{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:40:47Z","timestamp":1791380447612,"version":"4.3.3"},"reference-count":59,"publisher":"American Association for the Advancement of Science (AAAS)","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T00:00:00Z","timestamp":1666137600000},"content-version":"vor","delay-in-days":291,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["csbj.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comput Struct Biotechnol J"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Bifidobacterium longum<\/jats:italic>\n                      BB536 supplementation can be used to regulate bowel movements in various people, including healthy subjects and patients with irritable bowel syndrome (IBS); however, individuals vary in their responses to\n                      <jats:italic toggle=\"yes\">B. longum<\/jats:italic>\n                      BB536 treatment. One putative factor is the gut microbiota; recent studies have reported that the gut microbiota mediates the effects of diet or drugs on the host. Here, we investigated intestinal features, such as the microbiome and metabolome, related to\n                      <jats:italic toggle=\"yes\">B. longum<\/jats:italic>\n                      BB536 effectiveness in increasing bowel movement frequency.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A randomized, double-blind controlled crossover trial was conducted with 24 adults who mainly tended to be constipated. The subjects received a two-week dietary intervention consisting of\n                      <jats:italic toggle=\"yes\">B. longum<\/jats:italic>\n                      BB536 in acid-resistant seamless capsules or similarly encapsulated starch powder as the placebo control. Bowel movement frequency was recorded daily, and fecal samples were collected at several time points, and analyzed by metabologenomic approach that consists of an integrated analysis of metabolome data obtained using mass spectrometry and microbiome data obtained using high-throughput sequencing. There were differences among subjects in\n                      <jats:italic toggle=\"yes\">B. longum<\/jats:italic>\n                      intake-induced bowel movement frequency. The responders were predicted by machine learning based on the microbiome and metabolome features of the fecal samples collected before\n                      <jats:italic toggle=\"yes\">B. longum<\/jats:italic>\n                      intake. The abundances of eight bacterial genera were significantly different between responders and nonresponders.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Intestinal microbiome and metabolome profiles might be utilized as potential markers of improved bowel movement after\n                      <jats:italic toggle=\"yes\">B. longum<\/jats:italic>\n                      BB536 supplementation. These findings have implications for the development of personalized probiotic treatments.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.csbj.2022.10.026","type":"journal-article","created":{"date-parts":[[2022,10,25]],"date-time":"2022-10-25T01:32:12Z","timestamp":1666661532000},"page":"5847-5858","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["Integrated gut microbiome and metabolome analyses identified fecal biomarkers for bowel movement regulation by\n                    <i>Bifidobacterium longum<\/i>\n                    BB536 supplementation: A RCT"],"prefix":"10.34133","volume":"20","author":[{"given":"Yuya","family":"Nakamura","sequence":"first","affiliation":[{"name":"Metagen Inc., 246-2 Kakuganji, Tsuruoka, Yamagata 997-0052, Japan"},{"name":"Department of Life Science and Technology, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Life Science and Technology, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan"},{"name":"Education Academy of Computational Life Science (ACLS), 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinnosuke","family":"Murakami","sequence":"additional","affiliation":[{"name":"Metagen