{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T14:52:46Z","timestamp":1772895166754,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81760664"],"award-info":[{"award-number":["81760664"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31972926"],"award-info":[{"award-number":["31972926"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018628","name":"Scientific Research Foundation of Education Department of Anhui Province of China","doi-asserted-by":"publisher","award":["2024AH050763"],"award-info":[{"award-number":["2024AH050763"]}],"id":[{"id":"10.13039\/501100018628","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009110","name":"Xinjiang Uygur Autonomous Region Natural Science Foundation","doi-asserted-by":"publisher","award":["2016D01C017"],"award-info":[{"award-number":["2016D01C017"]}],"id":[{"id":"10.13039\/100009110","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009110","name":"Xinjiang Uygur Autonomous Region Natural Science Foundation","doi-asserted-by":"publisher","award":["2021D01C011"],"award-info":[{"award-number":["2021D01C011"]}],"id":[{"id":"10.13039\/100009110","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cryobiology"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.cryobiol.2025.105299","type":"journal-article","created":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T11:36:49Z","timestamp":1756726609000},"page":"105299","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Quercetin enhances the cold storage effect on human umbilical cord mesenchymal stem cells in Celsior solution"],"prefix":"10.1016","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1016-330X","authenticated-orcid":false,"given":"Peng","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanwen","family":"Si","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.cryobiol.2025.105299_bib1","series-title":"Analytical and Quantitative Cytopathology and Histopathology","article-title":"Quercetin inhibits heart injury in lipopolysaccharide-induced endotoxemic model by suppressing the effects of reactive oxygen species","author":"Akkoyun","year":"2016"},{"key":"10.1016\/j.cryobiol.2025.105299_bib2","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1111\/1541-4337.12342","article-title":"Bioavailability of quercetin in humans with a focus on interindividual variation","volume":"17","author":"Almeida","year":"2018","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"10.1016\/j.cryobiol.2025.105299_bib3","first-page":"294","volume":"vol. 151","author":"Ashton","year":"1980"},{"key":"10.1016\/j.cryobiol.2025.105299_bib4","doi-asserted-by":"crossref","first-page":"e579","DOI":"10.1002\/term.2330","article-title":"Human umbilical cord derivatives regenerate intervertebral disc","volume":"12","author":"Beeravolu","year":"2018","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"10.1016\/j.cryobiol.2025.105299_bib5","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1089\/bio.2012.0023","article-title":"Development of pancreas storage solutions: initial screening of cytoprotective supplements for \u03b2-cell survival and metabolic status after hypothermic storage","volume":"11","author":"Campbell","year":"2013","journal-title":"Biopreserv. Biobanking"},{"key":"10.1016\/j.cryobiol.2025.105299_bib6","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.jcyt.2018.05.010","article-title":"Functional impairment of MSC induced by transient warming events: correlation with loss of adhesion and altered cell size","volume":"20","author":"Chabot","year":"2018","journal-title":"Cytotherapy"},{"key":"10.1016\/j.cryobiol.2025.105299_bib7","doi-asserted-by":"crossref","first-page":"122","DOI":"10.4240\/wjgs.v11.i3.122","article-title":"Liver preservation prior to transplantation: past, present, and future","volume":"11","author":"Chedid","year":"2019","journal-title":"World J. Gastrointest. Surg."},{"key":"10.1016\/j.cryobiol.2025.105299_bib8","first-page":"5795","article-title":"Quercetin exerted protective effects in a rat model of sepsis via inhibition of reactive oxygen species (ROS) and downregulation of high mobility group box 1 (HMGB1) protein expression, medical science monitor","volume":"25","author":"Cui","year":"2019","journal-title":"International Medical Journal of Experimental and Clinical Research"},{"key":"10.1016\/j.cryobiol.2025.105299_bib9","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12947","article-title":"Safety and feasibility of umbilical cord mesenchymal stem cells in patients with COVID\u201019 pneumonia: a pilot study","volume":"53","author":"Feng","year":"2020","journal-title":"Cell Prolif."