{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T13:10:10Z","timestamp":1779023410975,"version":"3.51.4"},"reference-count":89,"publisher":"American Association for the Advancement of Science (AAAS)","license":[{"start":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T00:00:00Z","timestamp":1640649600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T00:00:00Z","timestamp":1640649600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,11]],"date-time":"2021-12-11T00:00:00Z","timestamp":1639180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFC1004400"],"award-info":[{"award-number":["2018YFC1004400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004374","name":"Chongqing Medical University","doi-asserted-by":"publisher","award":["BJRC201917"],"award-info":[{"award-number":["BJRC201917"]}],"id":[{"id":"10.13039\/501100004374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing","doi-asserted-by":"publisher","award":["cstc2018jcyjAX0309"],"award-info":[{"award-number":["cstc2018jcyjAX0309"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["csbj.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comput Struct Biotechnol J"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.csbj.2021.12.016","type":"journal-article","created":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T21:58:58Z","timestamp":1639605538000},"page":"322-332","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["LncRNA functional annotation with improved false discovery rate achieved by disease associations"],"prefix":"10.34133","volume":"20","author":[{"given":"Yongheng","family":"Wang","sequence":"first","affiliation":[{"name":"School of Basic Medicine, Chongqing Medical University, Chongqing 400016, China"},{"name":"Joint International Research Laboratory of Reproductive and Development, Department of Reproductive Biology, School of Public Health, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jincheng","family":"Zhai","sequence":"additional","affiliation":[{"name":"School of Basic Medicine, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianglu","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Public Health, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enoch Appiah","family":"Adu-Gyamfi","sequence":"additional","affiliation":[{"name":"Joint International Research Laboratory of Reproductive and Development, Department of Reproductive Biology, School of Public Health, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingping","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Public Health, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taihang","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Basic Medicine, Chongqing Medical University, Chongqing 400016, China"},{"name":"Joint International Research Laboratory of Reproductive and Development, Department of Reproductive Biology, School of Public Health, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meijiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Joint International Research Laboratory of Reproductive and Development, Department of Reproductive Biology, School of Public Health, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yubin","family":"Ding","sequence":"additional","affiliation":[{"name":"Joint International Research Laboratory of Reproductive and Development, Department of Reproductive Biology, School of Public Health, Chongqing Medical University, Chongqing 400016, China"},{"name":"School of Public Health, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Zhu","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingxiong","family":"Wang","sequence":"additional","affiliation":[{"name":"Joint International Research Laboratory of Reproductive and Development, Department of Reproductive Biology, School of Public