{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T20:52:08Z","timestamp":1781643128691,"version":"3.54.5"},"reference-count":46,"publisher":"American Association for the Advancement of Science (AAAS)","license":[{"start":{"date-parts":[[2024,4,6]],"date-time":"2024-04-06T00:00:00Z","timestamp":1712361600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,6]],"date-time":"2024-04-06T00:00:00Z","timestamp":1712361600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T00:00:00Z","timestamp":1711324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005699","name":"Universit\u00e0 degli Studi del Piemonte Orientale Amedeo Avogadro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005699","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["csbj.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comput Struct Biotechnol J"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.csbj.2024.03.023","type":"journal-article","created":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T22:06:33Z","timestamp":1711749993000},"page":"1397-1407","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Impact of an irreversible \u03b2-galactosylceramidase inhibitor on the lipid profile of zebrafish embryos"],"prefix":"10.34133","volume":"23","author":[{"given":"Jessica","family":"Guerra","sequence":"first","affiliation":[{"name":"Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirella","family":"Belleri","sequence":"additional","affiliation":[{"name":"Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Paiardi","sequence":"additional","affiliation":[{"name":"Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy"},{"name":"Molecular and Cellular Modeling Group, Heidelberg Institute for Theoretical Studies, Germany"},{"name":"Zentrum f\u00fcr Molekulare Biologie der Universit\u00e4t Heidelberg (ZMBH), DKFZ-ZMBH Alliance, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Tobia","sequence":"additional","affiliation":[{"name":"Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Capoferri","sequence":"additional","affiliation":[{"name":"Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzia","family":"Corli","sequence":"additional","affiliation":[{"name":"Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Scalvini","sequence":"additional","affiliation":[{"name":"Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Ghirimoldi","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy"},{"name":"Center for Allergic and Autoimmune Diseases, University of Piemonte Orientale, Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello","family":"Manfredi","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy"},{"name":"Center for Allergic and Autoimmune Diseases, University of Piemonte Orientale, Novara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca C.","family":"Wade","sequence":"additional","affiliation":[{"name":"Molecular and Cellular Modeling Group, Heidelberg Institute for Theoretical Studies, Germany"},{"name":"Zentrum f\u00fcr Molekulare Biologie der Universit\u00e4t Heidelberg (ZMBH), DKFZ-ZMBH Alliance, Heidelberg, Germany"},{"name":"Interdisciplinary Center for Scientific Computing (IWR), Heidelberg University, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Presta","sequence":"additional","affiliation":[{"name":"Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy"},{"name":"Consorzio Interuniversitario Biotecnologie (CIB), Unit of Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Mignani","sequence":"additional","affiliation":[{"name":"Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","published-online":{"date-parts":[[2024,4,6]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2021.135841"},{"key":"e_1_3_6_3_2","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s13023-018-0766-x","article-title":"Consensus guidelines for newborn screening, diagnosis and treatment of infantile Krabbe disease","volume":"13","author":"Kwon J.M.","year":"2018","unstructured":"Kwon J.M., Matern D., Kurtzberg J., Wrabetz L., Gelb M.H., Wenger D.A. et al: Consensus guidelines for newborn screening, diagnosis and treatment of infantile Krabbe disease. Orphanet J Rare Dis 2018; 13: 30.","journal-title":"Orphanet J Rare Dis"},{"key":"e_1_3_6_4_2","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1182\/blood.2020005477","article-title":"Long-term neurodevelopmental outcomes of hematopoietic stem cell transplantation for late-infantile Krabbe disease","volume":"137","author":"Yoon I.C.","year":"2021","unstructured":"Yoon I.C., Bascou N.A., Poe M.D., Szabolcs P. and