{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T14:15:03Z","timestamp":1784729703226,"version":"3.55.0"},"reference-count":112,"publisher":"American Association for the Advancement of Science (AAAS)","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T00:00:00Z","timestamp":1660521600000},"content-version":"vor","delay-in-days":226,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["csbj.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comput Struct Biotechnol J"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.csbj.2022.08.035","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T18:59:51Z","timestamp":1660762791000},"page":"4446-4463","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Computational design and characterization of a multiepitope vaccine against carbapenemase-producing\n                    <i>Klebsiella pneumoniae<\/i>\n                    strains, derived from antigens identified through reverse vaccinology"],"prefix":"10.34133","volume":"20","author":[{"given":"Nicola","family":"Cuscino","sequence":"first","affiliation":[{"name":"Dipartimento di Ricerca, IRCCS-ISMETT (Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione), Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayesha","family":"Fatima","sequence":"additional","affiliation":[{"name":"Beykoz Institute of Life Sciences and Biotechnology, Bezmialem Vakif University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Di Pilato","sequence":"additional","affiliation":[{"name":"SOD Microbiologia e Virologia, Azienda Ospedaliera Universitaria Careggi, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Bulati","sequence":"additional","affiliation":[{"name":"Dipartimento di Ricerca, IRCCS-ISMETT (Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione), Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Alfano","sequence":"additional","affiliation":[{"name":"Unit\u00e0 di Biologia Strutturale e Biofisica, Fondazione Ri.MED, Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Monaca","sequence":"additional","affiliation":[{"name":"Unit\u00e0 di Biologia Strutturale e Biofisica, Fondazione Ri.MED, Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppina","family":"Di Mento","sequence":"additional","affiliation":[{"name":"Dipartimento di Ricerca, IRCCS-ISMETT (Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione), Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Di Carlo","sequence":"additional","affiliation":[{"name":"Dipartimento di Ricerca, IRCCS-ISMETT (Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione), Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Cardinale","sequence":"additional","affiliation":[{"name":"Dipartimento di Ricerca, IRCCS-ISMETT (Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione), Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Monaco","sequence":"additional","affiliation":[{"name":"Dipartimento di Ricerca, IRCCS-ISMETT (Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione), Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Maria","family":"Rossolini","sequence":"additional","affiliation":[{"name":"SOD Microbiologia e Virologia, Azienda Ospedaliera Universitaria Careggi, Florence, Italy"},{"name":"Dipartimento di Medicina Sperimentale e Clinica, Universit\u00e0 degli Studi di Firenze, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asif M.","family":"Khan","sequence":"additional","affiliation":[{"name":"Beykoz Institute of Life Sciences and Biotechnology, Bezmialem Vakif University, Istanbul, Turkey"},{"name":"Centre for Bioinformatics, School of Data Sciences, Perdana University, Damansara Heights, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pier Giulio","family":"Conaldi","sequence":"additional","affiliation":[{"name":"Dipartimento di Ricerca, IRCCS-ISMETT (Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione), Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Douradinha","sequence":"additional","affiliation":[{"name":"Dipartimento di Ricerca, IRCCS-ISMETT (Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione), Palermo, Italy"},{"name":"Unit\u00e0 di Medicina Rigenerativa ed Immunologia, Fondazione Ri.MED, Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","published-online":{"date-parts":[[2022,8,20]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2021.106103"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00078-15"},{"key":"e_1_3_5_4_2","doi-asserted-by":"crossref","first-page":"e969","DOI":"10.1016\/S2214-109X(18)30278-X","article-title":"Estimating the number of infections caused by antibiotic-resistant Escherichia coli and Klebsiella pneumoniae in 2014: a modelling study","volume":"6","author":"Temkin E.","year":"2018","unstructured":"Temkin E., Fallach N., Almagor J., Gladstone B.P., Tacconelli E. and Carmeli Y.: Estimating the number of infections caused by antibiotic-resistant Escherichia coli and Klebsiella pneumoniae in 2014: a modelling study. Lancet Glob Heal 2018; 6: e969.","journal-title":"Lancet Glob Heal"},{"key":"e_1_3_5_5_2","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1007\/s40121-021-00533-4","article-title":"Current stage in the development of Klebsiella pneumoniae vaccines","volume":"10","author":"Assoni L.","year":"2021","unstructured":"Assoni L., Girardello R., Converso T.R. and Darrieux M.: Current stage in the development of Klebsiella pneumoniae vaccines. Infect Dis Ther 2021; 10: 2157.","journal-title":"Infect Dis Ther"},{"key":"e_1_3_5_6_2","unstructured":"LimmaTech Biologics AG (sponsor) GlaxoSmithKline (collaborator). Safety and Immunogenicity of a Klebsiella Pneumoniae Tetravalent Bioconjugate Vaccine (Kleb4V) 2021. https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04959344 (accessed March 27 2022)."