Inc., 246-2 Kakuganji, Tsuruoka, Yamagata 997-0052, Japan"},{"name":"Institute for Advanced Biosciences, Keio University, 246-2 Kakuganji, Tsuruoka, Yamagata 997-0052, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichiro","family":"Nishimoto","sequence":"additional","affiliation":[{"name":"Metagen Inc., 246-2 Kakuganji, Tsuruoka, Yamagata 997-0052, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Higashi","sequence":"additional","affiliation":[{"name":"National Institute of Genetics, Genome Evolution Laboratory, Yata 1111, Mishima 411-8540, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Watarai","sequence":"additional","affiliation":[{"name":"Department of Life Science and Technology, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junpei","family":"Umetsu","sequence":"additional","affiliation":[{"name":"Department of Life Science and Technology, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiharu","family":"Ishii","sequence":"additional","affiliation":[{"name":"Institute for Advanced Biosciences, Keio University, 246-2 Kakuganji, Tsuruoka, Yamagata 997-0052, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaro","family":"Ito","sequence":"additional","affiliation":[{"name":"Institute for Advanced Biosciences, Keio University, 246-2 Kakuganji, Tsuruoka, Yamagata 997-0052, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Mori","sequence":"additional","affiliation":[{"name":"Metagen Inc., 246-2 Kakuganji, Tsuruoka, Yamagata 997-0052, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamiko","family":"Kohno","sequence":"additional","affiliation":[{"name":"MORISHITA JINTAN CO., LTD, Health Care Product Department, Research & Development Division, 1-2-40 Tamatsukuri, Chuo-ku, Osaka 540-8566, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuji","family":"Yamada","sequence":"additional","affiliation":[{"name":"Metagen Inc., 246-2 Kakuganji, Tsuruoka, Yamagata 997-0052, Japan"},{"name":"Department of Life Science and Technology, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Metagen Inc., 246-2 Kakuganji, Tsuruoka, Yamagata 997-0052, Japan"},{"name":"Institute for Advanced Biosciences, Keio University, 246-2 Kakuganji, Tsuruoka, Yamagata 997-0052, Japan"},{"name":"Transborder Medical Research Center, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan"},{"name":"Gut Environmental Design Group, Kanagawa Institute of Industrial Science and Technology, 3-25-13 Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa 210-0821, Japan"},{"name":"Laboratory for Regenerative Microbiology, Juntendo University Graduate School of Medicine, Hongo, Tokyo 113-8421, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","published-online":{"date-parts":[[2022,10,31]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/532734","article-title":"Epidemiology characteristics of constipation for general population, pediatric population, and elderly population in China","author":"Chu H.","year":"2014","unstructured":"Chu H., Zhong L., Li H., Zhang X., Zhang J. and Hou X.: Epidemiology characteristics of constipation for general population, pediatric population, and elderly population in China. Gastroenterol Res Pract 2014; .","journal-title":"Gastroenterol Res Pract"},{"key":"e_1_3_5_3_2","article-title":"Prevalence of, and risk factors for, chronic idiopathic constipation in the community: Systematic review and meta-analysis","author":"Suares N.C.","year":"2011","unstructured":"Suares N.C. and Ford A.C.: Prevalence of, and risk factors for, chronic idiopathic constipation in the community: Systematic review and meta-analysis. Am J Gastroenterol 2011; .","journal-title":"Am J Gastroenterol"},{"key":"e_1_3_5_4_2","doi-asserted-by":"crossref","DOI":"10.1038\/sj.ejcn.1602573","article-title":"Association between dietary fiber, water and magnesium intake and functional constipation among young Japanese women","author":"Murakami K.","year":"2007","unstructured":"Murakami K., Sasaki S., Okubo H., Takahashi