Escolar M.L.: Long-term neurodevelopmental outcomes of hematopoietic stem cell transplantation for late-infantile Krabbe disease. Blood 2021; 137: 1719.","journal-title":"Blood"},{"key":"e_1_3_6_5_2","doi-asserted-by":"crossref","first-page":"20097","DOI":"10.1073\/pnas.1912108116","article-title":"Genetic ablation of acid ceramidase in Krabbe disease confirms the psychosine hypothesis and identifies a new therapeutic target","volume":"116","author":"Li Y.","year":"2019","unstructured":"Li Y., Xu Y., Benitez B.A., Nagree M.S., Dearborn J.T., Jiang X. et al: Genetic ablation of acid ceramidase in Krabbe disease confirms the psychosine hypothesis and identifies a new therapeutic target. Proc Natl Acad Sci USA 2019; 116: 20097.","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_6_6_2","first-page":"3","article-title":"Krabbe disease: a personal perspective and hypothesis","volume":"12","author":"Rafi M.A.","year":"2022","unstructured":"Rafi M.A.: Krabbe disease: a personal perspective and hypothesis. Bioimpacts 2022; 12: 3.","journal-title":"Bioimpacts"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.1995.tb00601.x"},{"key":"e_1_3_6_8_2","doi-asserted-by":"crossref","first-page":"4747","DOI":"10.3390\/ijms24054747","article-title":"Zebra-Sphinx: modeling sphingolipidoses in zebrafish","volume":"24","author":"Mignani L.","year":"2023","unstructured":"Mignani L., Guerra J., Corli M., Capoferri D. and Presta M.: Zebra-Sphinx: modeling sphingolipidoses in zebrafish. Int J Mol Sci 2023; 24: 4747.","journal-title":"Int J Mol Sci"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2014.01.008"},{"key":"e_1_3_6_10_2","first-page":"407","article-title":"Ultrastructural findings in 9 fetuses following prenatal diagnosis of neurolipidoses","volume":"232","author":"Suchlandt G.","year":"1982","unstructured":"Suchlandt G., Schlote W. and Harzer K.: Ultrastructural findings in 9 fetuses following prenatal diagnosis of neurolipidoses. Arch Psychiatr Nervenkr (1970) 1982; 232: 407.","journal-title":"Arch Psychiatr Nervenkr (1970)"},{"key":"e_1_3_6_11_2","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/BF00689987","article-title":"Fetal Krabbe leukodystrophy. A morphologic study of two cases","volume":"53","author":"Martin J.J.","year":"1981","unstructured":"Martin J.J., Leroy J.G., Ceuterick C., Libert J., Dodinval P. and Martin L.: Fetal Krabbe leukodystrophy. A morphologic study of two cases. Acta Neuropathol 1981; 53: 87.","journal-title":"Acta Neuropathol"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201600561"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky427"},{"key":"e_1_3_6_14_2","doi-asserted-by":"crossref","first-page":"20479","DOI":"10.1073\/pnas.1311990110","article-title":"Structural snapshots illustrate the catalytic cycle of \u03b2-galactocerebrosidase, the defective enzyme in Krabbe disease","volume":"110","author":"Hill C.H.","year":"2013","unstructured":"Hill C.H., Graham S.C., Read R.J. and Deane J.E.: Structural snapshots illustrate the catalytic cycle of \u03b2-galactocerebrosidase, the defective enzyme in Krabbe disease. Proc Natl Acad Sci USA 2013; 110: 20479.","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_6_15_2","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41467-017-02361-y","article-title":"The mechanism of glycosphingolipid degradation revealed by a GALC-SapA complex structure","volume":"9","author":"Hill C.H.","year":"2018","unstructured":"Hill C.H., Cook G.M., Spratley S.J., Fawke S., Graham S.C. and Deane J.E.: The mechanism of glycosphingolipid degradation revealed by a GALC-SapA complex structure. 11 Nat Commun 2018; 9: 151.","journal-title":"Nat Commun"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/pro.3330"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10822-013-9644-8"},{"key":"e_1_3_6_18_2","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/s10822-007-9133-z","article-title":"Epik: a software program for pKaprediction and protonation state generation for drug-like molecules","volume":"21","author":"Shelley J.C.","year":"2007","unstructured":"Shelley J.C., Cholleti A., Frye L.L., Greenwood J.R., Timlin M.R. and Uchimaya M.: Epik: a software program for pKaprediction and protonation state generation for drug-like molecules. J Comput Aided Mol Des 2007; 21: 681.","journal-title":"J Comput Aided Mol Des"},{"key":"e_1_3_6_19_2","unstructured":"Case D.A. Ben-Shalom I.Y. Brozell S.R. Cerutti D.S. Cheatham T.E.I.I.I. Cruzeiro V.W.D. \u00a0et al. 2018. AMBER 18. San Francisco CA USA: University of California."