{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T10:34:14Z","timestamp":1792233254189,"version":"4.4.0"},"reference-count":22,"publisher":"American Association for the Advancement of Science (AAAS)","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T00:00:00Z","timestamp":1583884800000},"content-version":"vor","delay-in-days":70,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002857","name":"China Pharmaceutical University","doi-asserted-by":"publisher","award":["3150120001"],"award-info":[{"award-number":["3150120001"]}],"id":[{"id":"10.13039\/501100002857","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["csbj.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comput Struct Biotechnol J"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.csbj.2020.03.007","type":"journal-article","created":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T12:57:02Z","timestamp":1584622622000},"page":"668-675","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":67,"title":["PreMSIm: An R package for predicting microsatellite instability from the expression profiling of a gene panel in cancer"],"prefix":"10.34133","volume":"18","author":[{"given":"Lin","family":"Li","sequence":"first","affiliation":[{"name":"Biomedical Informatics Research Lab, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China"},{"name":"Cancer Genomics Research Center, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China"},{"name":"Big Data Research Institute, China Pharmaceutical University, Nanjing 211198, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiushi","family":"Feng","sequence":"additional","affiliation":[{"name":"Biomedical Informatics Research Lab, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China"},{"name":"Cancer Genomics Research Center, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China"},{"name":"Big Data Research Institute, China Pharmaceutical University, Nanjing 211198, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaosheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Biomedical Informatics Research Lab, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China"},{"name":"Cancer Genomics Research Center, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China"},{"name":"Big Data Research Institute, China Pharmaceutical University, Nanjing 211198, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","published-online":{"date-parts":[[2020,3,30]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2009.237"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.27.0652"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1500596"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh034"},{"key":"e_1_3_4_6_2","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/gim.2013.166","article-title":"ACMG technical standards and guidelines for genetic testing for inherited colorectal cancer (Lynch syndrome, familial adenomatous polyposis, and MYH-associated polyposis)","volume":"16","author":"Hegde M.","year":"2014","unstructured":"Hegde M. et al: ACMG technical standards and guidelines for genetic testing for inherited colorectal cancer (Lynch syndrome, familial adenomatous polyposis, and MYH-associated polyposis). Genet Med 2014; 16: 101.","journal-title":"Genet Med"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2014.223677"},{"key":"e_1_3_4_8_2","doi-asserted-by":"crossref","unstructured":"Pang J. et al. Microsatellite instability detection using a large next-generation sequencing cancer panel across diverse tumour types. 2019.","DOI":"10.1136\/jclinpath-2019-206136"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt755"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.13918"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0462-y"},{"key":"e_1_3_4_12_2","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s40425-018-0472-1","article-title":"A gene expression assay for simultaneous measurement of microsatellite instability and anti-tumor immune activity","volume":"7","author":"Danaher P.","year":"2019","unstructured":"Danaher P. and Warren S.: A gene expression assay for simultaneous measurement of microsatellite instability and anti-tumor immune activity. J Immunother Cancer 2019; 7: 15.","journal-title":"J Immunother Cancer"},{"key":"e_1_3_4_13_2","doi-asserted-by":"crossref","first-page":"6763596","DOI":"10.1155\/2019\/6763596","article-title":"Cross-platform data analysis reveals a generic gene expression signature for microsatellite instability in colorectal cancer","volume":"2019","author":"Pacinkova A.","year":"2019","unstructured":"Pacinkova A. and Popovici V.: Cross-platform data analysis reveals a generic gene expression signature for microsatellite instability in colorectal cancer. Biomed Res Int 2019; 2019: 6763596.","journal-title":"Biomed Res Int"},{"key":"e_1_3_4_14_2","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1097\/COC.0b013e31825d5317","article-title":"Efficacy and safety of docetaxel combined with oxaliplatin as a neoadjuvant chemotherapy regimen for Chinese triple-negative local advanced breast cancer patients. A prospective, open, and unicentric Phase II clinical trial","volume":"36","author":"Fei F.","year":"2013","unstructured":"Fei F. et al: Efficacy and safety of docetaxel combined with oxaliplatin as a neoadjuvant chemotherapy regimen for Chinese triple-negative local advanced breast cancer patients. A prospective, open, and unicentric Phase II clinical trial. Am J Clin Oncol 2013; 36: 545.","journal-title":"Am J Clin Oncol"},{"key":"e_1_3_4_15_2","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1613\/jair.953","article-title":"SMOTE: synthetic minority over-sampling technique","volume":"16","author":"Chawla N.V.","year":"2002","unstructured":"Chawla N.V. et al: SMOTE: synthetic minority over-sampling technique. J Artificial Intelligence Res 2002; 16: 321.","journal-title":"J Artificial Intelligence Res"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1131"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4191"},{"key":"e_1_3_4_18_2","article-title":"Landscape of microsatellite instability across 39 cancer types","volume":"2017","author":"Bonneville R.","year":"2017","unstructured":"Bonneville R. et al: Landscape of microsatellite instability across 39 cancer types. JCO Precis Oncol 2017; 2017.","journal-title":"JCO Precis Oncol"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23601"},{"key":"e_1_3_4_20_2","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1038\/sj.onc.1202178","article-title":"MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas","volume":"17","author":"Esteller M.","year":"1998","unstructured":"Esteller M. et al: MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas. Oncogene 1998; 17: 2413.","journal-title":"Oncogene"},{"key":"e_1_3_4_21_2","first-page":"3925","article-title":"A hereditary nonpolyposis colorectal carcinoma case associated with hypermethylation of the MLH1 gene in normal tissue and loss of heterozygosity of the unmethylated allele in the resulting microsatellite instability-high tumor","volume":"62","author":"Gazzoli I.","year":"2002","unstructured":"Gazzoli I. et al: A hereditary nonpolyposis colorectal carcinoma case associated with hypermethylation of the MLH1 gene in normal tissue and loss of heterozygosity of the unmethylated allele in the resulting microsatellite instability-high tumor. Cancer Res 2002; 62: 3925.","journal-title":"Cancer Res"},{"key":"e_1_3_4_22_2","doi-asserted-by":"crossref","first-page":"509","DOI":"10.31557\/APJCP.2019.20.2.509","article-title":"Microsatellite instability and altered expressions of MLH1 and MSH2 in gastric cancer","volume":"20","author":"Haron N.H.","year":"2019","unstructured":"Haron N.H. et al: Microsatellite instability and altered expressions of MLH1 and MSH2 in gastric cancer. Asian Pac J Cancer Prev 2019; 20: 509.","journal-title":"Asian Pac J Cancer Prev"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.99-0851com"}],"container-title":["Computational and Structural Biotechnology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2001037019305446?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2001037019305446?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/spj.science.org\/doi\/pdf\/10.1016\/j.csbj.2020.03.007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T12:33:20Z","timestamp":1779021200000},"score":1,"resource":{"primary":{"URL":"https:\/\/spj.science.org\/doi\/10.1016\/j.csbj.2020.03.007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":22,"alternative-id":["10.1016\/j.csbj.2020.03.007"],"URL":"https:\/\/doi.org\/10.1016\/j.csbj.2020.03.007","relation":{},"ISSN":["2001-0370"],"issn-type":[{"value":"2001-0370","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PreMSIm: An R package for predicting microsatellite instability from the expression profiling of a gene panel in cancer","name":"articletitle","label":"Article Title"},{"value":"Computational and Structural Biotechnology Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.csbj.2020.03.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology.","name":"copyright","label":"Copyright"}]}}