Y., Hosoi Y. and Itabashi M.: Association between dietary fiber, water and magnesium intake and functional constipation among young Japanese women. Eur J Clin Nutr 2007; .","journal-title":"Eur J Clin Nutr"},{"key":"e_1_3_5_5_2","author":"Forootan M.","year":"2018","unstructured":"Forootan M., Bagheri N. and Darvishi M.: Chronic Constipation Med (United States) 2018; .","journal-title":"Chronic Constipation Med (United States)"},{"key":"e_1_3_5_6_2","doi-asserted-by":"crossref","DOI":"10.1111\/ene.13082","article-title":"Constipation: an emerging risk factor for Parkinson\u2019s disease?","author":"Stirpe P.","year":"2016","unstructured":"Stirpe P., Hoffman M., Badiali D. and Colosimo C.: Constipation: an emerging risk factor for Parkinson\u2019s disease?. Eur J Neurol 2016; .","journal-title":"Eur J Neurol"},{"key":"e_1_3_5_7_2","article-title":"Constipation and incident CKD","author":"Sumida K.","year":"2017","unstructured":"Sumida K., Molnar M.Z., Potukuchi P.K., Thomas F., Lu J.L., Matsushita K. et al: Constipation and incident CKD. J Am Soc Nephrol 2017; .","journal-title":"J Am Soc Nephrol"},{"key":"e_1_3_5_8_2","article-title":"Medical management of constipation","author":"Portalatin M.","year":"2012","unstructured":"Portalatin M. and Winstead N.: Medical management of constipation. Clin Colon Rectal Surg 2012; .","journal-title":"Clin Colon Rectal Surg"},{"key":"e_1_3_5_9_2","article-title":"Efficacy and safety of a natural mineral water rich in magnesium and sulphate for bowel function: a double-blind, randomized, placebo-controlled study","author":"Bothe G.","year":"2017","unstructured":"Bothe G., Coh A. and Auinger A.: Efficacy and safety of a natural mineral water rich in magnesium and sulphate for bowel function: a double-blind, randomized, placebo-controlled study. Eur J Nutr 2017; .","journal-title":"Eur J Nutr"},{"key":"e_1_3_5_10_2","doi-asserted-by":"crossref","DOI":"10.3402\/fnr.v59.28646","article-title":"Dietary fibre intakes and reduction in functional constipation rates among Canadian adults: A cost-of-illness analysis","author":"Abdullah M.M.H.","year":"2015","unstructured":"Abdullah M.M.H., Gyles C.L., Marinangeli C.P.F., Carlberg J.G. and Jones P.J.H.: Dietary fibre intakes and reduction in functional constipation rates among Canadian adults: A cost-of-illness analysis. Food Nutr Res 2015; .","journal-title":"Food Nutr Res"},{"key":"e_1_3_5_11_2","doi-asserted-by":"crossref","DOI":"10.1136\/gutjnl-2012-302167","article-title":"Intestinal microbiota in functional bowel disorders: A Rome foundation report","author":"Simre\u0144 M.","year":"2013","unstructured":"Simre\u0144 M., Barbara G., Flint H.J., Spiegel B.M.R., Spiller R.C., Vanner S. et al: Intestinal microbiota in functional bowel disorders: A Rome foundation report. Gut 2013; .","journal-title":"Gut"},{"key":"e_1_3_5_12_2","doi-asserted-by":"crossref","DOI":"10.1111\/j.1365-2036.2011.04633.x","article-title":"Randomised clinical trial: Bifidobacterium bifidum MIMBb75 significantly alleviates irritable bowel syndrome and improves quality of life - A double-blind, placebo-controlled study","author":"Guglielmetti S.","year":"2011","unstructured":"Guglielmetti S., Mora D., Gschwender M. and Popp K.: Randomised clinical trial: Bifidobacterium bifidum MIMBb75 significantly alleviates irritable bowel syndrome and improves quality of life - A double-blind, placebo-controlled study. Aliment Pharmacol Ther 2011; .","journal-title":"Aliment Pharmacol Ther"},{"key":"e_1_3_5_13_2","article-title":"Application of enteric seamless capsules containing Bifidobacterium longum to functional foods","author":"Kohno M.","year":"2016","unstructured":"Kohno M., Tanaka-Azuma Y., Kamaguchi R. and Tagawa D.: Application of enteric seamless capsules containing Bifidobacterium longum to functional foods. Folia Pharmacol Jpn 2016; .","journal-title":"Folia Pharmacol Jpn"},{"key":"e_1_3_5_14_2","doi-asserted-by":"crossref","unstructured":"Wong CB Odamaki T Xiao J zhong. Beneficial effects of Bifidobacterium longum subsp. longum BB536 on human health: Modulation of gut microbiome as the principal action. J Funct Foods 2019. 