{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:23:13Z","timestamp":1780359793573,"version":"3.54.1"},"reference-count":20,"publisher":"American Association for the Advancement of Science (AAAS)","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,28]],"date-time":"2022-10-28T00:00:00Z","timestamp":1666915200000},"content-version":"vor","delay-in-days":300,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021520","name":"National Supercomputing Center, Korea Institute of Science and Technology Information","doi-asserted-by":"publisher","award":["KSC-2020-CRE-0203"],"award-info":[{"award-number":["KSC-2020-CRE-0203"]}],"id":[{"id":"10.13039\/501100021520","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002456","name":"Chonnam National University","doi-asserted-by":"publisher","award":["2022-2574"],"award-info":[{"award-number":["2022-2574"]}],"id":[{"id":"10.13039\/501100002456","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["csbj.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comput Struct Biotechnol J"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.csbj.2022.10.045","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T14:24:30Z","timestamp":1667399070000},"page":"5962-5965","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Fever temperatures modulate intraprotein dynamics and enhance the binding affinity between monoclonal antibodies and the spike protein from SARS-CoV-2"],"prefix":"10.34133","volume":"20","author":[{"given":"Dong Gun","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hak Sung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoonjoo","family":"Choi","sequence":"additional","affiliation":[{"name":"Combinatorial Tumor Immunotherapy MRC, Chonnam National University Medical School, Hwasun 58128, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Razvan Costin","family":"Stan","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Science, Chonnam National University, Hwasun 58128, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","published-online":{"date-parts":[[2022,11,5]]},"reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2001737"},{"key":"e_1_3_5_3_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.mehy.2020.109880","article-title":"The use of ibuprofen to treat fever in COVID-19: a possible indirect association with worse outcome?","volume":"144","author":"Jamerson B.D.","year":"2020","unstructured":"Jamerson B.D. and Haryadi T.H.: The use of ibuprofen to treat fever in COVID-19: a possible indirect association with worse outcome?. Med Hypotheses 2020; 144: 109880.","journal-title":"Med Hypotheses"},{"key":"e_1_3_5_4_2","doi-asserted-by":"crossref","first-page":"1259.e5","DOI":"10.1016\/j.cmi.2020.06.003","article-title":"Ibuprofen use and clinical outcomes in COVID-19 patients","volume":"26","author":"Rinott E.","year":"2020","unstructured":"Rinott E., Kozer E., Shapira Y., Bar-Haim A. and Youngster I.: Ibuprofen use and clinical outcomes in COVID-19 patients. Clin Microbiol Infect 2020; 26: 1259.e5.","journal-title":"Clin Microbiol Infect"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2020.12.005"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19231-9"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2349-y"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19808-4"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abf3671"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0007239"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2008209117"},{"key":"e_1_3_5_12_2","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/B978-0-444-64074-1.00053-7","article-title":"Therapeutic hyperthermia","volume":"157","author":"Habash R.W.Y.","year":"2018","unstructured":"Habash R.W.Y.: Therapeutic hyperthermia. Handb Clin Neurol 2018; 157: 853.","journal-title":"Handb Clin Neurol"},{"key":"e_1_3_5_13_2","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1186\/s13054-020-03045-8","article-title":"Body temperature correlates with mortality in COVID-19 patients","volume":"24","author":"Tharakan S.","year":"2020","unstructured":"Tharakan S., Nomoto K., Miyashita S. and Ishikawa K.: Body temperature correlates with mortality in COVID-19 patients. Crit Care 2020; 24: 298.","journal-title":"Crit Care"},{"key":"e_1_3_5_14_2","first-page":"1","article-title":"Fever as an evolutionary agent to select immune complexes interfaces","volume":"11","author":"Tofan V.","year":"2022","unstructured":"Tofan V., Lenghel A., de Camargo M.M. and Stan R.C.: Fever as an evolutionary agent to select immune complexes interfaces. Immunogenetics 2022; 11: 1.","journal-title":"Immunogenetics"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1086\/317514"},{"key":"e_1_3_5_16_2","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s13613-021-00907-4","article-title":"Novel phenotypes of coronavirus disease: a temperature-based trajectory model","volume":"11","author":"Shen Y.","year":"2021","unstructured":"Shen Y., Chen D., Huang X., Cai G., Xu Q., Hu C. et al: Novel phenotypes of coronavirus disease: a temperature-based trajectory model. Ann Intensive Care 2021; 11: 121.","journal-title":"Ann Intensive Care"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"e_1_3_5_18_2","doi-asserted-by":"crossref","unstructured":"Herder V Dee K Wojtus JK Epifano I Goldfarb D Rozario C et al. Elevated temperature inhibits SARS-CoV-2 replication in respiratory epithelium independently of IFN-mediated innate immune defenses. PLoS Biol. 2021 Dec 21;19(12):e3001065. doi: 10.1371\/journal.pbio.3001065.","DOI":"10.1371\/journal.pbio.3001065"},{"key":"e_1_3_5_19_2","volume-title":"Water-filtered Infrared A (wIRA) Irradiation","author":"Heckel-Reusser S.","year":"2022","unstructured":"Heckel-Reusser S.: Whole-Body Hyperthermia (WBH): historical aspects, current use, and future perspectives. In: Water-filtered Infrared A (wIRA) Irradiation. Edited by P. Vaupel. Cham: Springer 2022."},{"key":"e_1_3_5_20_2","first-page":"5.6.1","article-title":"Comparative protein structure modeling using MODELLER","volume":"20","author":"Webb B.","year":"2016","unstructured":"Webb B. and Sali A.: Comparative protein structure modeling using MODELLER. Curr Protoc Bioinformatics 2016; 20: 5.6.1.","journal-title":"Curr Protoc Bioinformatics"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/pro.3943"}],"container-title":["Computational and Structural Biotechnology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2001037022004925?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2001037022004925?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/spj.science.org\/doi\/pdf\/10.1016\/j.csbj.2022.10.045","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T12:56:28Z","timestamp":1779022588000},"score":1,"resource":{"primary":{"URL":"https:\/\/spj.science.org\/doi\/10.1016\/j.csbj.2022.10.045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":20,"alternative-id":["10.1016\/j.csbj.2022.10.045"],"URL":"https:\/\/doi.org\/10.1016\/j.csbj.2022.10.045","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2022.10.24.513610","asserted-by":"object"}]},"ISSN":["2001-0370"],"issn-type":[{"value":"2001-0370","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fever temperatures modulate intraprotein dynamics and enhance the binding affinity between monoclonal antibodies and the spike protein from SARS-CoV-2","name":"articletitle","label":"Article Title"},{"value":"Computational and Structural Biotechnology Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.csbj.2022.10.045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology.","name":"copyright","label":"Copyright"}]}}