Health, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Tang","sequence":"additional","affiliation":[{"name":"School of Basic Medicine, Chongqing Medical University, Chongqing 400016, China"},{"name":"Joint International Research Laboratory of Reproductive and Development, Department of Reproductive Biology, School of Public Health, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","published-online":{"date-parts":[[2021,12,28]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s13059-017-1348-2","article-title":"The multidimensional mechanisms of long noncoding RNA function","volume":"18","author":"Marchese F.P.","year":"2017","unstructured":"Marchese F.P., Raimondi I. and Huarte M.: The multidimensional mechanisms of long noncoding RNA function. Genome Biol 2017; 18: 206.","journal-title":"Genome Biol"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.01.011"},{"key":"e_1_3_5_4_2","doi-asserted-by":"crossref","unstructured":"Chen G Wang Z Wang D Qiu C Liu M et al. LncRNADisease: a database for long-non-coding RNA-associated diseases. Nucleic Acids Res 2013;41(Database issue):D983-986. Doi: 10.1093\/nar\/gks1099.","DOI":"10.1093\/nar\/gks1099"},{"key":"e_1_3_5_5_2","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12791","article-title":"The lncRNA landscape of breast cancer reveals a role for DSCAM-AS1 in breast cancer progression","volume":"7","author":"Niknafs Y.S.","year":"2016","unstructured":"Niknafs Y.S., Han S., Ma T., Speers C., Zhang C., Wilder-Romans K. et al: The lncRNA landscape of breast cancer reveals a role for DSCAM-AS1 in breast cancer progression. Nat Commun 2016; 7.","journal-title":"Nat Commun"},{"key":"e_1_3_5_6_2","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aai9118","article-title":"The long noncoding RNA Wisper controls cardiac fibrosis and remodeling","volume":"9","author":"Micheletti R.","year":"2017","unstructured":"Micheletti R., Plaisance I., Abraham B.J., Sarre A., Ting C.-C., Alexanian M. et al: The long noncoding RNA Wisper controls cardiac fibrosis and remodeling. Sci Transl Med 2017; 9.","journal-title":"Sci Transl Med"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2017.03.004"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.08.010"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3771"},{"key":"e_1_3_5_10_2","doi-asserted-by":"crossref","unstructured":"Alam T Uludag M Essack M Salhi A Ashoor H et al. FARNA: knowledgebase of inferred functions of non-coding RNA transcripts. Nucleic Acids Res 2017;45(5):2838-2848. https:\/\/doi.org\/10.1093\/nar\/gkw973","DOI":"10.1093\/nar\/gkw973"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-9-559"},{"key":"e_1_3_5_12_2","doi-asserted-by":"crossref","unstructured":"Jiao J Shi B Wang T Fang Y Cao T et al. Characterization of long non-coding RNA and messenger RNA profiles in follicular fluid from mature and immature ovarian follicles of healthy women and women with polycystic ovary syndrome. Hum Reprod. 2018;33(9):1735-1748. https:\/\/doi.org\/10.1093\/humrep\/dey255","DOI":"10.1093\/humrep\/dey255"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1904108116"},{"key":"e_1_3_5_14_2","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1186\/s12859-019-2985-0","article-title":"A novel collaborative filtering model for LncRNA-disease association prediction based on the Naive Bayesian classifier","volume":"20","author":"Yu J.","year":"2019","unstructured":"Yu J., Xuan Z., Feng X., Zou Q. and Wang L.: A novel collaborative filtering model for LncRNA-disease association prediction based on the Naive Bayesian classifier. BMC Bioinf 2019; 20: 396.","journal-title":"BMC Bioinf"},{"key":"e_1_3_5_15_2","doi-asserted-by":"crossref","unstructured":"Bao Z Yang Z Huang Z Zhou Y Cui Q et al. LncRNADisease 2.0: an updated database of long non-coding