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But its effect on pregnancy related outcomes still remains unclear. Here we conducted a two-sample Mendelian randomization (MR) study to ascertain the putative causal roles of protein levels of BGAT in pregnancy related outcomes.\n                    <jats:italic toggle=\"yes\">Cis<\/jats:italic>\n                    -acting protein quantitative trait loci (pQTLs) robustly associated with protein level of BGAT (P\u00a0&lt;\u00a05\u00a0\u00d710\n                    <jats:sup>\u22128<\/jats:sup>\n                    ) were used as instruments to proxy the BGAT protein level (N\u00a0=\u00a035,559, data from deCODE), with two additional pQTL datasets from Fenland (N\u00a0=\u00a010,708) and INTERVAL (N\u00a0=\u00a03301) used as validation exposures. Ten pregnancy related diseases and complications were selected as outcomes. We observed that a higher protein level of BGAT showed a putative causal effect on venous complications and haemorrhoids in pregnancy (VH) (odds ratio [OR]=1.19, 95% confidence interval [95% CI]=1.12\u20131.27, colocalization probability=91%), which was validated by using pQTLs from Fenland and INTERVAL. The Mendelian randomization results further showed effects of the BGAT protein on gestational hypertension (GH) (OR=0.97, 95% CI=0.96\u20130.99), despite little colocalization evidence to support it. Sensitivity analyses, including proteome-wide Mendelian randomization of the\n                    <jats:italic toggle=\"yes\">cis<\/jats:italic>\n                    -acting BGAT pQTLs, showed little evidence of horizontal pleiotropy. Correctively, our study prioritised BGAT as a putative causal protein for venous complications and haemorrhoids in pregnancy. Future epidemiology and clinical studies are needed to investigate whether BGAT can be considered as a drug target to prevent adverse pregnancy outcomes.\n                  <\/jats:p>","DOI":"10.1016\/j.csbj.2024.04.040","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T11:55:03Z","timestamp":1714391703000},"page":"2067-2075","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["The effect of histo-blood group ABO system transferase (BGAT) on pregnancy related outcomes\uff1aA Mendelian randomization study"],"prefix":"10.34133","volume":"23","author":[{"given":"Yuqi","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"},{"name":"College of Health Science and Technology,Shanghai Jiao Tong 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