},{"key":"e_1_3_5_7_2","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1093\/jac\/dkaa431","article-title":"The changing epidemiology of carbapenemase-producing Klebsiella pneumoniae in Italy: toward polyclonal evolution with emergence of high-risk lineages","volume":"76","author":"Di Pilato V.","year":"2021","unstructured":"Di Pilato V., Errico G., Monaco M., Giani T., Del Grosso M., Antonelli A. et al: The changing epidemiology of carbapenemase-producing Klebsiella pneumoniae in Italy: toward polyclonal evolution with emergence of high-risk lineages. J Antimicrob Chemother 2021; 76: 355.","journal-title":"J Antimicrob Chemother"},{"key":"e_1_3_5_8_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.micres.2021.126959","article-title":"A retrospective molecular epidemiological scenario of carbapenemase-producing Klebsiella pneumoniae clinical isolates in a Sicilian transplantation hospital shows a swift polyclonal divergence among sequence types, resistome and virulome","volume":"256","author":"Di Mento G.","year":"2022","unstructured":"Di Mento G., Gona F., Russelli G., Cuscino N., Barbera F., Carreca A.P. et al: A retrospective molecular epidemiological scenario of carbapenemase-producing Klebsiella pneumoniae clinical isolates in a Sicilian transplantation hospital shows a swift polyclonal divergence among sequence types, resistome and virulome. Microbiol Res 2022; 256: 126959.","journal-title":"Microbiol Res"},{"key":"e_1_3_5_9_2","doi-asserted-by":"crossref","unstructured":"Del Tordello E Rappuoli R Delany I. Chapter 3 - Reverse Vaccinology: Exploiting Genomes for Vaccine Design. In: Modjarrad K Koff WCBT-HV editors. Hum. Vaccines Emerg. Technol. Des. Dev. Academic Press; 2017 p. 65\u201386. https:\/\/doi.org\/https:\/\/doi.org\/10.1016\/B978-0-12-802302-0.00002-9.","DOI":"10.1016\/B978-0-12-802302-0.00002-9"},{"key":"e_1_3_5_10_2","doi-asserted-by":"crossref","first-page":"184","DOI":"10.4161\/hv.4.3.6313","article-title":"Genome-based vaccine development: a short cut for the future","volume":"4","author":"Moriel D.G.","year":"2008","unstructured":"Moriel D.G., Scarselli M., Serino L., Mora M., Rappuoli R. and Masignani V.: Genome-based vaccine development: a short cut for the future. Hum Vaccin 2008; 4: 184.","journal-title":"Hum Vaccin"},{"key":"e_1_3_5_11_2","article-title":"Immunoinformatics-aided design and evaluation of a potential multi-epitope vaccine against klebsiella pneumoniae","volume":"7","author":"Dar H.A.","year":"2019","unstructured":"Dar H.A., Zaheer T., Shehroz M., Ullah N., Naz K., Muhammad S.A. et al: Immunoinformatics-aided design and evaluation of a potential multi-epitope vaccine against klebsiella pneumoniae. Vaccines 2019; 7.","journal-title":"Vaccines"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10989-020-10144-1"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiolchem.2020.107380"},{"key":"e_1_3_5_14_2","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1038\/s41598-020-80899-6","article-title":"In silico analysis of epitope-based vaccine candidate against tuberculosis using reverse vaccinology","volume":"11","author":"Bibi S.","year":"2021","unstructured":"Bibi S., Ullah I., Zhu B., Adnan M., Liaqat R., Kong W.-B. et al: In silico analysis of epitope-based vaccine candidate against tuberculosis using reverse vaccinology. Sci Rep 2021; 11: 1249.","journal-title":"Sci Rep"},{"key":"e_1_3_5_15_2","article-title":"A comprehensive computer aided vaccine design approach to propose a multi-epitopes subunit vaccine against genus Klebsiella using pan-genomics","volume":"9","author":"Allemailem K.S.","year":"2021","unstructured":"Allemailem K.S.: A comprehensive computer aided vaccine design approach to propose a multi-epitopes subunit vaccine against genus Klebsiella using pan-genomics. Reverse Vaccinology, and Biophysical Techniques Vaccines 2021; 9.","journal-title":"Reverse Vaccinology, and Biophysical Techniques Vaccines"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2020.03.023"},{"key":"e_1_3_5_17_2","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.2174\/15680266113136660187","article-title":"Structural vaccinology: a three-dimensional view for vaccine development","volume":"13","author":"Cozzi R.","year":"2013","unstructured":"Cozzi R., Scarselli M. and Ferlenghi I.: Structural vaccinology: a three-dimensional view for vaccine development. Curr Top Med Chem 2013; 13: 2629.","journal-title":"Curr Top Med Chem"},{"key":"e_1_3_5_18_2","doi-asserted-by":"crossref","unstructured":"Oyston PCF. Chapter 35 - Vaccines. In: Tang Y-W Sussman M Liu D Poxton I Schwartzman JBT-MMM (Second E editors. Mol. Med. Microbiol. Boston: Academic Press; 2015 p. 627\u201334. https:\/\/doi.org\/https:\/\/doi.org\/10.1016\/B978-0-12-397169-2.00035-4.","DOI":"10.1016\/B978-0-12-397169-2.00035-4"},{"key":"e_1_3_5_19_2","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.4014\/jmb.1704.04039","article-title":"Cooperative Interactions between Toll-Like Receptor 2 and Toll-Like Receptor 4 in Murine Klebsiella pneumoniae Infections","volume":"27","author":"Jeon H.