},{"key":"e_1_3_6_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.5b00255"},{"key":"e_1_3_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20035"},{"key":"e_1_3_6_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.10128"},{"key":"e_1_3_6_23_2","doi-asserted-by":"publisher","DOI":"10.1063\/1.445869"},{"key":"e_1_3_6_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0263-7855(96)00018-5"},{"key":"e_1_3_6_25_2","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1517\/17460441.2015.1032936","article-title":"The MM\/PBSA and MM\/GBSA methods to estimate ligand-binding affinities","volume":"10","author":"Genheden S.","year":"2015","unstructured":"Genheden S. and Ryde U.: The MM\/PBSA and MM\/GBSA methods to estimate ligand-binding affinities. Expert Opin Drug Discov 2015; 10: 449.","journal-title":"Expert Opin Drug Discov"},{"key":"e_1_3_6_26_2","volume-title":"The zebrafish book. A guide for the laboratory use of zebrafish (Danio rerio)","author":"Westerfield M.","year":"1995","unstructured":"Westerfield M.: The zebrafish book. A guide for the laboratory use of zebrafish (Danio rerio). Eugene: University of Oregon Press, 1995."},{"key":"e_1_3_6_27_2","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0361-9230(01)00694-3","article-title":"Expression domains of neuroD (nrd) in the early postembryonic zebrafish brain","volume":"57","author":"Mueller T.","year":"2002","unstructured":"Mueller T. and Wullimann M.F.: Expression domains of neuroD (nrd) in the early postembryonic zebrafish brain. Brain Res Bull 2002; 57: 377.","journal-title":"Brain Res Bull"},{"key":"e_1_3_6_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1002030302"},{"key":"e_1_3_6_29_2","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0009-3084(90)90042-P","article-title":"Synthesis, spectral properties and enzymatic hydrolysis of fluorescent derivatives of cerebroside sulfate containing long-wavelength-emission probes","volume":"53","author":"Marchesini S.","year":"1990","unstructured":"Marchesini S., Preti A., Aleo M.F., Casella A., Dagan A. and Gatt S.: Synthesis, spectral properties and enzymatic hydrolysis of fluorescent derivatives of cerebroside sulfate containing long-wavelength-emission probes. Chem Phys Lipids 1990; 53: 165.","journal-title":"Chem Phys Lipids"},{"key":"e_1_3_6_30_2","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1168455","article-title":"Immunometabolic interference between cancer and COVID-19","volume":"14","author":"Consonni F.M.","year":"2023","unstructured":"Consonni F.M., Durante B., Manfredi M., Bleve A., Pandolfo C., Garlatti V. et al: Immunometabolic interference between cancer and COVID-19. Front Immunol 2023; 14: 1168455.","journal-title":"Front Immunol"},{"key":"e_1_3_6_31_2","first-page":"25","article-title":"Modulating lysosomal pH: a molecular and nanoscale materials design perspective","volume":"2","author":"Zeng J.","year":"2020","unstructured":"Zeng J., Shirihai O.S. and Grinstaff M.W.: Modulating lysosomal pH: a molecular and nanoscale materials design perspective. J Life Sci 2020; 2: 25.","journal-title":"J Life Sci"},{"key":"e_1_3_6_32_2","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.28022.1"},{"key":"e_1_3_6_33_2","doi-asserted-by":"publisher","DOI":"10.1021\/ar000033j"},{"key":"e_1_3_6_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.01.016"},{"key":"e_1_3_6_35_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-19-3382"},{"key":"e_1_3_6_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2021.152844"},{"key":"e_1_3_6_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(80)90159-6"},{"key":"e_1_3_6_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2008.06.012"},{"key":"e_1_3_6_39_2","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1002\/jnr.23789","article-title":"Metabolic profiling reveals biochemical pathways and potential biomarkers associated with the pathogenesis of Krabbe disease","volume":"94","author":"Weinstock N.I.","year":"2016","unstructured":"Weinstock N.I., Wrabetz L., Feltri M.L. and Shin D.: Metabolic profiling reveals biochemical pathways and potential biomarkers associated with the pathogenesis of Krabbe disease. J Neurosci Res 2016; 94: 1094.","journal-title":"J Neurosci Res"},{"key":"e_1_3_6_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2017.01.002"},{"key":"e_1_3_6_41_2","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1182\/blood-2009-12-256461","article-title":"The galactocerebrosidase enzyme contributes to the maintenance of a functional hematopoietic stem cell