RNA-associated diseases. Nucleic Acids Res 2019;47(D1):D1034-D1037. https:\/\/doi.org\/10.1093\/nar\/gky905","DOI":"10.1093\/nar\/gky905"},{"key":"e_1_3_5_16_2","doi-asserted-by":"crossref","unstructured":"Volders PJ Anckaert J Verheggen K Nuytens J Martens L et al. LNCipedia 5: towards a reference set of human long non-coding RNAs. Nucleic Acids Res 2019;47(D1):D135-D139. https:\/\/doi.org\/10.1093\/nar\/gky1031","DOI":"10.1093\/nar\/gky1031"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2016.08.004"},{"key":"e_1_3_5_18_2","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-016-0873-8","article-title":"Long non-coding RNAs display higher natural expression variation than protein-coding genes in healthy humans","volume":"17","author":"Kornienko A.E.","year":"2016","unstructured":"Kornienko A.E., Dotter C.P., Guenzl P.M., Gisslinger H., Gisslinger B., Cleary C. et al: Long non-coding RNAs display higher natural expression variation than protein-coding genes in healthy humans. Genome Biol 2016; 17.","journal-title":"Genome Biol"},{"key":"e_1_3_5_19_2","doi-asserted-by":"crossref","first-page":"D231","DOI":"10.1093\/nar\/gkv1270","article-title":"DIANA-LncBase v2: indexing microRNA targets on non-coding transcripts","volume":"44","author":"Paraskevopoulou M.D.","year":"2016","unstructured":"Paraskevopoulou M.D., Vlachos I.S., Karagkouni D., Georgakilas G., Kanellos I., Vergoulis T. et al: DIANA-LncBase v2: indexing microRNA targets on non-coding transcripts. Nucleic Acids Res 2016; 44: D231.","journal-title":"Nucleic Acids Res"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.06.014"},{"key":"e_1_3_5_21_2","doi-asserted-by":"crossref","first-page":"420","DOI":"10.3389\/fimmu.2019.00420","article-title":"Disease-Associated SNPs in Inflammation-Related lncRNAs","volume":"10","author":"Castellanos-Rubio A.","year":"2019","unstructured":"Castellanos-Rubio A. and Ghosh S.: Disease-Associated SNPs in Inflammation-Related lncRNAs. Front Immunol 2019; 10: 420.","journal-title":"Front Immunol"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3637"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-014-0125-z"},{"key":"e_1_3_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.03.068"},{"key":"e_1_3_5_25_2","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s13072-018-0227-8","article-title":"Identification of a novel antisense noncoding RNA, ALID, transcribed from the putative imprinting control region of marsupial IGF2R","volume":"11","author":"Suzuki S.","year":"2018","unstructured":"Suzuki S., Shaw G. and Renfree M.B.: Identification of a novel antisense noncoding RNA, ALID, transcribed from the putative imprinting control region of marsupial IGF2R. Epigenet Chromatin 2018; 11: 55.","journal-title":"Epigenet Chromatin"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.03.008"},{"key":"e_1_3_5_27_2","doi-asserted-by":"crossref","first-page":"e10","DOI":"10.1182\/blood-2015-11-680843","article-title":"Long noncoding RNAs in B-cell development and activation","volume":"128","author":"Brazao T.F.","year":"2016","unstructured":"Brazao T.F., Johnson J.S., Muller J., Heger A., Ponting C.P. et al: Long noncoding RNAs in B-cell development and activation. Blood 2016; 128: e10.","journal-title":"Blood"},{"key":"e_1_3_5_28_2","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/978-1-4939-3578-9_5","article-title":"The Gene Expression Omnibus Database","volume":"1418","author":"Clough E.","year":"2016","unstructured":"Clough E. and Barrett T.: The Gene Expression Omnibus Database. Methods Mol Biol 2016; 1418: 93.","journal-title":"Methods Mol Biol"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.03.042"},{"key":"e_1_3_5_30_2","doi-asserted-by":"crossref","unstructured":"Ma L Li A Zou D Xu X Xia L et al. LncRNAWiki: harnessing community