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Previous studies have shown that ducklings younger than 21 days are more susceptible to DHAV-3. To elucidate the mechanism by which age affects the differential susceptibility of Pekin ducks to DHAV-3, intestinal (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u00a0=\u00a0520), liver (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u00a0=\u00a040) and blood (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u00a0=\u00a0260) samples were collected from control and DHAV-3-infected ducks at 7, 10, 14, and 21 days of age. Comparisons of plasma markers, mortality rates, and intestinal histopathological data showed that the resistance of Pekin ducks to DHAV-3 varied with age. 16\u00a0S sequencing revealed that the ileal microbial composition was influenced by age, and this correlation was greater than that recorded for caecal microbes.\n                    <jats:italic toggle=\"yes\">Candidatus Arthromitus<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">Bacteroides<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">Corynebacterium<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">Enterococcus<\/jats:italic>\n                    ,\n                    <jats:italic toggle=\"yes\">Romboutsia<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">Streptococcus<\/jats:italic>\n                    were the differntially abundant microbes in the ileum at the genus level after DHAV-3 infection and were significantly correlated with 7 differentially expressed genes (DEGs) in 7- and 21-day-old ducklings. 3 immunity-related pathways were significantly different between 7- and 21-day-old ducklings, especially for\n                    <jats:italic toggle=\"yes\">IFIH1<\/jats:italic>\n                    -mediated induction of the interferon-alpha\/beta pathway, which induces differential production of CD8(+) T cells and was influenced by a combination of differentially abundant microbiota and DEGs. We found that microbes in the ileum changed regularly with age. The intestinal microbiota was associated with the expression of genes in the liver through IFIH1-mediated induction of the interferon-alpha\/beta pathway, which may partially explain why younger ducklings were more susceptible to DHAV-3 infection.\n                  <\/jats:p>","DOI":"10.1016\/j.csbj.2024.01.005","type":"journal-article","created":{"date-parts":[[2024,1,21]],"date-time":"2024-01-21T03:38:24Z","timestamp":1705808304000},"page":"771-782","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effects of age on differential resistance to duck hepatitis A virus genotype 3 in Pekin ducks by 16\u00a0S and transcriptomics"],"prefix":"10.34133","volume":"23","author":[{"given":"Suyun","family":"Liang","sequence":"first","affiliation":[{"name":"Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meixi","family":"Lu","sequence":"additional","affiliation":[{"name":"Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daxin","family":"Yu","sequence":"additional","affiliation":[{"name":"Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangnan","family":"Xing","sequence":"additional","affiliation":[{"name":"Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanqing","family":"Ji","sequence":"additional","affiliation":[{"name":"Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanbao","family":"Guo","sequence":"additional","affiliation":[{"name":"Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Xie","sequence":"additional","affiliation":[{"name":"Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuisheng","family":"Hou","sequence":"additional","affiliation":[{"name":"Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","published-online":{"date-parts":[[2024,1,17]]},"reference":[{"key":"e_1_4_1_2_2","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s42770-021-00635-8","article-title":"Antimicrobial resistance in the globalized food chain: a one health perspective applied to the poultry industry","author":"de Mesquita Souza Saraiva M.","year":"2022","unstructured":"de Mesquita Souza SaraivaM.LimK.do MonteD.F.M.GivisiezP.E.N.AlvesL.B.R.de Freitas NetoO.C.KariukiS.Antimicrobial resistance in the globalized food chain: a one health perspective applied to the poultry industryBraz J Microbiol202246548634775576","journal-title":"Braz J Microbiol"},{"key":"e_1_4_1_3_2","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1002\/jeq2.20273","article-title":"Poultry manureshed management: opportunities and challenges for a vertically integrated industry","volume":"51","author":"Bryant R.B.","year":"2022","unstructured":"BryantR.B.EndaleD.M.SpiegalS.A.FlynnK.C.MeinenR.J.CavigelliM.A.Poultry manureshed management: opportunities and challenges for a vertically integrated industryJ Environ Qual51202254055134309029","journal-title":"J Environ Qual"},{"key":"e_1_4_1_4_2","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/aro2.36","article-title":"Selective analysis of resistance and susceptibility to duck hepatitis A virus genotype 3 in Pekin duck","volume":"2","author":"Liang S.","year":"2023","unstructured":"Liang S. 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