{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T13:08:53Z","timestamp":1779023333726,"version":"3.51.4"},"reference-count":22,"publisher":"American Association for the Advancement of Science (AAAS)","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,23]],"date-time":"2022-10-23T00:00:00Z","timestamp":1666483200000},"content-version":"vor","delay-in-days":295,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["csbj.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comput Struct Biotechnol J"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.csbj.2022.10.037","type":"journal-article","created":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T05:08:22Z","timestamp":1666933702000},"page":"5870-5872","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["On the intrinsic nature of viral pathogenesis: The assumption of a Darwinian paradigm to describe COVID-19 pandemic"],"prefix":"10.34133","volume":"20","author":[{"given":"Pier Francesco","family":"Roggero","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine, University of Padua, via A. Gabelli 63, 35121 Padua, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arianna","family":"Calistri","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, University of Padua, via A. Gabelli 63, 35121 Padua, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Pal\u00f9","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, University of Padua, via A. Gabelli 63, 35121 Padua, Italy"},{"name":"Italian Medicines Agency, Via del Tritone 181, 00187 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"221","published-online":{"date-parts":[[2022,10,31]]},"reference":[{"key":"e_1_3_2_2_2","volume-title":"Fields virology","author":"Knipe D.M.","year":"2013","unstructured":"Knipe D.M. and Howley P.: Fields virology. Philadelphia, PA: Wolters Kluwer Health 2013."},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1002\/2211-5463.13420","article-title":"Host-virus relationships: a sum of many battles","volume":"12","author":"L\u00f3pez-Lastra M.","year":"2022","unstructured":"L\u00f3pez-Lastra M.: Host-virus relationships: a sum of many battles. FEBS Open Bio 2022; 12: 1094.","journal-title":"FEBS Open Bio"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-021-00535-6"},{"key":"e_1_3_2_5_2","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/S0140-6736(21)02867-1","article-title":"Variation in the COVID-19 infection-fatality ratio by age, time, and geography during the pre-vaccine era: a systematic analysis","volume":"399","author":"COVID-19 Forecasting Team","year":"2022","unstructured":"COVID-19 Forecasting Team : Variation in the COVID-19 infection-fatality ratio by age, time, and geography during the pre-vaccine era: a systematic analysis. Lancet 2022; 399: 1469.","journal-title":"Lancet"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10061339"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/28.6.491"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-9877(02)00383-3"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3390\/v14040653"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009499"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03291-y"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2031364"},{"key":"e_1_3_2_13_2","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1038\/s41467-022-30163-4","article-title":"Cumulative SARS-CoV-2 mutations and corresponding changes in immunity in an immunocompromised patient indicate viral evolution within the host","volume":"13","author":"Sonnleitner S.T.","year":"2022","unstructured":"Sonnleitner S.T., Prelog M., Sonnleitner S., Hinterbichler E., Halbfurter H. et al: Cumulative SARS-CoV-2 mutations and corresponding changes in immunity in an immunocompromised patient indicate viral evolution within the host. Nat Commun 2022; 13: 2560.","journal-title":"Nat Commun"},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","first-page":"veac042","DOI":"10.1093\/ve\/veac042","article-title":"Competition for dominance within replicating quasispecies during prolonged SARS-CoV-2 infection in an immunocompromised host","volume":"8","author":"Caccuri F.","year":"2022","unstructured":"Caccuri F., Messali S., Bortolotti D., Di Silvestre D., De Palma A. et al: Competition for dominance within replicating quasispecies during prolonged