{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T04:14:14Z","timestamp":1793333654071,"version":"4.5.0"},"reference-count":198,"publisher":"American Association for the Advancement of Science (AAAS)","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T00:00:00Z","timestamp":1746489600000},"content-version":"vor","delay-in-days":125,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017614","name":"Xi'an Medical University","doi-asserted-by":"publisher","award":["2021TD15"],"award-info":[{"award-number":["2021TD15"]}],"id":[{"id":"10.13039\/501100017614","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008387","name":"Xi'an Science Technology Bureau","doi-asserted-by":"publisher","award":["24YXYJ0143"],"award-info":[{"award-number":["24YXYJ0143"]}],"id":[{"id":"10.13039\/501100008387","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009103","name":"Education Department of Shaanxi Provincial government","doi-asserted-by":"publisher","award":["XYFYPT-2023-04"],"award-info":[{"award-number":["XYFYPT-2023-04"]}],"id":[{"id":"10.13039\/501100009103","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009103","name":"Education Department of Shaanxi Provincial government","doi-asserted-by":"publisher","award":["24JC079"],"award-info":[{"award-number":["24JC079"]}],"id":[{"id":"10.13039\/501100009103","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007128","name":"Shaanxi Province Natural Science Foundation","doi-asserted-by":"publisher","award":["2023-YBSF-072"],"award-info":[{"award-number":["2023-YBSF-072"]}],"id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007128","name":"Shaanxi Province Natural Science Foundation","doi-asserted-by":"publisher","award":["2024JC-YBMS-664"],"award-info":[{"award-number":["2024JC-YBMS-664"]}],"id":[{"id":"10.13039\/501100007128","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013317","name":"Shanxi Provincial Key Research and Development Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013317","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015793","name":"Xi'an Medical University Affiliated Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015793","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["csbj.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Comput Struct Biotechnol J"],"published-print":{"date-parts":[[2025,1,1]]},"DOI":"10.1016\/j.csbj.2025.05.006","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T20:58:59Z","timestamp":1746737939000},"page":"1850-1863","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["New targets for the treatment of ulcerative colitis: Gut microbiota and its metabolites"],"prefix":"10.34133","volume":"27","author":[{"given":"Huanyu","family":"Li","sequence":"first","affiliation":[{"name":"Second Clinical Medical College, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712046, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Pan","sequence":"additional","affiliation":[{"name":"College of Basic Medical Sciences, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712046, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Li","sequence":"additional","affiliation":[{"name":"Second Clinical Medical College, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712046, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manli","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, the First Affiliated Hospital of Xi\u2019an Medical University, Xi\u2019an, Shaanxi 710077, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, the First Affiliated Hospital of Xi\u2019an Medical University, Xi\u2019an, Shaanxi 710077, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"221","published-online":{"date-parts":[[2025,5,9]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)32126-2"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)00966-2"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjy158"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-112-1-50"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.02.001"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60326-3"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2012.01.008"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0268-7"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1237-9"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2021.1990827"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-022-01275-2"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118878"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkl923"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.04.008"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijmm.IJMM_19_373"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.05.015"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/2049-2618-1-17"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22052506"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10330-022-0575-5"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-018-2943-4"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-111717-122956"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature06244"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.4161\/gmic.23362"},{"key":"e_1_3_3_25_2","first-page":"355","article-title":"Influence of the normal flora on mucosal morphology and cellular renewal in the ileum. A comparison of germ-free and conventional mice","volume":"12","author":"ABRAMS G.D.","year":"1963","unstructured":"ABRAMS G.D. and BAUER H.: Influence of the normal flora on mucosal morphology and cellular renewal in the ileum. A comparison of germ-free and conventional mice. (etc) Lab Investig 1963; 12: 355.","journal-title":"Lab Investig"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens8030126"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.12.015"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1159\/000230130"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni888"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2006.10.002"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1961.201.1.175"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1095-6433(99)00056-2"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1538\/expanim.45.155"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529609051994"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2007.09.006"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/134.2.479"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.05.005"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.05.041"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665120006916"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03562.x"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2012.06526.x"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17101696"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2021.1882927"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