{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T14:37:23Z","timestamp":1787668643299,"version":"build-2736575974"},"reference-count":171,"publisher":"American Association for the Advancement of Science (AAAS)","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T00:00:00Z","timestamp":1498003200000},"content-version":"vor","delay-in-days":171,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011102","name":"FP7","doi-asserted-by":"publisher","award":["#601852"],"award-info":[{"award-number":["#601852"]}],"id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010941","name":"University of Vermont","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010941","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["csbj.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comput Struct Biotechnol J"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.csbj.2017.09.002","type":"journal-article","created":{"date-parts":[[2017,9,22]],"date-time":"2017-09-22T06:30:34Z","timestamp":1506061834000},"page":"433-446","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Personalized Therapy Against Preeclampsia by Replenishing Placental Protein 13 (PP13) Targeted to Patients With Impaired PP13 Molecule or Function"],"prefix":"10.34133","volume":"15","author":[{"given":"Hamutal","family":"Meiri","sequence":"first","affiliation":[{"name":"Hy Laboratories, Rehovot, and TeleMarpe, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Osol","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, University of Vermont, Burlington, VT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Cetin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Milano, Italy"},{"name":"Department of Mother and Child, Hospital Luigi Sacco, and Center for Fetal Research \u201cGiorgio Pardi\u201d, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sveinbj\u00f6rn","family":"Gizurarson","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, School of Health Science, University of Iceland, Reykjavik, Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berthold","family":"Huppertz","sequence":"additional","affiliation":[{"name":"Institute of Cell Biology, Histology and Embryology & Biobank Graz, Medical University of Graz, Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","published-online":{"date-parts":[[2017,10,7]]},"reference":[{"key":"e_1_3_1_2_2","volume-title":"Global atlas on cardiovascular disease prevention and control","author":"Mendis S.","year":"2011","unstructured":"Global atlas on cardiovascular disease prevention and control. Edited by S. Mendis, P. Puska and B. Norrving. Geneva: World Health Organization (in collaboration with the World Heart Federation and World Stroke Organization) 2011. http:\/\/www.world-heart-federation.org\/fileadmin\/user_upload\/images\/CVD_Health\/Global_CVD_Atlas.pdf."},{"key":"e_1_3_1_3_2","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/3292938","article-title":"Prevalence and sociodemographic determinants of hypertension history among women in reproductive age in Ghana","volume":"2016","author":"Nyarko S.H.","year":"2016","unstructured":"Nyarko S.H.: Prevalence and sociodemographic determinants of hypertension history among women in reproductive age in Ghana. Int J Hypertens 2016; 2016: 3292938.","journal-title":"Int J Hypertens"},{"key":"e_1_3_1_4_2","first-page":"17","article-title":"Hypertension: a review of antihypertensive medication, past and present","volume":"82","author":"Schellack N.","year":"2015","unstructured":"Schellack N. and Naicker P.: Hypertension: a review of antihypertensive medication, past and present. S Afr Pharm J 2015; 82: 17.","journal-title":"S Afr Pharm J"},{"key":"e_1_3_1_4_3","unstructured":"World health statistics : 2010. https:\/\/books.google.co.il\/books?hl=en&lr=&id=Z69vxfRfFIsC&oi=fnd&pg=PA1&dq=world+mortality+diseases&ots=cGPQckFB7A&sig=v7AtTr7otk_td2wyisH8cHaPyQs&redir_esc=y#v=onepage&q=world%20mortality%20diseases&f=false."},{"key":"e_1_3_1_5_2","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1161\/HYP.0000000000000003","article-title":"An effective approach to high blood pressure control \u2014 a science advisory from the American Heart Association, the American College of Cardiology, and the Centers for Disease Control and Prevention","volume":"63","author":"Go A.S.","year":"2014","unstructured":"Go A.S., Bauman M.A., Coleman King S.M., Fonarow G.C., Lawrence W. et al: An effective approach to high blood pressure control \u2014 a science advisory from the American Heart Association, the American College of Cardiology, and the Centers for Disease Control and Prevention. Hypertension 2014; 63: 878.","journal-title":"Hypertension"},{"key":"e_1_3_1_6_2","doi-asserted-by":"crossref","first-page":"307","DOI":"10.2165\/00007256-200434050-00003","article-title":"Effects of exercise, diet and weight loss on high blood pressure","volume":"34","author":"Bacon S.L.","year":"2004","unstructured":"Bacon S.L., Sherwood A., Hinderliter A. and Blumenthal J.A.: Effects of exercise, diet and weight loss on high blood pressure. Sports Med 2004; 34: 307.","journal-title":"Sports Med"},{"key":"e_1_3_1_7_2","doi-asserted-by":"crossref","first-page":"S309","DOI":"10.33549\/physiolres.933442","article-title":"Blood pressure regulation in stress: focus on nitric oxide-dependent mechanisms","volume":"65","author":"Puzserova A.","year":"2016","unstructured":"Puzserova A. and Bernatova I.: Blood pressure regulation in stress: focus on nitric oxide-dependent mechanisms. Physiol Res 2016; 65: S309.","journal-title":"Physiol Res"},{"key":"e_1_3_1_8_2","doi-asserted-by":"crossref","first-page":"4658","DOI":"10.2174\/1381612822666160510124801","article-title":"Inflammation, endothelial dysfunction and arterial stiffness as therapeutic targets in cardiovascular medicine","volume":"22","author":"Della Corte V.","year":"2016","unstructured":"Della Corte V., Tuttolomondo A., Pecoraro R., Di Raimondo D., Vassallo V. and Pinto A.: Inflammation, endothelial dysfunction and arterial stiffness as therapeutic targets in cardiovascular medicine. Curr Pharm Des 2016; 22: 4658.","journal-title":"Curr Pharm Des"},{"key":"e_1_3_1_9_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11906-014-0483-3","article-title":"Psychosocial risk factors for hypertension: an update of the literature","volume":"16","author":"Cuffee Y.","year":"2014","unstructured":"Cuffee Y., Ogedegbe C., Williams N.J., Ogedegbe G. and Schoenthaler A.: Psychosocial risk factors for hypertension: an update of the literature. Curr Hypertens Rep 2014; 16: 1.","journal-title":"Curr Hypertens Rep"},{"key":"e_1_3_1_10_2","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1093\/humrep\/dew200","article-title":"Diabetes, medical comorbidities and couple fecundity","volume":"31","author":"Eisenberg M.L.","year":"2016","unstructured":"Eisenberg M.L., Sundaram R., Maisog J. and Buck Louis G.M.: Diabetes, medical comorbidities and couple fecundity. Hum Reprod 2016; 31: 2369.","journal-title":"Hum Reprod"},{"key":"e_1_3_1_11_2","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1097\/MBP.0000000000000206","article-title":"A Cushing's syndrome patient's severe insomnia and morning blood pressure surge both improved after her left adrenal tumor resection","volume":"21","author":"Imaizumi Y.","year":"2016","unstructured":"Imaizumi Y., Ibaraki A., Asada S., Mitsuhiro Tominaga M. et al: A Cushing's syndrome patient's severe insomnia and morning blood pressure surge both improved after her left adrenal tumor resection. Blood Press Monit 2016; 21: 361.","journal-title":"Blood Press Monit"},{"key":"e_1_3_1_12_2","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/clc.22524","article-title":"Racial and ethnic differences in acute coronary syndrome and myocardial infarction within the United States: from demographics to outcomes","volume":"39","author":"Graham G.","year":"2016","unstructured":"Graham G.: Racial and ethnic differences in acute coronary syndrome and myocardial infarction within the United States: from demographics to outcomes. Clin Cardiol 2016; 39: 299.","journal-title":"Clin Cardiol"},{"key":"e_1_3_1_13_2","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/S0140-6736(00)02800-2","article-title":"Pre-eclampsia","volume":"356","author":"Walker J.J.","year":"2000","unstructured":"Walker J.J.: Pre-eclampsia. Lancet 2000; 356: 1260.","journal-title":"Lancet"},{"key":"e_1_3_1_14_2","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0140-6736(00)03577-7","article-title":"Pathogenesis and genetics of pre-eclampsia","volume":"357","author":"Roberts J.M.","year":"2001","unstructured":"Roberts J.M. and Cooper : Pathogenesis and genetics of pre-eclampsia. Lancet 2001; 357: 53.","journal-title":"Lancet"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1111726"},{"key":"e_1_3_1_16_2","unstructured":"WHO fact sheet no.348: maternal mortality. 2014. Available from: http:\/\/www.who.int\/mediacentre\/factsheets\/fs348\/en\/."