{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T13:09:48Z","timestamp":1779023388618,"version":"3.51.4"},"reference-count":47,"publisher":"American Association for the Advancement of Science (AAAS)","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,14]],"date-time":"2021-11-14T00:00:00Z","timestamp":1636848000000},"content-version":"vor","delay-in-days":317,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["csbj.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comput Struct Biotechnol J"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.csbj.2021.11.022","type":"journal-article","created":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T12:07:48Z","timestamp":1637237268000},"page":"6169-6178","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Statistical mediation of the relationships between chronological age and lipoproteins by nonessential amino acids in healthy men"],"prefix":"10.34133","volume":"19","author":[{"given":"Roger","family":"Mallol","sequence":"first","affiliation":[{"name":"La Salle, Ramon Llull University, Barcelona, Spain"},{"name":"Department of Computational Biology, University of Lausanne, Lausanne, Switzerland"},{"name":"Swiss Institute of Bioinformatics, Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan Carles","family":"Vallv\u00e9","sequence":"additional","affiliation":[{"name":"Research Unit on Lipids and Atherosclerosis, Sant Joan University Hospital, Rovira i Virgili University, IISPV, Reus, Spain"},{"name":"Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Sol\u00e0","sequence":"additional","affiliation":[{"name":"Research Unit on Lipids and Atherosclerosis, Sant Joan University Hospital, Rovira i Virgili University, IISPV, Reus, Spain"},{"name":"Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josefa","family":"Girona","sequence":"additional","affiliation":[{"name":"Research Unit on Lipids and Atherosclerosis, Sant Joan University Hospital, Rovira i Virgili University, IISPV, Reus, Spain"},{"name":"Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"Bergmann","sequence":"additional","affiliation":[{"name":"Department of Computational Biology, University of Lausanne, Lausanne, Switzerland"},{"name":"Swiss Institute of Bioinformatics, Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Correig","sequence":"additional","affiliation":[{"name":"Metabolomics Platform, Department of Electronic Engineering, Rovira i Virgili University, IISPV, Tarragona, Spain"},{"name":"Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edmond","family":"Rock","sequence":"additional","affiliation":[{"name":"UMMM, INRA-Theix, St. Genes Champanelle, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte M","family":"Winklhofer-Roob","sequence":"additional","affiliation":[{"name":"Human Nutrition and Metabolism Research and Training Center, Institute of Molecular Biosciences, Karl-Franzens University, Graz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pere","family":"Rehues","sequence":"additional","affiliation":[{"name":"Research Unit on Lipids and Atherosclerosis, Sant Joan University Hospital, Rovira i Virgili University, IISPV, Reus, Spain"},{"name":"Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montse","family":"Guardiola","sequence":"additional","affiliation":[{"name":"Research Unit on Lipids and Atherosclerosis, Sant Joan University Hospital, Rovira i Virgili University, IISPV, Reus, Spain"},{"name":"Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Llu\u00eds","family":"Masana","sequence":"additional","affiliation":[{"name":"Research Unit on Lipids and Atherosclerosis, Sant Joan University Hospital, Rovira i Virgili University, IISPV, Reus, Spain"},{"name":"Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep","family":"Ribalta","sequence":"additional","affiliation":[{"name":"Research Unit on Lipids and Atherosclerosis, Sant Joan University Hospital, Rovira i Virgili University, IISPV, Reus, Spain"},{"name":"Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","published-online":{"date-parts":[[2021,11,23]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1113\/JP270538"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.10.039"},{"key":"e_1_3_5_4_2","doi-asserted-by":"crossref","first-page":"1800407","DOI":"10.1002\/pmic.201800407","article-title":"The