-Y.","year":"2017","unstructured":"Jeon H.-Y., Park J.-H., Park J.-I., Kim J.-Y., Seo S.-M., Ham S.-H. et al: Cooperative Interactions between Toll-Like Receptor 2 and Toll-Like Receptor 4 in Murine Klebsiella pneumoniae Infections. J Microbiol Biotechnol 2017; 27: 1529.","journal-title":"J Microbiol Biotechnol"},{"key":"e_1_3_5_20_2","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1183\/09031936.00076510","article-title":"Host defence during Klebsiella pneumoniae relies on haematopoietic-expressed Toll-like receptors 4 and 2","volume":"37","author":"Wieland C.W.","year":"2011","unstructured":"Wieland C.W., van Lieshout M.H.P., Hoogendijk A.J. and van der Poll T.: Host defence during Klebsiella pneumoniae relies on haematopoietic-expressed Toll-like receptors 4 and 2. Eur Respir J 2011; 37: 848.","journal-title":"Eur Respir J"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv1271"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-9-75"},{"key":"e_1_3_5_23_2","doi-asserted-by":"crossref","unstructured":"Altschul SF. BLAST Algorithm. ELS 2014. https:\/\/doi.org\/https:\/\/doi.org\/10.1002\/9780470015902.a0005253.pub2.","DOI":"10.1002\/9780470015902.a0005253.pub2"},{"key":"e_1_3_5_24_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.micres.2020.126551","article-title":"Phenotypical and molecular assessment of the virulence potential of KPC-3-producing Klebsiella pneumoniae ST392 clinical isolates","volume":"240","author":"D\u2019Apolito D.","year":"2020","unstructured":"D\u2019Apolito D., Arena F., Conte V., De Angelis L.H., Di Mento G., Carreca A.P. et al: Phenotypical and molecular assessment of the virulence potential of KPC-3-producing Klebsiella pneumoniae ST392 clinical isolates. Microbiol Res 2020; 240: 126551.","journal-title":"Microbiol Res"},{"key":"e_1_3_5_25_2","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ijantimicag.2018.04.018","article-title":"Infant colonisation with Escherichia coli and Klebsiella pneumoniae strains co-harbouring blaOXA-48and blaNDM-1carbapenemases genes: a case report","volume":"52","author":"Monaco F.","year":"2018","unstructured":"Monaco F., Di M.G., Cuscino N., Conaldi P.G. and Douradinha B.: Infant colonisation with Escherichia coli and Klebsiella pneumoniae strains co-harbouring blaOXA-48and blaNDM-1carbapenemases genes: a case report. Int J Antimicrob Agents 2018; 52: 121.","journal-title":"Int J Antimicrob Agents"},{"key":"e_1_3_5_26_2","first-page":"10","article-title":"Emergence of a Klebsiella pneumoniae ST392 clone harbouring KPC-3 in an Italian transplantation hospital","author":"Di Mento G.","year":"2017","unstructured":"Di Mento G., Cuscino N., Carcione C., Cardinale F., Conaldi P.G. and Douradinha B.: Emergence of a Klebsiella pneumoniae ST392 clone harbouring KPC-3 in an Italian transplantation hospital. J Hosp Infect 2017; : 10.","journal-title":"J Hosp Infect"},{"key":"e_1_3_5_27_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2807\/ese.18.22.20489-en","article-title":"Epidemic diffusion Of KPC carbapenemase-producing Klebsiella pneumoniae in Italy: results of the first countrywide survey, 15 may to 30 June 2011","volume":"18","author":"Giani T.","year":"2013","unstructured":"Giani T., Pini B., Arena F., Conte V., Bracco S., Migliavacca R. et al: Epidemic diffusion Of KPC carbapenemase-producing Klebsiella pneumoniae in Italy: results of the first countrywide survey, 15 may to 30 June 2011. Euro Surveill 2013; 18: 1.","journal-title":"Euro Surveill"},{"key":"e_1_3_5_28_2","doi-asserted-by":"crossref","first-page":"e13119","DOI":"10.1111\/tid.13119","article-title":"Epidemiology and successful containment of a carbapenem-resistant Enterobacteriaceae outbreak in a Southern Italian Transplant Institute","volume":"21","author":"Mularoni A.","year":"2019","unstructured":"Mularoni A., Martucci G., Douradinha B., Campanella O., Hazen B., Medaglia A. et al: Epidemiology and successful containment of a carbapenem-resistant Enterobacteriaceae outbreak in a Southern Italian Transplant Institute. Transpl Infect Dis 2019; 21: e13119.","journal-title":"Transpl Infect Dis"},{"key":"e_1_3_5_29_2","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.3390\/microorganisms9061317","article-title":"Klebsiella pneumoniae lipopolysaccharides serotype O2afg induce poor inflammatory immune responses ex vivo","volume":"9","author":"Bulati M.","year":"2021","unstructured":"Bulati M., Busa R., Carcione C., Iannolo G., Di Mento G., Cuscino N. et al: Klebsiella pneumoniae lipopolysaccharides serotype O2afg induce poor inflammatory immune responses ex vivo. Microorganisms 2021; 9: 1317.","journal-title":"Microorganisms"},{"key":"e_1_3_5_30_2","doi-asserted-by":"crossref","DOI":"10.1385\/1592598900","volume-title":"The Proteomics Protocols Handbook","author":"Walker J.M.","year":"2005","unstructured":"The Proteomics Protocols Handbook. Edited by J.M. Walker. Totowa, NJ: Humana Press 2005."