},{"key":"e_1_3_1_17_2","first-page":"1","volume-title":"Saving mothers 2011-2013: sixth report on the confidential enquiries into maternal deaths in South Africa","author":"Moodley J.","year":"2015","unstructured":"Moodley J. and Chair of NCCEMD : Saving mothers 2011-2013: sixth report on the confidential enquiries into maternal deaths in South Africa. Edited by R. Pattinson. South Africa: (NCCEMD) Department of Health 2015: 1. [http:\/\/www.kznhealth.gov.za\/mcwh\/Maternal\/Saving-Mothers-2011-2013-short-report.pdf]."},{"key":"e_1_3_1_18_2","first-page":"631","volume-title":"Obstetrics: normal and problem pregnancies","author":"Sibai B.M.","year":"2012","unstructured":"Sibai B.M.: Hypertension. In: Obstetrics: normal and problem pregnancies. Edited by S.G. Gabbe, J.R. Niebyl, J.L. Simpson and M.B. Landon. Philadelphia: Saunders 2012: 631."},{"key":"e_1_3_1_19_2","unstructured":"March of Dimes : Your premature baby. 2010. http:\/\/www.marchofdimes.com\/baby\/premature_indepth.html."},{"key":"e_1_3_1_20_2","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/j.1471-0528.2008.02027.x","article-title":"Systematic analysis of research funding in maternal and perinatal health","volume":"116","author":"Fisk N.M.","year":"2009","unstructured":"Fisk N.M. and Atun R.: Systematic analysis of research funding in maternal and perinatal health. Br J Obstet Gynaecol 2009; 116: 347.","journal-title":"Br J Obstet Gynaecol"},{"key":"e_1_3_1_21_2","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1097\/JPN.0000000000000112","article-title":"Maternal morbidity and mortality: identifying opportunities to improve clinical outcomes","volume":"29","author":"Witcher P.M.","year":"2015","unstructured":"Witcher P.M. and Sisson M.C.: Maternal morbidity and mortality: identifying opportunities to improve clinical outcomes. J Perinat Neonatal Nurs 2015; 29: 202.","journal-title":"J Perinat Neonatal Nurs"},{"key":"e_1_3_1_22_2","first-page":"1","volume-title":"Medicine in development: rare disease","author":"American Biopharmaceutical","year":"2013","unstructured":"American Biopharmaceutical : The drug discovery, development and approval process. In: Medicine in development: rare disease. : 2013: 1. [pharma.org\/sites\/defaut\/files\/pdf\/Rre_Diseases]."},{"key":"e_1_3_1_23_2","first-page":"1","article-title":"New pharmacological opportunities for prevention of preeclampsia","volume":"7","author":"Garcia Benavidas L.","year":"2016","unstructured":"Garcia Benavidas L., Hernandez Molina D., Barajas Vega J.L., Totsuka Sutto S.E., Ramiraz Lizardo E.J. and Grover Paez F.: New pharmacological opportunities for prevention of preeclampsia. J Clin Exp Cardiol 2016; 7: 1.","journal-title":"J Clin Exp Cardiol"},{"key":"e_1_3_1_24_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2009.02.010"},{"key":"e_1_3_1_25_2","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/978-1-62703-131-8_36","article-title":"The thalidomide disaster, lessons from the past","volume":"947","author":"Riding J.E.","year":"2013","unstructured":"Riding J.E.: The thalidomide disaster, lessons from the past. Methods Mol Biol 2013; 947: 575.","journal-title":"Methods Mol Biol"},{"key":"e_1_3_1_26_2","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1056\/NEJMp1104409","article-title":"The long-term effects of in utero exposures\u2014the DES story","volume":"364","author":"Goodman A.","year":"2011","unstructured":"Goodman A., Schorge J. and Greene M.F.: The long-term effects of in utero exposures\u2014the DES story. N Engl J Med 2011; 364: 2083.","journal-title":"N Engl J Med"},{"key":"e_1_3_1_27_2","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1161\/HYPERTENSIONAHA.106.075895","article-title":"Update on the use of antihypertensive drugs in pregnancy","volume":"51","author":"Podymow T.","year":"2008","unstructured":"Podymow T. and August P.: Update on the use of antihypertensive drugs in pregnancy. Hypertension 2008; 51: 960.","journal-title":"Hypertension"},{"key":"e_1_3_1_28_2","first-page":"323","article-title":"A comparison of labetalol plus hospitalization versus hospitalization alone in the management of preeclampsia remote from term","volume":"70","author":"Sibai B.M.","year":"1987","unstructured":"Sibai B.M., Gonzalez A.R., Mabie W.C. and Moretti M.: A comparison of labetalol plus hospitalization versus hospitalization alone in the management of preeclampsia remote from term. Obstet Gynecol 1987; 70: 323.","journal-title":"Obstet Gynecol"},{"key":"e_1_3_1_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2871"},{"key":"e_1_3_1_30_2","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s00404-016-4178-7","article-title":"Implications of maternal conditions and pregnancy course on offspring's medical problems in adult life","volume":"294","author":"von Ehr J.","year":"2016","unstructured":"von Ehr J. and von Versen-H\u00f6ynck F.: Implications of maternal conditions and pregnancy course on offspring's medical problems in adult life. Arch Gynecol Obstet 2016; 294: 673.","journal-title":"Arch Gynecol Obstet"},{"key":"e_1_3_1_31_2","doi-asserted-by":"publisher","DOI":"10.1079\/PHN2001145"},{"key":"e_1_3_1_32_2","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1136\/bmj.323.7323.1213","article-title":"Long term mortality of mothers and fathers after pre-eclampsia: population based cohort study","volume":"323","author":"Irgens H.U.","year":"2011","unstructured":"Irgens H.U., Reisaeter L., Irgens L.M. and Lie R.T.: Long term mortality of mothers and fathers after pre-eclampsia: population based cohort study. Br Med J 2011; 323: 1213.","journal-title":"Br Med J"},{"key":"e_1_3_1_33_2","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.ahj.2008.06.042","article-title":"Cardiovascular sequelae of preeclampsia\/eclampsia: a systematic review and meta-analyses","volume":"156","author":"McDonald S.D.","year":"2008","unstructured":"McDonald S.D., Malinowski A., Zhou Q. et al: Cardiovascular sequelae of preeclampsia\/eclampsia: a systematic review and meta-analyses. Am Heart J 2008; 156: 918.","journal-title":"Am Heart J"},{"key":"e_1_3_1_34_2","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1053\/j.semperi.2015.05.006","article-title":"Preeclampsia and future cardiovascular disease in women: how good are the data and how can we manage our patients?","volume":"39","author":"Seely E.W.","year":"2015","unstructured":"Seely E.W., Tsigas E. and Rich-Edwards J.W.: Preeclampsia and future cardiovascular disease in women: how good are the data and how can we manage our patients?. Semin Perinatol 2015; 39: 276.","journal-title":"Semin Perinatol"},{"key":"e_1_3_1_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.midw.2015.09.005"},{"key":"e_1_3_1_36_2","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s10654-015-0018-5","article-title":"Preeclampsia in pregnancy and later use of antihypertensive drugs","volume":"30","author":"England A.","year":"2015","unstructured":"England A., Bjorge T., Klunsoyr K., Skjaerven R., Skurtveit S. and Furu K.: Preeclampsia in pregnancy and later use of antihypertensive drugs. Eur J Epidemiol 2015; 30: 501.","journal-title":"Eur J Epidemiol"},{"key":"e_1_3_1_37_2","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1161\/HYPERTENSIONAHA.111.187039","article-title":"Blood pressure change in normotensive, gestational hypertensive, preeclamptic, and essential hypertensive pregnancies","volume":"59","author":"Macdonald-Wallis C.","year":"2012","unstructured":"Macdonald-Wallis C., Lawlor D.A., Fraser A., May M., Nelson S. and Tilling K.: Blood pressure change in normotensive, gestational hypertensive, preeclamptic, and essential hypertensive pregnancies. Hypertension 2012; 59: 1241.","journal-title":"Hypertension"},{"key":"e_1_3_1_38_2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.earlhumdev.2016.09.007","article-title":"Preeclampsia; short and long-term consequences for mother and neonate","volume":"102","author":"Bokslag A.","year":"2016","unstructured":"Bokslag A., van Weissenbruch M., Mol B.W. and de Groot C.J.: Preeclampsia; short and long-term consequences for mother and neonate. Early Hum Dev 2016; 102: 47.","journal-title":"Early Hum Dev"},{"key":"e_1_3_1_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dys066"},{"key":"e_1_3_1_40_2","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.preghy.2010.10.013","article-title":"The role of obesity in preeclampsia","volume":"1","author":"Roberts J.M.","year":"2011","unstructured":"Roberts J.M., Bodnar L.M., Patrick T.E. and Powers R.W.: The role of obesity in preeclampsia. Pregnancy Hypertens 2011; 1: 6.","journal-title":"Pregnancy Hypertens"},{"key":"e_1_3_1_41_2","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1007\/s00125-016-4035-z","article-title":"Maternal overweight and obesity and risk of pre-eclampsia in women with type 1 diabetes or type 2 diabetes","volume":"59","author":"Persson M.","year":"2016","unstructured":"Persson M., Cnattingius S., Wikstr\u00f6m A.K. and Johansson S.: Maternal overweight and obesity and risk of pre-eclampsia in women with type 1 diabetes or type 2 diabetes. Diabetologia 2016; 59: 2099.","journal-title":"Diabetologia"},{"key":"e_1_3_1_42_2","unstructured":"http:\/\/www.worldobesity.org\/resources\/world-map-obesity."