Aging Metabolome\u2014Biomarkers to Hub Metabolites","volume":"20","author":"Sharma R.","year":"2020","unstructured":"Sharma R. and Ramanathan A.: The Aging Metabolome\u2014Biomarkers to Hub Metabolites. Proteomics 2020; 20: 1800407.","journal-title":"Proteomics"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.01.024"},{"key":"e_1_3_5_6_2","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jgg.2019.11.009","article-title":"Integration of lipidomics and metabolomics for in-depth understanding of cellular mechanism and disease progression","volume":"47","author":"Wang R.","year":"2020","unstructured":"Wang R., Li B., Lam S.M. and Shui G.: Integration of lipidomics and metabolomics for in-depth understanding of cellular mechanism and disease progression. J Genet Genomics. 2020; 47: 69.","journal-title":"J Genet Genomics."},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/mas.20108"},{"key":"e_1_3_5_8_2","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1080\/10826076.2019.1701016","article-title":"Metabolomics analysis of human plasma metabolites reveals the age- and sex-specific associations","volume":"43","author":"Wang Y.","year":"2020","unstructured":"Wang Y., Wang G., Jing R., Hu T., Likhodii S., Sun G. et al: Metabolomics analysis of human plasma metabolites reveals the age- and sex-specific associations. J Liq Chromatogr Relat Technol 2020; 43: 185.","journal-title":"J Liq Chromatogr Relat Technol"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/metabo9070123"},{"key":"e_1_3_5_10_2","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1373\/clinchem.2004.032763","article-title":"Sex and Age Differences in Lipoprotein Subclasses Measured by Nuclear Magnetic Resonance Spectroscopy: The Framingham Study","volume":"50","author":"Freedman D.S.","year":"2004","unstructured":"Freedman D.S., Otvos J.D., Jeyarajah E.J., Shalaurova I., Cupples L.A., Parise H. et al: Sex and Age Differences in Lipoprotein Subclasses Measured by Nuclear Magnetic Resonance Spectroscopy: The Framingham Study. Clin Chem 2004; 50: 1189.","journal-title":"Clin Chem"},{"key":"e_1_3_5_11_2","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1093\/gerona\/glv074","article-title":"Human Aging Is a Metabolome-related Matter of Gender","volume":"71","author":"Jov\u00e9 M.","year":"2016","unstructured":"Jov\u00e9 M., Mat\u00e9 I., Naud\u00ed A., Mota-Martorell N., Portero-Ot\u00edn M., De la Fuente M. et al: Human Aging Is a Metabolome-related Matter of Gender. J Gerontol. 2016; 71: 578.","journal-title":"J Gerontol."},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.2217\/14622416.9.4.383"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyt094"},{"key":"e_1_3_5_14_2","doi-asserted-by":"crossref","DOI":"10.1186\/s12944-021-01456-2","article-title":"Age and sex are associated with the plasma lipidome: findings from the GOLDN study","volume":"20","author":"Slade E.","year":"2021","unstructured":"Slade E., Irvin M.R., Xie K., Arnett D.K., Claas S.A., Kind T. et al: Age and sex are associated with the plasma lipidome: findings from the GOLDN study. Lipids Health Dis 2021; 20.","journal-title":"Lipids Health Dis"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2012.00865.x"},{"key":"e_1_3_5_16_2","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/5fb9fa6f-4889-4407-8430-6dfc7ecdfbdd","article-title":"Metabolic Signatures of Extreme Longevity in Northern Italian Centenarians Reveal a Complex Remodeling of Lipids, Amino Acids, and Gut Microbiota Metabolism. Wertheimer A, editor","volume":"8","author":"Collino S.","year":"2013","unstructured":"Collino S., Montoliu I., Martin F.