10.1016\/j.jff.2019.02.002.","DOI":"10.1016\/j.jff.2019.02.002"},{"key":"e_1_3_5_15_2","unstructured":"Kohno M Yoshino T Matsuura Y Asada M Yuzo K. Effects of enteric capsules containing bifidobacteria and lactic acid bacteria on the fecal properties in healthy volunteers. J Intest Microbiol 2004. 10.11209\/jim.18.87."},{"key":"e_1_3_5_16_2","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2017.1412908","article-title":"Effects of 28-day Bifidobacterium animalis subsp. lactis HN019 supplementation on colonic transit time and gastrointestinal symptoms in adults with functional constipation: A double-blind, randomized, placebo-controlled, and dose-ranging trial","author":"Ibarra A.","year":"2018","unstructured":"Ibarra A., Latreille-Barbier M., Donazzolo Y., Pelletier X. and Ouwehand A.C.: Effects of 28-day Bifidobacterium animalis subsp. lactis HN019 supplementation on colonic transit time and gastrointestinal symptoms in adults with functional constipation: A double-blind, randomized, placebo-controlled, and dose-ranging trial. Gut Microbes 2018; .","journal-title":"Gut Microbes"},{"key":"e_1_3_5_17_2","doi-asserted-by":"crossref","DOI":"10.1111\/apt.15073","article-title":"Randomised clinical trial: Bifidobacterium lactis NCC2818 probiotic vs placebo, and impact on gut transit time, symptoms, and gut microbiology in chronic constipation","author":"Dimidi E.","year":"2019","unstructured":"Dimidi E., Zdanaviciene A., Christodoulides S., Taheri S., Louis P., Duncan P.I. et al: Randomised clinical trial: Bifidobacterium lactis NCC2818 probiotic vs placebo, and impact on gut transit time, symptoms, and gut microbiology in chronic constipation. Aliment Pharmacol Ther 2019; .","journal-title":"Aliment Pharmacol Ther"},{"key":"e_1_3_5_18_2","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1111\/j.1365-2036.2011.04633.x","article-title":"Randomised clinical trial: Bifidobacterium bifidum MIMBb75 significantly alleviates irritable bowel syndrome and improves quality of life\u2013a double-blind, placebo-controlled study","volume":"33","author":"Guglielmetti S.","year":"2011","unstructured":"Guglielmetti S., Mora D., Gschwender M. and Popp K.: Randomised clinical trial: Bifidobacterium bifidum MIMBb75 significantly alleviates irritable bowel syndrome and improves quality of life\u2013a double-blind, placebo-controlled study. Aliment Pharmacol Ther 2011; 33: 1123.","journal-title":"Aliment Pharmacol Ther"},{"key":"e_1_3_5_19_2","doi-asserted-by":"crossref","unstructured":"Charbonneau D Gibb RD Quigley EMM. Fecal excretion of Bifidobacterium infantis 35624 and changes in fecal microbiota after eight weeks of oral supplementation with encapsulated probiotic. Gut Microbes n.d.;4:201\u201311. 10.4161\/gmic.24196.","DOI":"10.4161\/gmic.24196"},{"key":"e_1_3_5_20_2","article-title":"Responders and non-responders to probiotic interventions: How can we improve the odds?","author":"Reid G.","year":"2010","unstructured":"Reid G., Gaudier E., Guarner F., Huffnagle G.B., Macklaim J.M., Munoz A.M. et al: Responders and non-responders to probiotic interventions: How can we improve the odds?. Gut Microbes 2010; .","journal-title":"Gut Microbes"},{"key":"e_1_3_5_21_2","article-title":"Artificial sweeteners induce glucose intolerance by altering the gut microbiota","author":"Suez J.","year":"2014","unstructured":"Suez J., Korem T., Zeevi D., Zilberman-Schapira G., Thaiss C.A., Maza O. et al: Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature 2014; .","journal-title":"Nature"},{"key":"e_1_3_5_22_2","doi-asserted-by":"crossref","DOI":"10.1038\/nature14232","article-title":"Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome","author":"Chassaing B.","year":"2015","unstructured":"Chassaing B., Koren O., Goodrich J.K., Poole A.C., Srinivasan S., Ley R.E. et al: Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome. Nature 