},{"key":"e_1_3_1_43_2","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/S0140-6736(16)30054-X","article-title":"Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19\u00b72 million participants","volume":"387","author":"NCD Risk Factor Collaboration (NCD-RisC)","year":"2016","unstructured":"NCD Risk Factor Collaboration (NCD-RisC): Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19\u00b72 million participants. Lancet 2016; 387: 1377.","journal-title":"Lancet"},{"key":"e_1_3_1_44_2","unstructured":"The European Perinatal Health Report 2010. http:\/\/www.europeristat.com."},{"key":"e_1_3_1_45_2","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1161\/01.str.0000442009.06663.48","article-title":"Guidelines for the prevention of stroke in women","volume":"45","author":"Bushnell C.","year":"2014","unstructured":"Bushnell C., McCullough L.D., Awad I.A., Chireau M.V., Fedder W.N., et al, on behalf of the of the American Heart Association Stroke Council , Council on Cardiovascular and Stroke Nursing , Council on Clinical Cardiology , Council on Epidemiology and Prevention and Council for High Blood Pressure Research : Guidelines for the prevention of stroke in women. Stroke 2014; 45: 1545. [http:\/\/stroke.ahajournals.org].","journal-title":"Stroke"},{"key":"e_1_3_1_46_2","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1159\/000367627","article-title":"Preeclampsia and maternal cardiovascular disease: consequence or predisposition?","volume":"51","author":"Osol G.","year":"2014","unstructured":"Osol G. and Bernstein I.: Preeclampsia and maternal cardiovascular disease: consequence or predisposition?. J Vasc Res 2014; 51: 290.","journal-title":"J Vasc Res"},{"key":"e_1_3_1_47_2","unstructured":"http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/Orphan_designation\/2014\/07\/WC500169895.pdf."},{"key":"e_1_3_1_48_2","unstructured":"Orphanet: preeclampsia (ORPHA275555). Available from: http:\/\/www.orpha.net\/consor\/cgi-bin\/OC_Exp.php?lng=EN&Expert=275555."},{"key":"e_1_3_1_49_2","doi-asserted-by":"crossref","first-page":"7.1","DOI":"10.3389\/fsurg.2015.00007","article-title":"Preeclampsia \u2013 will orphan drug status facilitate innovative biological therapies?","volume":"2","author":"Hahn S.","year":"2015","unstructured":"Hahn S.: Preeclampsia \u2013 will orphan drug status facilitate innovative biological therapies?. Front Surg 2015; 2: 7.1.","journal-title":"Front Surg"},{"key":"e_1_3_1_50_2","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1211\/ijpp.18.04.0007","article-title":"Off-label prescribing during pregnancy in the UK: an analysis of 18,000 prescriptions in Liverpool Women's Hospital","volume":"18","author":"Herring C.","year":"2010","unstructured":"Herring C., McManus A. and Weeks A.: Off-label prescribing during pregnancy in the UK: an analysis of 18,000 prescriptions in Liverpool Women's Hospital. Int J Pharm Pract 2010; 18: 226.","journal-title":"Int J Pharm Pract"},{"key":"e_1_3_1_51_2","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1056\/NEJMoa1704559","article-title":"Aspirin versus placebo in pregnancies at high risk of preterm preeclampsia","volume":"377","author":"Rolnik D.","year":"2017","unstructured":"Rolnik D., Wright D., Poon L.P., O\u2019Gorman N., Syngelaki A., de Paco Matallana C. et al: Aspirin versus placebo in pregnancies at high risk of preterm preeclampsia. N Engl J Med 2017; 377: 613.","journal-title":"N Engl J Med"},{"key":"e_1_3_1_52_2","article-title":"Antiplatelet therapy before or after 16weeks gestation for preventing preeclampsia: an individual participant data meta-analysis","volume":"216","author":"Meher S.","year":"2016","unstructured":"Meher S., Duley L., Hunter K. and Askie L.: Antiplatelet therapy before or after 16weeks gestation for preventing preeclampsia: an individual participant data meta-analysis. Am J Obstet Gynecol 2016; 216. [121-128.e2].","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_3_1_53_2","article-title":"The role of aspirin dose on the prevention of preeclampsia and fetal growth restriction: systematic review and meta-analysis","volume":"216","author":"Roberge S.","year":"2016","unstructured":"Roberge S., Nicolaides K., Demers S., Hyett J., Chaillet N. and Bujold E.: The role of aspirin dose on the prevention of preeclampsia and fetal growth restriction: systematic review and meta-analysis. Am J Obstet Gynecol 2016; 216. [110-120.e6].","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_3_1_54_2","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1002\/uog.15789","article-title":"Prevention of pre-eclampsia by low-molecular-weight heparin in addition to aspirin: a meta-analysis","volume":"47","author":"Roberge S.","year":"2016","unstructured":"Roberge S., Demers S., Nicolaides K.H., Bureau M., C\u00f4t\u00e9 S. and Bujold E.: Prevention of pre-eclampsia by low-molecular-weight heparin in addition to aspirin: a meta-analysis. Ultrasound Obstet Gynecol 2016; 47: 548.","journal-title":"Ultrasound Obstet Gynecol"},{"key":"e_1_3_1_55_2","first-page":"632","article-title":"Sildenafil citrate and uteroplacental perfusion in fetal growth restriction","volume":"17","author":"Dastjerdi M.V.","year":"2012","unstructured":"Dastjerdi M.V., Hosseini S. and Bayani L.: Sildenafil citrate and uteroplacental perfusion in fetal growth restriction. J Res Med Sci 2012; 17: 632.","journal-title":"J Res Med Sci"},{"key":"e_1_3_1_56_2","article-title":"Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems","author":"Hofmeyr G.J.","year":"2014","unstructured":"Hofmeyr G.J., Lawrie T.A., Atallah A.N., Duley L. and Torloni M.R.: Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems. Cochrane Database Syst Rev 2014; : CD001059.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_1_57_2","doi-asserted-by":"crossref","DOI":"10.1016\/S0167-5273(15)31026-3","article-title":"Global burden of CVD: focus on secondary prevention of cardiovascular disease","volume":"201","author":"Bansilal S.","year":"2015","unstructured":"Bansilal S., Castellano J.M. and Fuster V.: Global burden of CVD: focus on secondary prevention of cardiovascular disease. Int J Cardiol 2015; 201. [S1,1-S1,7].","journal-title":"Int J Cardiol"},{"key":"e_1_3_1_58_2","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.tcm.2014.08.006","article-title":"Aspirin in the primary prevention of cardiovascular disease: current knowledge and future research needs","volume":"24","author":"Hennekens C.H.","year":"2014","unstructured":"Hennekens C.H. and Dalen J.E.: Aspirin in the primary prevention of cardiovascular disease: current knowledge and future research needs. Trends Cardiovasc Med 2014; 24: 360.","journal-title":"Trends Cardiovasc Med"},{"key":"e_1_3_1_59_2","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1056\/NEJMoa1509819","article-title":"Metformin versus placebo in obese pregnant women without diabetes mellitus","volume":"374","author":"Syngelaki A.","year":"2016","unstructured":"Syngelaki A., Nicolaides K.N., Baleni Y., Hyer S., Akolekar R., Kotecha R. et al: Metformin versus placebo in obese pregnant women without diabetes mellitus. N Engl J Med 2016; 374: 434.","journal-title":"N Engl J Med"},{"key":"e_1_3_1_60_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2015.12.038","article-title":"Safety and pharmacokinetics of pravastatin used for the prevention of preeclampsia in high-risk pregnant women: a pilot randomized controlled trial","volume":"214","author":"Costantine M.M.","year":"2016","unstructured":"Costantine M.M., Cleary K. and Hebert M.F.: Safety and pharmacokinetics of pravastatin used for the prevention of preeclampsia in high-risk pregnant women: a pilot randomized controlled trial. Am J Obstet Gynecol 2016; 214. [720.e1-720.e17].","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_3_1_61_2","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1172\/JCI86957","article-title":"Pravastatin improves pregnancy outcomes in obstetric anti phospholipid syndrome refractory to antithrombotic therapy","volume":"126","author":"Lefkou E.","year":"2016","unstructured":"Lefkou E., Mamopoulos A., Dagklis T., Vosnakis C., Rousso D. and Girardi G.: Pravastatin improves pregnancy outcomes in obstetric anti phospholipid syndrome refractory to antithrombotic therapy. J Clin Invest 2016; 126: 2933.","journal-title":"J Clin Invest"},{"key":"e_1_3_1_62_2","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1161\/HYPERTENSIONAHA.114.04781","article-title":"Sofalcone upregulates the nuclear factor (erythroid-derived 2)-like 2\/heme oxygenase-1 pathway, reduces soluble fms-like tyrosine kinase-1, and quenches endothelial dysfunction: potential therapeutic for preeclampsia","volume":"65","author":"Onda K.","year":"2015","unstructured":"Onda K., Tong S., Nakahara A., Kondo M., Monchusho H. et al: Sofalcone upregulates the nuclear factor (erythroid-derived 2)-like 2\/heme oxygenase-1 pathway, reduces soluble fms-like tyrosine kinase-1, and quenches endothelial dysfunction: potential therapeutic for preeclampsia. Hypertension 2015; 65: 855.","journal-title":"Hypertension"},{"key":"e_1_3_1_63_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.08408"},{"key":"e_1_3_1_64_2","first-page":"1","article-title":"Double blind, randomised, placebo-controlled trial to evaluate the efficacy of esomeprazole to treat early onset pre-eclampsia (PIE Trial): a study protocol","volume":"5","author":"Cluver C.A.","year":"2015","unstructured":"Cluver C.A., Walker S.P., Mol B.W., Theron G.B., Hall D.R. et al: Double blind, randomised, placebo-controlled trial to evaluate the efficacy of esomeprazole to treat early onset pre-eclampsia (PIE Trial): a study protocol. Br Med J Open 2015; 5: 1.","journal-title":"Br Med J Open"},{"key":"e_1_3_1_65_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2016.11.1048","article-title":"Randomized double-blind placebo controlled evaluation of the safety and efficacy of recombinant antithrombin versus placebo in preterm preeclampsia","volume":"216","author":"Sibai B.","year":"2017","unstructured":"Sibai B., Paidas M.J. and the PRESERVE Study Group : Randomized double-blind placebo controlled evaluation of the safety and efficacy of recombinant antithrombin versus placebo in preterm preeclampsia. Am J Obstet Gynecol 2017; 216. [abstract LB02].","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_3_1_66_2","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s11906-015-0595-4","article-title":"Preeclampsia: syndrome or disease?","volume":"17","author":"Myatt L.","year":"2015","unstructured":"Myatt L. and Roberts J.M.: Preeclampsia: syndrome or disease?. Curr Hypertens Rep 2015; 17: 83.","journal-title":"Curr Hypertens Rep"},{"key":"e_1_3_1_67_2","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/uog.14770","article-title":"First-trimester screening for pre-eclampsia: moving from personalized risk prediction to prevention","volume":"45","author":"Baschat A.A.","year":"2015","unstructured":"Baschat A.A.: First-trimester screening for pre-eclampsia: moving from personalized risk prediction to prevention. Ultrasound Obstet Gynecol 2015; 45: 119.","journal-title":"Ultrasound Obstet Gynecol"},{"key":"e_1_3_1_68_2","doi-asserted-by":"crossref","first-page":"d1875","DOI":"10.1136\/bmj.d1875","article-title":"Clinical risk prediction for pre-eclampsia in nulliparous women: development of model in international prospective cohort","volume":"342","author":"North R.A.","year":"2011","unstructured":"North R.A., McCowan L.M., Dekker G.A., Poston L., Chan E.H. et al: Clinical risk prediction for pre-eclampsia in nulliparous women: development of model in international prospective cohort. Br Med J 2011; 342: d1875.","journal-title":"Br Med J"},{"key":"e_1_3_1_69_2","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.ajog.2011.07.017","article-title":"Evaluation and management of severe pre-eclampsia","volume":"205","author":"Sibai B.M.","year":"2011","unstructured":"Sibai B.M. and the Publications Committee, Society for Maternal-Fetal Medicine : Evaluation and management of severe pre-eclampsia. Am J Obstet Gynecol 2011; 205: 191.","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_3_1_70_2","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/j.1751-7176.2009.00085.x","article-title":"American Society of Hypertension position paper: hypertension in pregnancy","volume":"11","author":"Lindheimer M.D.","year":"2009","unstructured":"Lindheimer M.D., Taler S.J. and Cunningham F.G.: American Society of Hypertension position paper: hypertension in pregnancy. Clin Hypertens (Greenwich) 2009; 11: 214.","journal-title":"Clin Hypertens (Greenwich)"},{"key":"e_1_3_1_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2016.03.001"},{"key":"e_1_3_1_72_2","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.preghy.2014.04.016","article-title":"Oxygenation of the placenta and its role in pre-eclampsia","volume":"4","author":"Huppertz B.","year":"2014","unstructured":"Huppertz B.: Oxygenation of the placenta and its role in pre-eclampsia. Pregnancy Hypertens 2014; 4: 244.","journal-title":"Pregnancy Hypertens"},{"key":"e_1_3_1_73_2","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1016\/j.placenta.2013.12.008","article-title":"IFPA senior award lecture: making sense of preeclampsia \u2014 two placental causes for preeclampsia","volume":"35","author":"Redman C.W.","year":"2014","unstructured":"Redman C.W., Sargent I.L. and Staff A.C.: IFPA senior award lecture: making sense of preeclampsia \u2014 two placental causes for preeclampsia. Placenta 2014; 35: S20. [Suppl.].","journal-title":"Placenta"},{"key":"e_1_3_1_74_2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/uog.17378","article-title":"Placental syndromes: getting to the heart of the matter","volume":"49","author":"Thilaganathan B.","year":"2017","unstructured":"Thilaganathan B.: Placental syndromes: getting to the heart of the matter. Ultrasound Obstet Gynecol 2017; 49: 7.","journal-title":"Ultrasound Obstet Gynecol"},{"key":"e_1_3_1_75_2","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1161\/HYPERTENSIONAHA.107.107607","article-title":"Placental origins of preeclampsia: challenging the current hypothesis","volume":"51","author":"Huppertz B.","year":"2008","unstructured":"Huppertz B.: Placental origins of preeclampsia: challenging the current hypothesis. Hypertension 2008; 51: 970.","journal-title":"Hypertension"},{"key":"e_1_3_1_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2008.11.009"},{"key":"e_1_3_1_77_2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jri.2007.03.015","article-title":"Pre-eclampsia: is the immune maladaptation hypothesis still standing?: an epidemiological update","volume":"76","author":"Dekker G.","year":"2007","unstructured":"Dekker G. and Robillar P.Y.: Pre-eclampsia: is the immune maladaptation hypothesis still standing?: an epidemiological update. J Reprod Immunol 2007; 76: 8.","journal-title":"J Reprod Immunol"},{"key":"e_1_3_1_78_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2012.12.001"},{"key":"e_1_3_1_79_2","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1093\/humupd\/dms060","article-title":"Genetic variants in pre-eclampsia: a meta-analysis","volume":"19","author":"Bruijn J.A.","year":"2013","unstructured":"Bruijn J.A., Bloemenkamp K.W.M. and Dekkers O.M.: Genetic variants in pre-eclampsia: a meta-analysis. Hum Reprod Update 2013; 19: 289.","journal-title":"Hum Reprod Update"},{"key":"e_1_3_1_80_2","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/j.1471-0528.2006.01166.x","article-title":"The Magpie Trial: a randomised trial comparing magnesium sulphate with placebo for pre-eclampsia. Outcome for women at 2years","volume":"114","author":"Duley L.","year":"2007","unstructured":"Duley L. and the Magpie Trial Group : The Magpie Trial: a randomised trial comparing magnesium sulphate with placebo for pre-eclampsia. Outcome for women at 2years. Br J Obstet Gynaecol 2007; 114: 300.","journal-title":"Br J Obstet Gynaecol"},{"key":"e_1_3_1_81_2","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1161\/HYPERTENSIONAHA.109.143933","article-title":"Inching towards a targeted therapy for preeclampsia","volume":"55","author":"Thadhani R.","year":"2010","unstructured":"Thadhani R.: Inching towards a targeted therapy for preeclampsia. Hypertension 2010; 55: 238.","journal-title":"Hypertension"},{"key":"e_1_3_1_82_2","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1177\/1933719116630411","article-title":"Gene targeting to the uteroplacental circulation of pregnant guinea pigs","volume":"23","author":"Mehta V.","year":"2016","unstructured":"Mehta V., Ofir K., Swanson A., Kloczko E., Boyd M. et al: Gene targeting to the uteroplacental circulation of pregnant guinea pigs. Reprod Sci 2016; 23: 1087.","journal-title":"Reprod Sci"},{"key":"e_1_3_1_83_2","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/978-1-4939-2917-7_15","article-title":"VEGF gene transfer to the utero-placental circulation of pregnant sheep to enhance fetal growth","volume":"1332","author":"Carr D.J.","year":"2015","unstructured":"Carr D.J., Mehta V., Wallace J.M. and David A.L.: VEGF gene transfer to the utero-placental circulation of pregnant sheep to enhance fetal growth. Methods Mol Biol 2015; 1332: 197.","journal-title":"Methods Mol Biol"},{"key":"e_1_3_1_84_2","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1016\/j.ijgo.2015.02.008","article-title":"Moving beyond silos: how do we provide distributed personalized medicine to pregnant women everywhere at scale? Insights from PRE-EMPT","volume":"131","author":"von Dadelszen P.","year":"2015","unstructured":"von Dadelszen P., Magee L.A., Payne B.A., Dunsmuir D.T., Drebit S. et al: Moving beyond silos: how do we provide distributed personalized medicine to pregnant women everywhere at scale? Insights from PRE-EMPT. Int J Gynaecol Obstet 2015; 131: S10.","journal-title":"Int