-P.J., Scherer M., Mari D., Salvioli S. et al: Metabolic Signatures of Extreme Longevity in Northern Italian Centenarians Reveal a Complex Remodeling of Lipids, Amino Acids, and Gut Microbiota Metabolism. Wertheimer A, editor. PLoS One 2013; 8.","journal-title":"PLoS One"},{"key":"e_1_3_5_17_2","first-page":"70","article-title":"Vitamin A, vitamin E and carotenoid status and metabolism during ageing: functional and nutritional consequences (VITAGE PROJECT)","volume":"11","author":"Rock E.","year":"2001","unstructured":"Rock E., Winklhofer-Roob B.M., Ribalta J., Scotter M., Vasson M.P., Brtko J. et al: Vitamin A, vitamin E and carotenoid status and metabolism during ageing: functional and nutritional consequences (VITAGE PROJECT). Nutr Metab Cardiovasc Dis NMCD 2001; 11: 70.","journal-title":"Nutr Metab Cardiovasc Dis NMCD"},{"key":"e_1_3_5_18_2","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1021\/ac403110u","article-title":"Focus: A Robust Workflow for One-Dimensional NMR Spectral Analysis","volume":"86","author":"Alonso A.","year":"2014","unstructured":"Alonso A., Rodr\u00edguez M.A., Vinaixa M., Tortosa R., Correig X., Juli\u00e0 A. et al: Focus: A Robust Workflow for One-Dimensional NMR Spectral Analysis. Anal Chem 2014; 86: 1160.","journal-title":"Anal Chem"},{"key":"e_1_3_5_19_2","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1021\/ac503651e","article-title":"Expanding the Limits of Human Blood Metabolite Quantitation Using NMR Spectroscopy","volume":"87","author":"Nagana Gowda G.A.","year":"2015","unstructured":"Nagana Gowda G.A., Gowda Y.N. and Raftery D.: Expanding the Limits of Human Blood Metabolite Quantitation Using NMR Spectroscopy. Anal Chem 2015; 87: 706.","journal-title":"Anal Chem"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1089"},{"key":"e_1_3_5_21_2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/978-1-0716-0270-6_14","article-title":"BioMagResBank (BMRB) as a Resource for Structural Biology","volume":"2112","author":"Romero P.R.","year":"2020","unstructured":"Romero P.R., Kobayashi N., Wedell J.R., Baskaran K., Iwata T., Yokochi M. et al: BioMagResBank (BMRB) as a Resource for Structural Biology. Methods Mol Biol 2020; 2112: 187.","journal-title":"Methods Mol Biol"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cll.2006.07.006"},{"key":"e_1_3_5_23_2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0177749","article-title":"Human plasma metabolomics in age-related macular degeneration (AMD) using nuclear magnetic resonance spectroscopy. Clark SJ, editor","volume":"12","author":"La\u00edns I.","year":"2017","unstructured":"La\u00edns I., Duarte D., Barros A.S., Martins A.S., Gil J., Miller J.B. et al: Human plasma metabolomics in age-related macular degeneration (AMD) using nuclear magnetic resonance spectroscopy. Clark SJ, editor. PLoS One 2017; 12.","journal-title":"PLoS One"},{"key":"e_1_3_5_24_2","unstructured":"Nicholson JK Foxall PJD Spraul M. 750 MHz IH and IH-l3C NMR Spectroscopy of Human Blood Plasma. :19."},{"key":"e_1_3_5_25_2","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ahj.2014.01.019","article-title":"A metabolomic profile is associated with the risk of incident coronary heart disease","volume":"168","author":"Vaarhorst A.A.M.","year":"2014","unstructured":"Vaarhorst A.A.M., Verhoeven A., Weller C.M., B\u00f6hringer S., G\u00f6raler S., Meissner A. et al: A metabolomic profile is associated with the risk of incident coronary heart disease. Am Heart J 2014; 168: 45.","journal-title":"Am Heart J"},{"key":"e_1_3_5_26_2","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.jacl.2015.08.001","article-title":"Body mass index correlates with atherogenic lipoprotein profile even in nonobese, normoglycemic, and normolipidemic healthy men","volume":"9","author":"Guardiola M.","year":"2015","unstructured":"Guardiola M., Sol\u00e0 R., Vallv\u00e9 J.C., Girona J., God\u00e0s G., Heras M. et al: Body mass index correlates with atherogenic lipoprotein profile even in nonobese, normoglycemic, and normolipidemic healthy men. J Clin Lipidol. 2015; 9: 824.","journal-title":"J Clin Lipidol."