},{"key":"e_1_3_5_31_2","first-page":"1895","article-title":"Thermostability and aliphatic index of globular proteins","volume":"88","author":"Ikai A.","year":"1980","unstructured":"Ikai A.: Thermostability and aliphatic index of globular proteins. J Biochem 1980; 88: 1895.","journal-title":"J Biochem"},{"key":"e_1_3_5_32_2","doi-asserted-by":"crossref","first-page":"D847","DOI":"10.1093\/nar\/gkp830","article-title":"AntigenDB: an immunoinformatics database of pathogen antigens","volume":"38","author":"Ansari H.R.","year":"2010","unstructured":"Ansari H.R., Flower D.R. and Raghava G.P.S.: AntigenDB: an immunoinformatics database of pathogen antigens. Nucleic Acids Res 2010; 38: D847.","journal-title":"Nucleic Acids Res"},{"key":"e_1_3_5_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq551"},{"key":"e_1_3_5_34_2","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1471-2105-8-4","article-title":"VaxiJen: a server for prediction of protective antigens, tumour antigens and subunit vaccines","volume":"8","author":"Doytchinova I.A.","year":"2007","unstructured":"Doytchinova I.A. and Flower D.R.: VaxiJen: a server for prediction of protective antigens, tumour antigens and subunit vaccines. BMC Bioinf 2007; 8: 4.","journal-title":"BMC Bioinf"},{"key":"e_1_3_5_35_2","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1007\/s00894-014-2278-5","article-title":"AllerTOP vol 2\u2013a server for in silico prediction of allergens","volume":"20","author":"Dimitrov I.","year":"2014","unstructured":"Dimitrov I., Bangov I., Flower D.R. and Doytchinova I.: AllerTOP vol 2\u2013a server for in silico prediction of allergens. J Mol Model 2014; 20: 2278.","journal-title":"J Mol Model"},{"key":"e_1_3_5_36_2","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1093\/bioinformatics\/btt619","article-title":"AllergenFP: allergenicity prediction by descriptor fingerprints","volume":"30","author":"Dimitrov I.","year":"2014","unstructured":"Dimitrov I., Naneva L., Doytchinova I. and Bangov I.: AllergenFP: allergenicity prediction by descriptor fingerprints. Bioinformatics 2014; 30: 846.","journal-title":"Bioinformatics"},{"key":"e_1_3_5_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btx345"},{"key":"e_1_3_5_38_2","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/1471-2105-9-62","article-title":"VirulentPred: a SVM based prediction method for virulent proteins in bacterial pathogens","volume":"9","author":"Garg A.","year":"2008","unstructured":"Garg A. and Gupta D.: VirulentPred: a SVM based prediction method for virulent proteins in bacterial pathogens. BMC Bioinf 2008; 9: 62.","journal-title":"BMC Bioinf"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gki376"},{"key":"e_1_3_5_40_2","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/978-1-61737-967-3_16","article-title":"Enhancing the solubility of recombinant proteins in Escherichia coli by using hexahistidine-tagged maltose-binding protein as a fusion partner","volume":"705","author":"Sun P.","year":"2011","unstructured":"Sun P., Tropea J.E. and Waugh D.S.: Enhancing the solubility of recombinant proteins in Escherichia coli by using hexahistidine-tagged maltose-binding protein as a fusion partner. Methods Mol Biol 2011; 705: 259.","journal-title":"Methods Mol Biol"},{"key":"e_1_3_5_41_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA119.009531"},{"key":"e_1_3_5_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2019.01.028"},{"key":"e_1_3_5_43_2","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12889"},{"key":"e_1_3_5_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2015.03.022"},{"key":"e_1_3_5_45_2","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/263952","article-title":"Prediction of IL4 inducing peptides","volume":"2013","author":"Dhanda S.K.","year":"2013","unstructured":"Dhanda S.K., Gupta S., Vir P. and Raghava G.P.S.: Prediction of IL4 inducing peptides. Clin Dev Immunol 2013; 2013: 263952.","journal-title":"Clin Dev Immunol"},{"key":"e_1_3_5_46_2","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.3389\/fimmu.2017.01430","article-title":"IL17eScan: a tool for the identification of peptides inducing IL-17 Response","volume":"8","author":"Gupta S.","year":"2017","unstructured":"Gupta S., Mittal P., Madhu M.K. and Sharma V.K.: IL17eScan: a tool for the identification of peptides inducing IL-17 Response. Front Immunol 2017; 8: 1430.","journal-title":"Front Immunol"},{"key":"e_1_3_5_47_2","doi-asserted-by":"publisher","DOI":"10.1002\/prot.21078"},{"key":"e_1_3_5_48_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-3487"},{"key":"e_1_3_5_49_2","doi-asserted-by":"crossref","unstructured":"Gupta S Kapoor P Chaudhary K Gautam A Kumar R Consortium OSDD et al. In Silico Approach for Predicting Toxicity of Peptides and Proteins. PLoS One 