knowledge in collaborative curation of human long non-coding RNAs. Nucleic Acids Res. 2015;43(Database issue):D187-192. https:\/\/doi.org\/10.1093\/nar\/gku1167","DOI":"10.1093\/nar\/gku1167"},{"key":"e_1_3_5_31_2","doi-asserted-by":"crossref","unstructured":"Cheng L Wang P Tian R Wang S Guo Q et al. LncRNA2Target v2.0: a comprehensive database for target genes of lncRNAs in human and mouse. Nucleic Acids Res 2019;47(D1):D140-D144. https:\/\/doi.org\/10.1093\/nar\/gky1051","DOI":"10.1093\/nar\/gky1051"},{"key":"e_1_3_5_32_2","doi-asserted-by":"crossref","unstructured":"Gao Y Wang P Wang Y Ma X Zhi H et al. Lnc2Cancer v2.0: updated database of experimentally supported long non-coding RNAs in human cancers. Nucleic Acids Res 2019;47(D1):D1028-D1033. https:\/\/doi.org\/10.1093\/nar\/gky1096","DOI":"10.1093\/nar\/gky1096"},{"key":"e_1_3_5_33_2","doi-asserted-by":"crossref","unstructured":"Zhou B Zhao H Yu J Guo C Dou X et al. EVLncRNAs: a manually curated database for long non-coding RNAs validated by low-throughput experiments. Nucleic Acids Res 2018;46(D1):D100-D105. https:\/\/doi.org\/10.1093\/nar\/gkx677","DOI":"10.1093\/nar\/gkx677"},{"key":"e_1_3_5_34_2","doi-asserted-by":"crossref","unstructured":"Eicher JD Landowski C Stackhouse B Sloan A Chen W et al. GRASP v2.0: an update on the Genome-Wide Repository of Associations between SNPs and phenotypes. Nucleic Acids Res. 2015;43(Database issue):D799-804. https:\/\/doi.org\/10.1093\/nar\/gku1202","DOI":"10.1093\/nar\/gku1202"},{"key":"e_1_3_5_35_2","doi-asserted-by":"crossref","unstructured":"Buniello A MacArthur JAL Cerezo M Harris LW Hayhurst J et al. The NHGRI-EBI GWAS Catalog of published genome-wide association studies targeted arrays and summary statistics 2019. Nucleic Acids Res 2019;47(D1):D1005-D1012. https:\/\/doi.org\/10.1093\/nar\/gky1120","DOI":"10.1093\/nar\/gky1120"},{"key":"e_1_3_5_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1317"},{"key":"e_1_3_5_37_2","doi-asserted-by":"crossref","unstructured":"Frankish A Diekhans M Ferreira AM Johnson R Jungreis I et al. GENCODE reference annotation for the human and mouse genomes. Nucleic Acids Res. 2019;47(D1):D766-D773. https:\/\/doi.org\/10.1093\/nar\/gky955","DOI":"10.1093\/nar\/gky955"},{"key":"e_1_3_5_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr432"},{"key":"e_1_3_5_39_2","article-title":"HMGA2 Antisense Long Non-coding RNAs as New Players in the Regulation of HMGA2 Expression and Pancreatic Cancer Promotion","volume":"9","author":"Ros G.","year":"2019","unstructured":"Ros G., Pegoraro S., De Angelis P., Sgarra R., Zucchelli S., Gustincich S. et al: HMGA2 Antisense Long Non-coding RNAs as New Players in the Regulation of HMGA2 Expression and Pancreatic Cancer Promotion. Front Oncol 2019; 9.","journal-title":"Front Oncol"},{"key":"e_1_3_5_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/nph.13429"},{"key":"e_1_3_5_41_2","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-015-0586-4","article-title":"Localization and abundance analysis of human lncRNAs at single-cell and single-molecule resolution","volume":"16","author":"Cabili M.N.","year":"2015","unstructured":"Cabili M.N., Dunagin M.C., McClanahan P.D., Biaesch A., Padovan-Merhar O., Regev A. et al: Localization and abundance analysis of human lncRNAs at single-cell and single-molecule resolution. Genome Biol 2015; 16.","journal-title":"Genome Biol"},{"key":"e_1_3_5_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.3424"},{"key":"e_1_3_5_43_2","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.omtn.2018.05.022","article-title":"Integrative Analysis of lncRNAs in Th17 Cell Lineage to Discover New Potential Biomarkers and Therapeutic Targets in Autoimmune Diseases","volume":"12","author":"Teimuri S.","year":"2018","unstructured":"Teimuri S., Hosseini