J Gynaecol Obstet"},{"key":"e_1_3_1_85_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/910751","article-title":"Genetic aspects of preeclampsia and HELLP syndrome","volume":"910751","author":"Haram K.","year":"2014","unstructured":"Haram K., Mortensen J.H. and Nagy B.: Genetic aspects of preeclampsia and HELLP syndrome. J Pregnancy 2014; 910751: 1.","journal-title":"J Pregnancy"},{"key":"e_1_3_1_86_2","first-page":"37","article-title":"The role of genetics in preeclampsia and potential pharmacogenomics intervention","volume":"5","author":"Williams P.J.","year":"2012","unstructured":"Williams P.J. and Morgan L.: The role of genetics in preeclampsia and potential pharmacogenomics intervention. Pharmacogenomics Pers Med 2012; 5: 37.","journal-title":"Pharmacogenomics Pers Med"},{"key":"e_1_3_1_87_2","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/ajmg.a.30257","article-title":"Maternal and fetal genetic factors account for most of familial aggregation of preeclampsia: a population-based Swedish cohort study","volume":"130","author":"Cnattingius S.","year":"2004","unstructured":"Cnattingius S., Reilly M., Pawitan Y. and Lichtenstein P.: Maternal and fetal genetic factors account for most of familial aggregation of preeclampsia: a population-based Swedish cohort study. Am J Med Genet A 2004; 130: 365.","journal-title":"Am J Med Genet A"},{"key":"e_1_3_1_88_2","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1002\/uog.17399","article-title":"Accuracy of competing risks model in screening for pre-eclampsia by maternal factors and biomarkers at 11\u201313weeks' gestation","volume":"49","author":"O'Gorman N.","year":"2017","unstructured":"O'Gorman N., Wright D., Poon L.C., Rolnik D.L., Syngelaki A. and the ASPRE Team : Accuracy of competing risks model in screening for pre-eclampsia by maternal factors and biomarkers at 11\u201313weeks' gestation. Ultrasound Obstet Gynecol 2017; 49: 751. [accepted for publication].","journal-title":"Ultrasound Obstet Gynecol"},{"key":"e_1_3_1_89_2","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/ng1541","article-title":"Maternal segregation of the Dutch preeclampsia locus at 10q22 with a new member of the winged helix gene family","volume":"37","author":"Dijk M.","year":"2005","unstructured":"Dijk M., Mulders J., Poutsma A., K\u00f6nst A.M., Lachmeijer A.M.A. et al: Maternal segregation of the Dutch preeclampsia locus at 10q22 with a new member of the winged helix gene family. Nat Genet 2005; 37: 514.","journal-title":"Nat Genet"},{"key":"e_1_3_1_90_2","first-page":"1","article-title":"Mutations in complement regulatory proteins predispose to preeclampsia: a genetic analysis of the PROMISSE cohort","volume":"8","author":"Salmon J.E.","year":"2011","unstructured":"Salmon J.E., Heuser C., Triebwasser M., Liszewski M.K., Kavanag D. et al: Mutations in complement regulatory proteins predispose to preeclampsia: a genetic analysis of the PROMISSE cohort. PLoS One 2011; 8: 1.","journal-title":"PLoS One"},{"key":"e_1_3_1_91_2","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.placenta.2014.11.017","article-title":"Gene expression profile in cardiovascular disease and preeclampsia: a meta-analysis of the transcriptome based on raw data from human studies deposited in gene expression omnibus","volume":"36","author":"Sitras V.","year":"2015","unstructured":"Sitras V., Fenton C. and Acharya G.: Gene expression profile in cardiovascular disease and preeclampsia: a meta-analysis of the transcriptome based on raw data from human studies deposited in gene expression omnibus. Placenta 2015; 36: 170.","journal-title":"Placenta"},{"key":"e_1_3_1_92_2","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1210\/jc.2016-1767","article-title":"Erythropoietin and soluble erythropoietin receptor: a role for maternal vascular adaptation to high-altitude pregnancy","volume":"1","author":"Wolfson G.H.","year":"2017","unstructured":"Wolfson G.H., Vargas E., Browne V.A., Moore L.G. and Julian C.G.: Erythropoietin and soluble erythropoietin receptor: a role for maternal vascular adaptation to high-altitude pregnancy. J Clin Endocrinol Metab 2017; 1: 242.","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_3_1_93_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI17189"},{"key":"e_1_3_1_94_2","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/humupd\/dmt003","article-title":"Placental protein 13 (PP13): a new biological target shifting individualized risk assessment to personalized drug design combating pre-eclampsia","volume":"19","author":"Huppertz B.","year":"2013","unstructured":"Huppertz B., Meiri H., Gizurarson S., Osol G. and Sammar M.: Placental protein 13 (PP13): a new biological target shifting individualized risk assessment to personalized drug design combating pre-eclampsia. Hum Reprod Update 2013; 19: 391.","journal-title":"Hum Reprod Update"},{"key":"e_1_3_1_95_2","doi-asserted-by":"publisher","DOI":"10.1053\/plac.1999.0436"},{"key":"e_1_3_1_96_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2003.12.009"},{"key":"e_1_3_1_97_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.2004.04004.x"},{"key":"e_1_3_1_98_2","doi-asserted-by":"crossref","first-page":"9731","DOI":"10.1073\/pnas.0903568106","article-title":"A primate subfamily of galectins expressed at the maternal-fetal interface that promote immune cell death","volume":"16","author":"Than N.G.","year":"2009","unstructured":"Than N.G., Romero R., Goodman M., Amy Weckle A., Xing J. et al: A primate subfamily of galectins expressed at the maternal-fetal interface that promote immune cell death. Proc Natl Acad Sci U S A 2009; 16: 9731.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"e_1_3_1_99_2","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.placenta.2014.07.015","article-title":"Evolutionary origins of the placental expression of Chromosome 19 cluster galectins and their complex dysregulation in preeclampsia","volume":"35","author":"Than N.G.","year":"2014","unstructured":"Than N.G., Romero R., Xu Y., Erez O., Xu Z. et al: Evolutionary origins of the placental expression of Chromosome 19 cluster galectins and their complex dysregulation in preeclampsia. Placenta 2014; 35: 855.","journal-title":"Placenta"},{"key":"e_1_3_1_100_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1303707110"},{"key":"e_1_3_1_101_2","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1530\/REP-10-0221","article-title":"The choriocarcinoma cell line BeWo: syncytial fusion and expression of syncytium-specific proteins","volume":"140","author":"Orendi K.","year":"2010","unstructured":"Orendi K., Gauster M., Moser G., Meiri H. and Huppertz B.: The choriocarcinoma cell line BeWo: syncytial fusion and expression of syncytium-specific proteins. Reproduction 2010; 140: 759.","journal-title":"Reproduction"},{"key":"e_1_3_1_102_2","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1016\/j.placenta.2010.11.023","article-title":"Placental and trophoblastic in vitro models to study preventive and therapeutic agents for preeclampsia","volume":"32","author":"Orendi K.","year":"2011","unstructured":"Orendi K., Kivity V., Sammar M., Grimpel Y., Gonen R. et al: Placental and trophoblastic in vitro models to study preventive and therapeutic agents for preeclampsia. Placenta 2011; 32: S49. [Suppl.].","journal-title":"Placenta"},{"key":"e_1_3_1_103_2","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1159\/000151344","article-title":"Longitudinal determination of serum placental protein 13 during development of preeclampsia","volume":"24","author":"Huppertz B.","year":"2008","unstructured":"Huppertz B., Sammar M., Chefetz I., Neumaier-Wagner P., Bartz C. and Meiri H.: Longitudinal determination of serum placental protein 13 during development of preeclampsia. Fetal Diagn Ther 2008; 24: 230.","journal-title":"Fetal Diagn Ther"},{"key":"e_1_3_1_104_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-008-0658-x"},{"key":"e_1_3_1_105_2","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.1016\/j.placenta.2010.09.006","article-title":"Placenta-bound and body fluid PP13 and its mRNA in normal pregnancy compared to preeclampsia, HELLP and preterm delivery","volume":"32","author":"Sammar M.","year":"2011","unstructured":"Sammar M., Nisemblat S., Fleischfarb Z., Golan A., Sadan O. et al: Placenta-bound and body fluid PP13 and its mRNA in normal pregnancy compared to preeclampsia, HELLP and preterm delivery. Placenta 2011; 32: S30. [Suppl.].","journal-title":"Placenta"},{"key":"e_1_3_1_106_2","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1093\/protein\/14.11.875","article-title":"Homology modelling and molecular dynamics studies of human placental tissue protein 13","volume":"14","author":"Visegrady B.","year":"2001","unstructured":"Visegrady B., Than N.G., Kilar F., S\u00fcmegi B., Than G.N. and Bohn H.: Homology modelling and molecular dynamics studies of human placental tissue protein 13. Protein Eng 2001; 14: 875.","journal-title":"Protein