},{"key":"10.1016\/j.cryobiol.2025.105299_bib10","first-page":"267","article-title":"Fibroblast precursors in normal and irradiated mouse hematopoietic organs","volume":"4","author":"Friedenstein","year":"1976","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.cryobiol.2025.105299_bib11","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1096\/fj.13-235440","article-title":"Unexpected low\u2010dose toxicity of the universal solvent DMSO","volume":"28","author":"Galvao","year":"2014","journal-title":"FASEB J."},{"key":"10.1016\/j.cryobiol.2025.105299_bib12","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1159\/000327033","article-title":"Organ preservation: current concepts and new strategies for the next decade","volume":"38","author":"Guibert","year":"2011","journal-title":"Transfus. Med. Hemotherapy"},{"key":"10.1016\/j.cryobiol.2025.105299_bib13","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.biomaterials.2016.12.008","article-title":"The 6-chromanol derivate SUL-109 enables prolonged hypothermic storage of adipose tissue-derived stem cells","volume":"119","author":"Hajmousa","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.cryobiol.2025.105299_bib14","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.imr.2016.12.001","article-title":"Cryopreservation and its clinical applications","volume":"6","author":"Jang","year":"2017","journal-title":"Integrative medicine research"},{"key":"10.1016\/j.cryobiol.2025.105299_bib15","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.lfs.2018.07.027","article-title":"Quercetin suppresses the mobility of breast cancer by suppressing glycolysis through Akt-mTOR pathway mediated autophagy induction","volume":"208","author":"Jia","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.cryobiol.2025.105299_bib16","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.biomaterials.2017.03.050","article-title":"Spheroidal formation preserves human stem cells for prolonged time under ambient conditions for facile storage and transportation","volume":"133","author":"Jiang","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.cryobiol.2025.105299_bib17","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1007\/s12015-022-10369-1","article-title":"A brief overview of global trends in MSC-Based cell therapy","volume":"18","author":"Jovic","year":"2022","journal-title":"Stem cell reviews and reports"},{"key":"10.1016\/j.cryobiol.2025.105299_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0073643","article-title":"Antifreeze protein prolongs the life-time of insulinoma cells during hypothermic preservation","volume":"8","author":"Kamijima","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.cryobiol.2025.105299_bib19","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.cryobiol.2020.08.006","article-title":"Effect of quercetin on the motility of cryopreserved canine spermatozoa","volume":"96","author":"Kawasaki","year":"2020","journal-title":"Cryobiology"},{"key":"10.1016\/j.cryobiol.2025.105299_bib20","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.cryobiol.2004.12.001","article-title":"The effect of human serum albumin on the extended storage of human oral keratinocyte viability under mild hypothermia","volume":"50","author":"Lee","year":"2005","journal-title":"Cryobiology"},{"key":"10.1016\/j.cryobiol.2025.105299_bib21","doi-asserted-by":"crossref","DOI":"10.1177\/2325967120973052","article-title":"Allogeneic umbilical cord blood\u2013derived mesenchymal stem cell implantation versus microfracture for large, full-thickness cartilage defects in older patients: a multicenter randomized clinical trial and extended 5-year clinical follow-up","volume":"9","author":"Lim","year":"2021","journal-title":"Orthopaedic Journal of Sports Medicine"},{"key":"10.1016\/j.cryobiol.2025.105299_bib22","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.actbio.2021.07.001","article-title":"Advanced biomaterials in cell preservation: hypothermic preservation and cryopreservation","volume":"131","author":"Ma","year":"2021","journal-title":"Acta Biomater."},{"key":"10.1016\/j.cryobiol.2025.105299_bib23","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1006\/cryo.2000.2242","article-title":"Glutathione content during the rinsing and rewarming process of rat hepatocytes preserved in university of Wisconsin solution","volume":"40","author":"Mamprin","year":"2000","journal-title":"Cryobiology"},{"key":"10.1016\/j.cryobiol.2025.105299_bib24","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/1010-7940(94)90117-1","article-title":"Experimental evaluation of celsior [R] a new heart preservation solution","volume":"8","author":"Menasche","year":"1994","journal-title":"Eur. J. Cardio. Thorac. Surg."