A., Rezaenasab A., Ghaedi K., Ghoveud E., Etemadifar M. et al: Integrative Analysis of lncRNAs in Th17 Cell Lineage to Discover New Potential Biomarkers and Therapeutic Targets in Autoimmune Diseases. Mol Ther Nucleic Acids 2018; 12: 393.","journal-title":"Mol Ther Nucleic Acids"},{"key":"e_1_3_5_44_2","article-title":"Genome-wide identification and functional prediction of cold and\/or drought-responsive lncRNAs in cassava","volume":"7","author":"Li S.","year":"2017","unstructured":"Li S., Yu X., Lei N., Cheng Z., Zhao P., He Y. et al: Genome-wide identification and functional prediction of cold and\/or drought-responsive lncRNAs in cassava. Sci Rep 2017; 7.","journal-title":"Sci Rep"},{"key":"e_1_3_5_45_2","article-title":"Integrated analysis of mRNAs and long noncoding RNAs in the semen from Holstein bulls with high and low sperm motility","volume":"9","author":"Wang X.","year":"2019","unstructured":"Wang X., Yang C., Guo F., Zhang Y., Ju Z., Jiang Q. et al: Integrated analysis of mRNAs and long noncoding RNAs in the semen from Holstein bulls with high and low sperm motility. Sci Rep 2019; 9.","journal-title":"Sci Rep"},{"key":"e_1_3_5_46_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku1324"},{"key":"e_1_3_5_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.09.001"},{"key":"e_1_3_5_48_2","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s12864-019-5497-4","article-title":"PLAIDOH: a novel method for functional prediction of long non-coding RNAs identifies cancer-specific LncRNA activities","volume":"20","author":"Pyfrom S.C.","year":"2019","unstructured":"Pyfrom S.C., Luo H. and Payton J.E.: PLAIDOH: a novel method for functional prediction of long non-coding RNAs identifies cancer-specific LncRNA activities. BMC Genomics 2019; 20: 137.","journal-title":"BMC Genomics"},{"key":"e_1_3_5_49_2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1239303"},{"key":"e_1_3_5_50_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw1092"},{"key":"e_1_3_5_51_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu393"},{"key":"e_1_3_5_52_2","doi-asserted-by":"crossref","unstructured":"Hong J Luo Y Zhang Y Ying J Xue W et al. Protein functional annotation of simultaneously improved stability accuracy and false discovery rate achieved by a sequence-based deep learning. Brief Bioinform 2020;21(4):1437-1447. https:\/\/doi.org\/10.1093\/bib\/bbz081","DOI":"10.1093\/bib\/bbz081"},{"key":"e_1_3_5_53_2","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13115","article-title":"A lncRNA survey finds increases in neuroprotective LINC-PINT in Parkinson's disease substantia nigra","volume":"19","author":"Simchovitz A.","year":"2020","unstructured":"Simchovitz A., Hanan M., Yayon N., Lee S., Bennett E.R., Greenberg D.S. et al: A lncRNA survey finds increases in neuroprotective LINC-PINT in Parkinson's disease substantia nigra. Aging Cell 2020; 19.","journal-title":"Aging Cell"},{"key":"e_1_3_5_54_2","doi-asserted-by":"crossref","unstructured":"Zha T. Su F. Liu X. Yang C. and Liu L.: Role of Long Non-Coding RNA (LncRNA) LINC-PINT Downregulation in Cardiomyopathy and Retinopathy Progression Among Patients with Type 2 Diabetes. Med Sci Monit 2019; 25: 8509. https:\/\/doi.org\/10.12659\/MSM.918358.","DOI":"10.12659\/MSM.918358"},{"key":"e_1_3_5_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106614"},{"key":"e_1_3_5_56_2","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.bbacli.2015.09.001","article-title":"Circulating long noncoding RNA GAS5 levels are correlated to prevalence of type 2 diabetes mellitus","volume":"4","author":"Carter G.","year":"2015","unstructured":"Carter G., Miladinovic B., Patel A.A., Deland L., Mastorides S. and Patel N.A.: Circulating long noncoding RNA GAS5 levels are correlated to prevalence of type 2 diabetes mellitus. BBA