2013;8:e73957.","DOI":"10.1371\/journal.pone.0073957"},{"key":"e_1_3_5_50_2","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/16.4.404"},{"key":"e_1_3_5_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep18962"},{"key":"e_1_3_5_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3213"},{"key":"e_1_3_5_53_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03819-2"},{"key":"e_1_3_5_54_2","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20092301","article-title":"Methods for the refinement of protein structure 3D models","volume":"20","author":"Adiyaman R.","year":"2019","unstructured":"Adiyaman R. and McGuffin L.J.: Methods for the refinement of protein structure 3D models. Int J Mol Sci 2019; 20.","journal-title":"Int J Mol Sci"},{"key":"e_1_3_5_55_2","article-title":"GalaxyRefine: protein structure refinement driven by side-chain repacking","volume":"41","author":"Heo L.","year":"2013","unstructured":"Heo L., Park H. and Seok C.: GalaxyRefine: protein structure refinement driven by side-chain repacking. Nucleic Acids Res 2013; 41. W384-8.","journal-title":"Nucleic Acids Res"},{"key":"e_1_3_5_56_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm290"},{"key":"e_1_3_5_57_2","doi-asserted-by":"publisher","DOI":"10.1002\/prot.340170404"},{"key":"e_1_3_5_58_2","doi-asserted-by":"publisher","DOI":"10.1002\/pro.5560020916"},{"key":"e_1_3_5_59_2","doi-asserted-by":"publisher","DOI":"10.1002\/prot.20530"},{"key":"e_1_3_5_60_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkg565"},{"key":"e_1_3_5_61_2","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1186\/1471-2105-9-514","article-title":"ElliPro: a new structure-based tool for the prediction of antibody epitopes","volume":"9","author":"Ponomarenko J.","year":"2008","unstructured":"Ponomarenko J., Bui H.-H., Li W., Fusseder N., Bourne P.E., Sette A. et al: ElliPro: a new structure-based tool for the prediction of antibody epitopes. BMC Bioinform 2008; 9: 514.","journal-title":"BMC Bioinform"},{"key":"e_1_3_5_62_2","doi-asserted-by":"crossref","first-page":"e17695","DOI":"10.1371\/journal.pone.0017695","article-title":"CPORT: a consensus interface predictor and its performance in prediction-driven docking with HADDOCK","volume":"6","author":"de Vries S.J.","year":"2011","unstructured":"de Vries S.J. and Bonvin A.M.J.J.: CPORT: a consensus interface predictor and its performance in prediction-driven docking with HADDOCK. PLoS ONE 2011; 6: e17695.","journal-title":"PLoS ONE"},{"key":"e_1_3_5_63_2","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.729513","article-title":"Structural biology in the clouds: the WeNMR-EOSC ecosystem","volume":"8","author":"Honorato R.V.","year":"2021","unstructured":"Honorato R.V., Koukos P.I., Jim\u00e9nez-Garc\u00eda B., Tsaregorodtsev A., Verlato M., Giachetti A. et al: Structural biology in the clouds: the WeNMR-EOSC ecosystem. Front Mol Biosci 2021; 8.","journal-title":"Front Mol Biosci"},{"key":"e_1_3_5_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2016.169"},{"key":"e_1_3_5_65_2","doi-asserted-by":"crossref","unstructured":"Duhovny D Nussinov R Wolfson HJ. Efficient Unbound Docking of Rigid Molecules BT - Algorithms in Bioinformatics. In: Guig\u00f3 R Gusfield D editors. Berlin Heidelberg: Springer Berlin Heidelberg; 2002 p. 185\u2013200.","DOI":"10.1007\/3-540-45784-4_14"},{"key":"e_1_3_5_66_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gki481"},{"key":"e_1_3_5_67_2","doi-asserted-by":"publisher","DOI":"10.1002\/prot.21495"},{"key":"e_1_3_5_68_2","doi-asserted-by":"crossref","first-page":"W229","DOI":"10.1093\/nar\/gkn186","article-title":"FireDock: a web server for fast interaction refinement in molecular docking","volume":"36","author":"Mashiach E.","year":"2008","unstructured":"Mashiach E., Schneidman-Duhovny D., Andrusier N., Nussinov R. and Wolfson H.J.: FireDock: a web server for fast interaction refinement in molecular docking. Nucleic Acids Res 2008; 36: W229.","journal-title":"Nucleic Acids Res"},{"key":"e_1_3_5_69_2","doi-asserted-by":"crossref","first-page":"3676","DOI":"10.1093\/bioinformatics\/btw514","article-title":"PRODIGY: a web server for predicting the binding affinity of protein\u2013protein complexes","volume":"32","author":"Xue L.C.","year":"2016","unstructured":"Xue L.C., Rodrigues J.P., Kastritis P.L., Bonvin A.M. and Vangone A.: PRODIGY: a web server for predicting the binding affinity of protein\u2013protein complexes. Bioinformatics 2016; 32: 3676.","journal-title":"Bioinformatics"},{"key":"e_1_3_5_70_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkz397"},{"key":"e_1_3_5_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.softx.2015.06.001"},{"key":"e_1_3_5_72_2","first-page":"252","article-title":"Gromacs: a parallel computer for molecular dynamics simulations","volume":"92","author":"Bekker H.","year":"1993","unstructured":"Bekker H., Berendsen H., Dijkstra E.J., Achterop S., Drunen R., van der Spoel D. et al: Gromacs: a parallel computer for molecular dynamics simulations. Phys Comp 1993; 92: 252.","journal-title":"Phys Comp"},{"key":"e_1_3_5_73_2","doi-asserted-by":"publisher","DOI":"10.1021\/jp003020w"},{"key":"e_1_3_5_74_2","doi-asserted-by":"crossref","DOI":"10.1063\/1.2408420","article-title":"Canonical