12726"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1241165"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2018.05.003"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf9794"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2016.07.002"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2018.00013"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.02.047"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.105"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.115.064246"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2018.01.011"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4106"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.105358"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07859-7"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00185"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-020-06715-3"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M209706200"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0006-291x(02)02550-0"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.284.5418.1365"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.051551698"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1097-2765(00)80348-2"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.119"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41395-018-0042-7"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2015.11.009"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2018.07.019"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.05.067"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.09.008"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00435.2016"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i9.923"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-020-06208-3"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6951091"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12328-017-0813-5"},{"key":"e_1_3_3_75_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.01835"},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/5854285"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2020.1803396"},{"key":"e_1_3_3_78_2","doi-asserted-by":"publisher","DOI":"10.1111\/1751-2980.12795"},{"key":"e_1_3_3_79_2","doi-asserted-by":"publisher","DOI":"10.3390\/biom12091321"},{"key":"e_1_3_3_80_2","doi-asserted-by":"publisher","DOI":"10.15403\/jgld-2823"},{"key":"e_1_3_3_81_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000002611"},{"key":"e_1_3_3_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2020.03.007"},{"key":"e_1_3_3_83_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-017-1384-4"},{"key":"e_1_3_3_84_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu14020260"},{"key":"e_1_3_3_85_2","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2022.2083419"},{"key":"e_1_3_3_86_2","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.00616-22"},{"key":"e_1_3_3_87_2","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2016.1190073"},{"key":"e_1_3_3_88_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2016.06.004"},{"key":"e_1_3_3_89_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12866-019-1610-8"},{"key":"e_1_3_3_90_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-018-0483-8"},{"key":"e_1_3_3_91_2","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000215"},{"key":"e_1_3_3_92_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2020.104707"},{"key":"e_1_3_3_93_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21176044"},{"key":"e_1_3_3_94_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.7"},{"key":"e_1_3_3_95_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.03.005"},{"key":"e_1_3_3_96_2","doi-asserted-by":"publisher","DOI":"10.1111\/1462-2920.13589"},{"key":"e_1_3_3_97_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3344"},{"key":"e_1_3_3_98_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2007.07.016"},{"key":"e_1_3_3_99_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i22.3404"},{"key":"e_1_3_3_100_2","doi-asserted-by":"publisher","DOI":"10.1002\/biot.201800555"},{"key":"e_1_3_3_101_2","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izy182"},{"key":"e_1_3_3_102_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00279.2020"},{"key":"e_1_3_3_103_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-07594-6"},{"key":"e_1_3_3_104_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/9706140"},{"key":"e_1_3_3_105_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-019-0258-z"},{"key":"e_1_3_3_106_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.08.028"},{"key":"e_1_3_3_107_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-016-1242-9"},{"key":"e_1_3_3_108_2","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2020.1865708"},{"key":"e_1_3_3_109_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302578"},{"key":"e_1_3_3_110_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2020.01.021"},{"key":"e_1_3_3_111_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00564"},{"key":"e_1_3_3_112_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.10.012"},{"key":"e_1_3_3_113_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.04.001"},{"key":"e_1_3_3_114_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2016.02.005"},{"key":"e_1_3_3_115_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2017.08.006"},{"key":"e_1_3_3_116_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.01.069"},{"key":"e_1_3_3_117_2","doi-asserted-by":"publisher","DOI":"10.21037\/tgh.2019.06.04"},{"key":"e_1_3_3_118_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(89)91183-5"},{"key":"e_1_3_3_119_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2012.08.008"},{"key":"e_1_3_3_120_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e318292fa0d"},{"key":"e_1_3_3_121_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0000000000000544"},{"key":"e_1_3_3_122_2","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2019-233135"},{"key":"e_1_3_3_123_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-019-1010-4"},{"key":"e_1_3_3_124_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.12.032"},{"key":"e_1_3_3_125_2","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjx063"},{"key":"e_1_3_3_126_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2013.10.002"},{"key":"e_1_3_3_127_2","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2013.117"},{"key":"e_1_3_3_128_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2014.07.016"},{"key":"e_1_3_3_129_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu8040202"},{"key":"e_1_3_3_130_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.03.045"},{"key":"e_1_3_3_131_2","doi-asserted-by":"publisher","DOI":"10.1038\/ismej.2017.44"},{"key":"e_1_3_3_132_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-016-1271-4"},{"key":"e_1_3_3_133_2","