},{"key":"10.1016\/j.cryobiol.2025.105299_bib25","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/s41392-020-00286-5","article-title":"Human umbilical cord-derived mesenchymal stem cell therapy in patients with COVID-19: a phase 1 clinical trial","volume":"5","author":"Meng","year":"2020","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.cryobiol.2025.105299_bib26","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.3727\/096368914X679237","article-title":"Mesenchymal stem cells increase hippocampal neurogenesis and neuronal differentiation by enhancing the wnt signaling pathway in an alzheimer's disease model","volume":"24","author":"Oh","year":"2015","journal-title":"Cell Transplant."},{"key":"10.1016\/j.cryobiol.2025.105299_bib27","series-title":"Ciba Foundation Symposium 136\u2010Cell and Molecular Biology of Vertebrate Hard Tissues: Cell and Molecular Biology of Vertebrate Hard Tissues: Ciba Foundation Symposium 136","first-page":"42","article-title":"Stromal stem cells: marrow\u2010derived osteogenic precursors","author":"Owen","year":"2007"},{"key":"10.1016\/j.cryobiol.2025.105299_bib28","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.cryobiol.2018.02.010","article-title":"Role of superoxide ion formation in hypothermia\/rewarming induced contractile dysfunction in cardiomyocytes","volume":"81","author":"Schaible","year":"2018","journal-title":"Cryobiology"},{"key":"10.1016\/j.cryobiol.2025.105299_bib29","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.3390\/cells10051043","article-title":"Influence of hypothermic storage fluids on mesenchymal stem cell stability: a comprehensive review and personal experience","volume":"10","author":"\u015acie\u017cy\u0144ska","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.cryobiol.2025.105299_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2021.773123","article-title":"Banking of AT-MSC and its influence on their application to clinical procedures","volume":"9","author":"Semenova","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.cryobiol.2025.105299_bib31","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.tips.2020.06.009","article-title":"Mesenchymal stem cell immunomodulation: mechanisms and therapeutic potential","volume":"41","author":"Song","year":"2020","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.cryobiol.2025.105299_bib32","doi-asserted-by":"crossref","first-page":"339","DOI":"10.5966\/sctm.2015-0131","article-title":"Alginate-encapsulation for the improved hypothermic preservation of human adipose-derived stem cells","volume":"5","author":"Swioklo","year":"2016","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.cryobiol.2025.105299_bib33","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.ijsu.2018.03.043","article-title":"Quercetin dose affects the fate of hepatic ischemia and reperfusion injury in rats: an experimental research","volume":"53","author":"Uyla\u015f","year":"2018","journal-title":"Int. J. Surg."},{"key":"10.1016\/j.cryobiol.2025.105299_bib34","doi-asserted-by":"crossref","first-page":"3156","DOI":"10.1002\/cam4.891","article-title":"Quercetin suppresses lung cancer growth by targeting Aurora B kinase","volume":"5","author":"Xingyu","year":"2016","journal-title":"Cancer Med."},{"key":"10.1016\/j.cryobiol.2025.105299_bib35","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.3390\/molecules24061123","article-title":"Antioxidant activities of quercetin and its complexes for medicinal application","volume":"24","author":"Xu","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.cryobiol.2025.105299_bib36","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1038\/s41598-018-20213-7","article-title":"Synergistic anti-tumour effects of quercetin and oncolytic adenovirus expressing TRAIL in human hepatocellular carcinoma","volume":"8","author":"Zou","year":"2018","journal-title":"Sci. Rep."}],"container-title":["Cryobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0011224025001051?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0011224025001051?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T18:40:23Z","timestamp":1772822423000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0011224025001051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":36,"alternative-id":["S0011224025001051"],"URL":"https:\/\/doi.org\/10.1016\/j.cryobiol.2025.105299","relation":{},"ISSN":["0011-2240"],"issn-type":[{"value":"0011-2240","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quercetin enhances the cold storage effect on human umbilical cord mesenchymal stem cells in Celsior solution","name":"articletitle","label":"Article Title"},{"value":"Cryobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.cryobiol.2025.105299","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Society for Cryobiology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"105299"}}