sampling through velocity rescaling","volume":"126","author":"Bussi G.","year":"2007","unstructured":"Bussi G., Donadio D. and Parrinello M.: Canonical sampling through velocity rescaling. J Chem Phys 2007; 126.","journal-title":"J Chem Phys"},{"key":"e_1_3_5_75_2","doi-asserted-by":"publisher","DOI":"10.1063\/1.449071"},{"key":"e_1_3_5_76_2","doi-asserted-by":"publisher","DOI":"10.1063\/1.328693"},{"key":"e_1_3_5_77_2","doi-asserted-by":"publisher","DOI":"10.1063\/1.464397"},{"key":"e_1_3_5_78_2","doi-asserted-by":"crossref","unstructured":"Hess B Bekker H Berendsen HJC Fraaije JGEM. LINCS: A linear constraint solver for molecular simulations. J Comput Chem 1997;18:1463\u201372. https:\/\/doi.org\/https:\/\/doi.org\/10.1002\/(SICI)1096-987X(199709)18:12<1463::AID-JCC4>3.0.CO;2-H.","DOI":"10.1002\/(SICI)1096-987X(199709)18:12<1463::AID-JCC4>3.0.CO;2-H"},{"key":"e_1_3_5_79_2","unstructured":"Allen MP Tildesley DJ. Computer Simulation of Liquids 1988."},{"key":"e_1_3_5_80_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20291"},{"key":"e_1_3_5_81_2","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1093\/nar\/gkm423","article-title":"Protein interactions calculator","volume":"35","author":"Tina K.G.","year":"2007","unstructured":"Tina K.G., Bhadra R. and Srinivasan N.P.I.C.: Protein interactions calculator. Nucleic Acids Res 2007; 35: 473.","journal-title":"Nucleic Acids Res"},{"key":"e_1_3_5_82_2","doi-asserted-by":"publisher","DOI":"10.1021\/ci500020m"},{"key":"e_1_3_5_83_2","doi-asserted-by":"crossref","first-page":"e9862","DOI":"10.1371\/journal.pone.0009862","article-title":"Computational immunology meets bioinformatics: the use of prediction tools for molecular binding in the simulation of the immune system","volume":"5","author":"Rapin N.","year":"2010","unstructured":"Rapin N., Lund O., Bernaschi M. and Castiglione F.: Computational immunology meets bioinformatics: the use of prediction tools for molecular binding in the simulation of the immune system. PLoS ONE 2010; 5: e9862.","journal-title":"PLoS ONE"},{"key":"e_1_3_5_84_2","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1086\/588383","article-title":"Serum-induced iron-acquisition systems and TonB contribute to virulence in Klebsiella pneumoniae causing primary pyogenic liver abscess","volume":"197","author":"Hsieh P.-F.","year":"2008","unstructured":"Hsieh P.-F., Lin T.-L., Lee C.-Z., Tsai S.-F. and Wang J.-T.: Serum-induced iron-acquisition systems and TonB contribute to virulence in Klebsiella pneumoniae causing primary pyogenic liver abscess. J Infect Dis 2008; 197: 1717.","journal-title":"J Infect Dis"},{"key":"e_1_3_5_85_2","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1007\/s10989-021-10159-2","article-title":"Subtractive proteomics and reverse vaccinology strategies for designing a multiepitope vaccine targeting membrane proteins of klebsiella pneumoniae","volume":"27","author":"Solanki V.","year":"2021","unstructured":"Solanki V., Sharma S. and Tiwari V.: Subtractive proteomics and reverse vaccinology strategies for designing a multiepitope vaccine targeting membrane proteins of klebsiella pneumoniae. Int J Pept Res Ther 2021; 27: 1177.","journal-title":"Int J Pept Res Ther"},{"key":"e_1_3_5_86_2","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s12934-020-01399-w","article-title":"Expression, homology modeling and enzymatic characterization of a new \u03b2-mannanase belonging to glycoside hydrolase family 1 from Enterobacter aerogenes B19","volume":"19","author":"Liu S.","year":"2020","unstructured":"Liu S., Cui T. and Song Y.: Expression, homology modeling and enzymatic characterization of a new \u03b2-mannanase belonging to glycoside hydrolase family 1 from Enterobacter aerogenes B19. Microb Cell Fact 2020; 19: 142.","journal-title":"Microb Cell Fact"},{"key":"e_1_3_5_87_2","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1111\/jam.13533","article-title":"Biofilm formation and antibiotic resistance in Klebsiella pneumoniae urinary strains","volume":"123","author":"Vuotto C.","year":"2017","unstructured":"Vuotto C., Longo F., Pascolini C., Donelli G., Balice M.P., Libori M.F. et al: Biofilm formation and antibiotic resistance in Klebsiella pneumoniae urinary strains. J Appl Microbiol 2017; 123: 1003.","journal-title":"J Appl Microbiol"},{"key":"e_1_3_5_88_2","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens3030743"},{"key":"e_1_3_5_89_2","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1186\/s12879-019-4565-3","article-title":"Co-existence of virulence factors and antibiotic resistance in new Klebsiella pneumoniae clones emerging in south of Italy","volume":"19","author":"Fasciana T.","year":"2019","unstructured":"Fasciana T., Gentile B., Aquilina M., Ciammaruconi A., Mascarella C., Anselmo A. et al: Co-existence of virulence factors and antibiotic resistance in new Klebsiella pneumoniae clones emerging in south of Italy. BMC Infect Dis 2019; 19: 928.","journal-title":"BMC Infect Dis"},{"key":"e_1_3_5_90_2","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12941-020-00366-y","article-title":"Emerging high-risk ST101 and