2015; .","journal-title":"Nature"},{"key":"e_1_3_5_23_2","article-title":"Personalized nutrition by prediction of glycemic responses","author":"Zeevi D.","year":"2015","unstructured":"Zeevi D., Korem T., Zmora N., Israeli D., Rothschild D., Weinberger A. et al: Personalized nutrition by prediction of glycemic responses. Cell 2015; .","journal-title":"Cell"},{"key":"e_1_3_5_24_2","article-title":"Bread affects clinical parameters and induces gut microbiome-associated personal glycemic responses","author":"Korem T.","year":"2017","unstructured":"Korem T., Zeevi D., Zmora N., Weissbrod O., Bar N., Lotan-Pompan M. et al: Bread affects clinical parameters and induces gut microbiome-associated personal glycemic responses. Cell Metab 2017; .","journal-title":"Cell Metab"},{"key":"e_1_3_5_25_2","article-title":"Fecal microbiota signatures are associated with response to ustekinumab therapy among crohn\u2019s disease patients","author":"Doherty M.K.","year":"2018","unstructured":"Doherty M.K., Ding T., Koumpouras C., Telesco S.E., Monast C., Das A. et al: Fecal microbiota signatures are associated with response to ustekinumab therapy among crohn\u2019s disease patients. MBio 2018; .","journal-title":"MBio"},{"key":"e_1_3_5_26_2","article-title":"Microbiota composition may predict anti-TNF alpha response in spondyloarthritis patients: an exploratory study","author":"Bazin T.","year":"2018","unstructured":"Bazin T., Hooks K.B., Barnetche T., Truchetet M.E., Enaud R., Richez C. et al: Microbiota composition may predict anti-TNF alpha response in spondyloarthritis patients: an exploratory study. Sci Rep 2018; .","journal-title":"Sci Rep"},{"key":"e_1_3_5_27_2","doi-asserted-by":"crossref","first-page":"e13456","DOI":"10.1111\/nmo.13456","article-title":"The effect of a multispecies probiotic on microbiota composition in a clinical trial of patients with diarrhea-predominant irritable bowel syndrome","volume":"30","author":"Hod K.","year":"2018","unstructured":"Hod K., Dekel R., Aviv Cohen N., Sperber A., Ron Y., Boaz M. et al: The effect of a multispecies probiotic on microbiota composition in a clinical trial of patients with diarrhea-predominant irritable bowel syndrome. Neurogastroenterol Motil 2018; 30: e13456.","journal-title":"Neurogastroenterol Motil"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2016.09.001"},{"key":"e_1_3_5_29_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.chom.2017.04.010","article-title":"Gut microbiome function predicts response to anti-integrin biologic therapy in inflammatory bowel diseases","author":"Ananthakrishnan A.N.","year":"2017","unstructured":"Ananthakrishnan A.N., Luo C., Yajnik V., Khalili H., Garber J.J., Stevens B.W. et al: Gut microbiome function predicts response to anti-integrin biologic therapy in inflammatory bowel diseases. Cell Host Microbe 2017; .","journal-title":"Cell Host Microbe"},{"key":"e_1_3_5_30_2","article-title":"Asymptotic equivalence of Bayes cross validation and widely applicable information criterion in singular learning theory","author":"Watanabe S.","year":"2010","unstructured":"Watanabe S.: Asymptotic equivalence of Bayes cross validation and widely applicable information criterion in singular learning theory. J Mach Learn Res 2010; .","journal-title":"J Mach Learn Res"},{"key":"e_1_3_5_31_2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0090702","article-title":"Gut microbiota signatures predict host and microbiota responses to dietary interventions in obese individuals","author":"Korpela K.","year":"2014","unstructured":"Korpela K., Flint H.J., Johnstone A.M., Lappi J., Poutanen K., Dewulf E. et al: Gut microbiota signatures predict host and microbiota responses to dietary interventions in obese individuals. PLoS ONE 2014; .","journal-title":"PLoS ONE"},{"key":"e_1_3_5_32_2","article-title":"Effect of Bifidobacterium longum BB536 yogurt administration on the intestinal environment of healthy adults","author":"Ogata T.","year":"1999","unstructured":"Ogata T., Kingaku