SARS-CoV-2 infection in an immunocompromised host. Virus Evol 2022; 8: veac042.","journal-title":"Virus Evol"},{"key":"e_1_3_2_15_2","doi-asserted-by":"crossref","unstructured":"Aggarwal A Akerman A Milogiannakis V Silva MR Walker G et al (2022) SARS-CoV-2 Omicron BA.5: Evolving tropism and evasion of potent humoral responses and resistance to clinical immunotherapeutics relative to viral variants of concern. medRxiv 2022.07.07.22277128. https:\/\/doi.org\/10.1101\/2022.07.07.22277128.","DOI":"10.1016\/j.ebiom.2022.104270"},{"key":"e_1_3_2_16_2","doi-asserted-by":"crossref","first-page":"taac037","DOI":"10.1093\/jtm\/taac037","article-title":"The effective reproductive number of the Omicron variant of SARS-CoV-2 is several times relative to Delta","volume":"29","author":"Liu Y.","year":"2022","unstructured":"Liu Y. and Rockl\u00f6v J.: The effective reproductive number of the Omicron variant of SARS-CoV-2 is several times relative to Delta. J Travel Med 2022; 29: taac037.","journal-title":"J Travel Med"},{"key":"e_1_3_2_17_2","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41392-022-00997-x","article-title":"SARS-CoV-2 Omicron variant: recent progress and future perspectives","volume":"7","author":"Fan Y.","year":"2022","unstructured":"Fan Y., Li X., Zhang L., Wan S., Zhang L. et al: SARS-CoV-2 Omicron variant: recent progress and future perspectives. Signal Transduct Target Ther 2022; 7: 141.","journal-title":"Signal Transduct Target Ther"},{"key":"e_1_3_2_18_2","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jmii.2020.05.001","article-title":"A systematic review of asymptomatic infections with COVID-19","volume":"54","author":"Gao Z.","year":"2021","unstructured":"Gao Z., Xu Y., Sun C., Wang X., Guo Y. et al: A systematic review of asymptomatic infections with COVID-19. J Microbiol Immunol Infect 2021; 54: 12.","journal-title":"J Microbiol Immunol Infect"},{"key":"e_1_3_2_19_2","unstructured":"https:\/\/coronavirus.jhu.edu\/map.html accessed 14\/07\/2022."},{"key":"e_1_3_2_20_2","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1017\/ice.2021.140","article-title":"Why comparing coronavirus disease 2019 (COVID-19) and seasonal influenza fatality rates is like comparing apples to pears","volume":"43","author":"Papadakis M.","year":"2022","unstructured":"Papadakis M.: Why comparing coronavirus disease 2019 (COVID-19) and seasonal influenza fatality rates is like comparing apples to pears. Infect Control Hosp Epidemiol 2022; 43: 958.","journal-title":"Infect Control Hosp Epidemiol"},{"key":"e_1_3_2_21_2","doi-asserted-by":"crossref","unstructured":"Althaus CL (2014) Estimating the Reproduction Number of Ebola Virus (EBOV) During the 2014 Outbreak in West Africa. PLoS Curr. 2;6:ecurrents.outbreaks. DOI 10.1371\/currents.outbreaks.91afb5e0f279e7f29e7056095255b288.","DOI":"10.1371\/currents.outbreaks.91afb5e0f279e7f29e7056095255b288"},{"key":"e_1_3_2_22_2","unstructured":"WHO online resources (accessed 12\/10\/2022). https:\/\/web.archive.org\/web\/20130814150053\/http:\/\/www.who.int\/immunization_monitoring\/diseases\/measles\/en\/."},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2501.171901"}],"container-title":["Computational and Structural Biotechnology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2001037022004846?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2001037022004846?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/spj.science.org\/doi\/pdf\/10.1016\/j.csbj.2022.10.037","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T12:56:15Z","timestamp":1779022575000},"score":1,"resource":{"primary":{"URL":"https:\/\/spj.science.org\/doi\/10.1016\/j.csbj.2022.10.037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":22,"alternative-id":["10.1016\/j.csbj.2022.10.037"],"URL":"https:\/\/doi.org\/10.1016\/j.csbj.2022.10.037","relation":{},"ISSN":["2001-0370"],"issn-type":[{"value":"2001-0370","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"On the intrinsic nature of viral pathogenesis: The assumption of a Darwinian paradigm to describe COVID-19 pandemic","name":"articletitle","label":"Article Title"},{"value":"Computational and Structural Biotechnology Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.csbj.2022.10.037","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology.","name":"copyright","label":"Copyright"}]}}