niche","volume":"116","author":"Visigalli I.","year":"2010","unstructured":"Visigalli I., Ungari S., Martino S., Park H., Cesani M., Gentner B. et al: The galactocerebrosidase enzyme contributes to the maintenance of a functional hematopoietic stem cell niche. Blood 2010; 116: 1857.","journal-title":"Blood"},{"key":"e_1_3_6_42_2","first-page":"779","article-title":"Sphingolipid profile in the CNS of the twitcher (globoid cell leukodystrophy) mouse: a lipidomics approach","volume":"49","author":"Esch S.W.","year":"2003","unstructured":"Esch S.W., Williams T.D., Biswas S., Chakrabarty A. and LeVine S.M.: Sphingolipid profile in the CNS of the twitcher (globoid cell leukodystrophy) mouse: a lipidomics approach. Cell Mol Biol 2003; 49: 779.","journal-title":"Cell Mol Biol"},{"key":"e_1_3_6_43_2","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/dvdy.23913","article-title":"Identification and expression analysis of the zebrafish homologs of the ceramide synthase gene family","volume":"242","author":"Brondolin M.","year":"2013","unstructured":"Brondolin M., Berger S., Reinke M., Tanaka H., Ohshima T., Fu\u03b2 B. et al: Identification and expression analysis of the zebrafish homologs of the ceramide synthase gene family. Dev Dyn 2013; 242: 189.","journal-title":"Dev Dyn"},{"key":"e_1_3_6_44_2","article-title":"Ceramide acyl chain length and its relevance to intracellular lipid regulation","volume":"23","author":"Ho Q.W.C.","year":"2022","unstructured":"Ho Q.W.C., Zheng X. and Ali Y.: Ceramide acyl chain length and its relevance to intracellular lipid regulation. Int J Mol Sci 2022; 23.","journal-title":"Int J Mol Sci"},{"key":"e_1_3_6_45_2","doi-asserted-by":"crossref","first-page":"12528","DOI":"10.1039\/C7CC07730K","article-title":"Towards broad spectrum activity-based glycosidase probes: synthesis and evaluation of deoxygenated cyclophellitol aziridines","volume":"53","author":"Schr\u00f6der S.P.","year":"2017","unstructured":"Schr\u00f6der S.P., van de Sande J.W., Kallemeijn W.W., Kuo C.L., Artola M., van Rooden E.J. et al: Towards broad spectrum activity-based glycosidase probes: synthesis and evaluation of deoxygenated cyclophellitol aziridines. Chem Commun 2017; 53: 12528.","journal-title":"Chem Commun"},{"key":"e_1_3_6_46_2","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1093\/hmg\/9.11.1699","article-title":"Paradoxical influence of acid \u03b2-galactosidase gene dosage on phenotype of the twitcher mouse (genetic galactosylceramidase deficiency)","volume":"9","author":"Tohyama J.","year":"2000","unstructured":"Tohyama J., Vanier A.T., Suzuki K., Ezoe T., Matsuda J. and Suzuki K.: Paradoxical influence of acid \u03b2-galactosidase gene dosage on phenotype of the twitcher mouse (genetic galactosylceramidase deficiency). Hum Mol Genet 2000; 9: 1699.","journal-title":"Hum Mol Genet"},{"key":"e_1_3_6_47_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2021.188675","article-title":"Oncosuppressive and oncogenic activity of the sphingolipid-metabolizing enzyme \u03b2-galactosylceramidase","volume":"1877","author":"Belleri M.","year":"2022","unstructured":"Belleri M., Chiodelli P., Corli M., Capra M. and Presta M.: Oncosuppressive and oncogenic activity of the sphingolipid-metabolizing enzyme \u03b2-galactosylceramidase. Biochim Biophys Acta Rev Cancer 2022; 1877: 188675.","journal-title":"Biochim Biophys Acta Rev Cancer"}],"container-title":["Computational and Structural Biotechnology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S200103702400076X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S200103702400076X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/spj.science.org\/doi\/pdf\/10.1016\/j.csbj.2024.03.023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T19:57:41Z","timestamp":1781639861000},"score":1,"resource":{"primary":{"URL":"https:\/\/spj.science.org\/doi\/10.1016\/j.csbj.2024.03.023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,6]]},"references-count":46,"alternative-id":["10.1016\/j.csbj.2024.03.023"],"URL":"https:\/\/doi.org\/10.1016\/j.csbj.2024.03.023","relation":{},"ISSN":["2001-0370"],"issn-type":[{"value":"2001-0370","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of an irreversible \u03b2-galactosylceramidase inhibitor on the lipid profile of zebrafish embryos","name":"articletitle","label":"Article Title"},{"value":"Computational and Structural Biotechnology Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.csbj.2024.03.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology.","name":"copyright","label":"Copyright"}]}}