9","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s00405-015-3779-2","article-title":"Th1-, Th2-, and Th17-associated cytokine expression in hypopharyngeal carcinoma and clinical significance","volume":"273","author":"Chen","year":"2016","journal-title":"Eur. Arch. Oto-Rhino-Laryngol."},{"issue":"16","key":"10.1016\/j.cryobiol.2024.105164_bib10","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1001\/archinte.160.16.2429","article-title":"New guidelines for potassium replacement in clinical practice: a contemporary review by the National Council on Potassium in Clinical Practice","volume":"160","author":"Cohn","year":"2000","journal-title":"Arch. Intern. Med."},{"issue":"4","key":"10.1016\/j.cryobiol.2024.105164_bib11","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/j.1464-410X.2011.10885.x","article-title":"Cryoablation vs radiofrequency ablation for the treatment of renal cell carcinoma: a meta-analysis of case series studies","volume":"110","author":"El Dib","year":"2012","journal-title":"BJU Int."},{"issue":"3","key":"10.1016\/j.cryobiol.2024.105164_bib12","doi-asserted-by":"crossref","first-page":"301","DOI":"10.3109\/1547691X.2012.693547","article-title":"Combined treatment of human colorectal tumor cell lines with chemotherapeutic agents and ionizing irradiation can in vitro induce tumor cell death forms with immunogenic potential","volume":"9","author":"Frey","year":"2012","journal-title":"J. Immunot."},{"issue":"3","key":"10.1016\/j.cryobiol.2024.105164_bib13","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1006\/cryo.1998.2115","article-title":"Mechanisms of tissue injury in cryosurgery","volume":"37","author":"Gage","year":"1998","journal-title":"Cryobiology"},{"issue":"2","key":"10.1016\/j.cryobiol.2024.105164_bib14","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1177\/153303460400300212","article-title":"Cryosurgery for tumors - a clinical overview","volume":"3","author":"Gage","year":"2004","journal-title":"Technol. Cancer Res. Treat."},{"issue":"1","key":"10.1016\/j.cryobiol.2024.105164_bib15","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1177\/205873920601900121","article-title":"Detection of human papillomavirus DNA, p53 and ki67 expression in penile carcinomas","volume":"19","author":"Gentile","year":"2006","journal-title":"Int. J. Immunopathol. Pharmacol."},{"issue":"7","key":"10.1016\/j.cryobiol.2024.105164_bib16","doi-asserted-by":"crossref","DOI":"10.1115\/1.3156804","article-title":"Adjuvant approaches to enhance cryosurgery","volume":"131","author":"Goel","year":"2009","journal-title":"J. Biomech. Eng."},{"issue":"5","key":"10.1016\/j.cryobiol.2024.105164_bib17","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.jhep.2019.01.027","article-title":"Combined locoregional-immunotherapy for liver cancer","volume":"70","author":"Greten","year":"2019","journal-title":"J. Hepatol."},{"key":"10.1016\/j.cryobiol.2024.105164_bib18","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.cryobiol.2018.03.012","article-title":"Pirfenidone inhibits cryoablation induced local macrophage infiltration along with its associated TGFb1 expression and serum cytokine level in a mouse model","volume":"82","author":"Gu","year":"2018","journal-title":"Cryobiology"},{"key":"10.1016\/j.cryobiol.2024.105164_bib19","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/160250","article-title":"More than just tumor destruction: immunomodulation by thermal ablation of cancer","volume":"2011","author":"Haen","year":"2011","journal-title":"Clin. Dev. Immunol."},{"issue":"1","key":"10.1016\/j.cryobiol.2024.105164_bib20","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.cryobiol.2003.11.002","article-title":"Direct cell injury associated with eutectic crystallization during freezing","volume":"48","author":"Han","year":"2004","journal-title":"Cryobiology"},{"issue":"2","key":"10.1016\/j.cryobiol.2024.105164_bib21","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1177\/153303460400300203","article-title":"Improved cryosurgery by use of thermophysical and inflammatory adjuvants","volume":"3","author":"Han","year":"2004","journal-title":"Technol. Cancer Res. Treat."},{"key":"10.1016\/j.cryobiol.2024.105164_bib22","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/521691","article-title":"Cryoablation of early-stage primary lung cancer","volume":"2014","author":"Inoue","year":"2014","journal-title":"BioMed Res. Int."},{"issue":"5","key":"10.1016\/j.cryobiol.2024.105164_bib23","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.surg.2009.10.053","article-title":"Cryoablation induces greater inflammatory and coagulative responses than radiofrequency ablation or laser induced thermotherapy in a rat liver model","volume":"147","author":"Jansen","year":"2010","journal-title":"Surgery"},{"issue":"2","key":"10.1016\/j.cryobiol.2024.105164_bib24","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s00231-018-2407-2","article-title":"Effect of adjuvant on cutaneous cryotherapy","volume":"55","author":"Kumari","year":"2019","journal-title":"Heat Mass Tran."},{"issue":"3","key":"10.1016\/j.cryobiol.2024.105164_bib25","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s00232-005-0780-5","article-title":"Ion channels in cell proliferation and apoptotic cell death","volume":"205","author":"Lang","year":"2005","journal-title":"J. Membr. Biol."},{"issue":"9","key":"10.1016\/j.cryobiol.2024.105164_bib26","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/s41568-021-00383-9","article-title":"The immunological and metabolic landscape in primary and metastatic liver cancer","volume":"21","author":"Li","year":"2021","journal-title":"Nat. Rev. Cancer"},{"issue":"9","key":"10.1016\/j.cryobiol.2024.105164_bib27","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13250","article-title":"The modulatory effect of high salt on immune cells and related diseases","volume":"55","author":"Li","year":"2022","journal-title":"Cell Prolif."