},{"key":"e_1_3_5_27_2","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1001\/jama.1988.03410130125037","article-title":"Low-Density Lipoprotein Subclass Patterns and Risk of Myocardial Infarction","volume":"260","author":"Austin M.A.","year":"1988","unstructured":"Austin M.A., Breslow L., Hennekens C.H., Willett W.C. and Krauss R.M.: Low-Density Lipoprotein Subclass Patterns and Risk of Myocardial Infarction. JAMA 1988; 260: 1917.","journal-title":"JAMA"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0b013e3283468061"},{"key":"e_1_3_5_29_2","doi-asserted-by":"crossref","first-page":"e495","DOI":"10.1371\/journal.pmed.0030495","article-title":"Lipoprotein Particle Profiles Mark Familial and Sporadic Human Longevity","volume":"3","author":"Heijmans B.T.","year":"2006","unstructured":"Heijmans B.T., Beekman M., Houwing-Duistermaat J.J., Cobain M.R., Powell J., Blauw G.J. et al: Lipoprotein Particle Profiles Mark Familial and Sporadic Human Longevity. PLoS Med 2006; 3: e495.","journal-title":"PLoS Med"},{"key":"e_1_3_5_30_2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s11306-016-0968-y","article-title":"Changes in serum fatty acid and lipoprotein subclass concentrations from prepuberty to adulthood and during aging","volume":"12","author":"Rajalahti T.","year":"2016","unstructured":"Rajalahti T., Lin C., Mj\u00f8s S.A. and Kvalheim O.M.: Changes in serum fatty acid and lipoprotein subclass concentrations from prepuberty to adulthood and during aging. Metabolomics 2016 Mar; 12: 51.","journal-title":"Metabolomics"},{"key":"e_1_3_5_31_2","doi-asserted-by":"publisher","DOI":"10.3390\/metabo9030044"},{"key":"e_1_3_5_32_2","doi-asserted-by":"publisher","DOI":"10.18632\/aging.101837"},{"key":"e_1_3_5_33_2","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2012.00148","article-title":"A New Definition of Aging?","volume":"3","author":"Flatt T.","year":"2012","unstructured":"Flatt T.: A New Definition of Aging?. Front Genet 2012; 3.","journal-title":"Front Genet"},{"key":"e_1_3_5_34_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1998.78.2.547"},{"key":"e_1_3_5_35_2","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S158513"},{"key":"e_1_3_5_36_2","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.mad.2015.03.003","article-title":"Oxidized LDL and NO synthesis\u2014Biomarkers of endothelial dysfunction and ageing","volume":"151","author":"Gradinaru D.","year":"2015","unstructured":"Gradinaru D., Borsa C., Ionescu C. and Prada G.I.: Oxidized LDL and NO synthesis\u2014Biomarkers of endothelial dysfunction and ageing. Mech Ageing Dev 2015; 151: 101.","journal-title":"Mech Ageing Dev"},{"key":"e_1_3_5_37_2","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1161\/01.ATV.0000091338.93223.E8","article-title":"Small, Dense HDL Particles Exert Potent Protection of Atherogenic LDL Against Oxidative Stress","volume":"23","author":"Kontush A.","year":"2003","unstructured":"Kontush A., Chantepie S. and Chapman M.J.: Small, Dense HDL Particles Exert Potent Protection of Atherogenic LDL Against Oxidative Stress. Arterioscler Thromb Vasc Biol 2003; 23: 1881.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"e_1_3_5_38_2","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1097\/MOL.0b013e32833bcdc1","article-title":"Antiatherogenic function of HDL particle subpopulations: focus on antioxidative activities","volume":"21","author":"Kontush A.","year":"2010","unstructured":"Kontush A. and Chapman M.J.: Antiatherogenic function of HDL particle subpopulations: focus on antioxidative activities. Curr Opin Lipidol 2010; 21: 312.","journal-title":"Curr Opin Lipidol"},{"key":"e_1_3_5_39_2","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.molmed.2011.05.013","article-title":"Biological activities of HDL subpopulations and their relevance to cardiovascular disease","volume":"17","author":"Camont L.","year":"2011","unstructured":"Camont L., Chapman M.J. and Kontush A.: Biological activities of HDL subpopulations and their relevance to cardiovascular disease. Trends Mol Med 2011; 17: 594.","journal-title":"Trends Mol Med"},{"key":"e_1_3_5_40_2","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jacl.2015.10.006","article-title":"Small, dense high-density lipoprotein 3 particles exhibit defective antioxidative and anti-inflammatory function in familial hypercholesterolemia: Partial correction by low-density lipoprotein apheresis","volume":"10","author":"Hussein H.","year":"2016","unstructured":"Hussein H., Saheb S., Couturier M., Atassi M., Orsoni A., Carri\u00e9 A. et al: Small, dense high-density lipoprotein 3 particles exhibit defective antioxidative and anti-inflammatory function in familial hypercholesterolemia: Partial correction by low-density lipoprotein apheresis. J Clin Lipidol. 