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000975"},{"key":"e_1_3_3_134_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.20046"},{"key":"e_1_3_3_135_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.12.001"},{"key":"e_1_3_3_136_2","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjz060"},{"key":"e_1_3_3_137_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106661"},{"key":"e_1_3_3_138_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2022-327811"},{"key":"e_1_3_3_139_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-022-03569-3"},{"key":"e_1_3_3_140_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.1086885"},{"key":"e_1_3_3_141_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v29.i17.2666"},{"key":"e_1_3_3_142_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10112466"},{"key":"e_1_3_3_143_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.02259"},{"key":"e_1_3_3_144_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-75702-5"},{"key":"e_1_3_3_145_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu14194113"},{"key":"e_1_3_3_146_2","doi-asserted-by":"publisher","DOI":"10.2165\/00063030-200721010-00007"},{"key":"e_1_3_3_147_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/137.3.803S"},{"key":"e_1_3_3_148_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1127059"},{"key":"e_1_3_3_149_2","doi-asserted-by":"publisher","DOI":"10.4161\/gmic.25487"},{"key":"e_1_3_3_150_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.crohns.2014.06.001"},{"key":"e_1_3_3_151_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i19.5985"},{"key":"e_1_3_3_152_2","doi-asserted-by":"publisher","DOI":"10.1111\/den.12553"},{"key":"e_1_3_3_153_2","doi-asserted-by":"publisher","DOI":"10.5507\/bp.2016.044"},{"key":"e_1_3_3_154_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-018-4946-2"},{"key":"e_1_3_3_155_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-019-00595-4"},{"key":"e_1_3_3_156_2","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2021.458"},{"key":"e_1_3_3_157_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-023-03207-8"},{"key":"e_1_3_3_158_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.75"},{"key":"e_1_3_3_159_2","doi-asserted-by":"publisher","DOI":"10.1136\/egastro-2023-100012"},{"key":"e_1_3_3_160_2","doi-asserted-by":"publisher","DOI":"10.1136\/egastro-2023-100055"},{"key":"e_1_3_3_161_2","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/125.6.1401"},{"key":"e_1_3_3_162_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00052.2006"},{"key":"e_1_3_3_163_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.104985"},{"key":"e_1_3_3_164_2","doi-asserted-by":"publisher","DOI":"10.2174\/1381612053381675"},{"key":"e_1_3_3_165_2","doi-asserted-by":"publisher","DOI":"10.1258\/acb.2010.010093"},{"key":"e_1_3_3_166_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00277"},{"key":"e_1_3_3_167_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-020-01219-0"},{"key":"e_1_3_3_168_2","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1769"},{"key":"e_1_3_3_169_2","doi-asserted-by":"publisher","DOI":"10.1002\/INMD.20220007"},{"key":"e_1_3_3_170_2","doi-asserted-by":"publisher","DOI":"10.1002\/INMD.20230029"},{"key":"e_1_3_3_171_2","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000003413"},{"key":"e_1_3_3_172_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.42284"},{"key":"e_1_3_3_173_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c07924"},{"key":"e_1_3_3_174_2","doi-asserted-by":"publisher","DOI":"10.4161\/viru.2.5.17035"},{"key":"e_1_3_3_175_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2016.08.044"},{"key":"e_1_3_3_176_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2019.10.008"},{"key":"e_1_3_3_177_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2014.10.001"},{"key":"e_1_3_3_178_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2021.12.022"},{"key":"e_1_3_3_179_2","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202113034"},{"key":"e_1_3_3_180_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2016.11.066"},{"key":"e_1_3_3_181_2","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202104089"},{"key":"e_1_3_3_182_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2018.04.045"},{"key":"e_1_3_3_183_2","doi-asserted-by":"publisher","DOI":"10.3109\/02652048.2013.770099"},{"key":"e_1_3_3_184_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-013-0836-8"},{"key":"e_1_3_3_185_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0185999"},{"key":"e_1_3_3_186_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-018-0415-5"},{"key":"e_1_3_3_187_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.05.012"},{"key":"e_1_3_3_188_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.9b02391"},{"key":"e_1_3_3_189_2","doi-asserted-by":"publisher","DOI":"10.1039\/d0nr03037f"},{"key":"e_1_3_3_190_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.53105"},{"key":"e_1_3_3_191_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.644387"},{"key":"e_1_3_3_192_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.1c09215"},{"key":"e_1_3_3_193_2","doi-asserted-by":"publisher","DOI":"10.1039\/d1bm01765a"},{"key":"e_1_3_3_194_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.121077"},{"key":"e_1_3_3_195_2","doi-asserted-by":"publisher","DOI":"10.7150\/thno.73650"},{"key":"e_1_3_3_196_2","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abp8798"},{"key":"e_1_3_3_197_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-023-02065-0"},{"key":"e_1_3_3_198_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.3c02128"},{"key":"e_1_3_3_199_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.127987"}],"container-title":["Computational and Structural Biotechnology Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2001037025001692?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2001037025001692?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/spj.science.org\/doi\/pdf\/10.1016\/j.csbj.2025.05.006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T12:32:27Z","timestamp":1775219547000},"score":1,"resource":{"primary":{"URL":"https:\/\/spj.science.org\/doi\/10.1016\/j.csbj.2025.05.006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,1]]},"references-count":198,"alternative-id":["10.1016\/j.csbj.2025.05.006"],"URL":"https:\/\/doi.org\/10.1016\/j.csbj.2025.05.006","relation":{},"ISSN":["2001-0370"],"issn-type":[{"value":"2001-0370","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"New targets for the treatment of ulcerative colitis: Gut microbiota and its metabolites","name":"articletitle","label":"Article Title"},{"value":"Computational and Structural Biotechnology Journal","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.csbj.2025.05.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology.","name":"copyright","label":"Copyright"}]}}