},{"issue":"5","key":"10.1016\/j.cryobiol.2024.105164_bib28","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41575-020-00395-0","article-title":"Locoregional therapies in the era of molecular and immune treatments for hepatocellular carcinoma","volume":"18","author":"Llovet","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"5566","key":"10.1016\/j.cryobiol.2024.105164_bib29","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1126\/science.1071059","article-title":"The danger model: a renewed sense of self","volume":"296","author":"Matzinger","year":"2002","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.cryobiol.2024.105164_bib30","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1146\/annurev.iy.12.040194.005015","article-title":"Tolerance, danger, and the extended family","volume":"12","author":"Matzinger","year":"1994","journal-title":"Annu. Rev. Immunol."},{"issue":"4","key":"10.1016\/j.cryobiol.2024.105164_bib31","doi-asserted-by":"crossref","first-page":"E383","DOI":"10.1111\/j.1464-410X.2012.11735.x","article-title":"Ki-67, mini-chromosome maintenance 2 protein (MCM2) and geminin have no independent prognostic relevance for cancer-specific survival in surgically treated squamous cell carcinoma of the penis","volume":"112","author":"May","year":"2013","journal-title":"BJU Int."},{"issue":"9270","key":"10.1016\/j.cryobiol.2024.105164_bib32","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1016\/S0140-6736(00)04904-7","article-title":"An overview of the immune system","volume":"357","author":"Parkin","year":"2001","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.cryobiol.2024.105164_bib33","doi-asserted-by":"crossref","DOI":"10.1177\/1759091420974807","article-title":"Merits and limitations of studying neuronal depolarization-dependent processes using elevated external potassium","volume":"12","author":"Rienecker","year":"2020","journal-title":"ASN neuro"},{"issue":"4","key":"10.1016\/j.cryobiol.2024.105164_bib34","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1097\/00054725-199911000-00009","article-title":"Th1\/Th2 cells","volume":"5","author":"Romagnani","year":"1999","journal-title":"Inflamm. Bowel Dis."},{"issue":"3","key":"10.1016\/j.cryobiol.2024.105164_bib35","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.soc.2014.03.009","article-title":"Nonsurgical ablation of breast cancer: future options for small breast tumors","volume":"23","author":"Sabel","year":"2014","journal-title":"Surg. Oncol. Clin."},{"issue":"2","key":"10.1016\/j.cryobiol.2024.105164_bib36","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1053\/jhep.2003.50321","article-title":"Cellular retinol-binding protein-1 in hepatocellular carcinoma correlates with beta-catenin, Ki-67 index, and patient survival","volume":"38","author":"Schmitt-Gr\u00e4ff","year":"2003","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.cryobiol.2024.105164_bib37","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/(SICI)1097-4652(200003)182:3<311::AID-JCP1>3.0.CO;2-9","article-title":"The Ki-67 protein: from the known and the unknown","volume":"182","author":"Scholzen","year":"2000","journal-title":"J. Cell. Physiol."},{"issue":"1","key":"10.1016\/j.cryobiol.2024.105164_bib38","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2217\/imt.13.151","article-title":"Cancer immunotherapy using tumor cryoablation","volume":"6","author":"Sidana","year":"2014","journal-title":"Immunotherapy"},{"key":"10.1016\/j.cryobiol.2024.105164_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.cryobiol.2023.104559","article-title":"Cryoablation combined with a clinical Chinese medicine for the treatment of lung cancer","volume":"112","author":"Wang","year":"2023","journal-title":"Cryobiology"},{"issue":"4","key":"10.1016\/j.cryobiol.2024.105164_bib40","first-page":"216","article-title":"Effect of extracellular K+ on the apoptosis of neural stem cells","author":"Wang","year":"2008","journal-title":"Chinese Journal of Stereotactic and Functional Neurosurgery."},{"issue":"3","key":"10.1016\/j.cryobiol.2024.105164_bib41","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.yexmp.2016.03.009","article-title":"Potassium supplementation inhibits IL-17A production induced by salt loading in human T lymphocytes via p38\/MAPK-SGK1 pathway","volume":"100","author":"Wen","year":"2016","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.cryobiol.2024.105164_bib42","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.cryobiol.2017.11.005","article-title":"Immunological response induced by cryoablation against murine H22 hepatoma cell line in vivo","volume":"80","author":"Yang","year":"2018","journal-title":"Cryobiology"}],"container-title":["Cryobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0011224024003195?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0011224024003195?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T11:54:42Z","timestamp":1739447682000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0011224024003195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":42,"alternative-id":["S0011224024003195"],"URL":"https:\/\/doi.org\/10.1016\/j.cryobiol.2024.105164","relation":{},"ISSN":["0011-2240"],"issn-type":[{"value":"0011-2240","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"KCl enhances the cryoablation-induced antitumor immune response: A hepatocellular carcinoma murine model research","name":"articletitle","label":"Article Title"},{"value":"Cryobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cryobiol.2024.105164","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Society for Cryobiology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"105164"}}