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This analysis has facilitated the validation of novel pathogenesis hypotheses for understanding and treating diseases through\n                    <jats:italic toggle=\"yes\">ex vivo<\/jats:italic>\n                    and in vivo experiments. Androgenetic alopecia (AGA), a common hair loss disorder, has been a key focus of investigators attempting to uncover its underlying mechanisms. Abnormal changes in mRNA, proteins, and metabolites have been identified in individuals with AGA, and future developments in sequencing technologies may reveal new biomarkers for AGA. By integrating multiple omics analysis datasets such as genomics, transcriptomics, proteomics, and metabolomics\u2014along with clinical phenotype data\u2014we can achieve a comprehensive understanding of the molecular underpinnings of AGA. This review summarizes the data-mining studies conducted on various omics analysis datasets as related to AGA that have been adopted to interpret the biological data obtained from different omics layers. We herein discuss the challenges of integrative omics analyses, and suggest that collaborative multi-omics studies can enhance the understanding of the complete pathomechanism(s) of AGA by focusing on the interaction networks comprising DNA, RNA, proteins, and metabolites.\n                  <\/jats:p>","DOI":"10.1016\/j.csbj.2024.06.026","type":"journal-article","created":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T12:39:33Z","timestamp":1718887173000},"page":"2623-2636","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Application of multi-omics techniques to androgenetic alopecia: Current status and perspectives"],"prefix":"10.34133","volume":"23","author":[{"given":"Yujie","family":"Li","sequence":"first","affiliation":[{"name":"Hangzhou Third Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou 310009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingru","family":"Dong","sequence":"additional","affiliation":[{"name":"Hangzhou Third Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou 310009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Wan","sequence":"additional","affiliation":[{"name":"Hangzhou Third Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou 310009, China"},{"name":"Department of Dermatology, Hangzhou Third People's Hospital, Hangzhou 310009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renxue","family":"Xiong","sequence":"additional","affiliation":[{"name":"Hangzhou Third Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou 310009, China"},{"name":"Department of Dermatology, Hangzhou Third People's Hospital, Hangzhou 310009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyu","family":"Jin","sequence":"additional","affiliation":[{"name":"Hangzhou Third Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou 310009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeqin","family":"Dai","sequence":"additional","affiliation":[{"name":"Hangzhou Third Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou 310009, China"},{"name":"Department of Dermatology, Hangzhou Third People's Hospital, Hangzhou 310009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuiping","family":"Guan","sequence":"additional","affiliation":[{"name":"Hangzhou Third Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou 310009, China"},{"name":"Department of Dermatology, Hangzhou Third People's Hospital, Hangzhou 310009, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","published-online":{"date-parts":[[2024,6,20]]},"reference":[{"issue":"8","key":"e_1_4_2_2_2","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1517\/14656561003752730","article-title":"Male androgenetic alopecia","volume":"11","author":"Rathnayake D.","year":"2010","unstructured":"Rathnayake D. 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