M., Yaeshima T., Teraguchi S., Fukuwatari Y., Ishibashi N. et al: Effect of Bifidobacterium longum BB536 yogurt administration on the intestinal environment of healthy adults. Microb Ecol Health Dis 1999; .","journal-title":"Microb Ecol Health Dis"},{"key":"e_1_3_5_33_2","article-title":"Multivariate modelling of faecal bacterial profiles of patients with IBS predicts responsiveness to a diet low in FODMAPs","author":"Bennet S.M.P.","year":"2018","unstructured":"Bennet S.M.P., B\u00f6hn L., St\u00f6rsrud S., Liljebo T., Collin L., Lindfors P. et al: Multivariate modelling of faecal bacterial profiles of patients with IBS predicts responsiveness to a diet low in FODMAPs. Gut 2018; .","journal-title":"Gut"},{"key":"e_1_3_5_34_2","first-page":"7","article-title":"Bifidobacteria and butyrate-producing colon bacteria: Importance and strategies for their stimulation in the human gut","author":"Rivi\u00e8re A.","year":"2016","unstructured":"Rivi\u00e8re A., Selak M., Lantin D., Leroy F. and De Vuyst L.: Bifidobacteria and butyrate-producing colon bacteria: Importance and strategies for their stimulation in the human gut. Front Microbiol 2016; : 7.","journal-title":"Front Microbiol"},{"key":"e_1_3_5_35_2","doi-asserted-by":"crossref","DOI":"10.1186\/1757-4749-5-23","article-title":"Commensal Clostridia: Leading players in the maintenance of gut homeostasis","author":"Lopetuso L.R.","year":"2013","unstructured":"Lopetuso L.R., Scaldaferri F., Petito V. and Gasbarrini A.: Commensal Clostridia: Leading players in the maintenance of gut homeostasis. Gut Pathog 2013; .","journal-title":"Gut Pathog"},{"key":"e_1_3_5_36_2","doi-asserted-by":"crossref","DOI":"10.1136\/gutjnl-2013-305994","article-title":"Faecal microbiota composition and host-microbe cross-talk following gastroenteritis and in postinfectious irritable bowel syndrome","author":"Jalanka-Tuovinen J.","year":"2014","unstructured":"Jalanka-Tuovinen J., Saloj\u00e4rvi J., Salonen A., Immonen O., Garsed K., Kelly F.M. et al: Faecal microbiota composition and host-microbe cross-talk following gastroenteritis and in postinfectious irritable bowel syndrome. Gut 2014; .","journal-title":"Gut"},{"key":"e_1_3_5_37_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/19490976.2017.1310357","article-title":"Intestinal IgA as a modulator of the gut microbiota","volume":"8","author":"Okai S.","year":"2017","unstructured":"Okai S., Usui F., Ohta M., Mori H., Kurokawa K., Matsumoto S. et al: Intestinal IgA as a modulator of the gut microbiota. Gut Microbes 2017; 8: 1.","journal-title":"Gut Microbes"},{"key":"e_1_3_5_38_2","doi-asserted-by":"crossref","DOI":"10.1128\/AEM.02089-15","article-title":"Mutual cross-feeding interactions between Bifidobacterium longum subsp. longum NCC2705 and Eubacterium rectale ATCC 33656 explain the bifidogenic and butyrogenic effects of arabinoxylan oligosaccharides","author":"Rivi\u00e8re A.","year":"2015","unstructured":"Rivi\u00e8re A., Gagnon M., Weckx S., Roy D. and De Vuyst L.: Mutual cross-feeding interactions between Bifidobacterium longum subsp. longum NCC2705 and Eubacterium rectale ATCC 33656 explain the bifidogenic and butyrogenic effects of arabinoxylan oligosaccharides. Appl Environ Microbiol 2015; .","journal-title":"Appl Environ Microbiol"},{"key":"e_1_3_5_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2016.10.019"},{"key":"e_1_3_5_40_2","article-title":"Cross-feeding between Bifidobacterium longum BB536 and acetate-converting, butyrate-producing colon bacteria during growth on oligofructose","author":"Falony G.","year":"2006","unstructured":"Falony G., Vlachou A., Verbrugghe K. and De Vuyst L.: Cross-feeding between Bifidobacterium longum BB536 and acetate-converting, butyrate-producing colon bacteria during growth on oligofructose. Appl Environ Microbiol 2006; .","journal-title":"Appl Environ Microbiol"},{"key":"e_1_3_5_41_2","article-title":"Ruminococcus bromii is a keystone species for the degradation of resistant starch in the human colon","author":"Ze