Clin 2015; 4: 102.","journal-title":"BBA Clin"},{"key":"e_1_3_5_57_2","first-page":"2413","article-title":"Long noncoding RNA GAS5 impairs the proliferation and invasion of endometrial carcinoma induced by high glucose via targeting miR-222-3p\/p27","volume":"11","author":"Li Z.","year":"2019","unstructured":"Li Z., Yu Z., Meng X., Zhou S., Xiao S. et al: Long noncoding RNA GAS5 impairs the proliferation and invasion of endometrial carcinoma induced by high glucose via targeting miR-222-3p\/p27. Am J Transl Res 2019; 11: 2413.","journal-title":"Am J Transl Res"},{"key":"e_1_3_5_58_2","doi-asserted-by":"crossref","first-page":"721","DOI":"10.3233\/JAD-2011-101881","article-title":"Gene expression biomarkers in the brain of a mouse model for Alzheimer's disease: mining of microarray data by logic classification and feature selection","volume":"24","author":"Arisi I.","year":"2011","unstructured":"Arisi I., D'Onofrio M., Brandi R., Felsani A., Capsoni S., Drovandi G. et al: Gene expression biomarkers in the brain of a mouse model for Alzheimer's disease: mining of microarray data by logic classification and feature selection. J Alzheimers Dis 2011; 24: 721.","journal-title":"J Alzheimers Dis"},{"key":"e_1_3_5_59_2","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s12935-018-0618-8","article-title":"SOX2OT knockdown derived changes in mitotic regulatory gene network of cancer cells","volume":"18","author":"Saghaeian Jazi M.","year":"2018","unstructured":"Saghaeian Jazi M., Samaei N.M., Mowla S.J., Arefnezhad B. and Kouhsar M.: SOX2OT knockdown derived changes in mitotic regulatory gene network of cancer cells. Cancer Cell Int 2018; 18: 129.","journal-title":"Cancer Cell Int"},{"key":"e_1_3_5_60_2","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jpeds.2020.05.052","article-title":"Clinical and Genetic Spectrum of Children with Primary Ciliary Dyskinesia in China","volume":"225","author":"Guo Z.","year":"2020","unstructured":"Guo Z., Chen W., Wang L. and Qian L.: Clinical and Genetic Spectrum of Children with Primary Ciliary Dyskinesia in China. J Pediatr 2020; 225: 157.","journal-title":"J Pediatr"},{"key":"e_1_3_5_61_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature13595"},{"key":"e_1_3_5_62_2","first-page":"151","article-title":"Expression profile analysis of human peripheral blood mononuclear cells in response to aspirin","volume":"53","author":"Choi S.","year":"2005","unstructured":"Choi S., Park H.S., Cheon M.S. and Lee K.: Expression profile analysis of human peripheral blood mononuclear cells in response to aspirin. Arch Immunol Ther Exp (Warsz) 2005; 53: 151.","journal-title":"Arch Immunol Ther Exp (Warsz)"},{"key":"e_1_3_5_63_2","doi-asserted-by":"crossref","first-page":"4389","DOI":"10.1002\/cam4.2335","article-title":"LncRNA HCP5 promotes triple negative breast cancer progression as a ceRNA to regulate BIRC3 by sponging miR-219a-5p","volume":"8","author":"Wang L.","year":"2019","unstructured":"Wang L., Luan T., Zhou S., Lin J., Yang Y., Liu W. et al: LncRNA HCP5 promotes triple negative breast cancer progression as a ceRNA to regulate BIRC3 by sponging miR-219a-5p. Cancer Med. 2019; 8: 4389.","journal-title":"Cancer Med."},{"key":"e_1_3_5_64_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3564341"},{"key":"e_1_3_5_65_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00212.2016"},{"key":"e_1_3_5_66_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.2008.00474.x"},{"key":"e_1_3_5_67_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17030395"},{"key":"e_1_3_5_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2019.02.085"},{"key":"e_1_3_5_69_2","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.18632\/aging.101863","article-title":"Long non-coding RNA CDKN2B-AS1 reduces inflammatory response and promotes cholesterol efflux in atherosclerosis by inhibiting ADAM10 expression","volume":"11","author":"Li H.","year":"2019","unstructured":"Li H., Han S., Sun Q., Yao Y.e., Li S., Yuan C. et al: Long non-coding RNA CDKN2B-AS1 reduces inflammatory response and promotes cholesterol efflux in atherosclerosis by inhibiting ADAM10 expression. Aging (Albany NY). 