Eng"},{"key":"e_1_3_1_107_2","doi-asserted-by":"publisher","DOI":"10.4132\/jptm.2015.02.25"},{"key":"e_1_3_1_108_2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0021564","article-title":"PP13, maternal ABO blood groups and the risk assessment of pregnancy complications","volume":"6","author":"Than N.G.","year":"2011","unstructured":"Than N.G., Romero R., Meiri H., Erez O., Xu Y. et al: PP13, maternal ABO blood groups and the risk assessment of pregnancy complications. PLoS One 2011; 6: e21564.","journal-title":"PLoS One"},{"key":"e_1_3_1_109_2","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1111\/j.1471-0528.2008.01902.x","article-title":"Placental protein 13 as an early marker for pre-eclampsia: a prospective longitudinal study","volume":"115","author":"Gonen R.","year":"2008","unstructured":"Gonen R., Shahar R., Grimpel Y.I., Chefetz I., Sammar M. et al: Placental protein 13 as an early marker for pre-eclampsia: a prospective longitudinal study. Br J Obstet Gynaecol 2008; 115: 1465.","journal-title":"Br J Obstet Gynaecol"},{"key":"e_1_3_1_110_2","doi-asserted-by":"crossref","first-page":"S55","DOI":"10.1016\/j.placenta.2010.11.019","article-title":"Effects of calcium, magnesium, low-dose aspirin and low-molecular-weight heparin on the release of PP13 from placental explants","volume":"32","author":"Grimpel Y.I.","year":"2011","unstructured":"Grimpel Y.I., Kivity V., Cohen A., Meiri H., Sammar M. et al: Effects of calcium, magnesium, low-dose aspirin and low-molecular-weight heparin on the release of PP13 from placental explants. Placenta 2011; 32: S55. [Suppl.].","journal-title":"Placenta"},{"key":"e_1_3_1_111_2","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1530\/REP-10-0221","article-title":"The choriocarcinoma cell line BeWo: syncytial fusion and expression of syncytium-specific proteins","volume":"140","author":"Orendi K.","year":"2011","unstructured":"Orendi K., Gauster M., Moser G., Meiri H. and Huppertz B.: The choriocarcinoma cell line BeWo: syncytial fusion and expression of syncytium-specific proteins. Reproduction 2011; 140: 759.","journal-title":"Reproduction"},{"key":"e_1_3_1_112_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2011.03.023","article-title":"Placental protein 13 (PP13\/galectin-13) undergoes lipid raft-associated subcellular redistribution in the syncytiotrophoblast in preterm preeclampsia and HELLP syndrome","volume":"205","author":"Balogh A.","year":"2011","unstructured":"Balogh A., Pozsgay J., Matk\u00f3 J., Dong Z., Kim C.J. et al: Placental protein 13 (PP13\/galectin-13) undergoes lipid raft-associated subcellular redistribution in the syncytiotrophoblast in preterm preeclampsia and HELLP syndrome. Am J Obstet Gynecol 2011; 205. [156.e1-14].","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_3_1_113_2","first-page":"348","article-title":"Placental protein 13 (PP13) \u2014 a placental immunoregulatory galectin protecting pregnancy","volume":"5","author":"Than N.G.","year":"2014","unstructured":"Than N.G., Balogh B., Romero R., K\u00e1rp\u00e1ti E., Erez O. et al: Placental protein 13 (PP13) \u2014 a placental immunoregulatory galectin protecting pregnancy. Front Immunol 2014; 5: 348.","journal-title":"Front Immunol"},{"key":"e_1_3_1_114_2","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/uog.2686","article-title":"A novel approach to first-trimester screening for early pre-eclampsia combining serum PP-13 and Doppler ultrasound","volume":"27","author":"Nicolaides K.H.","year":"2006","unstructured":"Nicolaides K.H., Bindra R., Turan O.M., Chefetz I., Sammar M. et al: A novel approach to first-trimester screening for early pre-eclampsia combining serum PP-13 and Doppler ultrasound. Ultrasound Obstet Gynecol 2006; 27: 13.","journal-title":"Ultrasound Obstet Gynecol"},{"key":"e_1_3_1_115_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2007.02.025","article-title":"First-trimester placental protein 13 screening for preeclampsia and intrauterine growth restriction","volume":"197","author":"Chafetz I.","year":"2007","unstructured":"Chafetz I., Kuhnreich I., Sammar M., Tal Y., Gibor Y. et al: First-trimester placental protein 13 screening for preeclampsia and intrauterine growth restriction. Am J Obstet Gynecol 2007; 197. [35.e1-7].","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_3_1_116_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2008.01.013","article-title":"First-trimester maternal serum PP13 in the risk assessment for preeclampsia","volume":"199","author":"Romero R.","year":"2008","unstructured":"Romero R., Kusanovic J.P., Than N.G., Erez O., Gotsch F. et al: First-trimester maternal serum PP13 in the risk assessment for preeclampsia. Am J Obstet Gynecol 2008; 199. [122.e1-122.e11].","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_3_1_117_2","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1002\/uog.7559","article-title":"First-trimester markers for the prediction of pre-eclampsia in women with a-priori high risk","volume":"35","author":"Khalil A.","year":"2010","unstructured":"Khalil A., Cowans N.J., Spencer K., Goichman S., Meiri H. and Harrington K.: First-trimester markers for the prediction of pre-eclampsia in women with a-priori high risk. Ultrasound Obstet Gynecol 2010; 35: 671.","journal-title":"Ultrasound Obstet Gynecol"},{"key":"e_1_3_1_118_2","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1515\/jpm-2013-0298","article-title":"Prediction of preeclampsia by placental protein 13 and background risk factors and its prevention by aspirin","volume":"42","author":"Meiri H.","year":"2014","unstructured":"Meiri H., Sammar M., Herzog A., Grimpel Y.I., Fihaman G. et al: Prediction of preeclampsia by placental protein 13 and background risk factors and its prevention by aspirin. J Perinat Med 2014; 42: 591.","journal-title":"J Perinat Med"},{"key":"e_1_3_1_119_2","doi-asserted-by":"publisher","DOI":"10.1177\/1933719108328615"},{"key":"e_1_3_1_120_2","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2380"},{"key":"e_1_3_1_121_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2010.07.043","article-title":"Performance of messenger RNAs circulating in maternal blood in the prediction of preeclampsia at 10\u201314weeks","volume":"203","author":"Farina A.","year":"2010","unstructured":"Farina A., Zucchini C., Sekizawa A., Purwosunu Y., de Sanctis P. et al: Performance of messenger RNAs circulating in maternal blood in the prediction of preeclampsia at 10\u201314weeks. Am J Obstet Gynecol 2010; 203. [575.e1-575.e7].","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_3_1_122_2","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.jri.2009.07.004","article-title":"A novel exonic variant (221delT) in the LGALS13 gene encoding placental protein 13 (PP13) is associated with preterm labour in a low risk population","volume":"82","author":"Gebhardt S.","year":"2009","unstructured":"Gebhardt S., Bruiners N. and Hillerman R.: A novel exonic variant (221delT) in the LGALS13 gene encoding placental protein 13 (PP13) is associated with preterm labour in a low risk population. J Reprod Immunol 2009; 82: 166.","journal-title":"J Reprod Immunol"},{"key":"e_1_3_1_123_2","first-page":"1","volume-title":"Proceeding of the 8th World Congress of Prenatal Medicine and Fetal Development. Florence, Italy September 7\u201311, 2008","author":"Bruiners N.","year":"2008","unstructured":"Bruiners N., Bosman M., Postma A., Gebhardt S., Robelo G. et al: Promoter variant \u221298A-C of the LGALS13 gene and pre-eclampsia. In: Proceeding of the 8th World Congress of Prenatal Medicine and Fetal Development. Florence, Italy September 7\u201311, 2008. : 2008: 1."},{"key":"e_1_3_1_124_2","article-title":"Predicting the risk to develop preeclampsia (PE) in the first trimester combining promoter variant \u221298A\/C of LGALS13 (placental protein 13), black ethnicity, previous PE, obesity and maternal age","author":"Madar-Shapiro L.","year":"2017","unstructured":"Madar-Shapiro L., Karady I., Trahtenherts A., Syngelaki A., Akolekar R. et al: Predicting the risk to develop preeclampsia (PE) in the first trimester combining promoter variant \u221298A\/C of LGALS13 (placental protein 13), black ethnicity, previous PE, obesity and maternal age. Fetal Diagn Ther Jul 21, 2017; . [Epub ahead of print].","journal-title":"Fetal Diagn Ther"},{"key":"e_1_3_1_125_2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0102832","article-title":"The role of the carbohydrate recognition domain of placental protein 13 (PP13) in pregnancy evaluated with recombinant PP13 and the Delt221 PP13 variant","volume":"9","author":"Sammar M.","year":"2014","unstructured":"Sammar M., Nisamblatt S., Gonen R., Huppertz B., Gizurarson S., Osol G. and Meiri H.: The role of the carbohydrate recognition domain of placental protein 13 (PP13) in pregnancy evaluated with recombinant PP13 and the Delt221 PP13 variant. Plos One 2014; 9: e102832.","journal-title":"Plos