X.","year":"2012","unstructured":"Ze X., Duncan S.H., Louis P. and Flint H.J.: Ruminococcus bromii is a keystone species for the degradation of resistant starch in the human colon. ISME J 2012; .","journal-title":"ISME J"},{"key":"e_1_3_5_42_2","doi-asserted-by":"crossref","DOI":"10.3748\/wjg.v21.i29.8787","article-title":"Role of the normal gut microbiota","author":"Jandhyala S.M.","year":"2015","unstructured":"Jandhyala S.M., Talukdar R., Subramanyam C., Vuyyuru H., Sasikala M. and Reddy D.N.: Role of the normal gut microbiota. World J Gastroenterol 2015; .","journal-title":"World J Gastroenterol"},{"key":"e_1_3_5_43_2","article-title":"Effect of yogurt containing Bifidobacterium longum BB 536 on the defecation frequency and fecal characteristics of healthy adults : A double-blind cross over study","author":"Xiao J.","year":"2007","unstructured":"Xiao J., Kondo S., Odamaki T., Miyaji K., Yaeshima T., Iwatsuki K. et al: Effect of yogurt containing Bifidobacterium longum BB 536 on the defecation frequency and fecal characteristics of healthy adults : A double-blind cross over study. Japanese J Lact Acid Bact 2007; .","journal-title":"Japanese J Lact Acid Bact"},{"key":"e_1_3_5_44_2","unstructured":"Asada M Kamaguchi R Nakatsuji M Takadera T Yoshikado M. Seamless capsule 2009."},{"key":"e_1_3_5_45_2","unstructured":"Kamaguchi R Mizutani M. Capsule disintegrable in large-intestine-specific manner 2013."},{"key":"e_1_3_5_46_2","doi-asserted-by":"crossref","unstructured":"Murakami S Goto Y Ito K Hayasaka S Kurihara S Soga T et al. The consumption of bicarbonate-rich mineral water improves glycemic control. Evid Based Complement Altern Med 2015;2015. 10.1155\/2015\/824395.","DOI":"10.1155\/2015\/824395"},{"key":"e_1_3_5_47_2","article-title":"Robustness of gut microbiota of healthy adults in response to probiotic intervention revealed by high-throughput pyrosequencing","author":"Kim S.W.","year":"2013","unstructured":"Kim S.W., Suda W., Kim S., Oshima K., Fukuda S., Ohno H. et al: Robustness of gut microbiota of healthy adults in response to probiotic intervention revealed by high-throughput pyrosequencing. DNA Res 2013; .","journal-title":"DNA Res"},{"key":"e_1_3_5_48_2","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.2584","article-title":"VSEARCH: A versatile open source tool for metagenomics","author":"Rognes T.","year":"2016","unstructured":"Rognes T., Flouri T., Nichols B., Quince C. and Mah\u00e9 F.: VSEARCH: A versatile open source tool for metagenomics. PeerJ 2016; .","journal-title":"PeerJ"},{"key":"e_1_3_5_49_2","article-title":"Fastp: An ultra-fast all-in-one FASTQ preprocessor","author":"Chen S.","year":"2018","unstructured":"Chen S., Zhou Y., Chen Y. and Gu J.: Fastp: An ultra-fast all-in-one FASTQ preprocessor. Bioinformatics 2018; .","journal-title":"Bioinformatics"},{"key":"e_1_3_5_50_2","article-title":"SeqKit: A cross-platform and ultrafast toolkit for FASTA\/Q file manipulation","author":"Shen W.","year":"2016","unstructured":"Shen W., Le S., Li Y. and Hu F.: SeqKit: A cross-platform and ultrafast toolkit for FASTA\/Q file manipulation. PLoS ONE 2016; .","journal-title":"PLoS ONE"},{"key":"e_1_3_5_51_2","doi-asserted-by":"crossref","DOI":"10.1128\/mSystems.00191-16","article-title":"Deblur rapidly resolves single-nucleotide community sequence patterns","author":"Amir A.","year":"2017","unstructured":"Amir A., McDonald D., Navas-Molina J.A., Kopylova E., Morton J.T., Zech X.Z. et al: Deblur rapidly resolves single-nucleotide community sequence patterns. MSystems 2017; .","journal-title":"MSystems"},{"key":"e_1_3_5_52_2","article-title":"A standardized bacterial taxonomy based on genome phylogeny substantially revises the tree of life","author":"Parks D.H.","year":"2018","unstructured":"Parks D.H., Chuvochina M., Waite D.W., Rinke C., Skarshewski A., Chaumeil P.A. et al: A standardized bacterial taxonomy based on genome phylogeny substantially revises the tree of life. Nat Biotechnol 2018; .","journal-title":"Nat