ST307 carbapenem-resistant Klebsiella pneumoniae clones from bloodstream infections in Southern Italy","volume":"19","author":"Loconsole D.","year":"2020","unstructured":"Loconsole D., Accogli M., De Robertis A.L., Capozzi L., Bianco A., Morea A. et al: Emerging high-risk ST101 and ST307 carbapenem-resistant Klebsiella pneumoniae clones from bloodstream infections in Southern Italy. Ann Clin Microbiol Antimicrob 2020; 19: 24.","journal-title":"Ann Clin Microbiol Antimicrob"},{"key":"e_1_3_5_91_2","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1186\/s12879-017-2760-7","article-title":"Whole genome sequencing for the molecular characterization of carbapenem-resistant Klebsiella pneumoniae strains isolated at the Italian ASST Fatebenefratelli Sacco Hospital, 2012\u20132014","volume":"17","author":"Rimoldi S.G.","year":"2017","unstructured":"Rimoldi S.G., Gentile B., Pagani C., Di Gregorio A., Anselmo A., Palozzi A.M. et al: Whole genome sequencing for the molecular characterization of carbapenem-resistant Klebsiella pneumoniae strains isolated at the Italian ASST Fatebenefratelli Sacco Hospital, 2012\u20132014. BMC Infect Dis 2017; 17: 666.","journal-title":"BMC Infect Dis"},{"key":"e_1_3_5_92_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2008.11.006"},{"key":"e_1_3_5_93_2","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1080\/07391102.2020.1810126","article-title":"Immunoinformatics and molecular dynamics studies to predict T-cell-specific epitopes of four Klebsiella pneumoniae fimbriae antigens","volume":"40","author":"Rostamian M.","year":"2022","unstructured":"Rostamian M., Farasat A., Chegene Lorestani R., Nemati Zargaran F., Ghadiri K. and Akya A.: Immunoinformatics and molecular dynamics studies to predict T-cell-specific epitopes of four Klebsiella pneumoniae fimbriae antigens. J Biomol Struct Dyn 2022; 40: 166.","journal-title":"J Biomol Struct Dyn"},{"key":"e_1_3_5_94_2","doi-asserted-by":"crossref","first-page":"6221","DOI":"10.1016\/j.vaccine.2021.09.025","article-title":"Immunoinformatics and molecular docking studies reveal a novel Multi-Epitope peptide vaccine against pneumonia infection","volume":"39","author":"Mahapatra S.R.","year":"2021","unstructured":"Mahapatra S.R., Dey J., Kaur T., Sarangi R., Bajoria A.A., Kushwaha G.S. et al: Immunoinformatics and molecular docking studies reveal a novel Multi-Epitope peptide vaccine against pneumonia infection. Vaccine 2021; 39: 6221.","journal-title":"Vaccine"},{"key":"e_1_3_5_95_2","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2021.778190","article-title":"Proteomic and transcriptomic analyses indicate reduced biofilm-forming abilities in cefiderocol-resistant Klebsiella pneumoniae","volume":"12","author":"Bao J.","year":"2021","unstructured":"Bao J., Xie L., Ma Y., An R., Gu B. and Wang C.: Proteomic and transcriptomic analyses indicate reduced biofilm-forming abilities in cefiderocol-resistant Klebsiella pneumoniae. Front Microbiol 2021; 12: 778190.","journal-title":"Front Microbiol"},{"key":"e_1_3_5_96_2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.micpath.2010.03.009","article-title":"Identification and characterization of Th cell epitopes in MrkD adhesin of Klebsiella pneumoniae","volume":"49","author":"Li Y.","year":"2010","unstructured":"Li Y., Li Z., Han W., Lei L., Sun C., Feng X. et al: Identification and characterization of Th cell epitopes in MrkD adhesin of Klebsiella pneumoniae. Microb Pathog 2010; 49: 8.","journal-title":"Microb Pathog"},{"key":"e_1_3_5_97_2","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/bs.mie.2014.11.005","article-title":"Purification of GST-tagged proteins","volume":"559","author":"Sch\u00e4fer F.","year":"2015","unstructured":"Sch\u00e4fer F., Seip N., Maertens B., Block H. and Kubicek J.: Purification of GST-tagged proteins. Methods Enzym 2015; 559: 127.","journal-title":"Methods Enzym"},{"key":"e_1_3_5_98_2","unstructured":"Garidel P. Protein Solubility from a Biochemical Physicochemical and Colloidal Perspective. Am Pharm Rev 2013."},{"key":"e_1_3_5_99_2","doi-asserted-by":"crossref","unstructured":"Mak TW Saunders ME Jett BDBT-P to the IR (Second E editors. Chapter 13 - Immunity to Infection Boston: Academic Cell; 2014 p. 295\u2013332. https:\/\/doi.org\/https:\/\/doi.org\/10.1016\/B978-0-12-385245-8.00013-3.","DOI":"10.1016\/B978-0-12-385245-8.00013-3"},{"key":"e_1_3_5_100_2","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/j.intimp.2006.02.012","article-title":"Cellular and humoral systemic and mucosal immune responses stimulated in volunteers by an oral polybacterial immunomodulator \u201cDentavax\u201d","volume":"6","author":"Petrunov B.","year":"2006","unstructured":"Petrunov B., Marinova S., Markova R., Nenkov P., Nikolaeva S., Nikolova M. et al: Cellular and humoral systemic and mucosal immune responses stimulated in volunteers by an oral polybacterial immunomodulator \u201cDentavax\u201d. Int Immunopharmacol 2006; 6: 1181.","journal-title":"Int Immunopharmacol"},{"key":"e_1_3_5_101_2","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/cmi.2014.74","article-title":"Characterization of CD8+CD57+ T cells in patients with acute myocardial infarction","volume":"12","author":"Tae Y.H.","year":"2015","unstructured":"Tae Y.H., Youn J.