One"},{"key":"e_1_3_1_126_2","doi-asserted-by":"publisher","DOI":"10.1177\/1933719111424445"},{"key":"e_1_3_1_127_2","doi-asserted-by":"publisher","DOI":"10.1159\/000345964"},{"key":"e_1_3_1_128_2","doi-asserted-by":"publisher","DOI":"10.1159\/000381914"},{"key":"e_1_3_1_129_2","first-page":"1","article-title":"Placental protein 13 (PP13)-induced vasodilation in pregnant and non-pregnant rat arteries occurs via endothelial signaling pathways","volume":"19","author":"Drobnjak T.","year":"2017","unstructured":"Drobnjak T., Gizurarson S., Gokina N.I., Meiri H., Mandal\u00e1 M. et al: Placental protein 13 (PP13)-induced vasodilation in pregnant and non-pregnant rat arteries occurs via endothelial signaling pathways. Hypertens Pregnancy 2017; 19: 1.","journal-title":"Hypertens Pregnancy"},{"key":"e_1_3_1_130_2","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.vph.2015.07.009","article-title":"Mechanism of hydralazine-induced relaxation in resistance arteries during pregnancy: hydralazine induces vasodilation via a prostacyclin pathway","volume":"78","author":"Maille N.","year":"2016","unstructured":"Maille N., Gokina N., Mandal\u00e0 M., Colton I. and Osol G.: Mechanism of hydralazine-induced relaxation in resistance arteries during pregnancy: hydralazine induces vasodilation via a prostacyclin pathway. Vascul Pharmacol 2016; 78: 36.","journal-title":"Vascul Pharmacol"},{"key":"e_1_3_1_131_2","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1159\/000313874","article-title":"Effects of pregnancy, hypertension and nitric oxide inhibition on rat uterine artery myogenic reactivity","volume":"47","author":"Barron C.","year":"2010","unstructured":"Barron C., Mandala M. and Osol G.: Effects of pregnancy, hypertension and nitric oxide inhibition on rat uterine artery myogenic reactivity. J Vasc Res 2010; 47: 463.","journal-title":"J Vasc Res"},{"key":"e_1_3_1_132_2","doi-asserted-by":"publisher","DOI":"10.1111\/micc.12080"},{"key":"e_1_3_1_133_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1570031"},{"key":"e_1_3_1_134_2","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1111\/aji.12460","article-title":"Inventory of novel animal models addressing etiology of preeclampsia in the development of new therapeutic\/intervention opportunities","volume":"75","author":"Erlandsson L.","year":"2016","unstructured":"Erlandsson L., N\u00e4\u00e4v \u00c5., Hennessy A., Vaiman D., Gram M. et al: Inventory of novel animal models addressing etiology of preeclampsia in the development of new therapeutic\/intervention opportunities. Am J Reprod Immunol 2016; 75: 402.","journal-title":"Am J Reprod Immunol"},{"key":"e_1_3_1_135_2","first-page":"287","article-title":"Pathogenesis of pregnancy-induced hypertensive disorders. A review of experimental animal models","volume":"10","author":"Hutten J.W.M.","year":"1991","unstructured":"Hutten J.W.M., Kuijpers J.C., van Velzen D. and Wallenburg H.C.S.: Pathogenesis of pregnancy-induced hypertensive disorders. A review of experimental animal models. Clin Exp Hypertens 1991; 10: 287.","journal-title":"Clin Exp Hypertens"},{"key":"e_1_3_1_136_2","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/0002-9378(67)90448-6","article-title":"Chronic uterine ischemia and reversible experimental \u201ctoxemia of pregnancy\u201d","volume":"97","author":"Hodari A.A.","year":"1967","unstructured":"Hodari A.A.: Chronic uterine ischemia and reversible experimental \u201ctoxemia of pregnancy\u201d. Am J Obstet Gynecol 1967; 97: 597.","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_3_1_137_2","first-page":"R720","article-title":"Maternal blood volume and cardiac output during pregnancy: a hypothesis of endocrinologic control","volume":"245","author":"Longo L.D.","year":"1983","unstructured":"Longo L.D.: Maternal blood volume and cardiac output during pregnancy: a hypothesis of endocrinologic control. Am J Physiol 1983; 245: R720.","journal-title":"Am J Physiol"},{"key":"e_1_3_1_138_2","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.semnephrol.2004.07.011","article-title":"Placental ischemia and resultant phenotype in animal models of preeclampsia","volume":"24","author":"Podjarny E.","year":"2004","unstructured":"Podjarny E., Losonczy G. and Baylis B.: Placental ischemia and resultant phenotype in animal models of preeclampsia. Semin Nephrol 2004; 24: 596.","journal-title":"Semin Nephrol"},{"key":"e_1_3_1_139_2","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3181\/00379727-43-11091P","article-title":"Rise of blood pressure during ischemia of gravid uterus","volume":"43","author":"Ogden E.","year":"1940","unstructured":"Ogden E., Hildebrand G.J. and Page E.W.: Rise of blood pressure during ischemia of gravid uterus. Proc Soc Exp Biol Med 1940; 43: 49.","journal-title":"Proc Soc Exp Biol Med"},{"key":"e_1_3_1_140_2","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/j.1471-0528.1964.tb04270.x","article-title":"A study of the spiral arteries of the decidua basalis in normotensive and hypertensive pregnancies","volume":"71","author":"Brosens I.","year":"1964","unstructured":"Brosens I.: A study of the spiral arteries of the decidua basalis in normotensive and hypertensive pregnancies. J Obstet Gynaecol Br Commonw 1964; 71: 222.","journal-title":"J Obstet Gynaecol Br Commonw"},{"key":"e_1_3_1_141_2","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3109\/00365518409085374","article-title":"Uteroplacental blood flow in pregnancy induced hypertension","volume":"44","author":"Lunell N.O.","year":"1984","unstructured":"Lunell N.O., Lewander R. and Mamoun I.: Uteroplacental blood flow in pregnancy induced hypertension. Scand J Clin Lab Invest 1984; 44: 28. [Suppl.].","journal-title":"Scand J Clin Lab Invest"},{"key":"e_1_3_1_142_2","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1161\/01.HYP.35.1.367","article-title":"Decreased endothelium-dependent vascular relaxation during reduction of uterine perfusion pressure in pregnant rats","volume":"35","author":"Crews J.K.","year":"2000","unstructured":"Crews J.K., Herrington J.N., Granger J.P. and Khalil R.A.: Decreased endothelium-dependent vascular relaxation during reduction of uterine perfusion pressure in pregnant rats. Hypertension 2000; 35: 71.","journal-title":"Hypertension"},{"key":"e_1_3_1_143_2","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1161\/01.HYP.37.2.485","article-title":"Endothelin-A receptor blockade attenuates the hypertension in response to chronic reductions in uterine perfusion pressure","volume":"37","author":"Alexander B.T.","year":"2001","unstructured":"Alexander B.T., Rinewalt A.N., Cockrell K.L., Massey M.B., Bennett W.A. and Granger J.P.: Endothelin-A receptor blockade attenuates the hypertension in response to chronic reductions in uterine perfusion pressure. Hypertension 2001; 37: 485.","journal-title":"Hypertension"},{"key":"e_1_3_1_144_2","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1177\/1933719110396700","article-title":"Local versus systemic influences on uterine vascular reactivity during pregnancy in the single-horn gravid rat","volume":"18","author":"Fuller R.","year":"2011","unstructured":"Fuller R., Colton I., Gokina N., Mandala M. and Osol G.: Local versus systemic influences on uterine vascular reactivity during pregnancy in the single-horn gravid rat. Reprod Sci 2011; 18: 723.","journal-title":"Reprod Sci"},{"key":"e_1_3_1_145_2","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1159\/000178465","article-title":"Influence of constriction, wall tension, smooth muscle activation and cellular deformation on rat resistance artery vasodilator reactivity","volume":"29","author":"Colton I.","year":"2012","unstructured":"Colton I., Mandal\u00e0 M., Morton J., Davidge S.T. and Osol G.: Influence of constriction, wall tension, smooth muscle activation and cellular deformation on rat resistance artery vasodilator reactivity. Cell Physiol Biochem 2012; 29: 883.","journal-title":"Cell Physiol Biochem"},{"key":"e_1_3_1_146_2","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1161\/01.HYP.37.4.1191","article-title":"Reduced uterine perfusion pressure during pregnancy in the rat is associated with increases in arterial pressure and changes in renal nitric oxide","volume":"37","author":"Alexander B.T.","year":"2001","unstructured":"Alexander B.T., Kassab S.E., Miller M.T., Abram S.R., Reckelhoff J.F., Bennett W.A. et al: Reduced uterine perfusion pressure during pregnancy in the rat is associated with increases in arterial pressure and changes in renal nitric oxide. Hypertension 2001; 37: 1191.","journal-title":"Hypertension"},{"key":"e_1_3_1_147_2","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1161\/01.HYP.32.6.958","article-title":"Chronic nitric oxide inhibition model six years on","volume":"32","author":"Zatz R.","year":"1998","unstructured":"Zatz R. and Baylis C.: Chronic nitric oxide inhibition model six years on. Hypertension 1998; 32: 958.","journal-title":"Hypertension"},{"key":"e_1_3_1_148_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2001.280.1.R174"},{"key":"e_1_3_1_149_2","first-page":"117","article-title":"Adverse interactions between pregnancy and a new model of systemic hypertension produced by chronic blockade of endothelial derived relaxing factor (EDRF) in the rat","volume":"11","author":"Baylis C.","year":"1992","unstructured":"Baylis C. and Engels K.: Adverse interactions between pregnancy and a new model of systemic hypertension produced by chronic blockade of endothelial derived relaxing factor (EDRF) in the rat. Clin Exp Hypertens 1992; 11: 117.","journal-title":"Clin Exp Hypertens"},{"key":"e_1_3_1_150_2","doi-asserted-by":"crossref","first-page":"H1266","DOI":"10.1152\/ajpheart.00519.2011","article-title":"Reduced NO signaling during pregnancy attenuates outward uterine artery remodeling by altering MMP expression and collagen and elastin deposition","volume":"301","author":"Hale S.A.","year":"2011","unstructured":"Hale S.A., Weger L., Mandala M. and Osol G.: Reduced NO signaling during pregnancy attenuates outward uterine artery remodeling by altering MMP expression and collagen and elastin deposition. Am J Physiol Heart Circ Physiol 2011; 301: H1266.