2016; 10: 124.","journal-title":"J Clin Lipidol."},{"key":"e_1_3_5_41_2","first-page":"209","article-title":"Antioxidant and cytoprotective effects of L-Serine on human endothelial cells","volume":"7","author":"Maralani M.N.","year":"2012","unstructured":"Maralani M.N., Movahedian A. and Javanmard S.H.: Antioxidant and cytoprotective effects of L-Serine on human endothelial cells. Res Pharm Sci. 2012; 7: 209.","journal-title":"Res Pharm Sci."},{"key":"e_1_3_5_42_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004113"},{"key":"e_1_3_5_43_2","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1093\/ajcn\/82.2.342","article-title":"Inflammation contributes to low plasma amino acid concentrations in patients with chronic kidney disease","volume":"82","author":"Suliman M.E.","year":"2005","unstructured":"Suliman M.E., Qureshi A.R., Stenvinkel P., Pecoits-Filho R., B\u00e1r\u00e1ny P., Heimb\u00fcrger O. et al: Inflammation contributes to low plasma amino acid concentrations in patients with chronic kidney disease. Am J Clin Nutr 2005; 82: 342.","journal-title":"Am J Clin Nutr"},{"key":"e_1_3_5_44_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-011-0364-z"},{"key":"e_1_3_5_45_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7901908"},{"key":"e_1_3_5_46_2","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1039\/D0AY00305K","article-title":"Targeted profiling of amino acid metabolome in serum by a liquid chromatography-mass spectrometry method: application to identify potential markers for diet-induced hyperlipidemia","volume":"12","author":"Wang X.-F.","year":"2020","unstructured":"Wang X.-F., Zhang Y.-x. and Ma H.-Y.: Targeted profiling of amino acid metabolome in serum by a liquid chromatography-mass spectrometry method: application to identify potential markers for diet-induced hyperlipidemia. Anal Methods 2020; 12: 2355.","journal-title":"Anal Methods"},{"key":"e_1_3_5_47_2","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.116.003755","article-title":"Metabolites of Glutamate Metabolism Are Associated With Incident Cardiovascular Events in the PREDIMED PREvenci\u00f3n con DIeta MEDiterr\u00e1nea (PREDIMED) Trial","volume":"5","author":"Zheng Y.","year":"2016","unstructured":"Zheng Y., Hu F.B., Ruiz\u2010Canela M., Clish C.B., Dennis C., Salas\u2010Salvado J. et al: Metabolites of Glutamate Metabolism Are Associated With Incident Cardiovascular Events in the PREDIMED PREvenci\u00f3n con DIeta MEDiterr\u00e1nea (PREDIMED) Trial. J Am Heart Assoc. 2016; 5.","journal-title":"J Am Heart Assoc."},{"key":"e_1_3_5_48_2","doi-asserted-by":"crossref","DOI":"10.1186\/s12944-017-0654-8","article-title":"The SNP rs10911021 is associated with oxidative stress in coronary heart disease patients from Pakistan","volume":"17","author":"Shahid S.U.","year":"2018","unstructured":"Shahid S.U., Shabana and Humphries S.: The SNP rs10911021 is associated with oxidative stress in coronary heart disease patients from Pakistan. Lipids Health Dis 2018; 17.","journal-title":"Lipids Health Dis"}],"container-title":["Computational and Structural Biotechnology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2001037021004876?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2001037021004876?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/spj.science.org\/doi\/pdf\/10.1016\/j.csbj.2021.11.022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T12:52:09Z","timestamp":1779022329000},"score":1,"resource":{"primary":{"URL":"https:\/\/spj.science.org\/doi\/10.1016\/j.csbj.2021.11.022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":47,"alternative-id":["10.1016\/j.csbj.2021.11.022"],"URL":"https:\/\/doi.org\/10.1016\/j.csbj.2021.11.022","relation":{},"ISSN":["2001-0370"],"issn-type":[{"value":"2001-0370","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Statistical mediation of the relationships between chronological age and lipoproteins by nonessential amino acids in healthy men","name":"articletitle","label":"Article Title"},{"value":"Computational and Structural Biotechnology Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.csbj.2021.11.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology.","name":"copyright","label":"Copyright"}]}}