Biotechnol"},{"key":"e_1_3_5_53_2","doi-asserted-by":"crossref","DOI":"10.1016\/S0022-2836(05)80360-2","article-title":"Basic local alignment search tool","author":"Altschul S.F.","year":"1990","unstructured":"Altschul S.F., Gish W., Miller W., Myers E.W. and Lipman D.J.: Basic local alignment search tool. J Mol Biol 1990; .","journal-title":"J Mol Biol"},{"key":"e_1_3_5_54_2","doi-asserted-by":"crossref","DOI":"10.1186\/s12918-018-0545-2","article-title":"VITCOMIC2: Visualization tool for the phylogenetic composition of microbial communities based on 16S rRNA gene amplicons and metagenomic shotgun sequencing","author":"Mori H.","year":"2018","unstructured":"Mori H., Maruyama T., Yano M., Yamada T. and Kurokawa K.: VITCOMIC2: Visualization tool for the phylogenetic composition of microbial communities based on 16S rRNA gene amplicons and metagenomic shotgun sequencing. BMC Syst Biol 2018; .","journal-title":"BMC Syst Biol"},{"key":"e_1_3_5_55_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014060530"},{"key":"e_1_3_5_56_2","doi-asserted-by":"crossref","DOI":"10.1080\/01621459.1996.10476725","article-title":"A generalization of the Weibull distribution with application to the analysis of survival data","author":"Mudholkar G.S.","year":"1996","unstructured":"Mudholkar G.S., Srivastava D.K. and Kollia G.D.: A generalization of the Weibull distribution with application to the analysis of survival data. J Am Stat Assoc 1996; .","journal-title":"J Am Stat Assoc"},{"key":"e_1_3_5_57_2","doi-asserted-by":"crossref","DOI":"10.1007\/s11222-013-9416-2","article-title":"Understanding predictive information criteria for Bayesian models","author":"Gelman A.","year":"2014","unstructured":"Gelman A., Hwang J. and Vehtari A.: Understanding predictive information criteria for Bayesian models. Stat Comput 2014; .","journal-title":"Stat Comput"},{"key":"e_1_3_5_58_2","unstructured":"Carpenter B Gelman A Hoffman MD Lee D Goodrich B Betancourt M et al. Stan: A probabilistic programming language. J Stat Softw 2017. 10.18637\/jss.v076.i01."},{"key":"e_1_3_5_59_2","doi-asserted-by":"crossref","DOI":"10.2307\/2986324","article-title":"Bayesian inference for generalized linear and proportional hazards models via Gibbs sampling","author":"Dellaportas P.","year":"1993","unstructured":"Dellaportas P. and Smith A.F.M.: Bayesian inference for generalized linear and proportional hazards models via Gibbs sampling. Appl Stat 1993; .","journal-title":"Appl Stat"},{"key":"e_1_3_5_60_2","article-title":"General methods for monitoring convergence of iterative simulations","author":"Brooks S.P.","year":"1998","unstructured":"Brooks S.P. and Gelman A.: General methods for monitoring convergence of iterative simulations. J Comput Graph Stat 1998; .","journal-title":"J Comput Graph Stat"}],"container-title":["Computational and Structural Biotechnology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2001037022004731?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2001037022004731?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/spj.science.org\/doi\/pdf\/10.1016\/j.csbj.2022.10.026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T15:47:56Z","timestamp":1779032876000},"score":1,"resource":{"primary":{"URL":"https:\/\/spj.science.org\/doi\/10.1016\/j.csbj.2022.10.026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":59,"alternative-id":["10.1016\/j.csbj.2022.10.026"],"URL":"https:\/\/doi.org\/10.1016\/j.csbj.2022.10.026","relation":{},"ISSN":["2001-0370"],"issn-type":[{"value":"2001-0370","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrated gut microbiome and metabolome analyses identified fecal biomarkers for bowel movement regulation by Bifidobacterium longum BB536 supplementation: A RCT","name":"articletitle","label":"Article Title"},{"value":"Computational and Structural Biotechnology Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.csbj.2022.10.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology.","name":"copyright","label":"Copyright"}]}}