{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T13:07:49Z","timestamp":1779023269101,"version":"3.51.4"},"reference-count":53,"publisher":"American Association for the Advancement of Science (AAAS)","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T00:00:00Z","timestamp":1602547200000},"content-version":"vor","delay-in-days":286,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013088","name":"Qinglan Project of Jiangsu Province of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013088","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61771251"],"award-info":[{"award-number":["61771251"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005374","name":"Nanjing University of Posts and Telecommunications","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20171443"],"award-info":[{"award-number":["BK20171443"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["csbj.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comput Struct Biotechnol J"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.csbj.2020.10.015","type":"journal-article","created":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T22:45:26Z","timestamp":1603233926000},"page":"3243-3254","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Integrative omics analysis reveals relationships of genes with synthetic lethal interactions through a pan-cancer analysis"],"prefix":"10.34133","volume":"18","author":[{"given":"Li","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Bioinformatics, Smart Health Big Data Analysis and Location Services Engineering Lab of Jiangsu Province, School of Geographic and Biologic Information, Nanjing University of Posts and Telecommunications, Nanjing 210023, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunjing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, Smart Health Big Data Analysis and Location Services Engineering Lab of Jiangsu Province, School of Geographic and Biologic Information, Nanjing University of Posts and Telecommunications, Nanjing 210023, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bowen","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, Smart Health Big Data Analysis and Location Services Engineering Lab of Jiangsu Province, School of Geographic and Biologic Information, Nanjing University of Posts and Telecommunications, Nanjing 210023, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youquan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, Smart Health Big Data Analysis and Location Services Engineering Lab of Jiangsu Province, School of Geographic and Biologic Information, Nanjing University of Posts and Telecommunications, Nanjing 210023, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Duan","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory for Molecular and Medical Biotechnology, School of Life Science, Nanjing Normal University, Nanjing 210023, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenwen","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, Smart Health Big Data Analysis and Location Services Engineering Lab of Jiangsu Province, School of Geographic and Biologic Information, Nanjing University of Posts and Telecommunications, Nanjing 210023, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yihao","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, Smart Health Big Data Analysis and Location Services Engineering Lab of Jiangsu Province, School of Geographic and Biologic Information, Nanjing University of Posts and Telecommunications, Nanjing 210023, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuyang","family":"Dou","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, Smart Health Big Data Analysis and Location Services Engineering Lab of Jiangsu Province, School of Geographic and Biologic Information, Nanjing University of Posts and Telecommunications, Nanjing 210023, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guowei","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, Smart Health Big Data Analysis and Location Services Engineering Lab of Jiangsu Province, School of Geographic and Biologic Information, Nanjing University of Posts and Telecommunications, Nanjing 210023, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lulu","family":"Shen","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory for Molecular and Medical Biotechnology, School of Life Science, Nanjing Normal University, Nanjing 210023, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Bioinformatics, Smart Health Big Data Analysis and Location Services Engineering Lab of Jiangsu Province, School of Geographic and Biologic Information, Nanjing University of Posts and Telecommunications, Nanjing 210023, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingming","family":"Liang","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory for Molecular and Medical Biotechnology, School of Life Science, Nanjing Normal University, Nanjing 210023, China"},{"name":"Changzhou Institute of Innovation and Development, Nanjing Normal University, Nanjing 