2019; 11: 1695.","journal-title":"Aging (Albany NY)."},{"key":"e_1_3_5_70_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41431-018-0210-7"},{"key":"e_1_3_5_71_2","first-page":"100691","article-title":"Enhanced E2F1 activity increases invasive and proliferative activity of breast cancer cells through non-coding RNA CDKN2B-AS1. Meta","volume":"24","author":"Bozgeyik E.","year":"2020","unstructured":"Bozgeyik E., Saadat K.A.S.M., Arman K., Bozgeyik I. and Ikeda M.-A.: Enhanced E2F1 activity increases invasive and proliferative activity of breast cancer cells through non-coding RNA CDKN2B-AS1. Meta. Gene 2020; 24: 100691.","journal-title":"Gene"},{"key":"e_1_3_5_72_2","first-page":"575","article-title":"Gene co-expression analysis for functional classification and gene-disease predictions","volume":"19","author":"van Dam S.","year":"2018","unstructured":"van Dam S., Vosa U., van der Graaf A., Franke L. and de Magalhaes J.P.: Gene co-expression analysis for functional classification and gene-disease predictions. Brief Bioinform 2018; 19: 575.","journal-title":"Brief Bioinform"},{"key":"e_1_3_5_73_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-019-0563-5"},{"key":"e_1_3_5_74_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0101-9"},{"key":"e_1_3_5_75_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.107843"},{"key":"e_1_3_5_76_2","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2016.130"},{"key":"e_1_3_5_77_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4386"},{"key":"e_1_3_5_78_2","article-title":"Differential methylation of enhancer at IGF2 is associated with abnormal dopamine synthesis in major psychosis","volume":"10","author":"Pai S.","year":"2019","unstructured":"Pai S., Li P., Killinger B., Marshall L., Jia P., Liao J.i. et al: Differential methylation of enhancer at IGF2 is associated with abnormal dopamine synthesis in major psychosis. Nat Commun 2019; 10.","journal-title":"Nat Commun"},{"key":"e_1_3_5_79_2","doi-asserted-by":"crossref","first-page":"230","DOI":"10.3109\/09537104.2015.1083543","article-title":"Characterization of the platelet transcriptome by RNA sequencing in patients with acute myocardial infarction","volume":"27","author":"Eicher J.D.","year":"2016","unstructured":"Eicher J.D., Wakabayashi Y., Vitseva O., Esa N., Yang Y., Zhu J. et al: Characterization of the platelet transcriptome by RNA sequencing in patients with acute myocardial infarction. Platelets 2016; 27: 230.","journal-title":"Platelets"},{"key":"e_1_3_5_80_2","doi-asserted-by":"crossref","first-page":"5099","DOI":"10.1038\/s41598-020-61903-5","article-title":"Dynamic changes of innate lymphoid cells in acute ST-segment elevation myocardial infarction and its association with clinical outcomes","volume":"10","author":"Li J.","year":"2020","unstructured":"Li J., Wu J., Zhang M. and Zheng Y.: Dynamic changes of innate lymphoid cells in acute ST-segment elevation myocardial infarction and its association with clinical outcomes. Sci Rep 2020; 10: 5099.","journal-title":"Sci Rep"},{"key":"e_1_3_5_81_2","doi-asserted-by":"crossref","unstructured":"Hu YW Guo FX Xu YJ Li P Lu ZF et al. Long noncoding RNA NEXN-AS1 mitigates atherosclerosis by regulating the actin-binding protein NEXN. J Clin Invest 2019; 129(3):1115-1128. https:\/\/doi.org\/10.1172\/JCI98230","DOI":"10.1172\/JCI98230"},{"key":"e_1_3_5_82_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.119.314876"},{"key":"e_1_3_5_83_2","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.jaci.2018.09.016","article-title":"Interferon-induced