-C., Lee J., Park S., Chi H.-S., Lee J. et al: Characterization of CD8+CD57+ T cells in patients with acute myocardial infarction. Cell Mol Immunol 2015; 12: 466.","journal-title":"Cell Mol Immunol"},{"key":"e_1_3_5_102_2","doi-asserted-by":"crossref","first-page":"278","DOI":"10.3389\/fimmu.2017.00278","article-title":"The immune epitope database and analysis resource in epitope discovery and synthetic vaccine design","volume":"8","author":"Fleri W.","year":"2017","unstructured":"Fleri W., Paul S., Dhanda S.K., Mahajan S., Xu X., Peters B. et al: The immune epitope database and analysis resource in epitope discovery and synthetic vaccine design. Front Immunol 2017; 8: 278.","journal-title":"Front Immunol"},{"key":"e_1_3_5_103_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/2680160"},{"key":"e_1_3_5_104_2","doi-asserted-by":"crossref","first-page":"5499","DOI":"10.4049\/jimmunol.168.11.5499","article-title":"A rational strategy to design multiepitope immunogens based on multiple Th lymphocyte epitopes","volume":"168","author":"Livingston B.","year":"2002","unstructured":"Livingston B., Crimi C., Newman M., Higashimoto Y., Appella E., Sidney J. et al: A rational strategy to design multiepitope immunogens based on multiple Th lymphocyte epitopes. J Immunol 2002; 168: 5499.","journal-title":"J Immunol"},{"key":"e_1_3_5_105_2","first-page":"64","article-title":"Influences of Various Peptide Linkers on the Thermotoga maritima MSB8 Nitrilase Displayed on the Spore Surface of Bacillus subtilis","volume":"27","author":"Chen H.","year":"2017","unstructured":"Chen H., Chen Z., Wu B., Ullah J., Zhang T., Jia J. et al: Influences of Various Peptide Linkers on the Thermotoga maritima MSB8 Nitrilase Displayed on the Spore Surface of Bacillus subtilis. J Mol Microbiol Biotechnol 2017; 27: 64.","journal-title":"J Mol Microbiol Biotechnol"},{"key":"e_1_3_5_106_2","doi-asserted-by":"crossref","first-page":"259","DOI":"10.2174\/187153007782794371","article-title":"Protein structure based strategies for antigen discovery and vaccine development against malaria and other pathogens","volume":"7","author":"Corradin G.","year":"2007","unstructured":"Corradin G., Villard V. and Kajava A.V.: Protein structure based strategies for antigen discovery and vaccine development against malaria and other pathogens. Endocr Metab Immune Disord Drug Targets 2007; 7: 259.","journal-title":"Endocr Metab Immune Disord Drug Targets"},{"key":"e_1_3_5_107_2","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-022-00997-5"},{"key":"e_1_3_5_108_2","doi-asserted-by":"crossref","unstructured":"Perrakis A Sixma TK. AI revolutions in biology: The joys and perils of AlphaFold. EMBO Rep 2021;22:e54046. https:\/\/doi.org\/10.15252\/embr.202154046.","DOI":"10.15252\/embr.202154046"},{"key":"e_1_3_5_109_2","doi-asserted-by":"publisher","DOI":"10.1002\/pro.3330"},{"key":"e_1_3_5_110_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules15042730"},{"key":"e_1_3_5_111_2","doi-asserted-by":"publisher","DOI":"10.1021\/ci100275a"},{"key":"e_1_3_5_112_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2017.12.001"},{"key":"e_1_3_5_113_2","doi-asserted-by":"crossref","DOI":"10.3390\/vaccines8040563","article-title":"Intranasal immunization of mice with multiepitope chimeric vaccine candidate based on conserved autotransporters SigA, Pic and Sap, confers protection against Shigella flexneri","volume":"8","author":"Le\u00f3n Y.","year":"2020","unstructured":"Le\u00f3n Y., Zapata L., Molina R.E., Okanovi\u010d G., G\u00f3mez L.A., Daza-Castro C. et al: Intranasal immunization of mice with multiepitope chimeric vaccine candidate based on conserved autotransporters SigA, Pic and Sap, confers protection against Shigella flexneri. Vaccines 2020; 8.","journal-title":"Vaccines"}],"container-title":["Computational and Structural Biotechnology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2001037022003695?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2001037022003695?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/spj.science.org\/doi\/pdf\/10.1016\/j.csbj.2022.08.035","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T15:49:58Z","timestamp":1779032998000},"score":1,"resource":{"primary":{"URL":"https:\/\/spj.science.org\/doi\/10.1016\/j.csbj.2022.08.035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":112,"alternative-id":["10.1016\/j.csbj.2022.08.035"],"URL":"https:\/\/doi.org\/10.1016\/j.csbj.2022.08.035","relation":{},"ISSN":["2001-0370"],"issn-type":[{"value":"2001-0370","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Computational design and characterization of a multiepitope vaccine against carbapenemase-producing Klebsiella pneumoniae strains, derived from antigens identified through reverse vaccinology","name":"articletitle","label":"Article Title"},{"value":"Computational and Structural Biotechnology Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.csbj.2022.08.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology.","name":"copyright","label":"Copyright"}]}}