210023, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","published-online":{"date-parts":[[2020,11,7]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2013.09.018"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2016.06.004"},{"key":"e_1_3_5_4_2","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1093\/genetics\/31.3.269","article-title":"Genetics of natural populations; recombination and variability in populations of Drosophila pseudoobscura","volume":"31","author":"Dobzhansky T.","year":"1946","unstructured":"Dobzhansky T.: Genetics of natural populations; recombination and variability in populations of Drosophila pseudoobscura. Genetics 1946; 31: 269.","journal-title":"Genetics"},{"key":"e_1_3_5_5_2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/genetics\/59.1.37","article-title":"Synthetic lethality and semi-lethality among functionally related mutants of Drosophila melanfgaster","volume":"59","author":"Lucchesi J.C.","year":"1968","unstructured":"Lucchesi J.C.: Synthetic lethality and semi-lethality among functionally related mutants of Drosophila melanfgaster. Genetics 1968; 59: 37.","journal-title":"Genetics"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90483-U"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.5.6.958"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg.2017.47"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03443"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1205"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2016.256"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.278.5340.1064"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aac7557"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2005.11.003"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2016.06.022"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.116.190231"},{"key":"e_1_3_5_17_2","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s12920-019-0554-z","article-title":"Humanized yeast genetic interaction mapping predicts synthetic lethal interactions of FBXW7 in breast cancer","volume":"12","author":"Kirzinger M.W.B.","year":"2019","unstructured":"Kirzinger M.W.B., Vizeacoumar F.S., Haave B., Gonzalez-Lopez C., Bonham K. et al: Humanized yeast genetic interaction mapping predicts synthetic lethal interactions of FBXW7 in breast cancer. BMC Med Genomics 2019; 12: 112.","journal-title":"BMC Med Genomics"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2012.07.005"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku656"},{"key":"e_1_3_5_20_2","first-page":"245","article-title":"MicroRNAs and their variants in an RNA world: implications for complex interactions and diverse roles in an RNA regulatory network","volume":"19","author":"Guo L.","year":"2018","unstructured":"Guo L. and Liang T.: MicroRNAs and their variants in an RNA world: implications for complex interactions and diverse roles in an RNA regulatory network. Brief Bioinform 2018; 19: 245.","journal-title":"Brief Bioinform"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx082"},{"key":"e_1_3_5_22_2","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaf1420","article-title":"A global genetic interaction network maps a wiring diagram of cellular function","volume":"353","author":"Costanzo M.","year":"2016","unstructured":"Costanzo M., VanderSluis B., Koch E.N., Baryshnikova A., Pons C. et al: A global genetic interaction network maps a wiring diagram of cellular function. Science 2016; 353.","journal-title":"Science"},{"key":"e_1_3_5_23_2","doi-asserted-by":"crossref","first-page":"D263","DOI":"10.1093\/nar\/gkm1020","article-title":"InParanoid 6: eukaryotic ortholog clusters with inparalogs","volume":"36","author":"Berglund A.C.","year":"2008","unstructured":"Berglund A.C., Sjolund E., Ostlund G. and Sonnhammer E.L.: InParanoid 6: eukaryotic ortholog clusters with inparalogs. Nucleic Acids Res 2008; 36: D263.","journal-title":"Nucleic Acids Res"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1196380"},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1108"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1507"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks1111"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.211"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1299"},{"key":"e_1_3_5_31_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2015.11.015","article-title":"High-Resolution CRISPR screens reveal fitness genes and genotype-specific cancer liabilities","volume":"163","author":"Hart T.","year":"2015","unstructured":"Hart T., Chandrashekhar M., Aregger M., Steinhart Z., Brown K.R. et al: High-Resolution CRISPR screens reveal fitness genes and genotype-specific cancer liabilities. Cell 2015; 163.","journal-title":"Cell"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aac7041"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1235122"},{"key":"e_1_3_5_34_2","doi-asserted-by":"crossref","first-page":"3728","DOI":"10.1158\/0008-5472.CAN-15-0273","article-title":"TANRIC: an interactive open platform to explore the function of lncRNAs in cancer","volume":"75","author":"Li J.","year":"2015","unstructured":"Li J., Han L., Roebuck P., Diao L., Liu L. et al: TANRIC: an interactive open platform to explore the function of lncRNAs in cancer. Cancer Res 2015; 75: 3728.","journal-title":"Cancer