epithelial response to rhinovirus 16 in asthma relates to inflammation and FEV1","volume":"143","author":"Ravi A.","year":"2019","unstructured":"Ravi A., Koster J., Dijkhuis A., Bal S.M., Sabogal Pi\u00f1eros Y.S., Bonta P.I. et al: Interferon-induced epithelial response to rhinovirus 16 in asthma relates to inflammation and FEV1. J Allergy Clin Immunol 2019; 143: 442.","journal-title":"J Allergy Clin Immunol"},{"key":"e_1_3_5_84_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.02.019"},{"key":"e_1_3_5_85_2","doi-asserted-by":"crossref","unstructured":"Fenton CG Taman H Florholmen J Sorbye SW Paulssen RH. Transcriptional Signatures That Define Ulcerative Colitis in Remission. Inflamm Bowel Dis 2020. https:\/\/doi.org\/10.1093\/ibd\/izaa075","DOI":"10.1093\/ibd\/izaa075"},{"key":"e_1_3_5_86_2","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.126917","article-title":"A composite immune signature parallels disease progression across T1D subjects","volume":"4","author":"Speake C.","year":"2019","unstructured":"Speake C., Skinner S.O., Berel D., Whalen E., Dufort M.J., Young W.C. et al: A composite immune signature parallels disease progression across T1D subjects. JCI Insight 2019; 4.","journal-title":"JCI Insight"},{"key":"e_1_3_5_87_2","doi-asserted-by":"crossref","DOI":"10.1186\/s12920-019-0550-3","article-title":"Transcriptome profiling reveals significant changes in the gastric muscularis externa with obesity that partially overlap those that occur with idiopathic gastroparesis","volume":"12","author":"Herring B.P.","year":"2019","unstructured":"Herring B.P., Chen M., Mihaylov P., Hoggatt A.M., Gupta A., Nakeeb A. et al: Transcriptome profiling reveals significant changes in the gastric muscularis externa with obesity that partially overlap those that occur with idiopathic gastroparesis. BMC Med Genomics 2019; 12.","journal-title":"BMC Med Genomics"},{"key":"e_1_3_5_88_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21041455"},{"key":"e_1_3_5_89_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-19-1471"},{"key":"e_1_3_5_90_2","article-title":"Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation","volume":"11","author":"Ji Q.","year":"2020","unstructured":"Ji Q., Zhou L., Sui H., Yang L., Wu X., Song Q. et al: Primary tumors release ITGBL1-rich extracellular vesicles to promote distal metastatic tumor growth through fibroblast-niche formation. Nat Commun 2020; 11.","journal-title":"Nat Commun"}],"container-title":["Computational and Structural Biotechnology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2001037021005250?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2001037021005250?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/spj.science.org\/doi\/pdf\/10.1016\/j.csbj.2021.12.016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T12:56:39Z","timestamp":1779022599000},"score":1,"resource":{"primary":{"URL":"https:\/\/spj.science.org\/doi\/10.1016\/j.csbj.2021.12.016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,28]]},"references-count":89,"alternative-id":["10.1016\/j.csbj.2021.12.016"],"URL":"https:\/\/doi.org\/10.1016\/j.csbj.2021.12.016","relation":{},"ISSN":["2001-0370"],"issn-type":[{"value":"2001-0370","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,28]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"LncRNA functional annotation with improved false discovery rate achieved by disease associations","name":"articletitle","label":"Article Title"},{"value":"Computational and Structural Biotechnology Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.csbj.2021.12.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology.","name":"copyright","label":"Copyright"}]}}