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"e_1_3_1_151_2","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1071\/RD11208","article-title":"Uterine distension differentially affects remodelling and distensibility of the uterine vasculature in non-pregnant rats","volume":"24","author":"Osol G.","year":"2012","unstructured":"Osol G., Barron C. and Mandal\u00e0 M.: Uterine distension differentially affects remodelling and distensibility of the uterine vasculature in non-pregnant rats. Reprod Fertil Dev 2012; 24: 835.","journal-title":"Reprod Fertil Dev"},{"key":"e_1_3_1_152_2","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/s11906-017-0774-6","article-title":"Altered endothelial nitric oxide signaling as a paradigm for maternal vascular maladaptation in preeclampsia","volume":"19","author":"Osol G","year":"2017","unstructured":"Osol G, Ko N.L. and Mandal\u00e0 M.: Altered endothelial nitric oxide signaling as a paradigm for maternal vascular maladaptation in preeclampsia. Curr Hypertens Rep 2017; 19: 82.","journal-title":"Curr Hypertens Rep"},{"key":"e_1_3_1_153_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq152"},{"key":"e_1_3_1_154_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2011\/521826","article-title":"STOX1: key player in trophoblast dysfunction underlying early onset preeclampsia with growth retardation","volume":"521826","author":"van Dijk M.","year":"2011","unstructured":"van Dijk M. and Oudejans C.B.: STOX1: key player in trophoblast dysfunction underlying early onset preeclampsia with growth retardation. J Pregnancy 2011; 521826: 1.","journal-title":"J Pregnancy"},{"key":"e_1_3_1_155_2","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/ng0307-279","article-title":"STOX1 is not imprinted and is not likely to be involved in preeclampsia","volume":"39","author":"Iglesias-Platas I.","year":"2007","unstructured":"Iglesias-Platas I., Monk D., Jebbink J., Buimer M., Boer K. et al: STOX1 is not imprinted and is not likely to be involved in preeclampsia. Nat Genet 2007; 39: 279.","journal-title":"Nat Genet"},{"key":"e_1_3_1_156_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.202994"},{"key":"e_1_3_1_157_2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0003905","article-title":"STOX1 overexpression in choriocarcinoma cells mimics transcriptional alterations observed in preeclamptic placentas","volume":"3","author":"Rigourd V.","year":"2008","unstructured":"Rigourd V., Chauvet C., Chelbi S.T., Rebource R., Mondon F. et al: STOX1 overexpression in choriocarcinoma cells mimics transcriptional alterations observed in preeclamptic placentas. PLoS One 2008; 3: e3905. [1-9].","journal-title":"PLoS One"},{"key":"e_1_3_1_158_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5661"},{"key":"e_1_3_1_159_2","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2016.1253682"},{"key":"e_1_3_1_160_2","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.semnephrol.2010.09.007","article-title":"Hypertension induced by VEGF signaling pathway inhibition: mechanisms and potential use as a biomarker","volume":"30","author":"Robinson S.E.","year":"2010","unstructured":"Robinson S.E., Khankin E.V. and Karumanchi A.S.: Hypertension induced by VEGF signaling pathway inhibition: mechanisms and potential use as a biomarker. Semin Nephrol 2010; 30: 591.","journal-title":"Semin Nephrol"},{"key":"e_1_3_1_161_2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0156013","article-title":"Influence of the sFlt-1\/PlGF ratio on clinical decision-making in women with suspected preeclampsia","volume":"11","author":"Klein E.","year":"2016","unstructured":"Klein E., Schlembach D., Ramoni A., Langer E., Bahlmann F. et al: Influence of the sFlt-1\/PlGF ratio on clinical decision-making in women with suspected preeclampsia. PLoS One 2016; 11: e0156013. [1-19].","journal-title":"PLoS One"},{"key":"e_1_3_1_162_2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0106502","article-title":"Carbon monoxide prevents hypertension and proteinuria in an adenovirus sFLT-1 preeclampsia in a mouse model","volume":"9","author":"Vanditti C.C.","year":"2014","unstructured":"Vanditti C.C., Casselman R., Young L., Karumanchi S.A. and Smith G.N.: Carbon monoxide prevents hypertension and proteinuria in an adenovirus sFLT-1 preeclampsia in a mouse model. PLoS One 2014; 9: e106502. [1-7].","journal-title":"PLoS One"},{"key":"e_1_3_1_163_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119547"},{"key":"e_1_3_1_164_2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1159\/000329821","article-title":"Endothelial-derived hyperpolarization factor (EDHF) contributes to PlGF-induced dilation of mesenteric resistance arteries from pregnant rats","volume":"49","author":"Mandal\u00e0 M.","year":"2012","unstructured":"Mandal\u00e0 M., Gokina N., Barron C. and Osol G.: Endothelial-derived hyperpolarization factor (EDHF) contributes to PlGF-induced dilation of mesenteric resistance arteries from pregnant rats. J Vasc Res 2012; 49: 43.","journal-title":"J Vasc Res"},{"key":"e_1_3_1_165_2","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.preghy.2014.11.001","article-title":"Pre-eclampsia in 2014: seven ways to make a difference","volume":"4","author":"Brown M.A.","year":"2014","unstructured":"Brown M.A.: Pre-eclampsia in 2014: seven ways to make a difference. Pregnancy Hypertens 2014; 4: 249.","journal-title":"Pregnancy Hypertens"},{"key":"e_1_3_1_166_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2013.05.003"},{"key":"e_1_3_1_167_2","doi-asserted-by":"publisher","DOI":"10.1159\/000444853"},{"key":"e_1_3_1_168_2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0111816","article-title":"Genetic determinants of on-aspirin platelet reactivity: focus on the influence of PEAR1","volume":"9","author":"Wurtz M.","year":"2014","unstructured":"Wurtz M., Nissen P.H., Grove E.L., Kristensen S.D. and Hvas A.-M.: Genetic determinants of on-aspirin platelet reactivity: focus on the influence of PEAR1. PLoS One 2014; 9: e111816.","journal-title":"PLoS One"},{"key":"e_1_3_1_169_2","doi-asserted-by":"crossref","first-page":"305","DOI":"10.2217\/pgs.13.223","article-title":"Metformin resistance alleles in polycystic ovary syndrome: pattern and association with glucose metabolism","volume":"15","author":"Schweighofer N.","year":"2014","unstructured":"Schweighofer N., Lerchbaum E., Trummer O., Schwetz V., Pieber T. and Obermayer-Pietsch B.: Metformin resistance alleles in polycystic ovary syndrome: pattern and association with glucose metabolism. Pharmacogenomics 2014; 15: 305.","journal-title":"Pharmacogenomics"},{"key":"e_1_3_1_170_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2016.238"},{"key":"e_1_3_1_171_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.12.041"}],"container-title":["Computational and Structural Biotechnology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2001037017300697?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2001037017300697?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/spj.science.org\/doi\/pdf\/10.1016\/j.csbj.2017.09.002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T20:50:11Z","timestamp":1778014211000},"score":1,"resource":{"primary":{"URL":"https:\/\/spj.science.org\/doi\/10.1016\/j.csbj.2017.09.002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":171,"alternative-id":["10.1016\/j.csbj.2017.09.002"],"URL":"https:\/\/doi.org\/10.1016\/j.csbj.2017.09.002","relation":{},"ISSN":["2001-0370"],"issn-type":[{"value":"2001-0370","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Personalized Therapy Against Preeclampsia by Replenishing Placental Protein 13 (PP13) Targeted to Patients With Impaired PP13 Molecule or Function","name":"articletitle","label":"Article Title"},{"value":"Computational and Structural Biotechnology Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.csbj.2017.09.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology.","name":"copyright","label":"Copyright"}]}}