Res"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1840"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1997"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt1248"},{"key":"e_1_3_5_38_2","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1093\/bioinformatics\/btl039","article-title":"CFinder: locating cliques and overlapping modules in biological networks","volume":"22","author":"Adamcsek B.","year":"2006","unstructured":"Adamcsek B., Palla G., Farkas I.J., Derenyi I. and Vicsek T.: CFinder: locating cliques and overlapping modules in biological networks. Bioinformatics 2006; 22: 1021.","journal-title":"Bioinformatics"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1239303"},{"key":"e_1_3_5_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2019.03.008"},{"key":"e_1_3_5_42_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-18-3511"},{"key":"e_1_3_5_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2019.03.002"},{"key":"e_1_3_5_44_2","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201846685","article-title":"HRAS-driven cancer cells are vulnerable to TRPML1 inhibition","volume":"20","author":"Jung J.","year":"2019","unstructured":"Jung J., Cho K.J., Naji A.K., Clemons K.N., Wong C.O. et al: HRAS-driven cancer cells are vulnerable to TRPML1 inhibition. EMBO Rep 2019; 20: e46685.","journal-title":"EMBO Rep"},{"key":"e_1_3_5_45_2","doi-asserted-by":"crossref","first-page":"435","DOI":"10.20892\/j.issn.2095-3941.2018.0530","article-title":"From basic researches to new achievements in therapeutic strategies of KRAS-driven cancers","volume":"16","author":"Saliani M.","year":"2019","unstructured":"Saliani M., Jalal R. and Ahmadian M.R.: From basic researches to new achievements in therapeutic strategies of KRAS-driven cancers. Cancer Biol Med 2019; 16: 435.","journal-title":"Cancer Biol Med"},{"key":"e_1_3_5_46_2","doi-asserted-by":"publisher","DOI":"10.2174\/1568026619666190828162217"},{"key":"e_1_3_5_47_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a031518"},{"key":"e_1_3_5_48_2","doi-asserted-by":"crossref","first-page":"2976373","DOI":"10.1155\/2019\/2976373","article-title":"RAD51 and XRCC3 polymorphisms are associated with increased risk of prostate cancer","volume":"2019","author":"Nowacka-Zawisza M.","year":"2019","unstructured":"Nowacka-Zawisza M., Raszkiewicz A., Kwasiborski T., Forma E., Brys M. et al: RAD51 and XRCC3 polymorphisms are associated with increased risk of prostate cancer. J Oncol 2019; 2019: 2976373.","journal-title":"J Oncol"},{"key":"e_1_3_5_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2019.10.030"},{"key":"e_1_3_5_50_2","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/bies.950140410","article-title":"Redundancies, development and the Flow of Information","volume":"14","author":"Tautz D.","year":"1992","unstructured":"Tautz D.: Redundancies, development and the Flow of Information. BioEssays 1992; 14: 263.","journal-title":"BioEssays"},{"key":"e_1_3_5_51_2","doi-asserted-by":"publisher","DOI":"10.1002\/bies.950190312"},{"key":"e_1_3_5_52_2","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1126\/science.1056072","article-title":"Cell biology \u2013 Principles for the buffering of genetic variation","volume":"291","author":"Hartman J.L.","year":"2001","unstructured":"Hartman J.L., Garvik B. and Hartwell L.: Cell biology \u2013 Principles for the buffering of genetic variation. Science 2001; 291: 1001.","journal-title":"Science"},{"key":"e_1_3_5_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-019-0046-z"},{"key":"e_1_3_5_54_2","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.drudis.2019.11.014","article-title":"Synthetic lethality: a step forward for personalized medicine in cancer","volume":"25","author":"Jariyal H.","year":"2019","unstructured":"Jariyal H., Weinberg F., Achreja A., Nagarath D. and Srivastava A.: Synthetic lethality: a step forward for personalized medicine in cancer. Drug Discov Today 2019; 25: 305.","journal-title":"Drug Discov Today"}],"container-title":["Computational and Structural Biotechnology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2001037020304372?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2001037020304372?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/spj.science.org\/doi\/pdf\/10.1016\/j.csbj.2020.10.015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T12:36:11Z","timestamp":1779021371000},"score":1,"resource":{"primary":{"URL":"https:\/\/spj.science.org\/doi\/10.1016\/j.csbj.2020.10.015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":53,"alternative-id":["10.1016\/j.csbj.2020.10.015"],"URL":"https:\/\/doi.org\/10.1016\/j.csbj.2020.10.015","relation":{},"ISSN":["2001-0370"],"issn-type":[{"value":"2001-0370","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrative omics analysis reveals relationships of genes with synthetic lethal interactions through a pan-cancer analysis","name":"articletitle","label":"Article Title"},{"value":"Computational and Structural Biotechnology Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.csbj.2020.10.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology.","name":"copyright","label":"Copyright"}]}}